#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08393	uniprotkb:P56524	intact:EBI-6148881	intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205338|mint:MINT-6733515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733519(identity)|uniprotkb:P08393(P08393)	ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N|mint:MINT-6733516(identity)|uniprotkb:P56524(P56524)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:EJhE8LikofmF9H8ubNsola4pSpc9606	intact-crc:D7C878928D2B7AB8|rigid:uckLJKsUXED9n+lxEsAcVl8PFrM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:O15379	intact:EBI-6148881	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205325|mint:MINT-6733508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733509(identity)|uniprotkb:P08393(P08393)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-6733512(identity)|uniprotkb:O15379(O15379)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	intact-crc:8A0417BC88098F2F|rigid:glpz0yoki9P9JTAFEoskJItsO4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:P56524	intact:EBI-6148881	intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205390|mint:MINT-6733543	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733544(identity)|uniprotkb:P08393(P08393)	ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N|mint:MINT-6733547(identity)|uniprotkb:P56524(P56524)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:EJhE8LikofmF9H8ubNsola4pSpc9606	intact-crc:F05EAB56CD721782|rigid:uckLJKsUXED9n+lxEsAcVl8PFrM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUI4	uniprotkb:P08393	intact:EBI-1048378|uniprotkb:Q7Z5I1|uniprotkb:Q96K01|uniprotkb:Q9BR73|uniprotkb:Q9H7L0|uniprotkb:Q9NW41|uniprotkb:Q9NWA9|uniprotkb:Q9NYK9|uniprotkb:Q9UFU7|uniprotkb:B3KY08|uniprotkb:B4DWI0|uniprotkb:B4E0Q5|uniprotkb:Q6P1W9|uniprotkb:Q6W9G7|uniprotkb:Q7Z4K2|ensembl:ENSP00000404394	intact:EBI-6148881	psi-mi:hdac7_human(display_long)|uniprotkb:Histone deacetylase 7A(gene name synonym)|uniprotkb:HDAC7(gene name)|psi-mi:HDAC7(display_short)|uniprotkb:HDAC7A(gene name synonym)	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205364|mint:MINT-6733529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536783.1|refseq:XP_011536784.1|refseq:NP_001295019.1|refseq:NP_001091886.1|refseq:NP_056216.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|ensembl:ENSG00000061273(gene)|ensembl:ENST00000427332(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR023801|interpro:IPR037138|mint:Q8WUI4|rcsb pdb:3C0Y|rcsb pdb:3C0Z|rcsb pdb:3C10|rcsb pdb:3ZNR|rcsb pdb:3ZNS|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3108214|reactome:R-HSA-350054|reactome:R-HSA-8943724|dip:DIP-29860N|mint:MINT-6733533(identity)|uniprotkb:Q8WUI4(Q8WUI4)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733530(identity)|uniprotkb:P08393(P08393)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:lRG/KaW9IIP1O9X26GT+ho94JDg9606	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	intact-crc:671782F0FF0C1A76|rigid:ZnCoqz23q8aV9Rd41mJ0+a5nLTA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:Q9UQL6	intact:EBI-6148881	intact:EBI-715576|uniprotkb:O60340|uniprotkb:O60528|uniprotkb:Q96DY4|intact:EBI-28970762|uniprotkb:C9JFV9|ensembl:ENSP00000468004|ensembl:ENSP00000507606	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac5_human(display_long)|uniprotkb:Antigen NY-CO-9(gene name synonym)|uniprotkb:HDAC5(gene name)|psi-mi:HDAC5(display_short)|uniprotkb:KIAA0600(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205351|mint:MINT-6733522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733523(identity)|uniprotkb:P08393(P08393)	