#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8I0V0	uniprotkb:Q9TY95	intact:EBI-1568896|ensemblprotists:CAD51440	intact:EBI-826913|uniprotkb:A0A143ZWK2|ensemblprotists:CZT98089	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:sera5_plaf7(display_long)|uniprotkb:SERA5(gene name)|psi-mi:SERA5(display_short)|uniprotkb:111 kDa antigen(gene name synonym)|uniprotkb:Serine protease SERA5(gene name synonym)|uniprotkb:p126(gene name synonym)|uniprotkb:PFB0340c(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568875|imex:IM-11976-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	refseq:XP_001349586.1|interpro:IPR000668(Peptidase C1A, papain C-terminal)|rcsb pdb:3CH2|rcsb pdb:3CH3|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|rcsb pdb:2WBF|rcsb pdb:6X42|rcsb pdb:6X44|ensemblprotists:CZT98089(transcript)|ensemblprotists:PF3D7_0207600(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0035891"(exit from host cell)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 5A and 5B|resulting-ptm:Cleavage of Sera to a P56 form via a P73 intermediate|inhibition:Inhibited by MRT12113, a compound originally purified natural products from temperate plants.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	rogid:mLXHK7UEphu8Hpljy48KNrBnS+M36329	intact-crc:CE8BE87B9C4F348B|rigid:NWumNeD6Ro1fl1O4fucLvU6NVGw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8I0V0	uniprotkb:O96164	intact:EBI-1568896|ensemblprotists:CAD51440	intact:EBI-824760|ensemblprotists:CZT98090	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:o96164_plaf7(display_long)|uniprotkb:PF3D7_0207700(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568966|imex:IM-11976-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	interpro:IPR025661|interpro:IPR000668(Peptidase C1A, papain C-terminal)|refseq:XP_001349587.1|interpro:IPR038765|ensemblprotists:CZT98090(transcript)|ensemblprotists:PF3D7_0207700(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 6B|resulting-ptm:Cleavage of O96164|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	rogid:Vqwz2WBnCmVLMLBW4JFuPh9lG7A36329	intact-crc:7BBAA10B40C230DD|rigid:Uzmv6NKrwgRT1i7EOcnluY8H+lE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9TY96	uniprotkb:Q8I0V0	intact:EBI-827996|ensemblprotists:CZT98088	intact:EBI-1568896|ensemblprotists:CAD51440	psi-mi:sera6_plaf7(display_long)|uniprotkb:SERA6(gene name)|psi-mi:SERA6(display_short)|uniprotkb:Cysteine protease SERA6(gene name synonym)|uniprotkb:PF3D7_0207500(orf name)	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568974|imex:IM-11976-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|refseq:XP_001349585.2|interpro:IPR038765|ensemblprotists:CZT98088(transcript)|ensemblprotists:PF3D7_0207500(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 6B|resulting-ptm:Cleavage of Q9TY96|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:tOIWfJ4Fcqnp6rh9utqrK7mZmf436329	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	intact-crc:26560EC18D338C38|rigid:fUwF2w9bSpVbf9+4Vs0pO3YeD1g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8I0V0	uniprotkb:Q9TY95	intact:EBI-1568896|ensemblprotists:CAD51440	intact:EBI-826913|uniprotkb:A0A143ZWK2|ensemblprotists:CZT98089	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:sera5_plaf7(display_long)|uniprotkb:SERA5(gene name)|psi-mi:SERA5(display_short)|uniprotkb:111 kDa antigen(gene name synonym)|uniprotkb:Serine protease SERA5(gene name synonym)|uniprotkb:p126(gene name synonym)|uniprotkb:PFB0340c(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568914|imex:IM-11976-8	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	refseq:XP_001349586.1|interpro:IPR000668(Peptidase C1A, papain C-terminal)|rcsb pdb:3CH2|rcsb pdb:3CH3|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|rcsb pdb:2WBF|rcsb pdb:6X42|rcsb pdb:6X44|ensemblprotists:CZT98089(transcript)|ensemblprotists:PF3D7_0207600(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0035891"(exit from host cell)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 5C|resulting-ptm:Cleavage of Sera to a P56 form via a P73 intermediate|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	rogid:mLXHK7UEphu8Hpljy48KNrBnS+M36329	intact-crc:980A120AAAEA224C|rigid:NWumNeD6Ro1fl1O4fucLvU6NVGw	false	-	-	-	-	psi-mi:"MI:0093"(protein sequence identification)	psi-mi:"MI:0093"(protein sequence identification)
