#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P50613	uniprotkb:P51948	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1245984|imex:IM-19051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	-	-	-	figure legend:2a|comment:Identity of MAT1 protein confirmed by comigration with in vitro tranlsation protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	intact-crc:B217A0828FED528C|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51946	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1245984|imex:IM-19051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	-	-	-	figure legend:2a|comment:Identity of MAT1 protein confirmed by comigration with in vitro tranlsation protein.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	intact-crc:B217A0828FED528C|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51946	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1245996|imex:IM-19051-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	-	-	-	figure legend:Figs 4 and 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	intact-crc:341EF525B1CEE909|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51948	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1245996|imex:IM-19051-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	-	-	-	figure legend:Figs 4 and 5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	intact-crc:341EF525B1CEE909|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?	35s radiolabel:?-?|sufficient binding region:50-309	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51948	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246050|imex:IM-19051-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	intact-crc:1C9E02ED9E208F78|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51946	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246050|imex:IM-19051-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	-	-	-	figure legend:4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	intact-crc:1C9E02ED9E208F78|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51948	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246014|imex:IM-19051-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	intact-crc:EE5F013CCF4575A1|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?|myc tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P50613	uniprotkb:P51946	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246014|imex:IM-19051-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	intact-crc:EE5F013CCF4575A1|rigid:tpQFfxUvsWLKhSmPs4gEU/BTHdo	false	35s radiolabel:?-?|myc tag:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P51946	uniprotkb:P24941	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-375096|ensembl:ENSP00000266970|uniprotkb:A8K7C6|uniprotkb:O75100	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:cdk2_human(display_long)|uniprotkb:CDK2(gene name)|psi-mi:CDK2(display_short)|uniprotkb:p33 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:CDKN2(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246034|imex:IM-19051-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	