refseq:NP_001015053.1|refseq:NP_005465.2|refseq:XP_005256963.1|ensembl:ENST00000225983|ensembl:ENSP00000225983|ensembl:ENST00000336057|ensembl:ENSP00000337290|ensembl:ENSP00000468004|ensembl:ENSP00000507606|dip:DIP-38260N|rcsb pdb:5UWI|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8943724|mint:Q9UQL6|ensembl:ENSG00000108840(gene)|ensembl:ENST00000586802(transcript)|ensembl:ENST00000682912(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|mint:MINT-6733526(identity)|uniprotkb:Q9UQL6(Q9UQL6)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:fI8A5VuOawGthBb/65R47AEGZ/Y9606	intact-crc:74DF9E5FBF636F23|rigid:tVySlJHTsjgGC0pL1JlxQT2na14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:Q9UQL6	intact:EBI-6148881	intact:EBI-715576|uniprotkb:O60340|uniprotkb:O60528|uniprotkb:Q96DY4|intact:EBI-28970762|uniprotkb:C9JFV9|ensembl:ENSP00000468004|ensembl:ENSP00000507606	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac5_human(display_long)|uniprotkb:Antigen NY-CO-9(gene name synonym)|uniprotkb:HDAC5(gene name)|psi-mi:HDAC5(display_short)|uniprotkb:KIAA0600(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205419|mint:MINT-6733550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733554(identity)|uniprotkb:P08393(P08393)	refseq:NP_001015053.1|refseq:NP_005465.2|refseq:XP_005256963.1|ensembl:ENST00000225983|ensembl:ENSP00000225983|ensembl:ENST00000336057|ensembl:ENSP00000337290|ensembl:ENSP00000468004|ensembl:ENSP00000507606|dip:DIP-38260N|rcsb pdb:5UWI|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8943724|mint:Q9UQL6|ensembl:ENSG00000108840(gene)|ensembl:ENST00000586802(transcript)|ensembl:ENST00000682912(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|mint:MINT-6733551(identity)|uniprotkb:Q9UQL6(Q9UQL6)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:fI8A5VuOawGthBb/65R47AEGZ/Y9606	intact-crc:53494D9BFF3A0219|rigid:tVySlJHTsjgGC0pL1JlxQT2na14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUI4	uniprotkb:P08393	intact:EBI-1048378|uniprotkb:Q7Z5I1|uniprotkb:Q96K01|uniprotkb:Q9BR73|uniprotkb:Q9H7L0|uniprotkb:Q9NW41|uniprotkb:Q9NWA9|uniprotkb:Q9NYK9|uniprotkb:Q9UFU7|uniprotkb:B3KY08|uniprotkb:B4DWI0|uniprotkb:B4E0Q5|uniprotkb:Q6P1W9|uniprotkb:Q6W9G7|uniprotkb:Q7Z4K2|ensembl:ENSP00000404394	intact:EBI-6148881	psi-mi:hdac7_human(display_long)|uniprotkb:Histone deacetylase 7A(gene name synonym)|uniprotkb:HDAC7(gene name)|psi-mi:HDAC7(display_short)|uniprotkb:HDAC7A(gene name synonym)	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205432|mint:MINT-6733557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536783.1|refseq:XP_011536784.1|refseq:NP_001295019.1|refseq:NP_001091886.1|refseq:NP_056216.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|ensembl:ENSG00000061273(gene)|ensembl:ENST00000427332(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR023801|interpro:IPR037138|mint:Q8WUI4|rcsb pdb:3C0Y|rcsb pdb:3C0Z|rcsb pdb:3C10|rcsb pdb:3ZNR|rcsb pdb:3ZNS|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3108214|reactome:R-HSA-350054|reactome:R-HSA-8943724|dip:DIP-29860N|mint:MINT-6733561(identity)|uniprotkb:Q8WUI4(Q8WUI4)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733558(identity)|uniprotkb:P08393(P08393)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:lRG/KaW9IIP1O9X26GT+ho94JDg9606	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	intact-crc:40815134BF55774C|rigid:ZnCoqz23q8aV9Rd41mJ0+a5nLTA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:O15379	intact:EBI-6148881	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:"MI:0096"(pull down)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205377|mint:MINT-6733536	