#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04487	uniprotkb:P04487	intact:EBI-6150681	intact:EBI-6150681	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:rnb_hhv11(display_long)|uniprotkb:Vmw21(gene name synonym)|uniprotkb:US11(gene name)|psi-mi:US11(display_short)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694308|mint:MINT-6733658	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)|mint:MINT-6733659(identity)|uniprotkb:P04487(P04487)	refseq:YP_009137147.1|mint:P04487|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039521"(suppression by virus of host autophagy)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039554"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity)|go:"GO:0039580"(suppression by virus of host PKR signaling)|go:"GO:0039722"(suppression by virus of host toll-like receptor signaling pathway)|go:"GO:0039723"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044196"(host cell nucleolus)|go:"GO:0046792"(suppression by virus of host cell cycle arrest)|mint:MINT-6733662(identity)|uniprotkb:P04487(P04487)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	rogid:J3LGVy033NJ6MG95uzmCY2bCyZY10299	intact-crc:C71D3567D96653AE|rigid:IeqJJZ58YQTUFkv+UYeTR2wLIEM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10221	uniprotkb:P10221	intact:EBI-6880600	intact:EBI-6880600	psi-mi:itp_hhv11(display_long)|uniprotkb:UL37(gene name)|psi-mi:UL37(display_short)|uniprotkb:Viral deamidase UL37(gene name synonym)	psi-mi:itp_hhv11(display_long)|uniprotkb:UL37(gene name)|psi-mi:UL37(display_short)|uniprotkb:Viral deamidase UL37(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694385|mint:MINT-6733687	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0050568"(protein-glutamine glutaminase activity)|rcsb pdb:5VYL|interpro:IPR034738|interpro:IPR005655(Herpesvirus UL37 tegument protein)|mint:P10221|mint:MINT-6733688(identity)|uniprotkb:P10221(P10221)	go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0050568"(protein-glutamine glutaminase activity)|rcsb pdb:5VYL|interpro:IPR034738|interpro:IPR005655(Herpesvirus UL37 tegument protein)|mint:P10221|mint:MINT-6733691(identity)|uniprotkb:P10221(P10221)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:lvEEzHJRKc3EzANn8KSVFoJ94NM10299	rogid:lvEEzHJRKc3EzANn8KSVFoJ94NM10299	intact-crc:1D2FBF3881F44B95|rigid:uoDRcoIRbKPpcGWmmRth/GAUIBo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10200	uniprotkb:P04289	intact:EBI-7044955|intact:MINT-6732685	intact:EBI-7044930|intact:MINT-6732677|uniprotkb:Q09IC2|uniprotkb:B9VQD8	psi-mi:cep2_hhv11(display_long)|uniprotkb:UL16(gene name)|psi-mi:UL16(display_short)	psi-mi:cep3_hhv11(display_long)|uniprotkb:UL11(orf name)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694321|mint:MINT-6733665	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P10200|refseq:YP_009137090.1|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|interpro:IPR004286(Herpesvirus UL16/UL94)|mint:MINT-6733669(identity)|uniprotkb:P10200(P10200)	mint:P04289|refseq:YP_009137085.1|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0044178"(host cell Golgi membrane)|go:"GO:0046760"(viral budding from Golgi membrane)|go:"GO:0055036"(virion membrane)|interpro:IPR024351|interpro:IPR016395(Myristoylated tegument protein UL11)|mint:MINT-6733666(identity)|uniprotkb:P04289(P04289)	-	comment:mint	comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:QqQgEqwtOlIX/pApF4lhrw09giE10299	rogid:/BxQV6kAbL4HS5XUD4hW4liVVZg10299	intact-crc:8602BEB8BAA939B9|rigid:VORbk0ghvsHeJORc0VGsmdrz2NM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10220	uniprotkb:P10221	intact:EBI-7694334|uniprotkb:Q09I97|intact:MINT-6732711|uniprotkb:B9VQG4	intact:EBI-6880600	psi-mi:ltp_hhv11(display_long)|uniprotkb:UL36(orf name)	psi-mi:itp_hhv11(display_long)|uniprotkb:UL37(gene name)|psi-mi:UL37(display_short)|uniprotkb:Viral deamidase UL37(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694359|mint:MINT-6733672	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019033"(viral