#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04062	uniprotkb:O35114	intact:EBI-1564609|uniprotkb:B7Z5G2|uniprotkb:B7Z6S1|uniprotkb:J3KQG4|uniprotkb:J3KQK9|uniprotkb:Q16545|uniprotkb:Q4VX22|uniprotkb:Q6I9R6|uniprotkb:Q9UMJ8|uniprotkb:A8K796|ensembl:ENSP00000314508|ensembl:ENSP00000357357	intact:EBI-1564519|uniprotkb:Q3UNF8|ensembl:ENSMUSP00000031377	psi-mi:glcm_human(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Alglucerase(gene name synonym)|uniprotkb:Imiglucerase(gene name synonym)|uniprotkb:GBA(gene name)|psi-mi:GBA(display_short)|uniprotkb:GC(gene name synonym)|uniprotkb:GLUC(gene name synonym)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:scrb2_mouse(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)	psi-mi:"MI:0096"(pull down)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564575|imex:IM-11888-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001165282.1|refseq:NP_001165283.1|refseq:NP_000148.2|refseq:NP_001005741.1|refseq:NP_001005742.1|dip:DIP-38645N|ensembl:ENSG00000177628(gene)|ensembl:ENST00000327247(transcript)|ensembl:ENST00000368373(transcript)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007040"(lysosome organization)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|go:"GO:1905165"(regulation of lysosomal protein catabolic process)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P04062|rcsb pdb:1OGS|rcsb pdb:1Y7V|rcsb pdb:2F61|rcsb pdb:2J25|rcsb pdb:2NSX|rcsb pdb:2NT0|rcsb pdb:2NT1|rcsb pdb:2V3D|rcsb pdb:2V3E|rcsb pdb:2V3F|rcsb pdb:2VT0|rcsb pdb:2WCG|rcsb pdb:2WKL|rcsb pdb:2XWD|rcsb pdb:2XWE|rcsb pdb:3GXD|rcsb pdb:3GXF|rcsb pdb:3GXI|rcsb pdb:3GXM|rcsb pdb:3KE0|rcsb pdb:3KEH|rcsb pdb:3RIK|rcsb pdb:3RIL|rcsb pdb:5LVX|rcsb pdb:6MOZ|rcsb pdb:6Q1N|rcsb pdb:6Q1P|rcsb pdb:6Q6K|rcsb pdb:6Q6L|rcsb pdb:6Q6N|rcsb pdb:6TJJ|rcsb pdb:6TJK|rcsb pdb:6TJQ|rcsb pdb:6TN1|rcsb pdb:6YTP|rcsb pdb:6YTR|rcsb pdb:6YUT|rcsb pdb:6YV3|rcsb pdb:6Z39|rcsb pdb:6Z3I|reactome:R-HSA-1660662|reactome:R-HSA-390471	refseq:NP_031670.1|ensembl:ENSMUSG00000029426(gene)|ensembl:ENSMUST00000031377(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:O35114|reactome:R-MMU-8856825|reactome:R-MMU-8856828	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A, 1B|comment:Scarb2 competed off by excess GBA|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/05	2014/10/16	rogid:AWV635bfvuSWV1vflhTcun2riyk9606	rogid:xKljq8br/DAEOG1kYu9qTOVkQ5c10090	intact-crc:AEFFB17D2087B353|rigid:9gXOfrXTPhTUAfhnMh+hnw+1IG4	false	-	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:P17439	uniprotkb:Q14108	intact:EBI-1564504|uniprotkb:Q78NR7|ensembl:ENSMUSP00000076589|ensembl:ENSMUSP00000130660	intact:EBI-1564650|uniprotkb:Q53Y63|uniprotkb:B4DKD8|uniprotkb:E7EM68|ensembl:ENSP00000264896	psi-mi:glcm_mouse(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Gba(gene name)|psi-mi:Gba(display_short)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:scrb2_human(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:CD36 antigen-like 2(gene name synonym)|uniprotkb:SCARB2(gene name)|psi-mi:SCARB2(display_short)|uniprotkb:CD36L2(gene name synonym)|uniprotkb:LIMPII(gene name synonym)|uniprotkb:LIMP2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564646|imex:IM-11888-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070879.1|refseq:NP_032120.1|ensembl:ENSMUSG00000028048(gene)|ensembl:ENSMUST00000077367(transcript)|ensembl:ENSMUST00000167998(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P17439|reactome:R-MMU-1660662|go:"GO:0005794"(Golgi apparatus)	refseq:NP_001191184.1|refseq:NP_005497.1|ensembl:ENSG00000138760(gene)|ensembl:ENST00000264896(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010008"(endosome