#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q53HL2	uniprotkb:O15392	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:"MI:0417"(footprinting)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555165|imex:IM-12018-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	psi-mi:"MI:0469"(intact)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	intact-crc:DE8BB5B095803224|rigid:NuDNBH51waO6mRz0f+4CkZzrPik	false	sufficient binding region:10-109	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q53HL2	uniprotkb:Q96GD4	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555177|imex:IM-12018-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1F. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	intact-crc:CE60E9A34FA495AA|rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM	false	sufficient binding region:58-109|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53HL2	uniprotkb:Q9NQS7	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555177|imex:IM-12018-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1F. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	intact-crc:CE60E9A34FA495AA|rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM	false	sufficient binding region:58-109|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53HL2	uniprotkb:O15392	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555177|imex:IM-12018-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1F. 5D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	intact-crc:CE60E9A34FA495AA|rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM	false	sufficient binding region:58-109|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53HL2	uniprotkb:Q9NQS7	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555321|imex:IM-12018-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1F, 5D|comment:Mutation of CDCA8 at W70E,F74E has no effect on this interaction but prevents binding of BIRC5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	intact-crc:880A7159DEBD310B|rigid:4DIVUuVpwNf0DWcXhCFRPgVDnsk	false	sufficient binding region:58-109|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q53HL2	uniprotkb:Q96GD4	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555321|imex:IM-12018-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 1F, 5D|comment:Mutation of CDCA8 at W70E,F74E has no effect on this interaction but prevents binding of BIRC5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	intact-crc:880A7159DEBD310B|rigid:4DIVUuVpwNf0DWcXhCFRPgVDnsk	false	sufficient binding region:58-109|myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15392	uniprotkb:Q53HL2	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555332|imex:IM-12018-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 5D|comment:The mutation of CDCA8 R17/19E,K20E had no effect on this interaction but prevents binding of AURKB and INCENP|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:FBBD8B6285C70F88|rigid:NuDNBH51waO6mRz0f+4CkZzrPik	false	-	sufficient binding region:58-109|myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NQS7	uniprotkb:Q53HL2	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555353|imex:IM-12018-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:F95E3052C10FFE75|rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NQS7	uniprotkb:Q96GD4	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555353|imex:IM-12018-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	intact-crc:F95E3052C10FFE75|rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NQS7	uniprotkb:O15392	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555353|imex:IM-12018-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 6B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	intact-crc:F95E3052C10FFE75|rigid:E4GiFkYn5a9mW6C/zqRYxKbTwYM	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NQS7	uniprotkb:Q96GD4	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	intact:EBI-624291|uniprotkb:O14630|uniprotkb:O60446|uniprotkb:O95083|uniprotkb:Q96DV5|uniprotkb:Q9UQ46|ensembl:ENSP00000463999|uniprotkb:B4DNM4|uniprotkb:D3DTR4|uniprotkb:C7G533|uniprotkb:C7G534|uniprotkb:C7G535|uniprotkb:J9JID1	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:aurkb_human(display_long)|uniprotkb:AIRK2(gene name synonym)|uniprotkb:Aurora- and IPL1-like midbody-associated protein 1(gene name synonym)|uniprotkb:Aurora/IPL1-related kinase 2(gene name synonym)|uniprotkb:STK-1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 5(gene name synonym)|uniprotkb:STK1(gene name synonym)|uniprotkb:STK5(gene name synonym)|uniprotkb:Aurora 1(gene name synonym)|uniprotkb:AURKB(gene name)|psi-mi:AURKB(display_short)|uniprotkb:AIK2(gene name synonym)|uniprotkb:AIM1(gene name synonym)|uniprotkb:ARK2(gene name synonym)|uniprotkb:STK12(gene name synonym)|uniprotkb:Serine/threonine-protein kinase aurora-B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555366|imex:IM-12018-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035174"(histone serine kinase