#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35969	uniprotkb:P49764	intact:EBI-1554752|uniprotkb:O55094|uniprotkb:Q61517	intact:EBI-1554743|ensembl:ENSMUSP00000004913	psi-mi:vgfr1_mouse(display_long)|uniprotkb:Tyrosine-protein kinase receptor FLT(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 1(gene name synonym)|uniprotkb:Embryonic receptor kinase 2(gene name synonym)|uniprotkb:Flt1(gene name)|psi-mi:Flt1(display_short)|uniprotkb:Emrk2(gene name synonym)|uniprotkb:Flt(gene name synonym)|uniprotkb:Vegfr1(gene name synonym)	psi-mi:plgf_mouse(display_long)|uniprotkb:Pgf(gene name)|psi-mi:Pgf(display_short)|uniprotkb:Plgf(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fischer et al. (2007)	imex:IM-12017|pubmed:17981115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1554742|imex:IM-12017-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034358.2|mint:P35969|dip:DIP-39359N|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036323"(vascular endothelial growth factor receptor-1 signaling pathway)|go:"GO:0036332"(placental growth factor-activated receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009135(Vascular endothelial growth factor receptor 1, VEGFR1, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|reactome:R-MMU-194306|reactome:R-MMU-195399	refseq:NP_032853.1|reactome:R-MMU-194313|reactome:R-MMU-195399|ensembl:ENSMUSG00000004791(gene)|ensembl:ENSMUST00000004913(transcript)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060688"(regulation of morphogenesis of a branching structure)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR029034	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/13	2014/10/16	rogid:h8ZisQ4hFcNEoJwYpnhQ9OCMvcY10090	rogid:PMLsb0tyasDIV+hTUs7H2CJd50k10090	intact-crc:63C68724DA158494|rigid:VRqkmOTACLsYHi9JXrLt3XnIq4k	false	fusion protein:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P09619	uniprotkb:P01127	intact:EBI-641237|uniprotkb:Q8N5L4|uniprotkb:B5A957|ensembl:ENSP00000261799	intact:EBI-1554925|uniprotkb:P78431|uniprotkb:Q9UF23|uniprotkb:G3XAG8|uniprotkb:Q15354|uniprotkb:Q6FHE7|ensembl:ENSP00000330382	psi-mi:pgfrb_human(display_long)|uniprotkb:CD140 antigen-like family member B(gene name synonym)|uniprotkb:PDGFRB(gene name)|psi-mi:PDGFRB(display_short)|uniprotkb:Beta-type platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR(gene name synonym)|uniprotkb:Platelet-derived growth factor receptor 1(gene name synonym)|uniprotkb:Beta platelet-derived growth factor receptor(gene name synonym)|uniprotkb:PDGFR1(gene name synonym)	psi-mi:pdgfb_human(display_long)|uniprotkb:Platelet-derived growth factor B chain(gene name synonym)|uniprotkb:Platelet-derived growth factor beta polypeptide(gene name synonym)|uniprotkb:PDGF-2(gene name synonym)|uniprotkb:Proto-oncogene c-Sis(gene name synonym)|uniprotkb:PDGFB(gene name)|psi-mi:PDGFB(display_short)|uniprotkb:PDGF2(gene name synonym)|uniprotkb:SIS(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fischer et al. (2007)	imex:IM-12017|pubmed:17981115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1554878|imex:IM-12017-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002600.1|dip:DIP-558N|refseq:XP_011535960.1|refseq:XP_011535961.1|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035441"(cell migration involved in vasculogenesis)|go:"GO:0035789"(metanephric mesenchymal cell migration)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048839"(inner ear development)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060437"(lung growth)|go:"GO:0060981"(cell migration involved in coronary angiogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071670"(smooth muscle cell chemotaxis)|go:"GO:0072075"(metanephric mesenchyme development)|go:"GO:0072262"(metanephric glomerular mesangial cell proliferation involved in metanephros development)|go:"GO:0072277"(metanephric glomerular capillary formation)|go:"GO:0072278"(metanephric comma-shaped body morphogenesis)|go:"GO:0072284"(metanephric S-shaped body morphogenesis)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027288|interpro:IPR036179|mint:P09619|rcsb pdb:1GQ5|rcsb pdb:1H9O|rcsb pdb:1LWP|rcsb pdb:1SHA|rcsb pdb:2IUI|rcsb pdb:2L6W|rcsb pdb:2PLD|rcsb pdb:2PLE|rcsb