#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P14719	uniprotkb:Q8BVZ5	intact:EBI-525078|uniprotkb:Q05208|ensembl:ENSMUSP00000054914|ensembl:ENSMUSP00000095379	intact:EBI-1782653|uniprotkb:Q2YEJ4|uniprotkb:Q3TQN0|uniprotkb:Q99L46|ensembl:ENSMUSP00000025724|ensembl:ENSMUSP00000113829	psi-mi:ilrl1_mouse(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:Protein T1(gene name synonym)|uniprotkb:Lymphocyte antigen 84(gene name synonym)|uniprotkb:Il1rl1(gene name)|psi-mi:Il1rl1(display_short)|uniprotkb:Ly84(gene name synonym)|uniprotkb:St2(gene name synonym)|uniprotkb:Ste2(gene name synonym)|uniprotkb:Interleukin-33 receptor alpha chain(gene name synonym)	psi-mi:il33_mouse(display_long)|uniprotkb:Il33(gene name)|psi-mi:Il33(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chackerian et al. (2007)	pubmed:17675517|imex:IM-19167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1782649|imex:IM-19167-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020773.1|refseq:NP_034873.2|refseq:NP_001281100.1|refseq:XP_006495804.1|refseq:XP_006495807.1|ensembl:ENSMUSG00000026069(gene)|ensembl:ENSMUST00000053043(transcript)|ensembl:ENSMUST00000097772(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9014843|go:"GO:0032722"(positive regulation of chemokine production)|refseq:XP_017174571.1|dip:DIP-34958N	refseq:XP_011245701.1|refseq:NP_001158196.1|refseq:NP_598536.2|refseq:XP_006527526.1|ensembl:ENSMUSG00000024810(gene)|ensembl:ENSMUST00000025724(transcript)|ensembl:ENSMUST00000120388(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002112"(interleukin-33 receptor binding)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002282"(microglial cell activation involved in immune response)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002686"(negative regulation of leukocyte migration)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0010186"(positive regulation of cellular defense response)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030133"(transport vesicle)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045345"(positive regulation of MHC class I biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0120042"(negative regulation of macrophage proliferation)|go:"GO:0150142"(positive regulation of CD86 production)|go:"GO:0150145"(positive regulation of CD80 production)|interpro:IPR026145|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-5689880|reactome:R-MMU-6811558|reactome:R-MMU-9014843	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/17	2014/10/16	rogid:GPD5Bm6L00WnwYKuwUBCxlY7zQw10090	rogid:ANLT/fhx6oFPsbVvuPPtPboUzHc10090	intact-crc:5729C39041842AB9|rigid:B/vV3HU4L4DPLq5X8LJIAIhCA/o	false	fusion protein:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14719	uniprotkb:Q61730	intact:EBI-525078|uniprotkb:Q05208|ensembl:ENSMUSP00000054914|ensembl:ENSMUSP00000095379	intact:EBI-525035|uniprotkb:Q8VCB9|uniprotkb:Q3UVZ1|ensembl:ENSMUSP00000023156	psi-mi:ilrl1_mouse(display_long)|uniprotkb:Protein ST2(gene name synonym)|uniprotkb:Protein T1(gene name synonym)|uniprotkb:Lymphocyte antigen 84(gene name synonym)|uniprotkb:Il1rl1(gene name)|psi-mi:Il1rl1(display_short)|uniprotkb:Ly84(gene name synonym)|uniprotkb:St2(gene name synonym)|uniprotkb:Ste2(gene name synonym)|uniprotkb:Interleukin-33 receptor alpha chain(gene name synonym)	psi-mi:il1ap_mouse(display_long)|uniprotkb:Il1rap(gene name)|psi-mi:Il1rap(display_short)|uniprotkb:Interleukin-33 receptot beta chain(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chackerian et al. (2007)	pubmed:17675517|imex:IM-19167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1782649|imex:IM-19167-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020773.1|refseq:NP_034873.2|refseq:NP_001281100.1|refseq:XP_006495804.1|refseq:XP_006495807.1|ensembl:ENSMUSG00000026069(gene)|ensembl:ENSMUST00000053043(transcript)|ensembl:ENSMUST00000097772(transcript)|go:"GO:0002113"(interleukin-33 binding)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0002826"(negative regulation of T-helper 1 type immune response)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9014843|go:"GO:0032722"(positive regulation of chemokine production)|refseq:XP_017174571.1|dip:DIP-34958N	refseq:NP_032390.1|refseq:NP_598864.1|refseq:NP_001152790.1|ensembl:ENSMUSG00000022514(gene)|ensembl:ENSMUST00000023156(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:4YFD|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-388844|reactome:R-MMU-6811558|reactome:R-MMU-9014826|reactome:R-MMU-9014843|reactome:R-MMU-9020702|dip:DIP-296N	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/17	2014/10/16	rogid:GPD5Bm6L00WnwYKuwUBCxlY7zQw10090	rogid:t6go1Z8XGGOANmCmvimPb/wwc2g10090	intact-crc:5729C39041842AB9|rigid:B/vV3HU4L4DPLq5X8LJIAIhCA/o	false	fusion protein:?-?	his tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P13504	uniprotkb:P10749	intact:EBI-1782675|ensembl:ENSMUSP00000027241	intact:EBI-1782701|uniprotkb:Q2M4J6|ensembl:ENSMUSP00000028881	psi-mi:il1r1_mouse(display_long)|uniprotkb:Il1r1(gene name)|psi-mi:Il1r1(display_short)|uniprotkb:Il-1r1(gene name synonym)|uniprotkb:Il1ra(gene name synonym)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)	psi-mi:il1b_mouse(display_long)|uniprotkb:Il1b(gene name)|psi-mi:Il1b(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chackerian et al. (2007)	pubmed:17675517|imex:IM-19167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1782693|imex:IM-19167-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032388.1|refseq:XP_006495776.1|dip:DIP-40669N|ensembl:ENSMUSG00000026072(gene)|ensembl:ENSMUST00000027241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006954"(inflammatory response)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010286"(heat acclimation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030424"(axon)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1OU3|reactome:R-MMU-9020702	refseq:NP_032387.1|ensembl:ENSMUSG00000027398(gene)|ensembl:ENSMUST00000028881(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001660"(fever generation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007613"(memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010829"(negative regulation of glucose transmembrane transport)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030141"(secretory granule)|go:"GO:0030213"(hyaluronan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0033092"(positive regulation of immature T cell proliferation in thymus)|go:"GO:0033198"(response to ATP)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035176"(social behavior)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0035505"(positive regulation of myosin light chain kinase activity)|go:"GO:0035690"|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045833"(negative regulation of lipid metabolic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0050996"(positive regulation of lipid catabolic process)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0070164"(negative regulation of adiponectin secretion)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902680"(positive regulation of RNA biosynthetic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903597"(negative regulation of gap junction assembly)|go:"GO:2000173"(negative regulation of branching morphogenesis of a nerve)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000975(Interleukin-1)|go:"GO:0030593"(neutrophil chemotaxis)|interpro:IPR003296(Interleukin-1, beta IL1B)|interpro:IPR003502(Interleukin-1 propeptide)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR020877|rcsb pdb:2MIB|rcsb pdb:8I1B|reactome:R-MMU-448706|reactome:R-MMU-5620971|reactome:R-MMU-9020702	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/17	2014/10/16	rogid:C1dNhiQL96zOX0NoYggax/CpIYE10090	rogid:GbyvtUjjlJentCICABl+eSZIVq810090	intact-crc:F0F2E44825800139|rigid:kB6kxe2aG5OlsynXBeOztMbnlWY	false	fusion protein:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P13504	uniprotkb:Q61730	intact:EBI-1782675|ensembl:ENSMUSP00000027241	intact:EBI-525035|uniprotkb:Q8VCB9|uniprotkb:Q3UVZ1|ensembl:ENSMUSP00000023156	psi-mi:il1r1_mouse(display_long)|uniprotkb:Il1r1(gene name)|psi-mi:Il1r1(display_short)|uniprotkb:Il-1r1(gene name synonym)|uniprotkb:Il1ra(gene name synonym)|uniprotkb:Interleukin-1 receptor type I(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:CD121 antigen-like family member A(gene name synonym)|uniprotkb:Interleukin-1 receptor alpha(gene name synonym)	psi-mi:il1ap_mouse(display_long)|uniprotkb:Il1rap(gene name)|psi-mi:Il1rap(display_short)|uniprotkb:Interleukin-33 receptot beta chain(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Chackerian et al. (2007)	pubmed:17675517|imex:IM-19167	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1782693|imex:IM-19167-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032388.1|refseq:XP_006495776.1|dip:DIP-40669N|ensembl:ENSMUSG00000026072(gene)|ensembl:ENSMUST00000027241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0004909"(interleukin-1, type I, activating receptor activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006954"(inflammatory response)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010286"(heat acclimation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030424"(axon)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:2000391"(positive regulation of neutrophil extravasation)|go:"GO:2000556"(positive regulation of T-helper 1 cell cytokine production)|go:"GO:2000661"(positive regulation of interleukin-1-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR004076(Interleukin-1 receptor IL1R)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:1OU3|reactome:R-MMU-9020702	refseq:NP_032390.1|refseq:NP_598864.1|refseq:NP_001152790.1|ensembl:ENSMUSG00000022514(gene)|ensembl:ENSMUST00000023156(transcript)|go:"GO:0002114"(interleukin-33 receptor activity)|go:"GO:0004908"(interleukin-1 receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038172"(interleukin-33-mediated signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099545"(trans-synaptic signaling by trans-synaptic complex)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR004074(Interleukin-1 receptor, type I and type II)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015621(Interleukin-1 receptor)|interpro:IPR035897|interpro:IPR036179|interpro:IPR041416|rcsb pdb:4YFD|rcsb pdb:5VI4|reactome:R-MMU-1257604|reactome:R-MMU-388844|reactome:R-MMU-6811558|reactome:R-MMU-9014826|reactome:R-MMU-9014843|reactome:R-MMU-9020702|dip:DIP-296N	-	-	-	figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2008/06/17	2014/10/16	rogid:C1dNhiQL96zOX0NoYggax/CpIYE10090	rogid:t6go1Z8XGGOANmCmvimPb/wwc2g10090	intact-crc:F0F2E44825800139|rigid:kB6kxe2aG5OlsynXBeOztMbnlWY	false	fusion protein:?-?	his tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)