#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03132	uniprotkb:P03120	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1779322|uniprotkb:Q71BI4	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0019"(coimmunoprecipitation)	Marcello et al. (2000)	pubmed:10982355|mint:MINT-6549884|doi:10.1128/JVI.74.19.9090-9098.2000	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7387235|mint:MINT-6732447	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1|mint:MINT-6732450(identity)|uniprotkb:P03132(P03132)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-6732448(identity)|uniprotkb:P03120(P03120)	-	function:Essential for DNA replication|comment:mint	-	figure legend:F3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	intact-crc:211BDAD888627FF1|rigid:4/2JOtTcdp3xxYvwtn6+S5eUnpQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03132	uniprotkb:P03120	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1779322|uniprotkb:Q71BI4	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0096"(pull down)	Marcello et al. (2000)	pubmed:10982355|mint:MINT-6549884|doi:10.1128/JVI.74.19.9090-9098.2000	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7387278|mint:MINT-6732454	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1|mint:MINT-6732457(identity)|uniprotkb:P03132(P03132)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-6732455(identity)|uniprotkb:P03120(P03120)	-	function:Essential for DNA replication|comment:mint	-	figure legend:F4|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	intact-crc:9CC3601FD819E7B6|rigid:4/2JOtTcdp3xxYvwtn6+S5eUnpQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03120	uniprotkb:Q99966	intact:EBI-1779322|uniprotkb:Q71BI4	intact:EBI-2624951|uniprotkb:B5BU50|uniprotkb:B5BUI2|ensembl:ENSP00000246139|ensembl:ENSP00000362721|ensembl:ENSP00000403274|ensembl:ENSP00000499148	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:cite1_human(display_long)|uniprotkb:CITED1(gene name)|psi-mi:CITED1(display_short)|uniprotkb:MSG1(gene name synonym)|uniprotkb:Melanocyte-specific protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Marcello et al. (2000)	pubmed:10982355|mint:MINT-6549884|doi:10.1128/JVI.74.19.9090-9098.2000	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7387344|mint:MINT-6732464	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-6732465(identity)|uniprotkb:P03120(P03120)	refseq:XP_011529260.1|refseq:NP_001138357.1|refseq:NP_001138358.1|refseq:NP_001138359.1|refseq:NP_004134.2|ensembl:ENSG00000125931(gene)|ensembl:ENST00000246139(transcript)|ensembl:ENST00000373619(transcript)|ensembl:ENST00000445983(transcript)|ensembl:ENST00000651998(transcript)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001656"(metanephros development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001890"(placenta development)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0034097"(response to cytokine)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042438"(melanin biosynthetic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043473"(pigmentation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050693"(LBD domain binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0060231"(mesenchymal to epithelial transition)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0060712"(spongiotrophoblast layer development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070669"(response to interleukin-2)|go:"GO:0070670"(response to interleukin-4)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071104"(response to interleukin-9)|go:"GO:0071105"(response to interleukin-11)|go:"GO:0071107"(response to parathyroid hormone)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|interpro:IPR007576(CITED)|mint:Q99966|reactome:R-HSA-8866907|reactome:R-HSA-9018519|mint:MINT-6732467(identity)|uniprotkb:Q99966(Q99966)	-	-	-	figure legend:F6|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	rogid:1JGSSEi+2CxobFnmTPPwUa8jNFQ9606	intact-crc:EFABC5EB8A7D5B3A|rigid:uol3gKAQ+rwXiZW6sPJV5QjOQj8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03114	uniprotkb:P03120	intact:EBI-7387308|uniprotkb:P03115|uniprotkb:Q71BI5|intact:MINT-1526142	intact:EBI-1779322|uniprotkb:Q71BI4	psi-mi:ve1_hpv16(display_long)|uniprotkb:E1(gene name)|psi-mi:E1(display_short)|uniprotkb:ATP-dependent helicase E1(gene name synonym)	psi-mi:ve2_hpv16(display_long)|uniprotkb:E2(gene name)|psi-mi:E2(display_short)	psi-mi:"MI:0096"(pull down)	Marcello et al. (2000)	pubmed:10982355|mint:MINT-6549884|doi:10.1128/JVI.74.19.9090-9098.2000	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	taxid:333760(hpv16)|taxid:333760(Human papillomavirus type 16)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7387331|mint:MINT-6732459	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03114|interpro:IPR016393(Replication protein E1, papillomavirus)|interpro:IPR027417|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR014000(DNA helicase E1 protein, N-terminal, Papillomavirus)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001177(DNA helicase E1 protein, C-terminal, Papillomavirus)|mint:MINT-6732462(identity)|uniprotkb:P03114(P03114)	refseq:NP_041328.1|dip:DIP-44574N|mint:P03120|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0006260"(DNA replication)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044163"(host cytoskeleton)|interpro:IPR000427(E2 early regulatory protein, C-terminal)|interpro:IPR001866(E2 early regulatory protein, N-terminal)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033668|interpro:IPR035975|interpro:IPR036050|interpro:IPR042503|interpro:IPR042504|rcsb pdb:1BY9|rcsb pdb:1DTO|rcsb pdb:1R8P|rcsb pdb:1ZZF|rcsb pdb:2NNU|rcsb pdb:2Q79|rcsb pdb:3MI7|mint:MINT-6732460(identity)|uniprotkb:P03120(P03120)	-	comment:mint|comment:homomint|function:ATP-dependent DNA helicase required for initiation of viral DNA replication. It forms a complex with the viral E2 protein. The E1-E2 complex binds to the replication origin which contains binding sites for both proteins	-	figure legend:F5|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|curation depth:rapid curation	taxid:-3(unknown)|taxid:-3(Unknown)	-	2008/07/25	2014/10/16	rogid:1k8b6WS2HBpWDus+zuWQyaRg/PU333760	rogid:0/XZ8yUPpKVdUvpKjNxjHHQnmAE333760	intact-crc:69B0E39BC85C2710|rigid:RNg9HbZh2+83cIbQ00u6nc2aGbY	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)