#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P01019	uniprotkb:P25095	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7780817|mint:MINT-6177799|imex:IM-11509-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177806(identity)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177802(identity)	-	-	-	figure legend:st1|kinetics:kd 0.7 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:27FF63E238CBE300|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	binding-associated region:34-41(MINT-6177808)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25095	uniprotkb:P01019	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7780851|mint:MINT-6177817|imex:IM-11509-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177823(identity)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177819(identity)	-	-	-	figure legend:st1|kinetics:kd 1.8 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	intact-crc:0F2729DD370EF303|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	mutation decreasing interaction:76-76,289-289(MINT-6177828)	binding-associated region:34-41(MINT-6177820)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25095	uniprotkb:P01019	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7780875|mint:MINT-6177833|imex:IM-11509-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177839(identity)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177835(identity)	-	-	-	figure legend:st1|kinetics:kd 2.6 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	intact-crc:D764378DC2CCA0AD|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	mutation decreasing interaction:296-296,76-76(MINT-6177840)	binding-associated region:34-41(MINT-6177836)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25095	uniprotkb:P01019	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7780916|mint:MINT-6177849|imex:IM-11509-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177855(identity)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177851(identity)	-	-	-	figure legend:st1|kinetics:kd 2.6 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	intact-crc:48E9B6F04B34712A|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	mutation decreasing interaction:76-76,289-289,296-296(MINT-6177856)	binding-associated region:34-41(MINT-6177852)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:P25095	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7780988|mint:MINT-6177877|imex:IM-11509-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177879(identity)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177883(identity)	-	-	-	figure legend:st1|kinetics:kd 0.5 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:C0546C6504311150|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	binding-associated region:34-41(MINT-6177880)	mutation increasing interaction:294-294(MINT-6177893)|mutation increasing interaction:289-289,76-76(MINT-6177884)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:P25095	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7780942|mint:MINT-6177864|imex:IM-11509-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177866(identity)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177870(identity)	-	-	-	figure legend:st1|kinetics:kd 1.3 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:70F7F8CF402F33BC|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	binding-associated region:34-41(MINT-6177867)	mutation decreasing interaction:289-289,76-76(MINT-6177871)|mutation decreasing interaction:295-295(MINT-6177899)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:P25095	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7781039|mint:MINT-6177922|imex:IM-11509-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177924(identity)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177928(identity)	-	-	-	kinetics:kd 1.2 nanomolar|figure legend:st2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:B48812AFBD8C87EF|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	binding-associated region:34-41(MINT-6177925)	mutation decreasing interaction:257-257(MINT-6177929)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:P25095	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7781017|mint:MINT-6177905|imex:IM-11509-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177907(identity)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177911(identity)	-	-	-	figure legend:st1|kinetics:kd 0.5 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:2019016D74572BED|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	binding-associated region:34-41(MINT-6177908)	mutation decreasing interaction:149-149(MINT-6177914)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P01019	uniprotkb:P25095	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7781078|mint:MINT-6177937|imex:IM-11509-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177939(identity)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177943(identity)	-	-	-	kinetics:kd 1.3 nanomolar|figure legend:st2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	intact-crc:1FAA4C897D09D54D|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	binding-associated region:34-41(MINT-6177940)	mutation decreasing interaction:287-287(MINT-6177944)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25095	uniprotkb:P01019	intact:EBI-764979|uniprotkb:Q9QVS5|ensembl:ENSRNOP00000034687	intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627	psi-mi:agtra_rat(display_long)|uniprotkb:Angiotensin II type-1A receptor(gene name synonym)|uniprotkb:Agtr1(gene name)|psi-mi:Agtr1(display_short)|uniprotkb:Agtr1a(gene name synonym)|uniprotkb:At1a(gene name synonym)	psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym)	psi-mi:"MI:0440"(saturation binding)	Yasuda et al. (2008)	pubmed:18202720|imex:IM-11509|mint:MINT-6177779	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7781100|mint:MINT-6177954|imex:IM-11509-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2070|refseq:NP_112247.2|refseq:XP_008769816.1|refseq:XP_006253944.1|ensembl:ENSRNOG00000018346(gene)|ensembl:ENSRNOT00000038532(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001596"(angiotensin type I receptor activity)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001822"(kidney development)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0001991"(regulation of systemic arterial blood pressure by circulatory renin-angiotensin)|go:"GO:0002001"(renin secretion into blood stream)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002035"(brain renin-angiotensin system)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006885"(regulation of pH)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009651"(response to salt stress)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0012505"(endomembrane system)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031711"(bradykinin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031968"(organelle outer membrane)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000190(AT1 angiotensin II receptor)|interpro:IPR000248(Angiotensin II receptor)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P25095|rcsb pdb:2AC6|rcsb pdb:2AH3|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:1905665"(positive regulation of calcium ion import across plasma membrane)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042756"(drinking behavior)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0086097"(phospholipase C-activating angiotensin-activated signaling pathway)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0042310"(vasoconstriction)|mint:MINT-6177960(identity)	refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V|mint:MINT-6177956(identity)	-	-	-	figure legend:st2|kinetics:kd 1.5 nanomolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/11	2014/10/16	rogid:IBt+94S4gpjhzcKvbWNtv+8Xuqs10116	rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606	intact-crc:31378B7E09B10D05|rigid:lzzN6as6LxpoE0PqXmsN0Go5MbM	false	mutation decreasing interaction:292-292(MINT-6177961)	binding-associated region:34-41(MINT-6177957)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)