membrane)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904978"(regulation of endosome organization)|go:"GO:1905123"(regulation of glucosylceramidase activity)|go:"GO:1905671"(regulation of lysosome organization)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:Q14108|rcsb pdb:4F7B|rcsb pdb:4Q4B|rcsb pdb:4Q4F|rcsb pdb:4TVZ|rcsb pdb:4TW0|rcsb pdb:4TW2|rcsb pdb:5UPH|rcsb pdb:5XBM|rcsb pdb:6I2K|reactome:R-HSA-8856825|reactome:R-HSA-8856828	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1D, 1E|comment:Binding of the SCARB2 lumenal domain to the GBA resin was favored at neutral pH and attenuated as the pH approached that typical of the lysosomal lumen.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/12/05	2014/10/16	rogid:IpMWPXrEn/og+UKXNKkVwSP/G6010090	rogid:FXyG5dJv7OqGjSgl5slIqNxUqoI9606	intact-crc:AAE9AE79621D582D|rigid:T1iaPR5OfeMSZzoenphkegrWXTg	false	tag:?-?	sufficient binding region:28-433	-	-	psi-mi:"MI:0816"(molecular weight estimation by staining)	psi-mi:"MI:0816"(molecular weight estimation by staining)
uniprotkb:P17439	uniprotkb:O35114	intact:EBI-1564504|uniprotkb:Q78NR7|ensembl:ENSMUSP00000076589|ensembl:ENSMUSP00000130660	intact:EBI-1564519|uniprotkb:Q3UNF8|ensembl:ENSMUSP00000031377	psi-mi:glcm_mouse(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Gba(gene name)|psi-mi:Gba(display_short)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:scrb2_mouse(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564740|imex:IM-11888-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070879.1|refseq:NP_032120.1|ensembl:ENSMUSG00000028048(gene)|ensembl:ENSMUST00000077367(transcript)|ensembl:ENSMUST00000167998(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P17439|reactome:R-MMU-1660662|go:"GO:0005794"(Golgi apparatus)	refseq:NP_031670.1|ensembl:ENSMUSG00000029426(gene)|ensembl:ENSMUST00000031377(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:O35114|reactome:R-MMU-8856825|reactome:R-MMU-8856828	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig. 3C|delivery method:O35114 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2007/12/05	2014/10/16	rogid:IpMWPXrEn/og+UKXNKkVwSP/G6010090	rogid:xKljq8br/DAEOG1kYu9qTOVkQ5c10090	intact-crc:A16449D339B9DAFC|rigid:5eY491Cq8x2jXfNTprAETmozsEg	false	-	myc tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P17439	uniprotkb:P17047	intact:EBI-1564504|uniprotkb:Q78NR7|ensembl:ENSMUSP00000076589|ensembl:ENSMUSP00000130660	intact:EBI-1564749|uniprotkb:A2A430|uniprotkb:Q3TXG5|uniprotkb:Q8BSG8|ensembl:ENSMUSP00000016678	psi-mi:glcm_mouse(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Gba(gene name)|psi-mi:Gba(display_short)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:lamp2_mouse(display_long)|uniprotkb:Lysosomal membrane glycoprotein type B(gene name synonym)|uniprotkb:CD107 antigen-like family member B(gene name synonym)|uniprotkb:Lamp2(gene name)|psi-mi:Lamp2(display_short)|uniprotkb:Lamp-2(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564770|imex:IM-11888-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070879.1|refseq:NP_032120.1|ensembl:ENSMUSG00000028048(gene)|ensembl:ENSMUST00000077367(transcript)|ensembl:ENSMUST00000167998(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P17439|reactome:R-MMU-1660662|go:"GO:0005794"(Golgi apparatus)	refseq:NP_001017959.1|refseq:NP_034815.2|ensembl:ENSMUSG00000016534(gene)|ensembl:ENSMUST00000016678(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0006914"(autophagy)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031088"(platelet dense granule membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031902"(late endosome membrane)|go:"GO:0044754"(autolysosome)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0061742"(chaperone-mediated