#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0AEE3	uniprotkb:P0AFX7	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	intact:EBI-1117560|uniprotkb:P38106|uniprotkb:Q2MAF8|ensemblbacteria:AAC75625|ensemblbacteria:BAE76748	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:rsea_ecoli(display_long)|uniprotkb:yfiJ(gene name synonym)|uniprotkb:rseA(gene name)|psi-mi:rseA(display_short)|uniprotkb:mclA(gene name synonym)|uniprotkb:b2572(locus name)|uniprotkb:JW2556(locus name)|uniprotkb:Regulator of SigE(gene name synonym)|uniprotkb:Sigma-E anti-sigma factor RseA(gene name synonym)|uniprotkb:Sigma-E factor negative regulatory protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558308|imex:IM-12022-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	refseq:NP_417067.1|ensemblbacteria:AAC75625(transcript)|ensemblbacteria:b2572(gene)|ensemblbacteria:BAE76748(gene)|ensemblbacteria:BAE76748(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016989"(sigma factor antagonist activity)|interpro:IPR005572(Anti sigma-E protein RseA, N-terminal)|interpro:IPR005573(Anti sigma-E protein RseA, C-terminal)|interpro:IPR026279|interpro:IPR036147|rcsb pdb:1OR7|rcsb pdb:1YFN|rcsb pdb:3M4W|refseq:WP_001168459.1|dip:DIP-39581N	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	kinetics:Km = 570 +/- 50 uM|kinetics:Vmax = 0.8 +/- 0.1 s-1 Trimeric delta-DegS-1|kinetics:Hill constant = 1.8 +/- 0.2|figure legend:Fig. 1D|comment:"This construct (delta-DegS) is lacking the PDZ domain which appears to cause in inhibition of the reaction which is relieved by the addition of peptide."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:tpuDQBjnIhDZEQzGSs4rw3+LLcg83333	intact-crc:109B47D7F8BD25C3|rigid:LGzzFprpA8Z0qrqvAPbASa1M3Fw	false	his tag:n-n|sufficient binding region:27-280..280,327..327-355	his tag:?-?|sufficient binding region:121-216|35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEE3	uniprotkb:P0AFX7	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	intact:EBI-1117560|uniprotkb:P38106|uniprotkb:Q2MAF8|ensemblbacteria:AAC75625|ensemblbacteria:BAE76748	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:rsea_ecoli(display_long)|uniprotkb:yfiJ(gene name synonym)|uniprotkb:rseA(gene name)|psi-mi:rseA(display_short)|uniprotkb:mclA(gene name synonym)|uniprotkb:b2572(locus name)|uniprotkb:JW2556(locus name)|uniprotkb:Regulator of SigE(gene name synonym)|uniprotkb:Sigma-E anti-sigma factor RseA(gene name synonym)|uniprotkb:Sigma-E factor negative regulatory protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558452|imex:IM-12022-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	refseq:NP_417067.1|ensemblbacteria:AAC75625(transcript)|ensemblbacteria:b2572(gene)|ensemblbacteria:BAE76748(gene)|ensemblbacteria:BAE76748(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016989"(sigma factor antagonist activity)|interpro:IPR005572(Anti sigma-E protein RseA, N-terminal)|interpro:IPR005573(Anti sigma-E protein RseA, C-terminal)|interpro:IPR026279|interpro:IPR036147|rcsb pdb:1OR7|rcsb pdb:1YFN|rcsb pdb:3M4W|refseq:WP_001168459.1|dip:DIP-39581N	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 1B, 1C, 1D, 1E|kinetics:Km = 750 +/- 120 uM|kinetics:Vmax = 1.1 +/- 0.2 s-1, trimeric DegS-1|kinetics:Hill constant 1.6 +/- 0.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:tpuDQBjnIhDZEQzGSs4rw3+LLcg83333	intact-crc:C67B85EB10DFBC7A|rigid:mpV3B0pgETY1/e232rmrQMX1fL0	false	his tag:n-n|sufficient binding region:27-355|mutation decreasing interaction:148-149	his tag:?-?