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733540(identity)|uniprotkb:P08393(P08393)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-6733537(identity)|uniprotkb:O15379(O15379)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	intact-crc:0CEAC9BCE7F82118|rigid:glpz0yoki9P9JTAFEoskJItsO4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8WUI4	uniprotkb:P08393	intact:EBI-1048378|uniprotkb:Q7Z5I1|uniprotkb:Q96K01|uniprotkb:Q9BR73|uniprotkb:Q9H7L0|uniprotkb:Q9NW41|uniprotkb:Q9NWA9|uniprotkb:Q9NYK9|uniprotkb:Q9UFU7|uniprotkb:B3KY08|uniprotkb:B4DWI0|uniprotkb:B4E0Q5|uniprotkb:Q6P1W9|uniprotkb:Q6W9G7|uniprotkb:Q7Z4K2|ensembl:ENSP00000404394	intact:EBI-6148881	psi-mi:hdac7_human(display_long)|uniprotkb:Histone deacetylase 7A(gene name synonym)|uniprotkb:HDAC7(gene name)|psi-mi:HDAC7(display_short)|uniprotkb:HDAC7A(gene name synonym)	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205495|mint:MINT-6733587	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536783.1|refseq:XP_011536784.1|refseq:NP_001295019.1|refseq:NP_001091886.1|refseq:NP_056216.2|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|ensembl:ENSG00000061273(gene)|ensembl:ENST00000427332(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR023801|interpro:IPR037138|mint:Q8WUI4|rcsb pdb:3C0Y|rcsb pdb:3C0Z|rcsb pdb:3C10|rcsb pdb:3ZNR|rcsb pdb:3ZNS|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3108214|reactome:R-HSA-350054|reactome:R-HSA-8943724|dip:DIP-29860N|mint:MINT-6733588(identity)|uniprotkb:Q8WUI4(Q8WUI4)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733591(identity)|uniprotkb:P08393(P08393)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:lRG/KaW9IIP1O9X26GT+ho94JDg9606	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	intact-crc:E6EF34C6C5249120|rigid:ZnCoqz23q8aV9Rd41mJ0+a5nLTA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:O15379	intact:EBI-6148881	intact:EBI-607682|uniprotkb:O43268|uniprotkb:Q9UEI5|uniprotkb:Q9UEV0|uniprotkb:D3DQE1|ensembl:ENSP00000302967	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac3_human(display_long)|uniprotkb:HDAC3(gene name)|psi-mi:HDAC3(display_short)|uniprotkb:RPD3-2(gene name synonym)|uniprotkb:SMAP45(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205456|mint:MINT-6733566	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733567(identity)|uniprotkb:P08393(P08393)	refseq:NP_003874.2|dip:DIP-24253N|ensembl:ENSG00000171720(gene)|ensembl:ENST00000305264(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0072686"(mitotic spindle)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR003084(Histone deacetylase)|interpro:IPR023696|interpro:IPR023801|interpro:IPR037138|mint:O15379|rcsb pdb:4A69|reactome:R-HSA-1368071|reactome:R-HSA-193670|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2151201|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-390471|reactome:R-HSA-400206|reactome:R-HSA-5617472|reactome:R-HSA-8940973|reactome:R-HSA-8943724|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-400253|mint:MINT-6733570(identity)|uniprotkb:O15379(O15379)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:X5pnE98s15eXKev3nauN7ri5kqg9606	intact-crc:988B9495EFB52B6C|rigid:glpz0yoki9P9JTAFEoskJItsO4g	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:P56524	intact:EBI-6148881	intact:EBI-308629|uniprotkb:Q9UND6|uniprotkb:E9PGB9|uniprotkb:F5GX36|uniprotkb:Q86YH7|intact:EBI-28970476|ensembl:ENSP00000264606	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac4_human(display_long)|uniprotkb:HDAC4(gene name)|psi-mi:HDAC4(display_short)|uniprotkb:KIAA0288(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205469|mint:MINT-6733573	