#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15080	uniprotkb:P13498	intact:EBI-1036870|uniprotkb:O60808|uniprotkb:Q86U56|uniprotkb:Q9BU98|uniprotkb:Q9NP45|uniprotkb:A8K4F9|intact:EBI-28974814|ensembl:ENSP00000248899	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	psi-mi:ncf4_human(display_long)|uniprotkb:NCF4(gene name)|psi-mi:NCF4(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 4(gene name synonym)|uniprotkb:p40-phox(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 4(gene name synonym)|uniprotkb:SH3PXD4(gene name synonym)	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:"MI:0047"(far western blotting)	Tamura et al. (2007)	pubmed:17803994|imex:IM-11358|mint:MINT-5223350	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7595161|mint:MINT-6175915|imex:IM-11358-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000622.2|refseq:NP_038202.2|ensembl:ENSP00000248899|ensembl:ENST00000397147|ensembl:ENSP00000380334|ensembl:ENSG00000100365(gene)|ensembl:ENST00000248899(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0032010"(phagolysosome)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045730"(respiratory burst)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000919(Neutrophil cytosol factor P40)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034853|interpro:IPR034912|interpro:IPR035541|interpro:IPR036028|interpro:IPR036871|mint:Q15080|rcsb pdb:1H6H|rcsb pdb:1OEY|rcsb pdb:1W6X|rcsb pdb:1W70|rcsb pdb:1Z9Q|rcsb pdb:2DYB|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|dip:DIP-17019N|mint:MINT-6175918(identity)	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N|mint:MINT-6175917(identity)	-	-	-	figure legend:F7B F7C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/08	2014/10/16	rogid:gQ1MnSPLdf7S4yHbXzXKGskLtBE9606	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	intact-crc:959F033E471F4A2B|rigid:nyo9RTDTVlVm3UWgFSxy60wGLrc	false	mutation decreasing interaction:207-207(MINT-6175921)	mutation decreasing interaction:156-156(MINT-8021705)|binding-associated region:149-166(MINT-6175927)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)
uniprotkb:P14598	uniprotkb:P13498	intact:EBI-395044|uniprotkb:A6NEH2|uniprotkb:A8K7S9|uniprotkb:O43842|uniprotkb:Q2PP07|uniprotkb:Q9BU90|uniprotkb:Q9BXI7|uniprotkb:Q9BXI8|uniprotkb:Q9UDV9|uniprotkb:Q9UMU2|uniprotkb:Q53FR5|ensembl:ENSP00000289473	intact:EBI-986058|uniprotkb:Q14090|uniprotkb:Q9BR72|ensembl:ENSP00000261623	psi-mi:ncf1_human(display_long)|uniprotkb:NCF1(gene name)|psi-mi:NCF1(display_short)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:47 kDa autosomal chronic granulomatous disease protein(gene name synonym)|uniprotkb:Nox-organizing protein 2(gene name synonym)|uniprotkb:Nox organizer 2(gene name synonym)|uniprotkb:SH3 and PX domain-containing protein 1A(gene name synonym)|uniprotkb:NOXO2(gene name synonym)|uniprotkb:SH3PXD1A(gene name synonym)	psi-mi:cy24a_human(display_long)|uniprotkb:p22 phagocyte B-cytochrome(gene name synonym)|uniprotkb:Neutrophil cytochrome b 22 kDa polypeptide(gene name synonym)|uniprotkb:p22-phox(gene name synonym)|uniprotkb:"Cytochrome b(558) alpha chain"(gene name synonym)|uniprotkb:Cytochrome b558 subunit alpha(gene name synonym)|uniprotkb:Superoxide-generating NADPH oxidase light chain subunit(gene name synonym)|uniprotkb:CYBA(gene name)|psi-mi:CYBA(display_short)	psi-mi:"MI:0047"(far western blotting)	Tamura et al. (2007)	pubmed:17803994|imex:IM-11358|mint:MINT-5223350	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7595186|mint:MINT-6175930|imex:IM-11358-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006968"(cellular defense response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032010"(phagolysosome)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|mint:P14598|rcsb pdb:1GD5|rcsb pdb:1K4U|rcsb pdb:1KQ6|rcsb pdb:1NG2|rcsb pdb:1O7K|rcsb pdb:1OV3|rcsb pdb:1UEC|rcsb pdb:1W70|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|ensembl:ENSG00000158517(gene)|ensembl:ENST00000289473(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|refseq:NP_000256.4|dip:DIP-126N|mint:MINT-6175936(identity)	ensembl:ENSG00000051523(gene)|ensembl:ENST00000261623(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001725"(stress fiber)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003106"(negative regulation of glomerular filtration by angiotensin)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0009055"(electron transfer activity)|go:"GO:0014823"(response to activity)|go:"GO:0014895"(smooth muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017004"(cytochrome complex assembly)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0020037"(heme binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042493"|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0045730"(respiratory burst)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070257"(positive regulation of mucus secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1900426"(positive regulation of defense response to bacterium)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904845"(cellular response to L-glutamine)|interpro:IPR007732(Cytochrome b558 alpha-subunit)|mint:P13498|rcsb pdb:1WLP|reactome:R-HSA-1222556|reactome:R-HSA-1236973|reactome:R-HSA-3299685|reactome:R-HSA-4420097|reactome:R-HSA-5668599|reactome:R-HSA-6798695|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|reactome:R-HSA-9673324|refseq:NP_000092.2|dip:DIP-37650N|mint:MINT-6175932(identity)	-	-	-	figure legend:F7B F7C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/02/08	2018/04/30	rogid:cNIwxrttmz096/m5mr+NRK5D9Nc9606	rogid:FviZIB2lWLr0GrH9y2gxAA6mgCg9606	intact-crc:3DAF61CDF235F294|rigid:orL7JDOtD2zmI1FbIa6KyKLnKRE	false	-	binding-associated region:149-166(MINT-6175933)|mutation decreasing interaction:156-156(MINT-8021711)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0083"(peptide synthesis)