tegument)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0039708"(nuclear capsid assembly)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:4TT0|rcsb pdb:4TT1|mint:P10220|interpro:IPR006928(Peptidase C76,   herpesvirus UL36 UL36 deubiquitinylating peptidase)|interpro:IPR005210(Herpesvirus UL36 tegument protein, central region)|refseq:YP_009137111.1|interpro:IPR034702|interpro:IPR038765|mint:MINT-6733673(identity)|uniprotkb:P10220(P10220)	go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0050568"(protein-glutamine glutaminase activity)|rcsb pdb:5VYL|interpro:IPR034738|interpro:IPR005655(Herpesvirus UL37 tegument protein)|mint:P10221|mint:MINT-6733677(identity)|uniprotkb:P10221(P10221)	-	function:Tegument protein|comment:mint	-	figure legend:F1  F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:v5UsNbt9FXzQ1n57ZzLU/kTz/wQ10299	rogid:lvEEzHJRKc3EzANn8KSVFoJ94NM10299	intact-crc:FE75CF0837964599|rigid:2YQ407QvSh3dUu4tOwZ89rT/w4Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06492	uniprotkb:P10220	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	intact:EBI-7694334|uniprotkb:Q09I97|intact:MINT-6732711|uniprotkb:B9VQG4	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:ltp_hhv11(display_long)|uniprotkb:UL36(orf name)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694372|mint:MINT-6733680	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N|mint:MINT-6733684(identity)|uniprotkb:P06492(P06492)	go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019033"(viral tegument)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0039708"(nuclear capsid assembly)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:4TT0|rcsb pdb:4TT1|mint:P10220|interpro:IPR006928(Peptidase C76,   herpesvirus UL36 UL36 deubiquitinylating peptidase)|interpro:IPR005210(Herpesvirus UL36 tegument protein, central region)|refseq:YP_009137111.1|interpro:IPR034702|interpro:IPR038765|mint:MINT-6733681(identity)|uniprotkb:P10220(P10220)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	function:Tegument protein|comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rogid:v5UsNbt9FXzQ1n57ZzLU/kTz/wQ10299	intact-crc:9FC61A45566E7F5F|rigid:QJ3Yx5DyrfEFhFWhEq6F7EWvEnw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06492	uniprotkb:P10230	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	intact:EBI-7694458|uniprotkb:B9VQH4|uniprotkb:Q09I88|intact:MINT-6732730|uniprotkb:O09799	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:teg1_hhv11(display_long)|uniprotkb:UL46(orf name)|uniprotkb:Tegument protein VP11/12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694451|mint:MINT-6733694	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N|mint:MINT-6733695(identity)|uniprotkb:P06492(P06492)	go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039503"(suppression by virus of host innate immune response)|mint:P10230|interpro:IPR005051(Herpesvirus UL46 protein)|refseq:YP_009137121.1|mint:MINT-6733698(identity)|uniprotkb:P10230(P10230)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	function:Modulates alpha trans-inducing factor-dependent activation of alpha genes|comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rogid:vmkdkJduTTAYsz6YeglLJ9l046E10299	intact-crc:09BAD7691A954E02|rigid:zCsyJh2ZBll/rXun8nd57c3z7B0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06492	uniprotkb:P10231	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	intact:EBI-7694483|intact:MINT-6732739|uniprotkb:Q09I87	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:teg5_hhv11(display_long)|uniprotkb:VMW82/81(gene name synonym)|uniprotkb:VP13/14(gene name synonym)|uniprotkb:UL47(orf name)|uniprotkb:82/81 kDa tegument protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694503|mint:MINT-6733701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N|mint:MINT-6733705(identity)|uniprotkb:P06492(P06492)	go:"GO:0003723"(RNA binding)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0042025"(host cell nucleus)|mint:P10231|interpro:IPR005029(Herpesvirus UL47 