#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16070	uniprotkb:P61160	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-353580|ensembl:ENSP00000260641|uniprotkb:O15142|uniprotkb:Q96C82|uniprotkb:B2RCP5|uniprotkb:D6W5F4|uniprotkb:E9PF41	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:arp2_human(display_long)|uniprotkb:ACTR2(gene name)|psi-mi:ACTR2(display_short)|uniprotkb:ARP2(gene name synonym)|uniprotkb:Actin-like protein 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bourguignon et al. (2007)	pubmed:17092940|imex:IM-19264	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774564|imex:IM-19264-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	ensembl:ENSG00000138071(gene)|ensembl:ENST00000260641(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008306"(associative learning)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0016482"(cytosolic transport)|go:"GO:0030027"(lamellipodium)|go:"GO:0030478"(actin cap)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0035984"(cellular response to trichostatin A)|go:"GO:0045471"(response to ethanol)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061825"(podosome core)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:NP_001005386.1|refseq:NP_005713.1|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR043129|mint:P61160|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33165N	-	-	-	figure legend:1 B|agonist:"Hyaluronan (HA) - HA treatment enhanced these interactions."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skov_3)|taxid:9606(Homo sapiens ovarian adenocarcinoma cell line)	-	2008/05/19	2014/10/16	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:URQsZpIsMtsFZAnpLYDDvgKcPqA9606	intact-crc:49D317ADFAE4C1BD|rigid:q5oWW+BqOeWs+ndLkvlzkjA5ivw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16070	uniprotkb:P61158	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-351428|uniprotkb:P32391|ensembl:ENSP00000263238|uniprotkb:Q53QM2	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:arp3_human(display_long)|uniprotkb:ACTR3(gene name)|psi-mi:ACTR3(display_short)|uniprotkb:ARP3(gene name synonym)|uniprotkb:Actin-like protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bourguignon et al. (2007)	pubmed:17092940|imex:IM-19264	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774564|imex:IM-19264-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	refseq:NP_005712.1|ensembl:ENSG00000115091(gene)|ensembl:ENST00000263238(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008356"(asymmetric cell division)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016344"(meiotic chromosome movement towards spindle pole)|go:"GO:0030027"(lamellipodium)|go:"GO:0033206"(meiotic cytokinesis)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051653"(spindle localization)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070358"(actin polymerization-dependent cell motility)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR004000(Actin/actin-like)|interpro:IPR015623(Actin-related protein 3)|interpro:IPR020902|interpro:IPR043129|mint:P61158|rcsb pdb:6UHC|rcsb pdb:6YW6|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9664422|dip:DIP-33140N	-	-	-	figure legend:1 B|agonist:"Hyaluronan (HA) - HA treatment enhanced these interactions."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skov_3)|taxid:9606(Homo sapiens ovarian adenocarcinoma cell line)	-	2008/05/19	2014/10/16	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:XbkZeKzG8lGbT8dxYkGqeJT0vEg9606	intact-crc:49D317ADFAE4C1BD|rigid:q5oWW+BqOeWs+ndLkvlzkjA5ivw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16070	uniprotkb:O00401	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bourguignon et al. (2007)	pubmed:17092940|imex:IM-19264	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774564|imex:IM-19264-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	-	-	-	figure legend:1 B|agonist:"Hyaluronan (HA) - HA treatment enhanced these interactions."