#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53634	uniprotkb:O76096	intact:EBI-1047323|uniprotkb:A8K7V2|uniprotkb:Q53G93|uniprotkb:Q71E75|uniprotkb:Q71E76|uniprotkb:Q7M4N9|uniprotkb:Q8WY99|ensembl:ENSP00000227266|uniprotkb:Q8WYA7|uniprotkb:Q8WYA8|uniprotkb:Q7Z3G7|uniprotkb:Q7Z5U7|uniprotkb:B5MDD5|uniprotkb:Q2HIY8	intact:EBI-2807448|uniprotkb:Q6FH95|uniprotkb:Q9UED4|uniprotkb:Q7Z4J8|ensembl:ENSP00000420384	psi-mi:catc_human(display_long)|uniprotkb:Dipeptidyl peptidase I(gene name synonym)|uniprotkb:Cathepsin C(gene name synonym)|uniprotkb:Cathepsin J(gene name synonym)|uniprotkb:Dipeptidyl transferase(gene name synonym)|uniprotkb:CTSC(gene name)|psi-mi:CTSC(display_short)|uniprotkb:CPPI(gene name synonym)	psi-mi:cytf_human(display_long)|uniprotkb:CST7(gene name)|psi-mi:CST7(display_short)|uniprotkb:Cystatin-7(gene name synonym)|uniprotkb:Cystatin-like metastasis-associated protein(gene name synonym)|uniprotkb:Leukocystatin(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hamilton et al. (2008)	pubmed:18256700|imex:IM-11526|mint:MINT-6179675	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7802752|mint:MINT-6179696|imex:IM-11526-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:0031642"(negative regulation of myelination)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR014882(Cathepsin C exclusion)|interpro:IPR025660|interpro:IPR025661|interpro:IPR036496|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035578"(azurophil granule lumen)|interpro:IPR038765|interpro:IPR039412|mint:P53634|rcsb pdb:1K3B|go:"GO:0042802"(identical protein binding)|rcsb pdb:2DJF|rcsb pdb:2DJG|rcsb pdb:3PDF|rcsb pdb:4CDC|rcsb pdb:4CDD|rcsb pdb:4CDE|rcsb pdb:4CDF|rcsb pdb:4OEL|rcsb pdb:4OEM|reactome:R-HSA-204005|reactome:R-HSA-2132295|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-5694530|reactome:R-HSA-6798695|ensembl:ENSG00000109861(gene)|ensembl:ENST00000227266(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031404"(chloride ion binding)|refseq:NP_001805.3|refseq:NP_680475.1|refseq:NP_001107645.1|mint:MINT-6179699(identity)	refseq:NP_003641.3|ensembl:ENSG00000077984(gene)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|ensembl:ENST00000480798(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903979"(negative regulation of microglial cell activation)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR042886|mint:O76096|rcsb pdb:2CH9|mint:MINT-6179698(identity)	-	-	-	figure legend:f1a|comment:Interaction occurs also in YT cells.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha)	-	2008/02/15	2014/10/16	rogid:vA2MxBAxHODNS4fo9Nvm6UJGW149606	rogid:xNa8wSYNqctn1+5GA1bFyG9kk+k9606	intact-crc:40B09039CDCEE4B2|rigid:BzjDuOpU4CLSm6ELiV+8TnrwXHM	false	binding-associated region:395-463(MINT-6179704)	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:O76096	uniprotkb:P53634	intact:EBI-2807448|uniprotkb:Q6FH95|uniprotkb:Q9UED4|uniprotkb:Q7Z4J8|ensembl:ENSP00000420384	intact:EBI-1047323|uniprotkb:A8K7V2|uniprotkb:Q53G93|uniprotkb:Q71E75|uniprotkb:Q71E76|uniprotkb:Q7M4N9|uniprotkb:Q8WY99|ensembl:ENSP00000227266|uniprotkb:Q8WYA7|uniprotkb:Q8WYA8|uniprotkb:Q7Z3G7|uniprotkb:Q7Z5U7|uniprotkb:B5MDD5|uniprotkb:Q2HIY8	psi-mi:cytf_human(display_long)|uniprotkb:CST7(gene name)|psi-mi:CST7(display_short)|uniprotkb:Cystatin-7(gene name synonym)|uniprotkb:Cystatin-like metastasis-associated protein(gene name synonym)|uniprotkb:Leukocystatin(gene name synonym)	psi-mi:catc_human(display_long)|uniprotkb:Dipeptidyl peptidase I(gene name synonym)|uniprotkb:Cathepsin C(gene name synonym)|uniprotkb:Cathepsin J(gene name synonym)|uniprotkb:Dipeptidyl transferase(gene name synonym)|uniprotkb:CTSC(gene name)|psi-mi:CTSC(display_short)|uniprotkb:CPPI(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Hamilton et al. (2008)	pubmed:18256700|imex:IM-11526|mint:MINT-6179675	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7802770|mint:MINT-6179710|imex:IM-11526-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003641.3|ensembl:ENSG00000077984(gene)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|ensembl:ENST00000480798(transcript)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903979"(negative regulation of microglial cell activation)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR042886|mint:O76096|rcsb pdb:2CH9|mint:MINT-6179712(identity)	