activity)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0009838"(abscission)|go:"GO:0010369"(chromocenter)|go:"GO:0016570"(histone modification)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0004674"(protein serine/threonine kinase activity)|ensembl:ENSG00000178999(gene)|ensembl:ENST00000585124(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0002903"(negative regulation of B cell apoptotic process)|refseq:NP_001271455.1|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1905116"(positive regulation of lateral attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028772|interpro:IPR030616|mint:Q96GD4|rcsb pdb:4AF3|reactome:R-HSA-141444|reactome:R-HSA-174178|reactome:R-HSA-2467813|reactome:R-HSA-2500257|go:"GO:0051973"(positive regulation of telomerase activity)|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6804756|reactome:R-HSA-68877|reactome:R-HSA-9022692|reactome:R-HSA-9648025|refseq:NP_004208.2|refseq:NP_001243763.1|refseq:NP_001300879.1|refseq:NP_001300880.1|refseq:NP_001300881.1|refseq:NP_001300882.1|refseq:NP_001300883.1|refseq:NP_001300884.1|refseq:XP_011522372.1|refseq:XP_011522374.1|refseq:XP_016880796.1|dip:DIP-34530N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 6B|comment:Mutation of INCENP F22R,L34R had no effect on thi interaction but prevented binding to BIRC5 and CDCA8.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/11/14	2014/10/16	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	rogid:4pmZhSoAp5JmH19k2tT+w3z9Hgo9606	intact-crc:4935E3AC1F027BD2|rigid:9tF4MrDYK8QEbZnmITHpI8WXsR4	false	green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O15392	uniprotkb:Q53HL2	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555213|imex:IM-12018-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:06EC4F617CD1A10F|rigid:NuDNBH51waO6mRz0f+4CkZzrPik	false	-	sufficient binding region:10-109	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NQS7	uniprotkb:Q53HL2	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555222|imex:IM-12018-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/11/14	2014/10/16	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:87D91B5AFE7013FB|rigid:dwm5XnmS3Y2wrlU/UPG7uNeUOJ4	false	sufficient binding region:1-58	sufficient binding region:10-109	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q53HL2	uniprotkb:O15392	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555242|imex:IM-12018-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	intact-crc:4E19F172F0C2B7B6|rigid:NuDNBH51waO6mRz0f+4CkZzrPik	false	sufficient binding region:10-109	-	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:O15392	uniprotkb:Q53HL2	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555249|imex:IM-12018-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:941779F0CD0F75A0|rigid:eTyQfhKQzQZCkIcBtwTlq0sa4pc	false	-	sufficient binding region:10-109	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:O15392	uniprotkb:Q9NQS7	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:"MI:0071"(molecular sieving)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555249|imex:IM-12018-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	intact-crc:941779F0CD0F75A0|rigid:eTyQfhKQzQZCkIcBtwTlq0sa4pc	false	-	sufficient binding region:1-58	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:O15392	uniprotkb:Q53HL2	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555275|imex:IM-12018-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2D|comment:3.3 s dimer of molecular weight of 53 kDa|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:2CD0EAA22EED8EBC|rigid:NuDNBH51waO6mRz0f+4CkZzrPik	false	-	sufficient binding region:10-109	2	2	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:O15392	uniprotkb:Q53HL2	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0028"(cosedimentation in solution)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555282|imex:IM-12018-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2D|comment:3.0 s monomer of 35 kDa|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:C2156D8430DDFA9B|rigid:eTyQfhKQzQZCkIcBtwTlq0sa4pc	false	-	sufficient binding region:10-109	1	1	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:O15392	uniprotkb:Q9NQS7	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:"MI:0028"(cosedimentation in solution)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555282|imex:IM-12018-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figure 2D|comment:3.0 s monomer of 35 kDa|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	intact-crc:C2156D8430DDFA9B|rigid:eTyQfhKQzQZCkIcBtwTlq0sa4pc	false	-	sufficient binding region:1-58	1	1	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:O15392	uniprotkb:Q53HL2	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-979174|uniprotkb:Q53HN1|uniprotkb:Q96AM3|uniprotkb:Q9NVW5|ensembl:ENSP00000316121|ensembl:ENSP00000362146|intact:EBI-2557781|uniprotkb:D3DPT4	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:borea_human(display_long)|uniprotkb:Dasra-B(gene name synonym)|uniprotkb:Cell