#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ULX6	uniprotkb:Q68DV7	intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym)	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647059|imex:IM-20017-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	-	-	-	comment:"The authors state that their RNF43 cDNA clone contains two differences from the predicted protein sequence for NM_017763 (which is the same as Q68DV7): Ile47Val and Arg11His."|author-identifiers:BAIT gene NM_017763|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2008/03/10	2018/09/18	rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	intact-crc:6F64955867623CF6|rigid:qmTqlGnYwaCc87lV6nuDqkdBd3w	false	-	sufficient binding region:246-520	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ULX6	uniprotkb:Q68DV7	intact:EBI-357530|uniprotkb:O94792|uniprotkb:Q96J58|uniprotkb:Q9NRQ0|uniprotkb:Q9UGM0|uniprotkb:B5BU90|uniprotkb:B4DJ74|ensembl:ENSP00000380557	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	psi-mi:akp8l_human(display_long)|uniprotkb:AKAP8L(gene name)|psi-mi:AKAP8L(display_short)|uniprotkb:HRIHFB2018(orf name)|uniprotkb:NAKAP95(gene name synonym)|uniprotkb:Neighbor of A-kinase-anchoring protein 95(gene name synonym)|uniprotkb:Homologous to AKAP95 protein(gene name synonym)|uniprotkb:Helicase A-binding protein 95(gene name synonym)|uniprotkb:NAKAP(gene name synonym)	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647092|imex:IM-20017-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278407.1|refseq:NP_055186.3|dip:DIP-27541N|ensembl:ENSG00000011243(gene)|ensembl:ENST00000397410(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0033127"(regulation of histone phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044839"(cell cycle G2/M phase transition)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007071("A-kinase anchoring protein 95 (AKAP95)")|interpro:IPR034736|mint:Q9ULX6	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	-	-	-	figure legend:6 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/10	2018/09/18	rogid:SAs8jxuWxLOiWN/TRyjVvr5m/5Y9606	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	intact-crc:785EA48FF9DDEEC0|rigid:qmTqlGnYwaCc87lV6nuDqkdBd3w	false	ha tag:?-?	v5 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q68DV7	uniprotkb:P0CG47	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647301|imex:IM-20017-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	-	-	-	figure legend:3 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:A84B43C185F94970|rigid:PbqcvvDbJf1jFh6E/BURsuHA0Hw	false	v5 tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P0CG47	uniprotkb:Q68DV7	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1766264|imex:IM-20017-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	-	-	-	figure legend:3 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2008/03/10	2014/10/16	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	intact-crc:C5E6A34814732EAD|rigid:PbqcvvDbJf1jFh6E/BURsuHA0Hw	false	ha tag:?-?	flag tag:?-?|mutation:290-290,292-292	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q68DV7	uniprotkb:Q68DV7	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647320|imex:IM-20017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	go:"GO:0051865"(protein autoubiquitination)	-	-	figure legend:5|resulting-ptm:RNF43 is autoubiquitinated.|inhibition:TPEN - The presence of the metal chelating inhibitor TPEN resulted in the loss of polyubiquitination.|comment:The autoubiqutination of RNF43 was shown to be RING finger-dependent, as the mutations in this domain compromised autoubiqutination activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	intact-crc:7CE9EE35E6F9CD3B|rigid:/wjGdX3gQTiVR6x/uw3QdPtriBk	false	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q68DV7	uniprotkb:P62837	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-347677|uniprotkb:P51669|uniprotkb:Q3MN78|uniprotkb:D3DQC9|uniprotkb:Q96RP6|ensembl:ENSP00000381717|ensembl:ENSP00000381718	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:ub2d2_human(display_long)|uniprotkb:UBC5B(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 2(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 2"(gene name synonym)|uniprotkb:PUBC1(gene name synonym)|uniprotkb:p53-regulated ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647320|imex:IM-20017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	refseq:NP_003330.1|refseq:NP_862821.1|dip:DIP-29267N|ensembl:ENSG00000131508(gene)|ensembl:ENST00000398733(transcript)|ensembl:ENST00000398734(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P62837|rcsb pdb:1UR6|rcsb pdb:1W4U|rcsb pdb:2CLW|rcsb pdb:2ESK|rcsb pdb:2ESO|rcsb pdb:2ESP|rcsb pdb:2ESQ|rcsb pdb:3A33|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3L1Y|rcsb pdb:3TGD|rcsb pdb:3ZNI|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4AUQ|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4LDT|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZ3|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5D1K|rcsb pdb:5D1L|rcsb pdb:5D1M|rcsb pdb:5EDV|rcsb pdb:5MNJ|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5VZW|rcsb pdb:5ZBU|rcsb pdb:6HPR|rcsb pdb:6M2C|rcsb pdb:6SQO|rcsb pdb:6SQR|rcsb pdb:6SQS|rcsb pdb:6TTU|rcsb pdb:6W7Z|rcsb pdb:6W9D|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BOL|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168	go:"GO:0051865"(protein autoubiquitination)	-	-	figure legend:5|resulting-ptm:RNF43 is autoubiquitinated.