pdb:3MJG|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|ensembl:ENSG00000113721(gene)|ensembl:ENST00000261799(transcript)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004992"(platelet activating factor receptor activity)|go:"GO:0005017"(platelet-derived growth factor-activated receptor activity)|go:"GO:0005019"(platelet-derived growth factor beta-receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006024"(glycosaminoglycan biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008584"(male gonad development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009986"(cell surface)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)	refseq:NP_002599.1|refseq:NP_148937.1|dip:DIP-5737N|ensembl:ENSG00000100311(gene)|ensembl:ENST00000331163(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0003104"(positive regulation of glomerular filtration)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010512"(negative regulation of phosphatidylinositol biosynthetic process)|go:"GO:0010544"(negative regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035793"(positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071506"(cellular response to mycophenolic acid)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0072255"(metanephric glomerular mesangial cell development)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905176"(positive regulation of vascular associated smooth muscle cell dedifferentiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000591"(positive regulation of metanephric mesenchymal cell migration)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR006782(Platelet-derived growth factor, N-terminal)|interpro:IPR015583(Platelet-Derived Growth Factor B Chain)|interpro:IPR023581|interpro:IPR029034|rcsb pdb:1PDG|rcsb pdb:3MJG|rcsb pdb:4HQU|rcsb pdb:4HQX|rcsb pdb:4QCI|rcsb pdb:6T9E|reactome:R-HSA-114608|reactome:R-HSA-1257604|reactome:R-HSA-186763|reactome:R-HSA-186797|reactome:R-HSA-2219530|reactome:R-HSA-3000171|reactome:R-HSA-5673001|reactome:R-HSA-6811558	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure S1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/13	2014/10/16	rogid:J3OhdjjNQKvgErBLGYg4qBmoMBg9606	rogid:6zBbnXOTaM6thsuAbXfQoHHZ/EA9606	intact-crc:35E040EF87E60237|rigid:wzk8/ChEhgs7M5Bl2Ft580U4ScA	false	fusion protein:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P09038	uniprotkb:P21802-5	intact:EBI-977447|ensembl:ENSP00000264498|uniprotkb:A4LBB8|uniprotkb:O00527|uniprotkb:P78443|uniprotkb:Q16443|uniprotkb:Q5PY50|uniprotkb:Q7KZ11|uniprotkb:Q7KZ72|uniprotkb:Q9UC54|uniprotkb:Q9UCS5|uniprotkb:Q9UCS6	intact:EBI-1028732|ensembl:ENSP00000263451|ensembl:ENSP00000309878|ensembl:ENSP00000508257	psi-mi:fgf2_human(display_long)|uniprotkb:Basic fibroblast growth factor(gene name synonym)|uniprotkb:FGF2(gene name)|psi-mi:FGF2(display_short)|uniprotkb:FGFB(gene name synonym)|uniprotkb:Heparin-binding growth factor 2(gene name synonym)	psi-mi:p21802-5(display_long)|uniprotkb:K-sam-I(isoform synonym)|uniprotkb:BEK(isoform synonym)|uniprotkb:IgIIIc(isoform synonym)|uniprotkb:FGFR2(gene name)|psi-mi:FGFR2(display_short)|uniprotkb:BEK(gene name synonym)|uniprotkb:KGFR(gene name synonym)|uniprotkb:KSAM(gene name synonym)|uniprotkb:K-sam(gene name synonym)|uniprotkb:Keratinocyte growth factor receptor(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fischer et al. (2007)	imex:IM-12017|pubmed:17981115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1554892|imex:IM-12017-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001997.5|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046668"(regulation of retinal cell programmed cell death)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0048678"(response to axon injury)|go:"GO:0048864"(stem cell development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060591"(chondroblast differentiation)|go:"GO:0060644"(mammary gland epithelial cell differentiation)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|ensembl:ENSG00000138685(gene)|ensembl:ENST00000264498(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001759"(organ induction)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005104"(fibroblast growth factor receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006935"(chemotaxis)|go:"GO:0019956"(chemokine binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021940"(positive regulation of cerebellar granule cell precursor proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030324"(lung development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0038001"(paracrine signaling)|go:"GO:0014843"(growth factor dependent regulation of skeletal muscle satellite cell proliferation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042060"(wound healing)|go:"GO:0042660"(positive regulation of cell fate specification)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655302|reactome:R-HSA-5658623|reactome:R-HSA-5673001|reactome:R-HSA-5654732|reactome:R-HSA-6785807|reactome:R-HSA-6811558|reactome:R-HSA-8851708|reactome:R-HSA-8853338|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090049"(regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090722"(receptor-receptor interaction)|go:"GO:1902748"(positive regulation of lens fiber cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903587"(regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000544"(regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000546"(positive regulation of endothelial cell chemotaxis to fibroblast growth factor)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR002209(Heparin-binding growth factor/Fibroblast growth factor)|interpro:IPR008996(Cytokine, IL-1-like)|interpro:IPR028223|rcsb pdb:1BAS|rcsb pdb:1BFB|rcsb pdb:1BFC|go:"GO:0061045"(negative regulation of wound healing)|rcsb pdb:1BFG|rcsb pdb:1BLA|rcsb pdb:1BLD|rcsb pdb:1CVS|rcsb pdb:1EV2|rcsb pdb:1FGA|rcsb pdb:1FQ9|rcsb pdb:1II4|rcsb pdb:1IIL|rcsb pdb:2BFH|rcsb pdb:2FGF|rcsb pdb:2M49|rcsb pdb:4FGF|rcsb pdb:4OEE|rcsb pdb:4OEF|rcsb pdb:4OEG|rcsb pdb:1BFF|rcsb pdb:5X1O|rcsb pdb:6L4O|reactome:R-HSA-109704|reactome:R-HSA-1257604|reactome:R-HSA-1839122|reactome:R-HSA-1839130|reactome:R-HSA-190370|reactome:R-HSA-190372|reactome:R-HSA-190373|reactome:R-HSA-190375|reactome:R-HSA-190377|reactome:R-HSA-2033514|reactome:R-HSA-2033519|reactome:R-HSA-2219530|reactome:R-HSA-2892247|reactome:R-HSA-3000170|reactome:R-HSA-3000171|reactome:R-HSA-5654219|reactome:R-HSA-5654221|reactome:R-HSA-5654227|reactome:R-HSA-5654228|reactome:R-HSA-5654687|reactome:R-HSA-5654688|reactome:R-HSA-5654689|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-190322|reactome:R-HSA-5654726|reactome:R-HSA-5654727|dip:DIP-4012N	intact:EBI-1028658(fgfr2_human)|ensembl:ENSG00000066468(gene)|ensembl:ENST00000346997(transcript)|ensembl:ENST00000351936(transcript)|ensembl:ENST00000683211(transcript)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure S1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/13	2014/10/16	rogid:udCxjwNH9EeWxJlw1QnhGVzRUko9606	rogid:VVeU7Tf+qioX9gehKAhqtJ9qPQ49606	intact-crc:F0D8FA21C976881A|rigid:vb/t9STtWqiuLV7iJTROECCeyhE	false	-	fusion protein:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P14210	uniprotkb:P08581	intact:EBI-1039104|uniprotkb:A1L3U6|uniprotkb:Q02935|uniprotkb:Q13494|uniprotkb:Q14519|uniprotkb:Q8TCE2|uniprotkb:Q9BYL9|uniprotkb:Q9BYM0|uniprotkb:Q9UDU6|uniprotkb:Q3KRB2|ensembl:ENSP00000222390	intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860	psi-mi:hgf_human(display_long)|uniprotkb:HGF(gene name)|psi-mi:HGF(display_short)|uniprotkb:HPTA(gene name synonym)|uniprotkb:Scatter factor(gene name synonym)|uniprotkb:Hepatopoietin-A(gene name synonym)	psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fischer et al. (2007)	imex:IM-12017|pubmed:17981115	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1554953|imex:IM-12017-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000592.3|refseq:NP_001010931.1|refseq:NP_001010932.1|refseq:NP_001010933.1|refseq:NP_001010934.1|refseq:XP_006716019.1|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060665"(regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling)|go:"GO:0070572"(positive regulation of neuron projection regeneration)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902947"(regulation of tau-protein kinase activity)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000001(Kringle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR003609(Apple-like)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018056|interpro:IPR024174|interpro:IPR027284|interpro:IPR038178|interpro:IPR043504|rcsb pdb:1BHT|rcsb