division cycle-associated protein 8(gene name synonym)|uniprotkb:Pluripotent embryonic stem cell-related gene 3 protein(gene name synonym)|uniprotkb:CDCA8(gene name)|psi-mi:CDCA8(display_short)|uniprotkb:PESCRG3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555303|wwpdb:2QFA|imex:IM-12018-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000327331(transcript)|ensembl:ENST00000373055(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010369"(chromocenter)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051233"(spindle midzone)|go:"GO:0051276"(chromosome organization)|go:"GO:0051301"(cell division)|interpro:IPR018851|interpro:IPR018867|mint:Q53HL2|rcsb pdb:2KDD|rcsb pdb:2QFA|rcsb pdb:2RAW|ensembl:ENSG00000134690(gene)|rcsb pdb:2RAX|rcsb pdb:6YIE|rcsb pdb:6YIF|refseq:NP_001243804.1|refseq:NP_060571.1|dip:DIP-37995N	-	-	-	figure legend:Figure 3A|3d-resolution:1.4A|3d-r-factors:18.5% bound, 20.2% free,|3d-structure:"Borealin and INCENP bind Survivin to form a three-helix bundle. INCENP forms a single alpha-helix that is 10 turns long (residues 8-46) and stacks parallel to the Survivin C helix. Borealin is also characterized by a long alpha-helix (residues 15-60), which stacks with 12 turns against the Survivin C helix in an antiparallel fashion."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:LdL29UIjy+IvQfWTwvatWPabuq09606	intact-crc:185D46793CD8CD96|rigid:eTyQfhKQzQZCkIcBtwTlq0sa4pc	false	-	sufficient binding region:15-76	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O15392	uniprotkb:Q9NQS7	intact:EBI-518823|uniprotkb:B2R4R1|uniprotkb:Q2I3N8|uniprotkb:Q4VGX0|uniprotkb:Q53F61|uniprotkb:Q5MGC6|uniprotkb:Q6FHL2|uniprotkb:Q75SP2|uniprotkb:Q9P2W8|intact:EBI-979338|uniprotkb:A2SUH6	intact:EBI-307907|uniprotkb:Q5Y192|uniprotkb:A8MQD2|ensembl:ENSP00000378295	psi-mi:birc5_human(display_long)|uniprotkb:Apoptosis inhibitor survivin(gene name synonym)|uniprotkb:Apoptosis inhibitor 4(gene name synonym)|uniprotkb:BIRC5(gene name)|psi-mi:BIRC5(display_short)|uniprotkb:API4(gene name synonym)|uniprotkb:IAP4(gene name synonym)	psi-mi:ince_human(display_long)|uniprotkb:INCENP(gene name)|psi-mi:INCENP(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Jeyaprakash et al. (2007)	imex:IM-12018|pubmed:17956729	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1555303|wwpdb:2QFA|imex:IM-12018-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001012270.1|refseq:NP_001012271.1|refseq:NP_001159.2|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015631"(tubulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030496"(midbody)|go:"GO:0031021"(interphase microtubule organizing center)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031503"(protein-containing complex localization)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|rcsb pdb:1E31|rcsb pdb:1F3H|rcsb pdb:1XOX|rcsb pdb:2QFA|rcsb pdb:2RAW|rcsb pdb:2RAX|rcsb pdb:3UEC|rcsb pdb:3UED|rcsb pdb:3UEE|rcsb pdb:3UEF|rcsb pdb:3UEG|rcsb pdb:3UEH|rcsb pdb:3UEI|rcsb pdb:3UIG|rcsb pdb:3UIH|rcsb pdb:3UII|rcsb pdb:3UIJ|rcsb pdb:3UIK|rcsb pdb:4A0I|rcsb pdb:4A0J|rcsb pdb:4A0N|rcsb pdb:6SHO|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-6803205|reactome:R-HSA-68877|reactome:R-HSA-8951664|reactome:R-HSA-9648025|mint:O15392|dip:DIP-34662N	refseq:NP_001035784.1|refseq:NP_064623.2|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000800"(lateral element)|go:"GO:0000801"(central element)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0010369"(chromocenter)|ensembl:ENSG00000149503(gene)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0016604"(nuclear body)|go:"GO:0030496"(midbody)|go:"GO:0032133"(chromosome passenger complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0051257"(meiotic spindle midzone assembly)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:1902412"(regulation of mitotic cytokinesis)|go:"GO:1990385"(meiotic spindle midzone)|interpro:IPR005635(Inner centromere protein, ARK binding region)|interpro:IPR022006|interpro:IPR039130|mint:Q9NQS7|rcsb pdb:2QFA|rcsb pdb:4AF3|rcsb pdb:5IEH|rcsb pdb:5IEK|ensembl:ENST00000394818(transcript)|rcsb pdb:6GR8|rcsb pdb:6GR9|rcsb pdb:6YIE|rcsb pdb:6YIF|rcsb pdb:6YIH|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-4615885|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|dip:DIP-31304N	-	-	-	figure legend:Figure 3A|3d-resolution:1.4A|3d-r-factors:18.5% bound, 20.2% free,|3d-structure:"Borealin and INCENP bind Survivin to form a three-helix bundle. INCENP forms a single alpha-helix that is 10 turns long (residues 8-46) and stacks parallel to the Survivin C helix. Borealin is also characterized by a long alpha-helix (residues 15-60), which stacks with 12 turns against the Survivin C helix in an antiparallel fashion."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/14	2014/10/16	rogid:tfya/9aPPiS0zmJOVSP6EdN8XGM9606	rogid:+9LOzr4lV46zzZnWJVcLGeiB1Z09606	intact-crc:185D46793CD8CD96|rigid:eTyQfhKQzQZCkIcBtwTlq0sa4pc	false	-	sufficient binding region:1-47	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)