#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0018"(two hybrid) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7652953|mint:MINT-6504599|imex:IM-11550-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504601(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504602(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:084CDFB5471BD1EA|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false tag:?-?(MINT-6504607) tag:?-?(MINT-6504611)|binding-associated region:659-874(MINT-6504604) - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7653479|mint:MINT-6504637|imex:IM-11550-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504643(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504639(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:4F33A47336D0CB7E|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false flag tag:?-?(MINT-6504644) ha tag:?-?(MINT-6504640) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7653428|mint:MINT-6504614|imex:IM-11550-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504616(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504620(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:E6B0AE324B4A0545|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false flag tag:?-?(MINT-6504617) ha tag:?-?(MINT-6504621) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7653515|mint:MINT-6504651|imex:IM-11550-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504657(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504653(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:FE3A5DE9318096A4|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false binding-associated region:1-420(MINT-6504663)|flag tag:?-?(MINT-6504658) ha tag:?-?(MINT-6504654) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7653597|mint:MINT-6504666|imex:IM-11550-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504668(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504674(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:CDA4C6DC93C77307|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false binding-associated region:1-750(MINT-6504669)|flag tag:?-?(MINT-6504671) ha tag:?-?(MINT-6504675) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7653677|mint:MINT-6504694|imex:IM-11550-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504696(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504702(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:ACC256505F11A452|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false flag tag:?-?(MINT-6504699) ha tag:?-?(MINT-6504703)|binding-associated region:1-789(MINT-6504708) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q99KY4 uniprotkb:P97378 intact:EBI-7652906|uniprotkb:Q6P9S5|intact:MINT-1869993|uniprotkb:Q8BM74|uniprotkb:Q6P1I8|uniprotkb:Q8K0Q4 intact:EBI-6253448|ensembl:ENSMUSP00000010605|uniprotkb:B9EHD9 psi-mi:gak_mouse(display_long)|uniprotkb:Gak(gene name)|psi-mi:Gak(display_short) psi-mi:i12r2_mouse(display_long)|uniprotkb:Il12rb2(gene name)|psi-mi:Il12rb2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17937931|imex:IM-11550|mint:MINT-6504581 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7653637|mint:MINT-6504680|imex:IM-11550-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q99KY4|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007049"(cell cycle)|go:"GO:0009913"(epidermal cell differentiation)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030276"(clathrin binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031982"(vesicle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905224"(clathrin-coated pit assembly)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|reactome:R-MMU-432722|reactome:R-MMU-8856828|interpro:IPR000719(Protein kinase, core)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR035892|refseq:NP_001268980.1|refseq:NP_001268981.1|interpro:IPR014020(C2 tensin-type)|refseq:NP_705797.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR029021|interpro:IPR029023|interpro:IPR036869|mint:MINT-6504686(identity) ensembl:ENSMUSG00000018341(gene)|ensembl:ENSMUST00000018485(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034097"(response to cytokine)|go:"GO:0043235"(receptor complex)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR010457(Immunoglobulin C2-set-like, ligand-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:P97378|reactome:R-MMU-8984722|reactome:R-MMU-9020591|refseq:NP_001298070.1|refseq:XP_006505680.1|refseq:NP_032380.1|mint:MINT-6504682(identity) - comment:mint|function:Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 - figure legend:F3A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2008/04/08 2014/10/16 rogid:+isLMy/XaivbJaL7yTpD08COfyY10090 rogid:pisaSi+DR0Nt3cxmGroWkhoBfbs10090 intact-crc:51A20199FFD59472|rigid:pioys6Ii4Y1+HHZzSkdKqBMbNuU false flag tag:?-?(MINT-6504687)|binding-associated region:750-1213(MINT-6504689) ha tag:?-?(MINT-6504683) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)