uniprotkb:Q9TY95	uniprotkb:Q8I0V0	intact:EBI-826913|uniprotkb:A0A143ZWK2|ensemblprotists:CZT98089	intact:EBI-1568896|ensemblprotists:CAD51440	psi-mi:sera5_plaf7(display_long)|uniprotkb:SERA5(gene name)|psi-mi:SERA5(display_short)|uniprotkb:111 kDa antigen(gene name synonym)|uniprotkb:Serine protease SERA5(gene name synonym)|uniprotkb:p126(gene name synonym)|uniprotkb:PFB0340c(orf name)	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568925|imex:IM-11976-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001349586.1|interpro:IPR000668(Peptidase C1A, papain C-terminal)|rcsb pdb:3CH2|rcsb pdb:3CH3|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|rcsb pdb:2WBF|rcsb pdb:6X42|rcsb pdb:6X44|ensemblprotists:CZT98089(transcript)|ensemblprotists:PF3D7_0207600(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0019900"(kinase binding)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0035891"(exit from host cell)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig 5D and Supp. Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:mLXHK7UEphu8Hpljy48KNrBnS+M36329	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	intact-crc:EBD4E73D21CFB933|rigid:NWumNeD6Ro1fl1O4fucLvU6NVGw	false	fluorescent protein tag:?-?|mutation:386-386|mutation:395-395|sufficient binding region:882-891|mutation:882-882|mutation:891-891|sufficient binding region:386-395	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q8I0V0	uniprotkb:Q8I0V0	intact:EBI-1568896|ensemblprotists:CAD51440	intact:EBI-1568896|ensemblprotists:CAD51440	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568946|imex:IM-11976-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	go:"GO:0008236"(serine-type peptidase activity)	-	-	figure legend:Fig 5D and Supp. Fig. 5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	intact-crc:1CB0E1595BC88D4E|rigid:eA2LIH8pcNXwLgJbVTvkdW96QUo	false	-	sufficient binding region:212-222|mutation:212-212|mutation:222-222|fluorescent protein tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q9TY96	uniprotkb:Q8I0V0	intact:EBI-827996|ensemblprotists:CZT98088	intact:EBI-1568896|ensemblprotists:CAD51440	psi-mi:sera6_plaf7(display_long)|uniprotkb:SERA6(gene name)|psi-mi:SERA6(display_short)|uniprotkb:Cysteine protease SERA6(gene name synonym)|uniprotkb:PF3D7_0207500(orf name)	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568983|imex:IM-11976-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|refseq:XP_001349585.2|interpro:IPR038765|ensemblprotists:CZT98088(transcript)|ensemblprotists:PF3D7_0207500(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020005"(symbiont-containing vacuole membrane)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Supp. Fig. 7|resulting-ptm:Cleavage of Q9TY96|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:tOIWfJ4Fcqnp6rh9utqrK7mZmf436329	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	intact-crc:86FD260000420857|rigid:fUwF2w9bSpVbf9+4Vs0pO3YeD1g	false	sufficient binding region:366-375|sufficient binding region:923-932|fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:Q8I0V0	uniprotkb:O96164	intact:EBI-1568896|ensemblprotists:CAD51440	intact:EBI-824760|ensemblprotists:CZT98090	psi-mi:sub1_plaf7(display_long)|uniprotkb:SUB1(gene name)|psi-mi:SUB1(display_short)|uniprotkb:PfSUB1(gene name synonym)|uniprotkb:PF3D7_0507500(orf name)	psi-mi:o96164_plaf7(display_long)|uniprotkb:PF3D7_0207700(orf name)	psi-mi:"MI:0435"(protease assay)	Yeoh et al. (2007)	imex:IM-11976|pubmed:18083098	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	taxid:36329(plaf7)|taxid:36329("Plasmodium falciparum (isolate 3D7)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568997|imex:IM-11976-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_001351633.1|interpro:IPR017314(Pepridase S8A, subtilisin-like peptidase 1, plasmodium)|interpro:IPR000209(Peptidase S8 and S53, subtilisin, kexin, sedolisin)|interpro:IPR023827|interpro:IPR022398|interpro:IPR023828|interpro:IPR015500(Peptidase S8, subtilisin-related)|interpro:IPR041089|interpro:IPR034204|interpro:IPR036852|ensemblprotists:CAD51440(transcript)|ensemblprotists:PF3D7_0507500(gene)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0020004"(symbiont-containing vacuolar space)|go:"GO:0020026"(merozoite dense granule)|go:"GO:0044311"(exoneme)|go:"GO:0046872"(metal ion binding)	interpro:IPR025661|interpro:IPR000668(Peptidase C1A, papain C-terminal)|refseq:XP_001349587.1|interpro:IPR038765|ensemblprotists:CZT98090(transcript)|ensemblprotists:PF3D7_0207700(gene)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0020003"(symbiont-containing vacuole)|go:"GO:0050776"(regulation of immune response)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)	go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Supp. Fig. 7|resulting-ptm:Cleavage of O96164|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/17	2014/10/16	rogid:Ct2RQYew5fG/AxQrW0uXxgDHKV036329	rogid:Vqwz2WBnCmVLMLBW4JFuPh9lG7A36329	intact-crc:A6C8A6E52AC5AA2F|rigid:Uzmv6NKrwgRT1i7EOcnluY8H+lE	false	-	sufficient binding region:307-316|sufficient binding region:769-778|fluorescent protein tag:?-?	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)