#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-1555202	uniprotkb:O00329	-	intact:EBI-718309|uniprotkb:A6NCG0|uniprotkb:O15445|uniprotkb:Q5SR49|uniprotkb:G1FFP1|ensembl:ENSP00000366563	psi-mi:pi3kr1_cerae_protein(display_short)|psi-mi:EBI-1555202(display_long)	psi-mi:pk3cd_human(display_long)|uniprotkb:PIK3CD(gene name)|psi-mi:PIK3CD(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Chantry et al. (1997)	pubmed:9235916|imex:IM-19778	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555237|imex:IM-19778-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005017.3|ensembl:ENSG00000171608(gene)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:5DXU|rcsb pdb:5M6U|rcsb pdb:5T8F|rcsb pdb:5UBT|rcsb pdb:5VLR|rcsb pdb:6G6W|rcsb pdb:6OCO|rcsb pdb:6OCU|rcsb pdb:6PYR|rcsb pdb:6PYU|rcsb pdb:7JIS|rcsb pdb:7LM2|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-512988|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-983695|refseq:XP_006710750.1|refseq:XP_006710752.1|ensembl:ENST00000377346(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001819"(positive regulation of cytokine production)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P27986	crc64:A38B5D1A1081A3D0	figure legend:3|delivery method:O00329 transefection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/11/14	2014/10/16	-	rogid:CT7WEvRXYa2x7ZAkEYSrVwrGXRQ9606	intact-crc:67A336191758E2A9	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16749"	uniprotkb:O00329	intact:EBI-1373365	intact:EBI-718309|uniprotkb:A6NCG0|uniprotkb:O15445|uniprotkb:Q5SR49|uniprotkb:G1FFP1|ensembl:ENSP00000366563	psi-mi:1-phosphatidyl-1d-myo-inositol(display_short)|psi-mi:"CHEBI:16749"(display_long)	psi-mi:pk3cd_human(display_long)|uniprotkb:PIK3CD(gene name)|psi-mi:PIK3CD(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Chantry et al. (1997)	pubmed:9235916|imex:IM-19778	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555293|imex:IM-19778-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005017.3|ensembl:ENSG00000171608(gene)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0035754"(B cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:5DXU|rcsb pdb:5M6U|rcsb pdb:5T8F|rcsb pdb:5UBT|rcsb pdb:5VLR|rcsb pdb:6G6W|rcsb pdb:6OCO|rcsb pdb:6OCU|rcsb pdb:6PYR|rcsb pdb:6PYU|rcsb pdb:7JIS|rcsb pdb:7LM2|reactome:R-HSA-1257604|reactome:R-HSA-1660499|reactome:R-HSA-2219530|reactome:R-HSA-512988|reactome:R-HSA-6811558|reactome:R-HSA-8853659|reactome:R-HSA-9027276|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-983695|refseq:XP_006710750.1|refseq:XP_006710752.1|ensembl:ENST00000377346(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001819"(positive regulation of cytokine production)	-	-	crc64:A38B5D1A1081A3D0	figure legend:6|comment:The phosphatidylinositol is phosphorylated by p110delta.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	-	rogid:CT7WEvRXYa2x7ZAkEYSrVwrGXRQ9606	intact-crc:DCC1C0A3DCD4BF00	false	-	flag tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:O35904	uniprotkb:Q61411	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-400273|uniprotkb:Q80WD2|uniprotkb:Q6P716|uniprotkb:Q811B9|ensembl:ENSMUSP00000026572|ensembl:ENSMUSP00000095570|uniprotkb:F7BIB2	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:rash_mouse(display_long)|uniprotkb:Hras(gene name)|psi-mi:Hras(display_short)|uniprotkb:H-Ras-1(gene name synonym)|uniprotkb:Hras1(gene name synonym)|uniprotkb:Transforming protein p21(gene name synonym)|uniprotkb:c-H-ras(gene name synonym)|uniprotkb:p21ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Chantry et al. (1997)	pubmed:9235916|imex:IM-19778	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1569114|imex:IM-19778-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	refseq:NP_001123915.1|refseq:NP_001123916.1|refseq:NP_032310.2|ensembl:ENSMUSG00000025499(gene)|ensembl:ENSMUST00000026572(transcript)|ensembl:ENSMUST00000097957(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0019003"(GDP binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035900"(response to isolation stress)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090398"(cellular senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|mint:Q61411|rcsb