|sufficient binding region:121-216|35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEE3	intact:EBI-1558423	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	-	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:yyf peptide(display_short)|psi-mi:EBI-1558423(display_long)	psi-mi:"MI:0435"(protease assay)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558452|imex:IM-12022-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	-	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig. 1B, 1C, 1D, 1E|kinetics:Km = 750 +/- 120 uM|kinetics:Vmax = 1.1 +/- 0.2 s-1, trimeric DegS-1|kinetics:Hill constant 1.6 +/- 0.2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:bGWaaOKOqg18OKDuq6vMACcRtSY-1	intact-crc:C67B85EB10DFBC7A|rigid:mpV3B0pgETY1/e232rmrQMX1fL0	false	his tag:n-n|sufficient binding region:27-355|mutation decreasing interaction:148-149	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AFX7	uniprotkb:P0AEE3	intact:EBI-1117560|uniprotkb:P38106|uniprotkb:Q2MAF8|ensemblbacteria:AAC75625|ensemblbacteria:BAE76748	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	psi-mi:rsea_ecoli(display_long)|uniprotkb:yfiJ(gene name synonym)|uniprotkb:rseA(gene name)|psi-mi:rseA(display_short)|uniprotkb:mclA(gene name synonym)|uniprotkb:b2572(locus name)|uniprotkb:JW2556(locus name)|uniprotkb:Regulator of SigE(gene name synonym)|uniprotkb:Sigma-E anti-sigma factor RseA(gene name synonym)|uniprotkb:Sigma-E factor negative regulatory protein(gene name synonym)	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558478|imex:IM-12022-4	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417067.1|ensemblbacteria:AAC75625(transcript)|ensemblbacteria:b2572(gene)|ensemblbacteria:BAE76748(gene)|ensemblbacteria:BAE76748(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016989"(sigma factor antagonist activity)|interpro:IPR005572(Anti sigma-E protein RseA, N-terminal)|interpro:IPR005573(Anti sigma-E protein RseA, C-terminal)|interpro:IPR026279|interpro:IPR036147|rcsb pdb:1OR7|rcsb pdb:1YFN|rcsb pdb:3M4W|refseq:WP_001168459.1|dip:DIP-39581N	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 1F, 4A, 4B, Table 3|kinetics:Km = 33 +/- 5 uM|comment:"Fusing the C-terminal tripeptide of E. coli OmpC (YQF) to the C terminus of RseA may mean the fusion substrate would bind more tightly by tethering itself to the PDZ domain of DegS and also be self activating. In fact, the fusion substrate interacts with DegS in a manner that precludes favorable substrate-substrate interactions."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:tpuDQBjnIhDZEQzGSs4rw3+LLcg83333	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	intact-crc:9373F7E1790CEB9E|rigid:LGzzFprpA8Z0qrqvAPbASa1M3Fw	false	his tag:?-?|sufficient binding region:121-216|35s radiolabel:?-?|fusion protein:216-216	his tag:n-n|sufficient binding region:27-355|mutation disrupting interaction:162-162|mutation decreasing interaction:162-162|mutation increasing interaction:243-243|mutation increasing interaction:256-256|mutation decreasing interaction:256-256|mutation increasing interaction:320-320|mutation increasing interaction:253-254|mutation decreasing interaction:122-122|mutation decreasing interaction:178-178|mutation increasing interaction:227-227	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEE3	uniprotkb:P0AFX7	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	intact:EBI-1117560|uniprotkb:P38106|uniprotkb:Q2MAF8|ensemblbacteria:AAC75625|ensemblbacteria:BAE76748	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:rsea_ecoli(display_long)|uniprotkb:yfiJ(gene name synonym)|uniprotkb:rseA(gene name)|psi-mi:rseA(display_short)|uniprotkb:mclA(gene name synonym)|uniprotkb:b2572(locus name)|uniprotkb:JW2556(locus name)|uniprotkb:Regulator of SigE(gene name synonym)|uniprotkb:Sigma-E anti-sigma factor RseA(gene name synonym)|uniprotkb:Sigma-E factor negative regulatory protein(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558402|imex:IM-12022-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	refseq:NP_417067.1|ensemblbacteria:AAC75625(transcript)|ensemblbacteria:b2572(gene)|ensemblbacteria:BAE76748(gene)|ensemblbacteria:BAE76748(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016989"(sigma factor antagonist activity)|interpro:IPR005572(Anti sigma-E protein RseA, N-terminal)|interpro:IPR005573(Anti sigma-E protein RseA, C-terminal)|interpro:IPR026279|interpro:IPR036147|rcsb pdb:1OR7|rcsb pdb:1YFN|rcsb pdb:3M4W|refseq:WP_001168459.1|dip:DIP-39581N	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:tpuDQBjnIhDZEQzGSs4rw3+LLcg83333	intact-crc:F92DB78CE93F4D59|rigid:mpV3B0pgETY1/e232rmrQMX1fL0	false	his tag:n-n|sufficient binding region:27-355	his tag:?