ensembl:ENSG00000123374(gene)|ensembl:ENST00000266970(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090398"(cellular senescence)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P24941|rcsb pdb:1AQ1|rcsb pdb:1B39|rcsb pdb:1B38|rcsb pdb:1BUH|rcsb pdb:1CKP|rcsb pdb:1DI8|rcsb pdb:1DM2|rcsb pdb:1E1V|rcsb pdb:1E1X|rcsb pdb:1E9H|rcsb pdb:1F5Q|rcsb pdb:1FIN|rcsb pdb:1FQ1|rcsb pdb:1FVT|rcsb pdb:1FVV|rcsb pdb:1G5S|rcsb pdb:1GIH|rcsb pdb:1GII|rcsb pdb:1GIJ|rcsb pdb:1GY3|rcsb pdb:3R6X|rcsb pdb:3R71|rcsb pdb:3R73|rcsb pdb:3R7E|rcsb pdb:3R7I|rcsb pdb:3R7U|rcsb pdb:3R7V|rcsb pdb:3R7Y|rcsb pdb:3R83|rcsb pdb:3R8L|rcsb pdb:3R8M|rcsb pdb:3R8P|rcsb pdb:3R8U|rcsb pdb:3R8V|rcsb pdb:3R8Z|rcsb pdb:3R9D|rcsb pdb:3R9H|rcsb pdb:3R9N|rcsb pdb:3R9O|rcsb pdb:3RAH|rcsb pdb:3RAI|rcsb pdb:3RAK|rcsb pdb:3RAL|rcsb pdb:3RJC|refseq:NP_001789.2|refseq:NP_439892.2|rcsb pdb:1URC|rcsb pdb:1URW|rcsb pdb:1V1K|rcsb pdb:1VYW|rcsb pdb:1VYZ|rcsb pdb:1W0X|rcsb pdb:1W8C|rcsb pdb:1GZ8|rcsb pdb:1H00|rcsb pdb:1H01|rcsb pdb:1H07|rcsb pdb:1H08|rcsb pdb:1H0V|rcsb pdb:1H0W|rcsb pdb:1H1P|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1HCK|rcsb pdb:1HCL|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1JSV|rcsb pdb:1JVP|rcsb pdb:1KE5|rcsb pdb:1KE6|rcsb pdb:1KE7|rcsb pdb:1KE8|rcsb pdb:1KE9|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIQ|rcsb pdb:1OIR|rcsb pdb:1OIT|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P2A|rcsb pdb:1P5E|rcsb pdb:1PF8|rcsb pdb:1PKD|rcsb pdb:1PW2|rcsb pdb:1PXI|rcsb pdb:1PXJ|rcsb pdb:1PXK|rcsb pdb:1PXL|rcsb pdb:1PXM|rcsb pdb:1PXN|rcsb pdb:1PXO|rcsb pdb:1PXP|rcsb pdb:1PYE|rcsb pdb:1QMZ|rcsb pdb:1R78|rcsb pdb:1W98|rcsb pdb:1WCC|rcsb pdb:1Y8Y|rcsb pdb:1Y91|rcsb pdb:1YKR|rcsb pdb:2A0C|rcsb pdb:2A4L|rcsb pdb:2B52|rcsb pdb:2B53|rcsb pdb:2B54|rcsb pdb:2B55|rcsb pdb:2BHE|rcsb pdb:2BHH|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2BTR|rcsb pdb:2BTS|rcsb pdb:2C4G|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C5Y|rcsb pdb:2C68|rcsb pdb:2C69|rcsb pdb:2C6I|rcsb pdb:2C6K|rcsb pdb:2C6L|rcsb pdb:2C6M|rcsb pdb:2C6O|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:3BHT|rcsb pdb:2CJM|rcsb pdb:2CLX|rcsb pdb:2DS1|rcsb pdb:2DUV|rcsb pdb:2EXM|rcsb pdb:2FVD|rcsb pdb:2G9X|rcsb pdb:2HIC|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2J9M|rcsb pdb:2JGZ|rcsb pdb:2R3F|rcsb pdb:2R3G|rcsb pdb:2R3H|rcsb pdb:2R3I|rcsb pdb:2R3J|rcsb pdb:2R3K|rcsb pdb:2R3L|rcsb pdb:2R3M|rcsb pdb:2R3N|rcsb pdb:2R3O|rcsb pdb:2R3P|rcsb pdb:2R3Q|rcsb pdb:2R3R|rcsb pdb:2R64|rcsb pdb:2UUE|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2UZN|rcsb pdb:2UZO|rcsb pdb:2V0D|rcsb pdb:2V22|rcsb pdb:2VTA|rcsb pdb:2VTH|rcsb pdb:2VTI|rcsb pdb:2VTJ|rcsb pdb:2VTL|rcsb pdb:2VTM|rcsb pdb:2VTN|rcsb pdb:2VTO|rcsb pdb:2VTP|rcsb pdb:2VTQ|rcsb pdb:2VTR|rcsb pdb:2VTS|rcsb pdb:2VTT|rcsb pdb:2VU3|rcsb pdb:2VV9|rcsb pdb:2W05|rcsb pdb:2W06|rcsb pdb:2W17|rcsb pdb:2W1H|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:2WIH|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:2XMY|rcsb