go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:0031642"(negative regulation of myelination)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR014882(Cathepsin C exclusion)|interpro:IPR025660|interpro:IPR025661|interpro:IPR036496|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|go:"GO:0035578"(azurophil granule lumen)|interpro:IPR038765|interpro:IPR039412|mint:P53634|rcsb pdb:1K3B|go:"GO:0042802"(identical protein binding)|rcsb pdb:2DJF|rcsb pdb:2DJG|rcsb pdb:3PDF|rcsb pdb:4CDC|rcsb pdb:4CDD|rcsb pdb:4CDE|rcsb pdb:4CDF|rcsb pdb:4OEL|rcsb pdb:4OEM|reactome:R-HSA-204005|reactome:R-HSA-2132295|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-5694530|reactome:R-HSA-6798695|ensembl:ENSG00000109861(gene)|ensembl:ENST00000227266(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0016020"(membrane)|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0031404"(chloride ion binding)|refseq:NP_001805.3|refseq:NP_680475.1|refseq:NP_001107645.1|mint:MINT-6179714(identity)	-	-	-	figure legend:f1a|comment:Interaction occurs also in YT cells.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-u937_pr9)|taxid:9606(Homo sapiens U937-PR9 lymphoma cells expressing zinc-inducible PML-RAR alpha)	-	2008/02/15	2014/10/16	rogid:xNa8wSYNqctn1+5GA1bFyG9kk+k9606	rogid:vA2MxBAxHODNS4fo9Nvm6UJGW149606	intact-crc:E3A4E56B5C7D20C4|rigid:BzjDuOpU4CLSm6ELiV+8TnrwXHM	false	-	binding-associated region:231-394(MINT-6179715)	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P97821	uniprotkb:O89098	intact:EBI-7802854|ensembl:ENSMUSP00000032779|intact:UNK-5384539|uniprotkb:O08853	intact:EBI-7802885|ensembl:ENSMUSP00000086606|intact:MINT-6179726	psi-mi:catc_mouse(display_long)|uniprotkb:Dipeptidyl peptidase I(gene name synonym)|uniprotkb:Ctsc(gene name)|psi-mi:Ctsc(display_short)|uniprotkb:Cathepsin C(gene name synonym)|uniprotkb:Cathepsin J(gene name synonym)|uniprotkb:Dipeptidyl transferase(gene name synonym)	psi-mi:cytf_mouse(display_long)|uniprotkb:Cst7(gene name)|psi-mi:Cst7(display_short)|uniprotkb:Leukocystatin(gene name synonym)|uniprotkb:Cystatin-7(gene name synonym)|uniprotkb:Cystatin-like metastasis-associated protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Hamilton et al. (2008)	pubmed:18256700|imex:IM-11526|mint:MINT-6179675	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7802847|mint:MINT-6179733|imex:IM-11526-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030560(gene)|ensembl:ENSMUST00000032779(transcript)|go:"GO:0001913"(T cell mediated cytotoxicity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0006508"(proteolysis)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031404"(chloride ion binding)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|go:"GO:0051087"(chaperone binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903980"(positive regulation of microglial cell activation)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR014882(Cathepsin C exclusion)|interpro:IPR025660|interpro:IPR025661|interpro:IPR036496|go:"GO:0016505"(peptidase activator activity involved in apoptotic process)|interpro:IPR039412|mint:P97821|reactome:R-MMU-204005|reactome:R-MMU-2132295|reactome:R-MMU-5694530|reactome:R-MMU-6798695|interpro:IPR038765|refseq:NP_034112.3|mint:MINT-6179735(identity)	ensembl:ENSMUSG00000068129(gene)|ensembl:ENSMUST00000089200(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006955"(immune response)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903979"(negative regulation of microglial cell activation)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR042886|mint:O89098|refseq:NP_034107.2|mint:MINT-6179736(identity)	-	comment:mint|function:Thiol protease. Has dipeptidylpeptidase activity. Can act as both an exopeptidase and endopeptidase. Can degrade glucagon. Plays a role in the generation of cytotoxic lymphocyte effector function	function:Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system|comment:mint	figure legend:f5b|comment:Only Cystatin-F lacking the N-terminus shows colocalization with Cathepsin C.|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmm)|taxid:10090(mouse bone marrow derived macrophages)	-	2008/02/15	2014/10/16	rogid:RuRrSCkzjgkM1F3uw+oRTE6meBg10090	rogid:vHv6UEvWjR5dMsM4ycINxzEei2Y10090	intact-crc:ACF42826021C1C12|rigid:BDG3f60P30KqJzrwielsREO4NrY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)