#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P24766 uniprotkb:O00585 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 intact:EBI-953695|ensembl:ENSP00000259607|uniprotkb:Q6ICR7 psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:ccl21_human(display_long)|uniprotkb:Small-inducible cytokine A21(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Secondary lymphoid-tissue chemokine(gene name synonym)|uniprotkb:CCL21(gene name)|psi-mi:CCL21(display_short)|uniprotkb:SCYA21(gene name synonym)|uniprotkb:UNQ784/PRO1600(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783152|mint:MINT-6629125 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629126(identity)|uniprotkb:P24766(P24766) ensembl:ENSG00000137077(gene)|ensembl:ENST00000259607(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031295"(T cell costimulation)|go:"GO:0031529"(ruffle organization)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031732"(CCR7 chemokine receptor binding)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035759"(mesangial cell-matrix adhesion)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048469"(cell maturation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097026"(dendritic cell dendrite assembly)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000406"(positive regulation of T cell migration)|go:"GO:2000529"(positive regulation of myeloid dendritic cell chemotaxis)|go:"GO:2000548"(negative regulation of dendritic cell dendrite assembly)|go:"GO:2000669"(negative regulation of dendritic cell apoptotic process)|interpro:IPR030593|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O00585|rcsb pdb:2L4N|rcsb pdb:5EKI|reactome:R-HSA-380108|reactome:R-HSA-418594|interpro:IPR001811(Small chemokine, interleukin-8-like)|refseq:NP_002980.1|dip:DIP-5854N|mint:MINT-6629439(identity) - comment:mint - figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 rogid:kCftuxbCJ6ojbhtg8Tloh6nUv5Q9606 intact-crc:1ECBCE45D515D17C|rigid:VKQb8dIz7E2JEQRStup/8kmeDqk false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P84443 uniprotkb:P24766 intact:EBI-7783177|uniprotkb:Q5M8M5|intact:MINT-123866|uniprotkb:O09006|uniprotkb:Q91V84|uniprotkb:O09002 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 psi-mi:cc21a_mouse(display_long)|uniprotkb:Ccl21a(gene name)|psi-mi:Ccl21a(display_short)|uniprotkb:Scya21(gene name synonym)|uniprotkb:Scya21a(gene name synonym)|uniprotkb:Ccl21c(gene name)|psi-mi:Ccl21c(display_short)|uniprotkb:Scya21c(gene name synonym)|uniprotkb:Small-inducible cytokine A21a(gene name synonym)|uniprotkb:Small-inducible cytokine A21c(gene name synonym)|uniprotkb:6Ckine(gene name synonym)|uniprotkb:Thymus-derived chemotactic age(gene name synonym)|uniprotkb:Beta-chemokine exodus-2(gene name synonym) psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783217|mint:MINT-6629128 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR001811(Small chemokine, interleukin-8-like)|go:"GO:0006954"(inflammatory response)|refseq:XP_001473308.1|go:"GO:0008009"(chemokine activity)|go:"GO:0006955"(immune response)|ensembl:ENSMUSG00000073869|go:"GO:0005615"(extracellular space)|ensembl:ENSMUSG00000079766|refseq:NP_075539.1|go:"GO:0006935"(chemotaxis)|ensembl:ENSMUSG00000078732|ensembl:ENSMUSG00000073884|refseq:XP_001472312.1|refseq:XP_001478660.1|ensembl:ENSMUSG00000079785|refseq:XP_001473444.1|refseq:NP_035465.2|ensembl:ENSMUSG00000073878|ipi:IPI00126207|mint:MINT-6629129(identity)|uniprotkb:P84443(P84443) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629131(identity)|uniprotkb:P24766(P24766) - function:Inhibits hemopoiesis and stimulates chemotaxis. Chemotactic in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Potent mesangial cell chemoattractant. Shows preferential activity towards naive T-cells. May play a role in mediating homing of lymphocytes to secondary lymphoid organs|comment:mint comment:mint figure legend:T1 T2|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:JXtmbP/XltejWUcr9SMPYqSuDXg10090 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 intact-crc:FA719B9519972EC7|rigid:ns3ct6tWH70Lka3Jklj0lWU5B8w false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9NRJ3 uniprotkb:P24766 intact:EBI-7783254|ensembl:ENSP00000354416|ensembl:ENSP00000426424|intact:MINT-8163536|intact:MINT-6629016|uniprotkb:D7RIE7 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 psi-mi:ccl28_human(display_long)|uniprotkb:Mucosae-associated epithelial chemokine(gene name synonym)|uniprotkb:CCL28(gene name)|psi-mi:CCL28(display_short)|uniprotkb:SCYA28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym)|uniprotkb:Protein CCK1(gene name