pdb:2XNB|rcsb pdb:3BHU|rcsb pdb:3BHV|rcsb pdb:3DDP|rcsb pdb:3DDQ|rcsb pdb:3DOG|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3EZR|rcsb pdb:3EZV|rcsb pdb:3F5X|rcsb pdb:3FZ1|rcsb pdb:3IG7|rcsb pdb:3IGG|rcsb pdb:3LE6|rcsb pdb:3LFN|rcsb pdb:3LFQ|rcsb pdb:3LFS|rcsb pdb:3MY5|rcsb pdb:3NS9|rcsb pdb:3PJ8|rcsb pdb:3PXF|rcsb pdb:3PXQ|rcsb pdb:3PXR|rcsb pdb:3PXY|rcsb pdb:3PXZ|rcsb pdb:3PY0|rcsb pdb:3PY1|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:3QL8|rcsb pdb:3QQF|rcsb pdb:3QQG|rcsb pdb:3QQH|rcsb pdb:3QQJ|rcsb pdb:3QQK|rcsb pdb:3QQL|rcsb pdb:3QRT|rcsb pdb:3QRU|rcsb pdb:3QTQ|rcsb pdb:3QTR|rcsb pdb:3QTS|rcsb pdb:3QTU|rcsb pdb:3QTW|rcsb pdb:3QTX|rcsb pdb:3QTZ|rcsb pdb:3QU0|rcsb pdb:3QWJ|rcsb pdb:3QWK|rcsb pdb:3QX2|rcsb pdb:3QX4|rcsb pdb:3QXO|rcsb pdb:3QXP|rcsb pdb:3QZF|rcsb pdb:3QZG|rcsb pdb:3QZH|rcsb pdb:3QZI|rcsb pdb:3R1Q|rcsb pdb:3R1S|rcsb pdb:3R1Y|rcsb pdb:3R28|refseq:NP_001277159.1|rcsb pdb:3RK5|rcsb pdb:3RK7|rcsb pdb:3RK9|rcsb pdb:3RKB|rcsb pdb:3RM6|rcsb pdb:3RM7|rcsb pdb:3RMF|rcsb pdb:3RNI|rcsb pdb:3ROY|rcsb pdb:3RPO|rcsb pdb:3RPR|rcsb pdb:3RPV|rcsb pdb:3RPY|rcsb pdb:3RZB|rcsb pdb:3S00|rcsb pdb:3S0O|rcsb pdb:3S1H|rcsb pdb:3S2P|rcsb pdb:3SQQ|rcsb pdb:3SW4|rcsb pdb:3SW7|rcsb pdb:3TI1|rcsb pdb:3TIY|rcsb pdb:3TIZ|rcsb pdb:3TNW|rcsb pdb:3ULI|rcsb pdb:3UNJ|rcsb pdb:3UNK|rcsb pdb:3WBL|rcsb pdb:4ACM|rcsb pdb:4BCK|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCO|rcsb pdb:4BCP|rcsb pdb:4BCQ|rcsb pdb:4BGH|rcsb pdb:4BZD|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4D1X|rcsb pdb:4D1Z|rcsb pdb:4EK3|rcsb pdb:4EK4|rcsb pdb:4EK5|rcsb pdb:4EK6|rcsb pdb:4EK8|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4ERW|rcsb pdb:4EZ3|rcsb pdb:4EZ7|rcsb pdb:4FKG|rcsb pdb:4FKI|rcsb pdb:4FKJ|rcsb pdb:4FKL|rcsb pdb:4FKO|rcsb pdb:4FKP|rcsb pdb:4FKQ|rcsb pdb:4FKR|rcsb pdb:4FKS|rcsb pdb:4FKT|rcsb pdb:4FKU|rcsb pdb:4FKV|rcsb pdb:4FKW|rcsb pdb:4FX3|rcsb pdb:4GCJ|rcsb pdb:4I3Z|rcsb pdb:4II5|rcsb pdb:4KD1|rcsb pdb:4LYN|rcsb pdb:5IEV|rcsb pdb:5IEX|rcsb pdb:5IEY|rcsb pdb:5IF1|rcsb pdb:5JQ5|rcsb pdb:5JQ8|rcsb pdb:5K4J|rcsb pdb:5L2W|rcsb pdb:5LMK|rcsb pdb:5MHQ|rcsb pdb:5NEV|rcsb pdb:5OO0|rcsb pdb:5OO1|rcsb pdb:5OO3|rcsb pdb:5OSJ|rcsb pdb:5OSM|rcsb pdb:5UQ1|rcsb pdb:5UQ2|rcsb pdb:5UQ3|rcsb pdb:6ATH|rcsb pdb:6GUB|rcsb pdb:6GUC|rcsb pdb:6GUE|rcsb pdb:6GUF|rcsb pdb:6GUH|rcsb pdb:6GUK|rcsb pdb:6GVA|rcsb pdb:6INL|rcsb pdb:6JGM|rcsb pdb:4NJ3|rcsb pdb:4RJ3|rcsb pdb:5A14|rcsb pdb:5AND|rcsb pdb:5ANE|rcsb pdb:5ANG|rcsb pdb:5ANI|rcsb pdb:5ANJ|rcsb pdb:5ANK|rcsb pdb:5ANO|rcsb pdb:5CYI|rcsb pdb:5D1J|rcsb pdb:5FP5|rcsb pdb:5FP6|rcsb pdb:6OQI|rcsb pdb:6P3W|rcsb pdb:6Q3B|rcsb pdb:6Q3C|rcsb pdb:6Q3F|rcsb pdb:6Q48|rcsb pdb:6Q49|rcsb pdb:6Q4A|rcsb pdb:6Q4B|rcsb pdb:6Q4C|rcsb pdb:6Q4D|rcsb pdb:6Q4E|rcsb pdb:6Q4F|rcsb pdb:6Q4G|rcsb pdb:6Q4H|rcsb pdb:6Q4I|rcsb pdb:6Q4J|rcsb pdb:6Q4K|rcsb pdb:6RIJ|rcsb pdb:6SG4|rcsb pdb:6YL1|rcsb pdb:6YL6|rcsb pdb:6YLK|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7E34|rcsb pdb:7KJS|rcsb