#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15131	uniprotkb:P15036	intact:EBI-1646959|uniprotkb:A8MXU6|uniprotkb:Q0VGZ7|uniprotkb:Q15130|uniprotkb:Q6PJC0|uniprotkb:D3DX82|uniprotkb:D3DX83|uniprotkb:A8K370|uniprotkb:A8K8I6|uniprotkb:B3KQJ3|uniprotkb:B7Z420|ensembl:ENSP00000338673	intact:EBI-1646991|uniprotkb:D3DSH6|uniprotkb:A6NM68|uniprotkb:Q53Y89|ensembl:ENSP00000353344|ensembl:ENSP00000354194|ensembl:ENSP00000499226|ensembl:ENSP00000499315|ensembl:ENSP00000499775	psi-mi:cdk10_human(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym)|uniprotkb:Cell division protein kinase 10(gene name synonym)	psi-mi:ets2_human(display_long)|uniprotkb:ETS2(gene name)|psi-mi:ETS2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Iorns et al. (2008)	imex:IM-12028|pubmed:18242510	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1646958|imex:IM-12028-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092003.2|refseq:NP_001153839.1|refseq:NP_443713.2|refseq:NP_443714.3|refseq:XP_016879297.1|refseq:XP_016879298.1|refseq:XP_016879299.1|ensembl:ENSG00000185324(gene)|ensembl:ENST00000353379(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030030"(cell projection organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044093|mint:Q15131	refseq:NP_005230.1|refseq:XP_016883779.1|ensembl:ENSG00000157557(gene)|ensembl:ENST00000360214(transcript)|ensembl:ENST00000360938(transcript)|ensembl:ENST00000653642(transcript)|ensembl:ENST00000662305(transcript)|ensembl:ENST00000666778(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|refseq:XP_005260992.1|dip:DIP-40452N|interpro:IPR000418(Ets)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016311(Transforming factor C-ets)|interpro:IPR027276|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4BQA|rcsb pdb:4MHV|reactome:R-HSA-2559585	psi-mi:"MI:0469"(intact)	-	-	figure legend:7 D|delivery method:Q15131 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/10	2014/10/16	rogid:JeOkdG542xQIEDF5hL+83aPl1IQ9606	rogid:mHFB3G4Y52dZ3dUM2zbx+vamz9c9606	intact-crc:A16C229AFE60F164|rigid:yhCXqYL23Z6P06dWdkLptUs1wW0	false	ha tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15131	uniprotkb:P15036	intact:EBI-1646959|uniprotkb:A8MXU6|uniprotkb:Q0VGZ7|uniprotkb:Q15130|uniprotkb:Q6PJC0|uniprotkb:D3DX82|uniprotkb:D3DX83|uniprotkb:A8K370|uniprotkb:A8K8I6|uniprotkb:B3KQJ3|uniprotkb:B7Z420|ensembl:ENSP00000338673	intact:EBI-1646991|uniprotkb:D3DSH6|uniprotkb:A6NM68|uniprotkb:Q53Y89|ensembl:ENSP00000353344|ensembl:ENSP00000354194|ensembl:ENSP00000499226|ensembl:ENSP00000499315|ensembl:ENSP00000499775	psi-mi:cdk10_human(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym)|uniprotkb:Cell division protein kinase 10(gene name synonym)	psi-mi:ets2_human(display_long)|uniprotkb:ETS2(gene name)|psi-mi:ETS2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Iorns et al. (2008)	imex:IM-12028|pubmed:18242510	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647017|imex:IM-12028-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001092003.2|refseq:NP_001153839.1|refseq:NP_443713.2|refseq:NP_443714.3|refseq:XP_016879297.1|refseq:XP_016879298.1|refseq:XP_016879299.1|ensembl:ENSG00000185324(gene)|ensembl:ENST00000353379(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030030"(cell projection organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044093|mint:Q15131	refseq:NP_005230.1|refseq:XP_016883779.1|ensembl:ENSG00000157557(gene)|ensembl:ENST00000360214(transcript)|ensembl:ENST00000360938(transcript)|ensembl:ENST00000653642(transcript)|ensembl:ENST00000662305(transcript)|ensembl:ENST00000666778(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|refseq:XP_005260992.1|dip:DIP-40452N|interpro:IPR000418(Ets)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016311(Transforming factor C-ets)|interpro:IPR027276|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4BQA|rcsb