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skov_3)|taxid:9606(Homo sapiens ovarian adenocarcinoma cell line)	-	2008/05/19	2014/10/16	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	intact-crc:49D317ADFAE4C1BD|rigid:q5oWW+BqOeWs+ndLkvlzkjA5ivw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16070	uniprotkb:P04626	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-641062|ensembl:ENSP00000269571|uniprotkb:Q14256|uniprotkb:Q6LDV1|uniprotkb:Q9UMK4|uniprotkb:B2RZG3|uniprotkb:B4DHN3|uniprotkb:X5D2V5	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:erbb2_human(display_long)|uniprotkb:p185erbB2(gene name synonym)|uniprotkb:MLN19(gene name synonym)|uniprotkb:Proto-oncogene c-ErbB-2(gene name synonym)|uniprotkb:Tyrosine kinase-type cell surface receptor HER2(gene name synonym)|uniprotkb:Proto-oncogene Neu(gene name synonym)|uniprotkb:ERBB2(gene name)|psi-mi:ERBB2(display_short)|uniprotkb:HER2(gene name synonym)|uniprotkb:NEU(gene name synonym)|uniprotkb:NGL(gene name synonym)|uniprotkb:Metastatic lymph node gene 19 protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bourguignon et al. (2007)	pubmed:17092940|imex:IM-19264	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774582|imex:IM-19264-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	rcsb pdb:4HRN|rcsb pdb:5K33|rcsb pdb:5KWG|rcsb pdb:5MY6|rcsb pdb:5O4G|rcsb pdb:5OB4|rcsb pdb:5TQS|rcsb pdb:6ATT|rcsb pdb:6BGT|rcsb pdb:6J71|rcsb pdb:6LBX|rcsb pdb:6OGE|reactome:R-HSA-1227986|reactome:R-HSA-1250196|reactome:R-HSA-1251932|reactome:R-HSA-1257604|reactome:R-HSA-1306955|reactome:R-HSA-1358803|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2219530|reactome:R-HSA-416572|reactome:R-HSA-5673001|reactome:R-HSA-6785631|reactome:R-HSA-6811558|reactome:R-HSA-8847993|reactome:R-HSA-8863795|reactome:R-HSA-8866910|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|interpro:IPR000494(EGF receptor, L domain)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR006211(Furin-like cysteine rich region)|interpro:IPR006212(Furin-like repeat)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016245(Tyrosine protein kinase, receptor-type, EGF/ERB/XmrK)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR032778|interpro:IPR036941|ensembl:ENSG00000141736(gene)|ensembl:ENST00000269571(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0007507"(heart development)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|mint:P04626|rcsb pdb:1MFG|rcsb pdb:1MFL|rcsb pdb:1MW4|rcsb pdb:1N8Z|rcsb pdb:1OVC|rcsb pdb:1QR1|rcsb pdb:1S78|rcsb pdb:2A91|rcsb pdb:2JWA|rcsb pdb:2KS1|rcsb pdb:2L4K|rcsb pdb:2N2A|rcsb pdb:3BE1|rcsb pdb:3H3B|rcsb pdb:3MZW|rcsb pdb:3N85|rcsb pdb:3PP0|rcsb pdb:3RCD|rcsb pdb:3WLW|rcsb pdb:3WSQ|rcsb pdb:4GFU|rcsb pdb:4HRL|rcsb pdb:4HRM|go:"GO:0010008"(endosome membrane)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0033088"(negative regulation of immature T cell proliferation in thymus)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038143"("ERBB3:ERBB2 complex")|go:"GO:0042060"(wound healing)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|refseq:NP_004439.2|dip:DIP-8N|refseq:NP_001005862.1|refseq:NP_001276865.1|refseq:NP_001276867.1	-	-	-	figure legend:2 A, 7 A|agonist:"Hyaluronan (HA) - HA treatment enhanced these interactions."|inhibition:"The WASL (N-WASP) domain inhibits these interactions."