pdb:7NVQ|reactome:R-HSA-1538133|reactome:R-HSA-171319|reactome:R-HSA-176187|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69017|reactome:R-HSA-69200|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|reactome:R-HSA-8849470|reactome:R-HSA-912446|reactome:R-HSA-9616222|reactome:R-HSA-9661069|reactome:R-HSA-983231|dip:DIP-161N	go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Figs. 4, 5|resulting-ptm:Phosphorylation of CDK2|comment:"Kinase-dead CDK7 (Lys41Arg) did not prevent the CAK complex froming but did prevent phosphorylation of CDK2"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:ysjMzOZyhhtpss+M7hJCqtLahFQ9606	intact-crc:A7E9758BEB07F02B|rigid:pkK6jMFykbmgbW10a1pawYHCUTw	false	35s radiolabel:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P51946	uniprotkb:P50613	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-1245958|uniprotkb:Q9BS60|uniprotkb:Q9UE19|ensembl:ENSP00000256443|ensembl:ENSP00000479116	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:cdk7_human(display_long)|uniprotkb:CDK7(gene name)|psi-mi:CDK7(display_short)|uniprotkb:MO15(gene name synonym)|uniprotkb:CAK(gene name synonym)|uniprotkb:CAK1(gene name synonym)|uniprotkb:TFIIH basal transcription factor complex kinase subunit(gene name synonym)|uniprotkb:39 kDa protein kinase(gene name synonym)|uniprotkb:CDKN7(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:Cell division protein kinase 7(gene name synonym)|uniprotkb:CDK-activating kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246034|imex:IM-19051-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001790.1|refseq:NP_001310998.1|refseq:NP_001310999.1|refseq:NP_001311000.1|refseq:NP_001311006.1|dip:DIP-5995N|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSG00000134058(gene)|ensembl:ENSG00000277273(gene)|ensembl:ENST00000256443(transcript)|ensembl:ENST00000615305(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR037770|rcsb pdb:1LG3|rcsb pdb:1PA8|rcsb pdb:1UA2|rcsb pdb:2HIC|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823	go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Figs. 4, 5|resulting-ptm:Phosphorylation of CDK2|comment:"Kinase-dead CDK7 (Lys41Arg) did not prevent the CAK complex froming but did prevent phosphorylation of CDK2"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:pA9dLwvlBxPUAXW3bgv5M00qezk9606	intact-crc:A7E9758BEB07F02B|rigid:pkK6jMFykbmgbW10a1pawYHCUTw	false	35s radiolabel:?-?	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P51946	uniprotkb:P51948	intact:EBI-741406|uniprotkb:Q8TBL9|uniprotkb:Q53X72|intact:EBI-28985782|ensembl:ENSP00000256897	intact:EBI-716139|uniprotkb:Q15817|uniprotkb:G3V1U8|uniprotkb:Q6ICQ7|ensembl:ENSP00000261245	psi-mi:ccnh_human(display_long)|uniprotkb:MO15-associated protein(gene name synonym)|uniprotkb:p37(gene name synonym)|uniprotkb:p34(gene name synonym)|uniprotkb:CCNH(gene name)|psi-mi:CCNH(display_short)	psi-mi:mat1_human(display_long)|uniprotkb:RING finger protein MAT1(gene name synonym)|uniprotkb:Menage a trois(gene name synonym)|uniprotkb:CDK7/cyclin-H assembly factor(gene name