|inhibition:TPEN - The presence of the metal chelating inhibitor TPEN resulted in the loss of polyubiquitination.|comment:The autoubiqutination of RNF43 was shown to be RING finger-dependent, as the mutations in this domain compromised autoubiqutination activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9606	intact-crc:7CE9EE35E6F9CD3B|rigid:/wjGdX3gQTiVR6x/uw3QdPtriBk	false	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	his tag:?-?|his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q68DV7	uniprotkb:Q29504	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-975625	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:uba1_rabit(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647320|imex:IM-20017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR042302|refseq:NP_001075840.1|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018965|interpro:IPR019572|interpro:IPR018075|interpro:IPR018074|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR038252|interpro:IPR033127|interpro:IPR032418|interpro:IPR032420|interpro:IPR042449|interpro:IPR035985|interpro:IPR042063	go:"GO:0051865"(protein autoubiquitination)	-	-	figure legend:5|resulting-ptm:RNF43 is autoubiquitinated.|inhibition:TPEN - The presence of the metal chelating inhibitor TPEN resulted in the loss of polyubiquitination.|comment:The autoubiqutination of RNF43 was shown to be RING finger-dependent, as the mutations in this domain compromised autoubiqutination activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:kBSF1JlX6FGGw2Fs4klp7fFz5cQ9986	intact-crc:7CE9EE35E6F9CD3B|rigid:/wjGdX3gQTiVR6x/uw3QdPtriBk	false	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q68DV7	uniprotkb:Q68DV7	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647344|imex:IM-20017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	go:"GO:0051865"(protein autoubiquitination)	-	-	figure legend:5|resulting-ptm:RNF43 is autoubiquitinated.|inhibition:TPEN - The presence of the metal chelating inhibitor TPEN resulted in the loss of polyubiquitination.|comment:The autoubiqutination of RNF43 was shown to be RING finger-dependent, as the mutations in this domain compromised autoubiqutination activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	intact-crc:EF740237B62FA348|rigid:/8AwD3rJ/5llCYwQjx2DucCAiSw	false	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q68DV7	uniprotkb:P61077	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647344|imex:IM-20017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	go:"GO:0051865"(protein autoubiquitination)	-	-	figure legend:5|resulting-ptm:RNF43 is autoubiquitinated.|inhibition:TPEN - The presence of the metal chelating inhibitor TPEN resulted in the loss of polyubiquitination.|comment:The autoubiqutination of RNF43 was shown to be RING finger-dependent, as the mutations in this domain compromised autoubiqutination activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	intact-crc:EF740237B62FA348|rigid:/8AwD3rJ/5llCYwQjx2DucCAiSw	false	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q68DV7	uniprotkb:Q29504	intact:EBI-1647060|uniprotkb:Q65ZA4|uniprotkb:Q6AI04|uniprotkb:Q9NXD0|uniprotkb:A8K4R2|uniprotkb:B7Z443|uniprotkb:B7Z5D5|uniprotkb:B7Z5J5|ensembl:ENSP00000462764|ensembl:ENSP00000463069|ensembl:ENSP00000385328	intact:EBI-975625	psi-mi:rnf43_human(display_long)|uniprotkb:RNF43(gene name)|psi-mi:RNF43(display_short)|uniprotkb:RING finger protein 43(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF43(gene name synonym)	psi-mi:uba1_rabit(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Sugiura et al. (2008)	pubmed:18313049|imex:IM-20017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647344|imex:IM-20017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060233.3|refseq:NP_001292473.1|refseq:NP_001292474.1|refseq:XP_011523257.1|refseq:XP_016880289.1|ensembl:ENSG00000108375(gene)|reactome:R-HSA-4641263|reactome:R-HSA-5340588|ensembl:ENST00000407977(transcript)|ensembl:ENST00000577716(transcript)|ensembl:ENST00000584437(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|rcsb pdb:4KNG	go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|interpro:IPR042302|refseq:NP_001075840.1|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018965|interpro:IPR019572|interpro:IPR018075|interpro:IPR018074|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR038252|interpro:IPR033127|interpro:IPR032418|interpro:IPR032420|interpro:IPR042449|interpro:IPR035985|interpro:IPR042063	go:"GO:0051865"(protein autoubiquitination)	-	-	figure legend:5|resulting-ptm:RNF43 is autoubiquitinated.|inhibition:TPEN - The presence of the metal chelating inhibitor TPEN resulted in the loss of polyubiquitination.|comment:The autoubiqutination of RNF43 was shown to be RING finger-dependent, as the mutations in this domain compromised autoubiqutination activity.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/03/10	2014/10/16	rogid:4+i7kH6zyDyZLFa91B4V/jjLrbo9606	rogid:kBSF1JlX6FGGw2Fs4klp7fFz5cQ9986	intact-crc:EF740237B62FA348|rigid:/8AwD3rJ/5llCYwQjx2DucCAiSw	false	mutation decreasing interaction:290-290,292-292|sufficient binding region:1-322|maltose binding protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)