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skov_3)|taxid:9606(Homo sapiens ovarian adenocarcinoma cell line)	-	2008/05/19	2014/10/16	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:6o8GoqTQ64og/aKbzFZZMQ8gRHI9606	intact-crc:D81ADBE2C0D4B4EB|rigid:tLJveuvKCq75qRApWOF4rWCeNQk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P16070	uniprotkb:O00401	intact:EBI-490245|uniprotkb:P22511|uniprotkb:Q04858|uniprotkb:Q13419|uniprotkb:Q13957|uniprotkb:Q13958|uniprotkb:Q13959|uniprotkb:Q13960|uniprotkb:Q13961|uniprotkb:Q13967|uniprotkb:Q13968|uniprotkb:Q13980|uniprotkb:Q15861|uniprotkb:Q16064|uniprotkb:Q16065|uniprotkb:Q16066|uniprotkb:Q16208|uniprotkb:Q16522|uniprotkb:Q86T72|uniprotkb:Q86Z27|uniprotkb:Q8N694|uniprotkb:Q92493|uniprotkb:Q96J24|uniprotkb:Q9UJ36|uniprotkb:Q9H5A5|uniprotkb:A5YRN9|uniprotkb:Q9UC28|uniprotkb:Q9UC29|uniprotkb:Q9UC30|uniprotkb:Q9UCB0|uniprotkb:D3DR12|uniprotkb:D3DR13|uniprotkb:B6EAT9|uniprotkb:O95370|ensembl:ENSP00000398632	intact:EBI-957615|ensembl:ENSP00000223023|uniprotkb:Q7Z746|uniprotkb:A1JUI9	psi-mi:cd44_human(display_long)|uniprotkb:Epican(gene name synonym)|uniprotkb:CDw44(gene name synonym)|uniprotkb:Phagocytic glycoprotein I(gene name synonym)|uniprotkb:Extracellular matrix receptor III(gene name synonym)|uniprotkb:HUTCH-I(gene name synonym)|uniprotkb:Phagocytic glycoprotein 1(gene name synonym)|uniprotkb:GP90 lymphocyte homing/adhesion receptor(gene name synonym)|uniprotkb:Hermes antigen(gene name synonym)|uniprotkb:Hyaluronate receptor(gene name synonym)|uniprotkb:Heparan sulfate proteoglycan(gene name synonym)|uniprotkb:CD44(gene name)|psi-mi:CD44(display_short)|uniprotkb:LHR(gene name synonym)|uniprotkb:MDU2(gene name synonym)|uniprotkb:MDU3(gene name synonym)|uniprotkb:MIC4(gene name synonym)	psi-mi:wasl_human(display_long)|uniprotkb:WASL(gene name)|psi-mi:WASL(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bourguignon et al. (2007)	pubmed:17092940|imex:IM-19264	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1774582|imex:IM-19264-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000601.3|refseq:NP_001001389.1|refseq:NP_001001390.1|refseq:NP_001001391.1|refseq:NP_001001392.1|refseq:NP_001189484.1|refseq:NP_001189485.1|refseq:NP_001189486.1|refseq:XP_011518790.1|ensembl:ENSG00000026508(gene)|ensembl:ENST00000428726(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005925"(focal adhesion)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051216"(cartilage development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900625"(positive regulation of monocyte aggregation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000392"(regulation of lamellipodium morphogenesis)|interpro:IPR000538(Link)|interpro:IPR001231(CD44 antigen)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR043210|rcsb pdb:1POZ|rcsb pdb:1UUH|rcsb pdb:2I83|rcsb pdb:4PZ3|rcsb pdb:4PZ4|rcsb pdb:6TXS|reactome:R-HSA-1474228|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-2160916|reactome:R-HSA-6798695|reactome:R-HSA-877300|dip:DIP-1121N	go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0009617"(response to bacterium)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|rcsb pdb:2FF3|rcsb pdb:2LNH|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|rcsb pdb:2VCP|rcsb pdb:4CC2|rcsb pdb:4CC7|reactome:R-HSA-2029482|reactome:R-HSA-203641|reactome:R-HSA-373753|reactome:R-HSA-3928662|reactome:R-HSA-418885|reactome:R-HSA-5663213|reactome:R-HSA-8856828|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013424|reactome:R-HSA-9664422|ensembl:ENSG00000106299(gene)|ensembl:ENST00000223023(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:O00401|go:"GO:0005634"(nucleus)|refseq:NP_003932.3|dip:DIP-29042N	-	-	-	figure legend:2 A, 7 A|agonist:"Hyaluronan (HA) - HA treatment enhanced these interactions."|inhibition:"The WASL (N-WASP) domain inhibits these interactions."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skov_3)|taxid:9606(Homo sapiens ovarian adenocarcinoma cell line)	-	2008/05/19	2014/10/16	rogid:QOb28rF7/ryqfz/ylJFTyL3aoAc9606	rogid:PinEPh47IRuCgiaJJZqStRhIAGQ9606	intact-crc:D81ADBE2C0D4B4EB|rigid:tLJveuvKCq75qRApWOF4rWCeNQk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)