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733574(identity)|uniprotkb:P08393(P08393)	ensembl:ENSP00000264606|ensembl:ENSG00000068024(gene)|ensembl:ENST00000345617(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:P56524|rcsb pdb:2H8N|rcsb pdb:2O94|rcsb pdb:2VQJ|rcsb pdb:2VQM|rcsb pdb:2VQO|rcsb pdb:2VQQ|rcsb pdb:2VQV|rcsb pdb:2VQW|rcsb pdb:3UXG|rcsb pdb:3UZD|rcsb pdb:3V31|rcsb pdb:4CBT|rcsb pdb:4CBY|rcsb pdb:5A2S|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6FYZ|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-8941284|reactome:R-HSA-8951936|refseq:NP_006028.2|dip:DIP-34565N|mint:MINT-6733577(identity)|uniprotkb:P56524(P56524)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:EJhE8LikofmF9H8ubNsola4pSpc9606	intact-crc:5630CEA4B703F1EE|rigid:uckLJKsUXED9n+lxEsAcVl8PFrM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P08393	uniprotkb:Q9UQL6	intact:EBI-6148881	intact:EBI-715576|uniprotkb:O60340|uniprotkb:O60528|uniprotkb:Q96DY4|intact:EBI-28970762|uniprotkb:C9JFV9|ensembl:ENSP00000468004|ensembl:ENSP00000507606	psi-mi:icp0_hhv11(display_long)|uniprotkb:ICP0(gene name)|psi-mi:ICP0(display_short)|uniprotkb:Alpha-0 protein(gene name synonym)|uniprotkb:IE110(gene name synonym)|uniprotkb:Immediate-early protein IE110(gene name synonym)|uniprotkb:Trans-acting transcriptional protein ICP0(gene name synonym)|uniprotkb:VMW110(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ICP0(gene name synonym)	psi-mi:hdac5_human(display_long)|uniprotkb:Antigen NY-CO-9(gene name synonym)|uniprotkb:HDAC5(gene name)|psi-mi:HDAC5(display_short)|uniprotkb:KIAA0600(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Lomonte et al. (2004)	pubmed:15194749|mint:MINT-6666541|doi:10.1128/JVI.78.13.6744-6757.2004	taxid:10299(hhv11)|taxid:10299("Human herpesvirus 1 (strain 17) (HHV-1)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7205482|mint:MINT-6733580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:YP_009137074.1|refseq:YP_009137133.1|mint:P08393|dip:DIP-42446N|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0019033"(viral tegument)|go:"GO:0019046"(release from viral latency)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0034340"(response to type I interferon)|go:"GO:0039548"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity)|go:"GO:0039593"(suppression by virus of host exit from mitosis)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0042025"(host cell nucleus)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0075342"(disruption by symbiont of host cell PML body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:5C56|rcsb pdb:6JXU|rcsb pdb:6JXV|rcsb pdb:6JXW|rcsb pdb:6JXX|mint:MINT-6733584(identity)|uniprotkb:P08393(P08393)	refseq:NP_001015053.1|refseq:NP_005465.2|refseq:XP_005256963.1|ensembl:ENST00000225983|ensembl:ENSP00000225983|ensembl:ENST00000336057|ensembl:ENSP00000337290|ensembl:ENSP00000468004|ensembl:ENSP00000507606|dip:DIP-38260N|rcsb pdb:5UWI|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-350054|reactome:R-HSA-8943724|mint:Q9UQL6|ensembl:ENSG00000108840(gene)|ensembl:ENST00000586802(transcript)|ensembl:ENST00000682912(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006342"|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|mint:MINT-6733581(identity)|uniprotkb:Q9UQL6(Q9UQL6)	-	-	-	figure legend:F2|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:keAdk+TW9AFPk4Yn7Rm/mC65Kv010299	rogid:fI8A5VuOawGthBb/65R47AEGZ/Y9606	intact-crc:F5272869854BE475|rigid:tVySlJHTsjgGC0pL1JlxQT2na14	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)