pdb:6KYH|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|go:"GO:1900029"(positive regulation of ruffle assembly)|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9607240|reactome:R-MMU-9634635|reactome:R-MMU-9648002|refseq:XP_006536222.2|dip:DIP-29361N	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/14	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:hjBAnRVG6bLFePkCYnkl3ZCjnmw10090	intact-crc:870834B13E0CF1E7|rigid:LW/mH2SzKMdWmIJhnrpijRgOKJc	false	sufficient binding region:141-291	mutation:12-12	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P27986	uniprotkb:O35904	intact:EBI-79464|intact:EBI-28974553|ensembl:ENSP00000428056|ensembl:ENSP00000429277|uniprotkb:Q15747|uniprotkb:Q4VBZ7|uniprotkb:Q53EM6|uniprotkb:Q8IXA2|uniprotkb:Q8N1C5|uniprotkb:D3DWA0|uniprotkb:B3KT19|uniprotkb:E7EX19	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	psi-mi:p85a_human(display_long)|uniprotkb:PIK3R1(gene name)|psi-mi:PIK3R1(display_short)|uniprotkb:GRB1(gene name synonym)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chantry et al. (1997)	pubmed:9235916|imex:IM-19778	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2911755|imex:IM-19778-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001229395.1|refseq:NP_852556.2|refseq:NP_852664.1|refseq:NP_852665.1|ensembl:ENSG00000145675(gene)|ensembl:ENST00000521381(transcript)|ensembl:ENST00000521657(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENST00000320694|ensembl:ENSP00000323512|ensembl:ENST00000336483|ensembl:ENSP00000338554|ensembl:ENSP00000428056|ensembl:ENSP00000429277|ensembl:ENST00000523872|ensembl:ENSP00000430098|rcsb pdb:5SXA|rcsb pdb:5SXB|rcsb pdb:5SXC|rcsb pdb:5SXD|rcsb pdb:5SXE|rcsb pdb:5SXF|rcsb pdb:5SXI|rcsb pdb:5SXJ|rcsb pdb:5SXK|rcsb pdb:5UBT|rcsb pdb:5UK8|rcsb pdb:5UKJ|rcsb pdb:5SX9|rcsb pdb:5UL1|rcsb pdb:5VLR|rcsb pdb:5XGH|rcsb pdb:5XGI|rcsb pdb:5XGJ|rcsb pdb:6NCT|rcsb pdb:6PYR|rcsb pdb:6PYU|reactome:R-HSA-1660499|rcsb pdb:7CIO|rcsb pdb:7LM2|reactome:R-HSA-180292|reactome:R-HSA-109704|reactome:R-HSA-1839117|reactome:R-HSA-112399|reactome:R-HSA-114604|reactome:R-HSA-1236382|reactome:R-HSA-186763|reactome:R-HSA-1963642|reactome:R-HSA-1250342|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-198203|reactome:R-HSA-202424|reactome:R-HSA-2029485|reactome:R-HSA-1433557|reactome:R-HSA-210993|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2730905|reactome:R-HSA-373753|reactome:R-HSA-388841|reactome:R-HSA-389357|reactome:R-HSA-416476|reactome:R-HSA-430116|reactome:R-HSA-4420097|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654689|reactome:R-HSA-5654695|reactome:R-HSA-5654710|reactome:R-HSA-5654720|reactome:R-HSA-9035034|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9603381|reactome:R-HSA-9607240|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8980692|reactome:R-HSA-9009391|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-5655291|reactome:R-HSA-9013423|reactome:R-HSA-9013424|reactome:R-HSA-9027276|reactome:R-HSA-9028335|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043125"(ErbB-3 class receptor binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P27986|rcsb pdb:1A0N|rcsb pdb:1AZG|rcsb pdb:1H9O|rcsb pdb:1PBW|rcsb pdb:1PHT|rcsb pdb:1PIC|rcsb pdb:1PKS|rcsb pdb:1PKT|rcsb pdb:2IUG|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|rcsb pdb:2IUH|rcsb pdb:2IUI|rcsb pdb:2RD0|rcsb pdb:3HHM|rcsb pdb:3HIZ|rcsb pdb:3I5R|rcsb pdb:3I5S|rcsb pdb:4A55|rcsb pdb:4JPS|rcsb pdb:4L1B|rcsb pdb:4L23|rcsb pdb:4L2Y|rcsb pdb:4OVU|rcsb pdb:4OVV|rcsb pdb:4WAF|rcsb pdb:4YKN|rcsb pdb:4ZOP|rcsb pdb:5AUL|rcsb pdb:5FI4|rcsb pdb:5GJI|rcsb pdb:5ITD|rcsb pdb:5M6U|rcsb pdb:5SW8|rcsb pdb:5SWG|rcsb pdb:5SWO|rcsb pdb:2V1Y|rcsb pdb:5SWP|rcsb pdb:5SWR|rcsb pdb:5SWT|rcsb pdb:5SX8|refseq:XP_016865074.1|refseq:XP_005248599.1|dip:DIP-119N	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	-	-	-	figure legend:4|delivery method:O35904 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/11/14	2014/10/16	rogid:pANLtVCSWVr64OXaS6bCjGBwfig9606	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	intact-crc:7E70567F2263A7C4|rigid:wq3YiTckACOFZVS2Xtc8AeMIF08	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)