autophagy translocation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0097637"(integral component of autophagosome membrane)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1990836"(lysosomal matrix)|interpro:IPR002000("Lysosome-associated membrane glycoprotein (Lamp)/CD68")|interpro:IPR018134|mint:P17047|rcsb pdb:5GV3|reactome:R-MMU-114608|reactome:R-MMU-6798695	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig. 3G|delivery method:O35114 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2007/12/05	2014/10/16	rogid:IpMWPXrEn/og+UKXNKkVwSP/G6010090	rogid:em1v9qxpoHR13ocQdAffj+zQSDE10090	intact-crc:883390C01E00113C|rigid:EnPfOUVDZuvFKxb2Swb1Y0G86r0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P17439	uniprotkb:O35114	intact:EBI-1564504|uniprotkb:Q78NR7|ensembl:ENSMUSP00000076589|ensembl:ENSMUSP00000130660	intact:EBI-1564519|uniprotkb:Q3UNF8|ensembl:ENSMUSP00000031377	psi-mi:glcm_mouse(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Gba(gene name)|psi-mi:Gba(display_short)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:scrb2_mouse(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)	psi-mi:"MI:0416"(fluorescence microscopy)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564770|imex:IM-11888-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070879.1|refseq:NP_032120.1|ensembl:ENSMUSG00000028048(gene)|ensembl:ENSMUST00000077367(transcript)|ensembl:ENSMUST00000167998(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P17439|reactome:R-MMU-1660662|go:"GO:0005794"(Golgi apparatus)	refseq:NP_031670.1|ensembl:ENSMUSG00000029426(gene)|ensembl:ENSMUST00000031377(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:O35114|reactome:R-MMU-8856825|reactome:R-MMU-8856828	go:"GO:0005764"(lysosome)	-	-	figure legend:Fig. 3G|delivery method:O35114 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2007/12/05	2014/10/16	rogid:IpMWPXrEn/og+UKXNKkVwSP/G6010090	rogid:xKljq8br/DAEOG1kYu9qTOVkQ5c10090	intact-crc:883390C01E00113C|rigid:EnPfOUVDZuvFKxb2Swb1Y0G86r0	false	-	myc tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
intact:EBI-1633174	uniprotkb:O35114	-	intact:EBI-1564519|uniprotkb:Q3UNF8|ensembl:ENSMUSP00000031377	psi-mi:glcm_cerae_protein(display_short)|psi-mi:EBI-1633174(display_long)	psi-mi:scrb2_mouse(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564852|imex:IM-11888-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_031670.1|ensembl:ENSMUSG00000029426(gene)|ensembl:ENSMUST00000031377(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:O35114|reactome:R-MMU-8856825|reactome:R-MMU-8856828	psi-mi:"MI:0469"(intact)	no-uniprot-update:An amino acid sequence which is not represented in UniProt	-	figure legend:Fig. 4G and 5E|comment:A Scar2 mutant fused to an endoplasmic retention signal was also coimmunoprecipitated with Gba.|delivery method:O35114 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/12/05	2014/10/16	-	rogid:xKljq8br/DAEOG1kYu9qTOVkQ5c10090	intact-crc:BB84BD9793060A44	false	-	myc tag:?-?|mutation decreasing interaction:160-160|necessary binding region:150-167	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35114	uniprotkb:P17439	intact:EBI-1564519|uniprotkb:Q3UNF8|ensembl:ENSMUSP00000031377	intact:EBI-1564504|uniprotkb:Q78NR7|ensembl:ENSMUSP00000076589|ensembl:ENSMUSP00000130660	psi-mi:scrb2_mouse(display_long)|uniprotkb:Lysosome membrane protein II(gene name synonym)|uniprotkb:Scavenger receptor class B member 2(gene name synonym)|uniprotkb:85 kDa lysosomal membrane sialoglycoprotein(gene name synonym)|uniprotkb:Scarb2(gene name)|psi-mi:Scarb2(display_short)	psi-mi:glcm_mouse(display_long)|uniprotkb:Beta-glucocerebrosidase(gene name