protein)|refseq:YP_009137122.1|mint:MINT-6733702(identity)|uniprotkb:P10231(P10231)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	function:"Modulator of alpha-TIF (Vmw65 phosphoprotein) trans-activation. Possibly UL47 may have kinase activity"|comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rogid:7XQmvePY4VocFEqOchdMeIWT/so10299	intact-crc:D1A4FE3EF51558ED|rigid:wxLgw6Tx0vJgNb2Ejegx36A3nHA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06492	uniprotkb:P10233	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	intact:EBI-7490002|uniprotkb:B9VQH7|uniprotkb:Q09I85|intact:MINT-6732747	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:vp22_hhv11(display_long)|uniprotkb:UL49(orf name)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694516|mint:MINT-6733708	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N|mint:MINT-6733709(identity)|uniprotkb:P06492(P06492)	refseq:YP_009137124.1|mint:P10233|go:"GO:0019033"(viral tegument)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044177"(host cell Golgi apparatus)|interpro:IPR006908(Herpesvirus UL49 tegument protein)|rcsb pdb:4XAL|dip:DIP-57160N|mint:MINT-6733712(identity)|uniprotkb:P10233(P10233)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rogid:DM3Zmc28xl4p1fOVo8YqkCjc3OU10299	intact-crc:805FB734F47993FC|rigid:/3tgpwlj1J6s24DPu0flyraZ23A	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10233	uniprotkb:P10233	intact:EBI-7490002|uniprotkb:B9VQH7|uniprotkb:Q09I85|intact:MINT-6732747	intact:EBI-7490002|uniprotkb:B9VQH7|uniprotkb:Q09I85|intact:MINT-6732747	psi-mi:vp22_hhv11(display_long)|uniprotkb:UL49(orf name)	psi-mi:vp22_hhv11(display_long)|uniprotkb:UL49(orf name)	psi-mi:"MI:0018"(two hybrid)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694529|mint:MINT-6733715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137124.1|mint:P10233|go:"GO:0019033"(viral tegument)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044177"(host cell Golgi apparatus)|interpro:IPR006908(Herpesvirus UL49 tegument protein)|rcsb pdb:4XAL|dip:DIP-57160N|mint:MINT-6733719(identity)|uniprotkb:P10233(P10233)	refseq:YP_009137124.1|mint:P10233|go:"GO:0019033"(viral tegument)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044177"(host cell Golgi apparatus)|interpro:IPR006908(Herpesvirus UL49 tegument protein)|rcsb pdb:4XAL|dip:DIP-57160N|mint:MINT-6733716(identity)|uniprotkb:P10233(P10233)	-	comment:mint	comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:DM3Zmc28xl4p1fOVo8YqkCjc3OU10299	rogid:DM3Zmc28xl4p1fOVo8YqkCjc3OU10299	intact-crc:E6E70867B6FBCCFA|rigid:DUZtZ/gLdV5ce6MOYSHe03WxQBM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06492	uniprotkb:P10230	intact:EBI-7489933|uniprotkb:Q09I86|intact:MINT-275736|uniprotkb:B9VQH6	intact:EBI-7694458|uniprotkb:B9VQH4|uniprotkb:Q09I88|intact:MINT-6732730|uniprotkb:O09799	psi-mi:vp16_hhv11(display_long)|uniprotkb:Vmw65(gene name synonym)|uniprotkb:ICP25(gene name synonym)|uniprotkb:Alpha-TIF(gene name synonym)|uniprotkb:Alpha trans-inducing protein(gene name synonym)|uniprotkb:UL48(orf name)	psi-mi:teg1_hhv11(display_long)|uniprotkb:UL46(orf name)|uniprotkb:Tegument protein VP11/12(gene name synonym)	psi-mi:"MI:0096"(pull down)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694552|mint:MINT-6733724	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137123.1|mint:P06492|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0019033"(viral tegument)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039660"(structural constituent of virion)|go:"GO:0039695"(DNA-templated viral transcription)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044161"(host cell cytoplasmic vesicle)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046782"(regulation of viral transcription)|go:"GO:0046809"(replication compartment)|go:"GO:0051701"(biological process involved in interaction with host)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003174("Alpha trans-inducing protein (Alpha-TIF)")|interpro:IPR021051|interpro:IPR036538|rcsb pdb:16VP|rcsb pdb:2PHE|rcsb