-?|sufficient binding region:121-216|35s radiolabel:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEE3	intact:EBI-1558423	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	-	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:yyf peptide(display_short)|psi-mi:EBI-1558423(display_long)	psi-mi:"MI:0435"(protease assay)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558402|imex:IM-12022-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	-	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:bGWaaOKOqg18OKDuq6vMACcRtSY-1	intact-crc:F92DB78CE93F4D59|rigid:mpV3B0pgETY1/e232rmrQMX1fL0	false	his tag:n-n|sufficient binding region:27-355	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEE3	intact:EBI-1558423	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	-	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:yyf peptide(display_short)|psi-mi:EBI-1558423(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0570"(protein cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558512|imex:IM-12022-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0840"(stimulator)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0327"(peptide)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	-	go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0030163"(protein catabolic process)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Fig. 2B|kinetics:Kd full-length DegS = 4.6E-6M|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:bGWaaOKOqg18OKDuq6vMACcRtSY-1	intact-crc:F248A7088F04E308|rigid:R8PmL6Ve0zzlDhM2OHhMxdL4LsI	false	his tag:n-n|sufficient binding region:281..281-326..326(IPR001478)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0AEE3	uniprotkb:P0AEE3	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	intact:EBI-1132101|uniprotkb:P31137|uniprotkb:Q2M8X8|ensemblbacteria:AAC76267|ensemblbacteria:BAE77278	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:degs_ecoli(display_long)|uniprotkb:degS(gene name)|psi-mi:degS(display_short)|uniprotkb:hhoB(gene name synonym)|uniprotkb:htrH(gene name synonym)|uniprotkb:b3235(locus name)|uniprotkb:JW3204(locus name)|uniprotkb:Site-1 protease DegS(gene name synonym)|uniprotkb:Site-1-type intramembrane protease(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sohn et al. (2007)	imex:IM-12022|pubmed:17981123	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1558533|wwpdb:2QF0|wwpdb:2QF3|imex:IM-12022-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	refseq:NP_417702.1|refseq:WP_000497723.1|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0042802"(identical protein binding)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0071575"(integral component of external side of plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR011783(Peptidase S1C, DegS)|interpro:IPR036034|interpro:IPR043504|rcsb pdb:1SOT|rcsb pdb:1SOZ|rcsb pdb:1TE0|rcsb pdb:1VCW|rcsb pdb:2QF0|rcsb pdb:2QF3|rcsb pdb:2QGR|rcsb pdb:2R3U|rcsb pdb:2R3Y|rcsb pdb:2RCE|rcsb pdb:3B8J|rcsb pdb:3GCN|rcsb pdb:3GCO|rcsb pdb:3GDS|rcsb pdb:3GDU|rcsb pdb:3GDV|rcsb pdb:3LGI|rcsb pdb:3LGT|rcsb pdb:3LGU|rcsb pdb:3LGV|rcsb pdb:3LGW|rcsb pdb:3LGY|rcsb pdb:3LH1|rcsb pdb:3LH3|rcsb pdb:4RQY|rcsb pdb:4RQZ|rcsb pdb:4RR0|rcsb pdb:4RR1|rcsb pdb:6EW9|ensemblbacteria:AAC76267(transcript)|ensemblbacteria:b3235(gene)|ensemblbacteria:BAE77278(gene)|ensemblbacteria:BAE77278(transcript)|dip:DIP-39580N	-	-	-	comment:Protein is selenomethionine-substituted|3d-r-factors:2.04-2.5A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/23	2014/10/16	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	rogid:jsWC6E3dpCclb0kpHnIO4kGxPMg83333	intact-crc:1ED5CDBE334D4779|rigid:GyjDQSSwEXPAyAAON+a57V2TYPA	false	sufficient binding region:27-256	sufficient binding region:27-256	3	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)