synonym)|uniprotkb:Acid beta-glucosidase(gene name synonym)|uniprotkb:D-glucosyl-N-acylsphingosine glucohydrolase(gene name synonym)|uniprotkb:Gba(gene name)|psi-mi:Gba(display_short)|uniprotkb:Cholesterol glucosyltransferase(gene name synonym)|uniprotkb:Cholesteryl-beta-glucosidase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Reczek et al. (2007)	imex:IM-11888|pubmed:18022370	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1633167|imex:IM-11888-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031670.1|ensembl:ENSMUSG00000029426(gene)|ensembl:ENSMUST00000031377(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0010467"(gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015917"(aminophospholipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043471"(regulation of cellular carbohydrate catabolic process)|go:"GO:0051087"(chaperone binding)|go:"GO:1905123"(regulation of glucosylceramidase activity)|interpro:IPR002159(CD36 antigen)|interpro:IPR005429(Lysosome membrane protein II)|mint:O35114|reactome:R-MMU-8856825|reactome:R-MMU-8856828	refseq:NP_001070879.1|refseq:NP_032120.1|ensembl:ENSMUSG00000028048(gene)|ensembl:ENSMUST00000077367(transcript)|ensembl:ENSMUST00000167998(transcript)|go:"GO:0000423"(mitophagy)|go:"GO:0004348"(glucosylceramidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005124"(scavenger receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006680"(glucosylceramide catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0007417"(central nervous system development)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008422"(beta-glucosidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009268"(response to pH)|go:"GO:0014004"(microglia differentiation)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019915"(lipid storage)|go:"GO:0021694"(cerebellar Purkinje cell layer formation)|go:"GO:0021859"(pyramidal neuron differentiation)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0023021"(termination of signal transduction)|go:"GO:0030259"(lipid glycosylation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0033574"(response to testosterone)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0043627"(response to estrogen)|go:"GO:0046512"(sphingosine biosynthetic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0046527"(glucosyltransferase activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050295"(steryl-beta-glucosidase activity)|go:"GO:0050877"(nervous system process)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061518"(microglial cell proliferation)|go:"GO:0061744"(motor behavior)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072676"(lymphocyte migration)|go:"GO:0097066"(response to thyroid hormone)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901805"(beta-glucoside catabolic process)|go:"GO:1903052"(positive regulation of proteolysis involved in cellular protein catabolic process)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1904457"(positive regulation of neuronal action potential)|go:"GO:1904925"(positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization)|go:"GO:1905037"(autophagosome organization)|interpro:IPR001139(Glycoside hydrolase, family 30)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR033452|interpro:IPR033453|mint:P17439|reactome:R-MMU-1660662|go:"GO:0005794"(Golgi apparatus)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. S5A|delivery method:P17439; O35114 transfection|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/12/05	2014/10/16	rogid:xKljq8br/DAEOG1kYu9qTOVkQ5c10090	rogid:IpMWPXrEn/og+UKXNKkVwSP/G6010090	intact-crc:D41A8C5DD305E01D|rigid:5eY491Cq8x2jXfNTprAETmozsEg	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)