pdb:1GMN|rcsb pdb:1GMO|rcsb pdb:1GP9|rcsb pdb:1NK1|rcsb pdb:1SHY|rcsb pdb:1SI5|rcsb pdb:2HGF|rcsb pdb:2QJ2|rcsb pdb:3HMS|rcsb pdb:3HMT|rcsb pdb:3HN4|rcsb pdb:3MKP|rcsb pdb:3SP8|rcsb pdb:4D3C|rcsb pdb:4K3J|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:5COE|rcsb pdb:5CP9|rcsb pdb:5CS1|rcsb pdb:5CS3|rcsb pdb:5CS5|rcsb pdb:5CS9|rcsb pdb:5CSQ|rcsb pdb:5CT1|rcsb pdb:5CT2|rcsb pdb:5CT3|rcsb pdb:7MO7|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-114608|reactome:R-HSA-1257604|reactome:R-HSA-1266695|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6785807|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|ensembl:ENSG00000019991(gene)|ensembl:ENST00000222390(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0008083"(growth factor activity)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|refseq:XP_016867586.1|refseq:XP_016867587.1|refseq:XP_011514417.1|dip:DIP-37535N	refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure S1D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/13	2014/10/16	rogid:qlqHs1bJXvEHZyzrKNZM0VD62pg9606	rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606	intact-crc:5555A7C466C295D2|rigid:f7quTxFXVAc7wOyeq32qeIc4m/I	false	-	fusion protein:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q00731	uniprotkb:P35918	intact:EBI-444774|uniprotkb:O70123|uniprotkb:Q66S31|uniprotkb:Q6GT23|uniprotkb:Q6WZL9	intact:EBI-1555005|uniprotkb:C5H7S5|uniprotkb:Q8VCD0|ensembl:ENSMUSP00000109144	psi-mi:vegfa_mouse(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:Vegfa(gene name)|psi-mi:Vegfa(display_short)|uniprotkb:Vegf(gene name synonym)	psi-mi:vgfr2_mouse(display_long)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:Kinase NYK(gene name synonym)|uniprotkb:Kdr(gene name)|psi-mi:Kdr(display_short)|uniprotkb:Flk-1(gene name synonym)|uniprotkb:Flk1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Fischer et al. (2007)	imex:IM-12017|pubmed:17981115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555043|imex:IM-12017-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020421.2|refseq:NP_001020428.2|refseq:NP_001103736.1|refseq:NP_001103737.1|refseq:NP_001103738.1|refseq:NP_033531.3|refseq:NP_001303970.1|refseq:NP_001273985.1|refseq:NP_001273986.1|refseq:NP_001273987.1|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001568"(blood vessel development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001944"(vasculature development)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016477"(cell migration)|go:"GO:0019838"(growth factor binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0031982"(vesicle)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045601"(regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048469"(cell maturation)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048666"(neuron development)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061430"(bone trabecula morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901492"(positive regulation of lymphangiogenesis)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|go:"GO:0090037"(positive regulation of protein kinase C signaling)|reactome:R-MMU-114608|reactome:R-MMU-194313|reactome:R-MMU-195399|reactome:R-MMU-4420097|reactome:R-MMU-5218921|dip:DIP-31909N	refseq:NP_034742.2|dip:DIP-215N|ensembl:ENSMUSG00000062960(gene)|ensembl:ENSMUST00000113516(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001945"(lymph vessel development)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003157"(endocardium development)|go:"GO:0003158"(endothelium development)|go:"GO:0003416"(endochondral bone growth)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048469"(cell maturation)|go:"GO:0048597"(post-embryonic camera-type eye morphogenesis)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0055074"(calcium ion homeostasis)|go:"GO:0060837"(blood vessel endothelial cell differentiation)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071944"(cell periphery)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1903010"(regulation of bone development)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|reactome:R-MMU-194306|reactome:R-MMU-195399|reactome:R-MMU-216083|reactome:R-MMU-4420097|reactome:R-MMU-5218921	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure S1F|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/13	2021/02/11	rogid:zU6IdMrWdycj52MXNBPdDYMtNx410090	rogid:fjJurWAn1jZTUrOJyl7X9tmNKSU10090	intact-crc:FB63483451FADA07|rigid:+nwXSadnDmYmneSqtpbumJmQLuA	false	-	fusion protein:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P97333	uniprotkb:P97333	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	intact:EBI-1555129|uniprotkb:Q6PAR3|ensembl:ENSMUSP00000026917	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:nrp1_mouse(display_long)|uniprotkb:A5 protein(gene name synonym)|uniprotkb:Nrp1(gene name)|psi-mi:Nrp1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Fischer et al. (2007)	imex:IM-12017|pubmed:17981115	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555065|imex:IM-12017-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	refseq:NP_032763.2|refseq:XP_006530829.1|dip:DIP-39360N|ensembl:ENSMUSG00000025810(gene)|ensembl:ENSMUST00000026917(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001764"(neuron migration)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005883"(neurofilament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021612"(facial nerve structural organization)|go:"GO:0021636"(trigeminal nerve morphogenesis)|go:"GO:0021637"(trigeminal nerve structural organization)|go:"GO:0021649"(vestibulocochlear nerve structural organization)|go:"GO:0021675"(nerve development)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021828"(gonadotrophin-releasing hormone neuronal migration to the hypothalamus)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036486"(ventral trunk neural crest cell migration)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048666"(neuron development)|go:"GO:0048841"(regulation of axon extension involved in axon guidance)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048843"(negative regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060385"(axonogenesis involved in innervation)|go:"GO:0060666"(dichotomous subdivision of terminal units involved in salivary gland branching)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060980"(cell migration involved in coronary vasculogenesis)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0061441"(renal artery morphogenesis)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061551"(trigeminal ganglion development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097374"(sensory neuron axon guidance)|go:"GO:0097443"(sorting endosome)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097490"(sympathetic neuron projection extension)|go:"GO:0097491"(sympathetic neuron projection guidance)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150018"(basal dendrite development)|go:"GO:0150020"(basal dendrite arborization)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1901998"(toxin transport)|go:"GO:1902285"(semaphorin-plexin signaling pathway involved in neuron projection guidance)|go:"GO:1902287"(semaphorin-plexin signaling pathway involved in axon guidance)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902378"(VEGF-activated neuropilin signaling pathway involved in axon guidance)|go:"GO:1902946"(protein localization to early endosome)|go:"GO:1903375"(facioacoustic ganglion development)|go:"GO:1904835"(dorsal root ganglion morphogenesis)|go:"GO:1905040"(otic placode development)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000859(CUB)|interpro:IPR000998(MAM)|interpro:IPR008979(Galactose-binding like)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR014648(Neuropilin)|interpro:IPR022579|interpro:IPR027146|interpro:IPR035914|mint:P97333|rcsb pdb:4GZ9|rcsb pdb:4GZA|rcsb pdb:7M0R|reactome:R-MMU-194306|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-445144|go:"GO:0060982"(coronary artery morphogenesis)	psi-mi:"MI:0469"(intact)	-	-	agonist:"Placenta growth factor precursor (PlGF)"|figure legend:Figure S1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9823(pig-endothelium)|taxid:9823(Pig endothelium)	-	2007/11/13	2014/10/16	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	rogid:s76+a5oN+rLJk/U7l8Bz+Zc+rRc10090	intact-crc:FD964EBCDC01D22E|rigid:PwzfzPUNnNWmstPZLq/sIwObx6o	false	cyan fluorescent protein tag:?-?	yellow fluorescent protein tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)