#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P40692	uniprotkb:P62328	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568755|imex:IM-19105-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	-	-	-	dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2007/12/17	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	intact-crc:3C0923610030859B|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40692	uniprotkb:P62328	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568768|imex:IM-19105-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	-	-	-	figure legend:1|delivery method:P62328; P40692 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	intact-crc:03CFFD1B8CF1D144|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40692	uniprotkb:P62328	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568783|imex:IM-19105-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	-	-	-	figure legend:1|delivery method:P62328; P40692 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	intact-crc:E3CCE1135FC78DEE|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62328	uniprotkb:P40692	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568800|imex:IM-19105-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	-	-	-	figure legend:1|delivery method:P40692 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:AAEB107647A91298|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P62328	uniprotkb:P40692	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568806|imex:IM-19105-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	-	-	-	figure legend:1|agonist:"5-aza-2'-deoxycytidine (5-Aza-CdR) - This interaction is enhanced by treatment of cells with 5-Aza-CdR, which restored hMLH1 expression in 293T cells by demethylation of the hMLH1 promoter."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:1484C16726C22462|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40692	uniprotkb:P62328	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568828|imex:IM-19105-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	-	-	-	figure legend:1|delivery method:P40692 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	intact-crc:F043E6A39EADE495|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40692	uniprotkb:P62328	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568838|imex:IM-19105-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	-	-	-	figure legend:1|agonist:"5-aza-2'-deoxycytidine (5-Aza-CdR) - This interaction is enhanced by treatment of cells with 5-Aza-CdR, which restored hMLH1 expression in 293T cells by demethylation of the hMLH1 promoter."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	intact-crc:9EAD16F0CA4413BF|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40692	uniprotkb:P62328	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568858|imex:IM-19105-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	go:"GO:0005634"(nucleus)	-	-	figure legend:2|delivery method:P40692 transfection|comment:"When the NLS (nuclear localization signal) of hMLH1 was mutated (K471N or R472G), hMLH1 and thymosin beta 4 remained in the cytoplasm, which indicates that translocation of thymosin beta 4 relies on interaction with hMLH1 harboring a functional NLS."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	intact-crc:C7D324C879967444|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P62328	uniprotkb:P40692	intact:EBI-712598|uniprotkb:P01253|uniprotkb:P01254|uniprotkb:Q546P5|ensembl:ENSP00000370007|ensembl:ENSP00000370009|ensembl:ENSP00000370010|ensembl:ENSP00000414376|uniprotkb:Q63576|uniprotkb:Q9UE55	intact:EBI-744248|uniprotkb:B4DI13|uniprotkb:B4DQ11|uniprotkb:E9PCU2|ensembl:ENSP00000231790	psi-mi:tyb4_human(display_long)|uniprotkb:Fx(gene name synonym)|uniprotkb:TMSB4X(gene name)|psi-mi:TMSB4X(display_short)|uniprotkb:TB4X(gene name synonym)|uniprotkb:THYB4(gene name synonym)|uniprotkb:TMSB4(gene name synonym)	psi-mi:mlh1_human(display_long)|uniprotkb:MutL protein homolog 1(gene name synonym)|uniprotkb:MLH1(gene name)|psi-mi:MLH1(display_short)|uniprotkb:COCA2(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Brieger et al. (2007)	pubmed:17967441|imex:IM-19105	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1568869|imex:IM-19105-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000205542(gene)|ensembl:ENST00000380633(transcript)|go:"GO:0019899"(enzyme binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|ensembl:ENST00000380635(transcript)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|ensembl:ENST00000380636(transcript)|go:"GO:0042989"(sequestering of actin monomers)|ensembl:ENST00000451311(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903026"(negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1905273"(positive regulation of proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR001152(Thymosin beta-4)|go:"GO:0005737"(cytoplasm)|interpro:IPR038386|mint:P62328|rcsb pdb:1UY5|go:"GO:0005829"(cytosol)|rcsb pdb:3TU5|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|rcsb pdb:4PL8|rcsb pdb:4PL7|reactome:R-HSA-114608|refseq:NP_066932.1	refseq:NP_000240.1|refseq:NP_001161089.1|refseq:NP_001161090.1|refseq:NP_001161091.1|refseq:NP_001245200.1|refseq:NP_001245202.1|refseq:NP_001245203.1|dip:DIP-27601N|refseq:XP_005265220.1|refseq:XP_005265221.1|ensembl:ENSG00000076242(gene)|ensembl:ENST00000231790(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005712"(chiasma)|go:"GO:0005715"(late recombination nodule)|go:"GO:0006298"(mismatch repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0007060"(male meiosis chromosome segregation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0019899"(enzyme binding)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032389"(MutLalpha complex)|go:"GO:0043060"(meiotic metaphase I plate congression)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0045190"(isotype switching)|go:"GO:0045950"(negative regulation of mitotic recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0048477"(oogenesis)|go:"GO:0051257"(meiotic spindle midzone assembly)|interpro:IPR002099(DNA mismatch repair protein)|interpro:IPR013507(DNA mismatch repair protein, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR014762(DNA mismatch repair, conserved site)|interpro:IPR020568|interpro:IPR032189|interpro:IPR036890|interpro:IPR038973|mint:P40692|rcsb pdb:3RBN|rcsb pdb:4P7A|rcsb pdb:5U5P|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5545483|reactome:R-HSA-5632987|reactome:R-HSA-6796648|reactome:R-HSA-912446	go:"GO:0005634"(nucleus)	-	-	figure legend:2|agonist:"5-aza-2'-deoxycytidine (5-Aza-CdR) - This interaction is enhanced by treatment of cells with 5-Aza-CdR, which restored hMLH1 expression in 293T cells by demethylation of the hMLH1 promoter."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/12/17	2014/10/16	rogid:xkqTI8zw7X+xH6HCvkuLtGlNbvs9606	rogid:v/ydpM1Cf5bF27dC+3JF6XXMp0Q9606	intact-crc:A289FB1724CF8138|rigid:zVpzIMhjxX6y3sE79o769PkLAWw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)