pdb:2PHG|dip:DIP-41776N|mint:MINT-6733728(identity)|uniprotkb:P06492(P06492)	go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0019033"(viral tegument)|go:"GO:0020002"(host cell plasma membrane)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039503"(suppression by virus of host innate immune response)|mint:P10230|interpro:IPR005051(Herpesvirus UL46 protein)|refseq:YP_009137121.1|mint:MINT-6733725(identity)|uniprotkb:P10230(P10230)	-	comment:mint|function:"Responsible for transcriptional activation of immediate early promoters (alpha genes). Activation requires the formation of a heteromeric complex with the host cell factor. These two proteins then assemble with the octamer motif-binding protein Oct-1 on the cis-acting target sequence: 5'-TAATGARAT-3'"	function:Modulates alpha trans-inducing factor-dependent activation of alpha genes|comment:mint	figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:8rAT+y7LSTotMP4XcD+eSyMpff010299	rogid:vmkdkJduTTAYsz6YeglLJ9l046E10299	intact-crc:E3397BA73CF4BB91|rigid:zCsyJh2ZBll/rXun8nd57c3z7B0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10220	uniprotkb:P10221	intact:EBI-7694334|uniprotkb:Q09I97|intact:MINT-6732711|uniprotkb:B9VQG4	intact:EBI-6880600	psi-mi:ltp_hhv11(display_long)|uniprotkb:UL36(orf name)	psi-mi:itp_hhv11(display_long)|uniprotkb:UL37(gene name)|psi-mi:UL37(display_short)|uniprotkb:Viral deamidase UL37(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694575|mint:MINT-6733733	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0019033"(viral tegument)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0039708"(nuclear capsid assembly)|go:"GO:0042025"(host cell nucleus)|rcsb pdb:4TT0|rcsb pdb:4TT1|mint:P10220|interpro:IPR006928(Peptidase C76,   herpesvirus UL36 UL36 deubiquitinylating peptidase)|interpro:IPR005210(Herpesvirus UL36 tegument protein, central region)|refseq:YP_009137111.1|interpro:IPR034702|interpro:IPR038765|mint:MINT-6733734(identity)|uniprotkb:P10220(P10220)	go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0050568"(protein-glutamine glutaminase activity)|rcsb pdb:5VYL|interpro:IPR034738|interpro:IPR005655(Herpesvirus UL37 tegument protein)|mint:P10221|mint:MINT-6733737(identity)|uniprotkb:P10221(P10221)	-	function:Tegument protein|comment:mint	-	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:v5UsNbt9FXzQ1n57ZzLU/kTz/wQ10299	rogid:lvEEzHJRKc3EzANn8KSVFoJ94NM10299	intact-crc:04FA65B353EE3F96|rigid:2YQ407QvSh3dUu4tOwZ89rT/w4Q	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10221	uniprotkb:P10221	intact:EBI-6880600	intact:EBI-6880600	psi-mi:itp_hhv11(display_long)|uniprotkb:UL37(gene name)|psi-mi:UL37(display_short)|uniprotkb:Viral deamidase UL37(gene name synonym)	psi-mi:itp_hhv11(display_long)|uniprotkb:UL37(gene name)|psi-mi:UL37(display_short)|uniprotkb:Viral deamidase UL37(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Vittone et al. (2005)	pubmed:16014918|mint:MINT-6666723|doi:10.1128/JVI.79.15.9566-9571.2005	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7694588|mint:MINT-6733740	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0050568"(protein-glutamine glutaminase activity)|rcsb pdb:5VYL|interpro:IPR034738|interpro:IPR005655(Herpesvirus UL37 tegument protein)|mint:P10221|mint:MINT-6733744(identity)|uniprotkb:P10221(P10221)	go:"GO:0019033"(viral tegument)|go:"GO:0019068"(virion assembly)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0039701"(microtubule-dependent intracellular transport of viral material towards cell periphery)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0044177"(host cell Golgi apparatus)|go:"GO:0050568"(protein-glutamine glutaminase activity)|rcsb pdb:5VYL|interpro:IPR034738|interpro:IPR005655(Herpesvirus UL37 tegument protein)|mint:P10221|mint:MINT-6733741(identity)|uniprotkb:P10221(P10221)	-	-	-	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:lvEEzHJRKc3EzANn8KSVFoJ94NM10299	rogid:lvEEzHJRKc3EzANn8KSVFoJ94NM10299	intact-crc:86D36772417D19FB|rigid:uoDRcoIRbKPpcGWmmRth/GAUIBo	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)