synonym) psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783247|mint:MINT-6629133 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001288802.1|refseq:NP_001288803.1|ensembl:ENSG00000151882(gene)|ensembl:ENST00000361115(transcript)|ensembl:ENST00000489442(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007584"(response to nutrient)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9NRJ3|rcsb pdb:6CWS|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:NP_683513.1|dip:DIP-57392N|mint:MINT-6629134(identity)|uniprotkb:Q9NRJ3(Q9NRJ3) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629136(identity)|uniprotkb:P24766(P24766) - function:Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner|comment:mint comment:mint figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:s++M3xMbRLf+mNYq68dD7mfdRxE9606 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 intact-crc:361EB30AFD1D28D3|rigid:Lc9xh2X7WLhZfFpC17GldEz/BO0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9JIL2 uniprotkb:P24766 intact:EBI-7783309|ensembl:ENSMUSP00000096847|intact:MINT-6629031 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 psi-mi:ccl28_mouse(display_long)|uniprotkb:Ccl28(gene name)|psi-mi:Ccl28(display_short)|uniprotkb:Scya28(gene name synonym)|uniprotkb:Small-inducible cytokine A28(gene name synonym) psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783302|mint:MINT-6629138 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000074715(gene)|ensembl:ENSMUST00000099241(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008009"(chemokine activity)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0051715"(cytolysis in another organism)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|mint:Q9JIL2|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_064675.1|mint:MINT-6629139(identity)|uniprotkb:Q9JIL2(Q9JIL2) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629141(identity)|uniprotkb:P24766(P24766) - function:"Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose-dependent manner"|comment:mint comment:mint figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:Nzhlxchp0dWgGlA1hOcRNuZkJgA10090 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 intact-crc:08675533ABB92A97|rigid:eigqIkzQ7Yb+MdgjDjr8kXYUbks false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24766 uniprotkb:O15444 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 intact:EBI-7783341|ensembl:ENSP00000324756|ensembl:ENSP00000375086|ensembl:ENSP00000504875|ensembl:ENSP00000505422|uniprotkb:A1L4J4|uniprotkb:B5MCA5|uniprotkb:A8K9E7|intact:MINT-106224|uniprotkb:A6NI52|uniprotkb:Q96KJ7 psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:ccl25_human(display_long)|uniprotkb:CCL25(gene name)|psi-mi:CCL25(display_short)|uniprotkb:SCYA25(gene name synonym)|uniprotkb:TECK(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783334|mint:MINT-6629143 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629146(identity)|uniprotkb:P24766(P24766) go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O15444|reactome:R-HSA-380108|reactome:R-HSA-418594|refseq:XP_011526479.1|refseq:XP_016882609.1|refseq:XP_016882610.1|refseq:XP_016882611.1|ensembl:ENSG00000131142(gene)|ensembl:ENST00000315626(transcript)|ensembl:ENST00000390669(transcript)|ensembl:ENST00000680506(transcript)|ensembl:ENST00000680646(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|refseq:NP_005615.2|refseq:NP_001188288.1|dip:DIP-5883N|mint:MINT-6629144(identity)|uniprotkb:O15444(O15444) - comment:mint comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1 figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 rogid:NRbEGkpQKoD/tUBdbJ+JJ4rL0pA9606 intact-crc:1E3516F29BD5C392|rigid:/VuGWIDZDynYt+WHL8T/S1NxiCo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9Y258 uniprotkb:P24766 intact:EBI-7783416|ensembl:ENSP00000005180|ensembl:ENSP00000378365|intact:MINT-105215|uniprotkb:Q52LV8|uniprotkb:A0N0Q5 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 psi-mi:ccl26_human(display_long)|uniprotkb:CCL26(gene name)|psi-mi:CCL26(display_short)|uniprotkb:SCYA26(gene name synonym)|uniprotkb:UNQ216/PRO242(orf name)|uniprotkb:Macrophage inflammatory protein 4-alpha(gene name synonym)|uniprotkb:Small-inducible cytokine A26(gene name synonym)|uniprotkb:Eotaxin-3(gene name synonym)|uniprotkb:Thymic stroma chemokine-1(gene name synonym)|uniprotkb:CC chemokine IMAC(gene name synonym) psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783452|mint:MINT-6629153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016867161.1|ensembl:ENSG00000006606(gene)|ensembl:ENST00000005180(transcript)|ensembl:ENST00000394905(transcript)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0031737"(CX3C chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048245"(eosinophil chemotaxis)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000827(Small chemokine, C-C group, conserved site)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR036048|interpro:IPR039809|mint:Q9Y258|rcsb pdb:1G2S|rcsb pdb:1G2T|refseq:NP_006063.1|dip:DIP-5877N|mint:MINT-6629154(identity)|uniprotkb:Q9Y258(Q9Y258) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629156(identity)|uniprotkb:P24766(P24766) - comment:mint|function:Chemotactic for eosinophils and basophils. Binds to CCR3 comment:mint figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:FA3EOdBSzYvofoN1KWneNE0H7fo9606 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 intact-crc:96E5BF29322F05E7|rigid:rl8TBv8bCvapQQdigonUQyGhakM false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24766 uniprotkb:O35903 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 intact:EBI-7783383|ensembl:ENSMUSP00000024004|intact:MINT-106264|uniprotkb:Q9QYY6 psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:ccl25_mouse(display_long)|uniprotkb:Ccl25(gene name)|psi-mi:Ccl25(display_short)|uniprotkb:Scya25(gene name synonym)|uniprotkb:Teck(gene name synonym)|uniprotkb:Small-inducible cytokine A25(gene name synonym)|uniprotkb:Thymus-expressed chemokine(gene name synonym)|uniprotkb:Chemokine TECK(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783404|mint:MINT-6629148 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629151(identity)|uniprotkb:P24766(P24766) refseq:XP_011240345.2|refseq:XP_011240346.2|ensembl:ENSMUSG00000023235(gene)|ensembl:ENSMUST00000024004(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0005615"(extracellular space)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0008009"(chemokine activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0042379"(chemokine receptor binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0048020"(CCR chemokine receptor binding)|go:"GO:0048247"(lymphocyte chemotaxis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1903237"(negative regulation of leukocyte tethering or rolling)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR034133|interpro:IPR036048|interpro:IPR039809|mint:O35903|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|refseq:NP_033164.1|dip:DIP-5885N|mint:MINT-6629149(identity)|uniprotkb:O35903(O35903) - comment:mint comment:mint|function:Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9 figure legend:T1 T2|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 rogid:iFXjSeVsixwKlvqlDbax1vvLGCE10090 intact-crc:0B8250AD058C303D|rigid:Q0vttKM2JaacL1jaSN14y7lPRd4 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P12850 uniprotkb:P24766 intact:EBI-7783495|ensembl:ENSMUSP00000031327|intact:MINT-6629043 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 psi-mi:groa_mouse(display_long)|uniprotkb:Platelet-derived growth factor-inducible protein KC(gene name synonym)|uniprotkb:Cxcl1(gene name)|psi-mi:Cxcl1(display_short)|uniprotkb:Gro(gene name synonym)|uniprotkb:Gro1(gene name synonym)|uniprotkb:Mgsa(gene name synonym)|uniprotkb:Scyb1(gene name synonym)|uniprotkb:C-X-C motif chemokine 1(gene name synonym)|uniprotkb:Secretory protein N51(gene name synonym) psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783519|mint:MINT-6629163 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000029380(gene)|ensembl:ENSMUST00000031327(transcript)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008009"(chemokine activity)|go:"GO:0008083"(growth factor activity)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070965"(positive regulation of neutrophil mediated killing of fungus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:P12850|reactome:R-MMU-380108|reactome:R-MMU-418594|reactome:R-MMU-6798695|refseq:NP_032202.1|mint:MINT-6629164(identity)|uniprotkb:P12850(P12850) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629166(identity)|uniprotkb:P24766(P24766) - function:"Has chemotactic activity for neutrophils. Contributes to neutrophil activation during inflammation (By similarity). Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. KC(5-72) shows a highly enhanced hematopoietic activity"|comment:mint comment:mint figure legend:T1 T2|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:pMYYFK+G2faFQJahpT4LOS/uQyE10090 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 intact-crc:52EEB10B336BA762|rigid:iRJDiWeXlOxb4iHQOPXaUxSXIyo false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O55038 uniprotkb:P24766 intact:EBI-7783538|ensembl:ENSMUSP00000023840|intact:UNK-5364318 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 psi-mi:cxl13_mouse(display_long)|uniprotkb:Cxcl13(gene name)|psi-mi:Cxcl13(display_short)|uniprotkb:Blc(gene name synonym)|uniprotkb:Scyb13(gene name synonym)|uniprotkb:Small-inducible cytokine B13(gene name synonym)|uniprotkb:B lymphocyte chemoattractant(gene name synonym)|uniprotkb:CXC chemokine BLC(gene name synonym) psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783531|mint:MINT-6629168 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000023078(gene)|ensembl:ENSMUST00000023840(transcript)|go:"GO:0002518"(lymphocyte chemotaxis across high endothelial venule)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0031724"(CXCR5 chemokine receptor binding)|go:"GO:0031735"(CCR10 chemokine receptor binding)|go:"GO:0033625"(positive regulation of integrin activation)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0035768"(endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:0035769"(B cell chemotaxis across high endothelial venule)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0048535"(lymph node development)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:2000545"(negative regulation of endothelial cell chemotaxis to fibroblast growth factor)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR033899|interpro:IPR036048|mint:O55038|rcsb pdb:5IZB|rcsb pdb:5L7M|reactome:R-MMU-380108|reactome:R-MMU-418594|refseq:NP_061354.1|dip:DIP-57395N|mint:MINT-6629169(identity)|uniprotkb:O55038(O55038) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629171(identity)|uniprotkb:P24766(P24766) - comment:mint|function:Strongly chemotactic for B-lymphocytes, weakly for spleen monocytes and macrophages but no chemotactic activity for granulocytes. Binds to BLR1/CXCR5. May play a role in directing the migration of B-lymphocytes to follicles in secondary lymphoid organs comment:mint figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:t0RrvxBL8SPEUul/xdwDGEG/IDQ10090 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 intact-crc:17262C2B245A1B74|rigid:/Gd4nJsGdn1Gfx3J+3NatfJ25Ro false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P24766 uniprotkb:P02776 intact:EBI-7783137|intact:MINT-6629008|uniprotkb:Q76ZN6 intact:EBI-2565740|uniprotkb:Q53X61|uniprotkb:Q9UC64|uniprotkb:Q9UC65|ensembl:ENSP00000296029 psi-mi:a41_vaccw(display_long)|uniprotkb:VACWR166(locus name)|uniprotkb:A41L(orf name) psi-mi:plf4_human(display_long)|uniprotkb:PF4(gene name)|psi-mi:PF4(display_short)|uniprotkb:CXCL4(gene name synonym)|uniprotkb:SCYB4(gene name synonym)|uniprotkb:C-X-C motif chemokine 4(gene name synonym)|uniprotkb:Oncostatin-A(gene name synonym)|uniprotkb:Iroplact(gene name synonym) psi-mi:"MI:0107"(surface plasmon resonance) Bahar et al. (2008) pubmed:18208323|mint:MINT-6629118 taxid:10254(vaccw)|taxid:10254("vaccinia virus (stra") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7783465|mint:MINT-6629158 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P24766|go:"GO:0005576"(extracellular region)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0039553"(suppression by virus of host chemokine activity)|rcsb pdb:2VGA|refseq:YP_233048.1|interpro:IPR003184(Major secreted virus protein, 35kDa)|interpro:IPR036540|mint:MINT-6629161(identity)|uniprotkb:P24766(P24766) refseq:NP_002610.1|ensembl:ENSG00000163737(gene)|ensembl:ENST00000296029(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0006954"(inflammatory response)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0008009"(chemokine activity)|go:"GO:0008201"(heparin binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045653"(negative regulation of megakaryocyte differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048248"(CXCR3 chemokine receptor binding)|go:"GO:0051873"(killing by host of symbiont cells)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR001089(Small chemokine, C-X-C)|interpro:IPR001811(Small chemokine, interleukin-8-like)|interpro:IPR018048|interpro:IPR027222|interpro:IPR033899|interpro:IPR036048|mint:P02776|rcsb pdb:1DN3|rcsb pdb:1F9Q|rcsb pdb:1F9R|rcsb pdb:1F9S|rcsb pdb:1PFM|rcsb pdb:1PFN|rcsb pdb:1RHP|rcsb pdb:4R9W|rcsb pdb:4R9Y|rcsb pdb:4RAU|reactome:R-HSA-114608|reactome:R-HSA-140875|reactome:R-HSA-202733|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-8936459|dip:DIP-56941N|mint:MINT-6629159(identity)|uniprotkb:P02776(P02776) - comment:mint - figure legend:T1 T2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2008/06/26 2014/10/16 rogid:qP6fJZIsysVzX46ph62fOEU1K9010254 rogid:7jf/vdPXt9JwZzkBEW8jO8dC6f09606 intact-crc:BE1A8AB0721F3B7E|rigid:R2uO8R47ZovuV+woBhWRpwHf4U0 false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)