#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32361	uniprotkb:P32361	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Lee et al. (2008)	imex:IM-11872|pubmed:18191223	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633604|wwpdb:2RIO|imex:IM-11872-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	-	crc64:BD65D74E74365945	crc64:BD65D74E74365945	3d-resolution:2.40 A|figure legend:Figs. 2 and 3|3d-r-factors:Working = 23.8% Free = 27.2%.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/06	2014/10/16	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	intact-crc:65EBB082A209F3E3|rigid:RRO6U+iv6t5QbRJEqQwDjAPNEww	false	mutation:869-892|his tag:?-?|sufficient binding region:658-1115	mutation:869-892|his tag:?-?|sufficient binding region:658-1115	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32361	intact:EBI-1633657	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	-	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:xbp1-mini(display_short)|psi-mi:EBI-1633657(display_long)	psi-mi:"MI:0415"(enzymatic study)	Lee et al. (2008)	imex:IM-11872|pubmed:18191223	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633716|imex:IM-11872-3	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0320"(ribonucleic acid)	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	-	go:"GO:0004540"(ribonuclease activity)|go:"GO:0006401"(RNA catabolic process)	crc64:BD65D74E74365945	-	resulting-ptm:Cleavage of RNA|comment:"Alanine substitution of kinase domain dimer interface residues R697, D723, and R730 or charge reversal mutations R697D, D723R, R730D, greatly perturbed ribonuclease function. Dimer interface mutations including E988Q, K992D, and Y1059A also compromised the enzyme's ability to cleave Xbp1mini. Both R697D/D723R and D723R/R730D double-mutant proteins displayed partial (two-fold) improvement in ribonuclease function relative to the most perturbing single-site mutant proteins (i.e., R697D and R730D, respectively) potentially by reconstituting a dimer spanning salt-bridge in Ire1. Mutations in the candidate ribonuclease active site of Ire1cyto D995A, Y1043A, R1053E, R1056A, N1057A, and H1061A mutant proteins displayed a complete loss of RNA cleavage function."|figure legend:Figs. 4A, 5A, Supp Fig. S3B, S3C, S3D, S3E|caution:It is unclear from this paper whether the protein in these experiments is His- or GST- tagged, or produced as a GST-tagged molecule with the tag subsequently cleaved by TEV protease.|comment:Enforced dimerization of the enzyme, by the presence of a GST tag, enhances the enzymic activity.|comment:"Loss of autophosphorylation activtiy (Asp797Ala) resulted in a loss of enzyme activity"|comment:Addition of ADP, which is assumed to cause enzyme dimerization, enhanced enzyme activity.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/06	2014/10/16	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	crc64:908AC35651ACED60	intact-crc:267004D5A43FD84E	false	mutation decreasing interaction:730-730|mutation decreasing interaction:797-797|mutation decreasing interaction:992-992|mutation decreasing interaction:1059-1059|mutation decreasing interaction:697-697|mutation decreasing interaction:723-723|mutation decreasing interaction:723-723,697-697|mutation decreasing interaction:723-723,730-730|mutation decreasing interaction:1057-1057|mutation decreasing interaction:1056-1056|mutation decreasing interaction:1061-1061|mutation decreasing interaction:995-995|mutation decreasing interaction:998-998|mutation decreasing interaction:1053-1053|phosphorylated residue:?-?|mutation decreasing interaction:988-988|mutation decreasing interaction:697-697|mutation decreasing interaction:723-723|mutation decreasing interaction:1043-1043|mutation decreasing interaction:1037-1037|mutation decreasing interaction:1039-1039|mutation decreasing interaction:1040-1040|mutation decreasing interaction:1041-1041|mutation decreasing interaction:730-730|glutathione s tranferase tag:?-?|sufficient binding region:658-1115	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P32361	intact:EBI-1188073	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Lee et al. (2008)	imex:IM-11872|pubmed:18191223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1635362|imex:IM-11872-4	-	-	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	go:"GO:0043531"(ADP binding)	-	crc64:BD65D74E74365945	figure legend:Fig. 6|comment:pH 7.0|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/06	2014/10/16	-	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	intact-crc:B71ACC7C758ECFF7	false	-	glutathione s tranferase tag:?-?|sufficient binding region:658-1115|mutation decreasing interaction:797-797|O4'-phospho-L-tyrosine:?-?	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32361	uniprotkb:P32361	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lee et al. (2008)	imex:IM-11872|pubmed:18191223	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1635423|imex:IM-11872-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	go:"GO:0004672"(protein kinase activity)|go:"GO:0046777"(protein autophosphorylation)	crc64:BD65D74E74365945	crc64:BD65D74E74365945	figure legend:Fig. S1B|resulting-ptm:Autophosphorylation of Ire1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/06	2014/10/16	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	intact-crc:518C36A7CD61C53F|rigid:PIk7OrLcgKxGyVWLMJp9BICByCI	false	glutathione s tranferase tag:?-?|sufficient binding region:658-1115	O4'-phospho-L-tyrosine:?-?|glutathione s tranferase tag:?-?|sufficient binding region:658-1115	-	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P32361	intact:EBI-1188073	intact:EBI-9364|ensemblfungi:YHR079C|uniprotkb:D3DL29	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ire1_yeast(display_long)|uniprotkb:IRE1(gene name)|psi-mi:IRE1(display_short)|uniprotkb:ERN1(gene name synonym)|uniprotkb:YHR079C(locus name)|uniprotkb:Endoplasmic reticulum-to-nucleus signaling 1(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Lee et al. (2008)	imex:IM-11872|pubmed:18191223	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1635664|wwpdb:2RIO|imex:IM-11872-5	-	-	psi-mi:"MI:0682"(cofactor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensemblfungi:YHR079C(gene)|ensemblfungi:YHR079C_mRNA(transcript)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005524"(ATP binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006020"(inositol metabolic process)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031505"(fungal-type cell wall organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0036290"(protein trans-autophosphorylation)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR010513(Ribonuclease L)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR018391|interpro:IPR038357|rcsb pdb:2BE1|rcsb pdb:2RIO|rcsb pdb:3FBV|rcsb pdb:3LJ0|rcsb pdb:3LJ1|rcsb pdb:3LJ2|rcsb pdb:3SDJ|rcsb pdb:3SDM|reactome:R-SCE-381070|refseq:NP_011946.1|sgd:S000001121|mint:P32361|dip:DIP-233N	-	-	crc64:BD65D74E74365945	figure legend:Fig. S8|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/06	2014/10/16	-	rogid:5j7Ysqx11W9m7L8UESE8Q7YeDyw559292	intact-crc:EEFEFDCA8C985E16	false	-	sufficient binding region:658-1115	-	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)