synonym)|uniprotkb:p36(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Cyclin-G1-interacting protein(gene name synonym)|uniprotkb:RING finger protein 66(gene name synonym)|uniprotkb:MNAT1(gene name)|psi-mi:MNAT1(display_short)|uniprotkb:CAP35(gene name synonym)|uniprotkb:MAT1(gene name synonym)|uniprotkb:RNF66(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Tassan et al. (1995)	pubmed:8521818|imex:IM-19051	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1246034|imex:IM-19051-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230.1|ensembl:ENSG00000134480(gene)|ensembl:ENST00000256897(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0007049"(cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0070985"(transcription factor TFIIK complex)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR027081|interpro:IPR031658|interpro:IPR036915|interpro:IPR043198|rcsb pdb:1JKW|rcsb pdb:1KXU|rcsb pdb:6O9L|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8939236|ensembl:ENSP00000256897|dip:DIP-5996N	refseq:NP_001171434.1|refseq:NP_002422.1|interpro:IPR017907|rcsb pdb:1G25|rcsb pdb:6NMI|rcsb pdb:6O9L|rcsb pdb:6O9M|rcsb pdb:6TUN|rcsb pdb:6XBZ|rcsb pdb:6XD3|rcsb pdb:7B5O|rcsb pdb:7B5Q|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVW|rcsb pdb:7NVX|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167246|reactome:R-HSA-427413|reactome:R-HSA-5696395|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-69202|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-72086|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|interpro:IPR015877(Cdk-activating kinase assembly factor, MAT1)|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|ensembl:ENST00000261245(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000439"(transcription factor TFIIH core complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007512"(adult heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019907"(cyclin-dependent protein kinase activating kinase holoenzyme complex)|go:"GO:0021591"(ventricular system development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070516"(CAK-ERCC2 complex)|go:"GO:0070985"(transcription factor TFIIK complex)|ensembl:ENSG00000020426(gene)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR004575("Cdk-activating kinase assembly factor (MAT1)")|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-HSA-8939236|refseq:XP_005267744.1	go:"GO:0019912"(cyclin-dependent protein kinase activating kinase activity)|go:"GO:0006468"(protein phosphorylation)	-	-	figure legend:Figs. 4, 5|resulting-ptm:Phosphorylation of CDK2|comment:"Kinase-dead CDK7 (Lys41Arg) did not prevent the CAK complex froming but did prevent phosphorylation of CDK2"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/20	2014/10/16	rogid:OORqAxdGyjEcCe38DaFXd7BwjxI9606	rogid:5Y/RExMrWjtftdbXuadagc0b+Kc9606	intact-crc:A7E9758BEB07F02B|rigid:pkK6jMFykbmgbW10a1pawYHCUTw	false	35s radiolabel:?-?	35s radiolabel:?-?|sufficient binding region:50-309	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)