pdb:4MHV|reactome:R-HSA-2559585	psi-mi:"MI:0469"(intact)	-	-	figure legend:S5|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/10	2014/10/16	rogid:JeOkdG542xQIEDF5hL+83aPl1IQ9606	rogid:mHFB3G4Y52dZ3dUM2zbx+vamz9c9606	intact-crc:BB9DC5171A3C3933|rigid:yhCXqYL23Z6P06dWdkLptUs1wW0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15131	ensembl:ENSG00000132155	intact:EBI-1646959|uniprotkb:A8MXU6|uniprotkb:Q0VGZ7|uniprotkb:Q15130|uniprotkb:Q6PJC0|uniprotkb:D3DX82|uniprotkb:D3DX83|uniprotkb:A8K370|uniprotkb:A8K8I6|uniprotkb:B3KQJ3|uniprotkb:B7Z420|ensembl:ENSP00000338673	intact:EBI-1647033	psi-mi:cdk10_human(display_long)|uniprotkb:CDK10(gene name)|psi-mi:CDK10(display_short)|uniprotkb:Serine/threonine-protein kinase PISSLRE(gene name synonym)|uniprotkb:Cell division protein kinase 10(gene name synonym)	psi-mi:raf1_human_gene(display_short)|psi-mi:ENSG00000132155(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Iorns et al. (2008)	imex:IM-12028|pubmed:18242510	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647035|imex:IM-12028-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001092003.2|refseq:NP_001153839.1|refseq:NP_443713.2|refseq:NP_443714.3|refseq:XP_016879297.1|refseq:XP_016879298.1|refseq:XP_016879299.1|ensembl:ENSG00000185324(gene)|ensembl:ENST00000353379(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030030"(cell projection organization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR044093|mint:Q15131	-	-	-	-	figure legend:7 F|delivery method:Q15131 transfection|comment:"CDK10 binds to the ETS2-binding site in the c-RAF promoter (GGAT)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/10	2014/10/16	rogid:JeOkdG542xQIEDF5hL+83aPl1IQ9606	-	intact-crc:1CD3EE88E3DDB954	false	ha tag:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSG00000132155	uniprotkb:P15036	intact:EBI-1647033	intact:EBI-1646991|uniprotkb:D3DSH6|uniprotkb:A6NM68|uniprotkb:Q53Y89|ensembl:ENSP00000353344|ensembl:ENSP00000354194|ensembl:ENSP00000499226|ensembl:ENSP00000499315|ensembl:ENSP00000499775	psi-mi:raf1_human_gene(display_short)|psi-mi:ENSG00000132155(display_long)	psi-mi:ets2_human(display_long)|uniprotkb:ETS2(gene name)|psi-mi:ETS2(display_short)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Iorns et al. (2008)	imex:IM-12028|pubmed:18242510	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1647043|imex:IM-12028-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005230.1|refseq:XP_016883779.1|ensembl:ENSG00000157557(gene)|ensembl:ENST00000360214(transcript)|ensembl:ENST00000360938(transcript)|ensembl:ENST00000653642(transcript)|ensembl:ENST00000662305(transcript)|ensembl:ENST00000666778(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001712"(ectodermal cell fate commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007498"(mesoderm development)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0090009"(primitive streak formation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|refseq:XP_005260992.1|dip:DIP-40452N|interpro:IPR000418(Ets)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR016311(Transforming factor C-ets)|interpro:IPR027276|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4BQA|rcsb pdb:4MHV|reactome:R-HSA-2559585	-	-	-	figure legend:7 F, G|delivery method:Q15131 transfection|comment:Silencing of CDK10 leads to enhanced binding of ETS2 to the ETS2 binding site in the c-RAF promoter.|inhibition:CDK10 - Transfection with the CDK10 expression vector decreases this interaction.|comment:"ETS2 binds to the ETS2-binding site in the c-RAF promoter (GGAT)."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mcf7)|taxid:9606(Homo sapiens  mammary carcinoma cells)	-	2008/03/10	2014/10/16	-	rogid:mHFB3G4Y52dZ3dUM2zbx+vamz9c9606	intact-crc:DFCDEF710DD4442B	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)