#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61016	uniprotkb:Q6JP77	intact:EBI-7620725|intact:MINT-5227067|uniprotkb:P20006|ensembl:ENSRNOP00000000469	intact:EBI-6096191|uniprotkb:D3ZMQ5	psi-mi:ppla_rat(display_long)|uniprotkb:Pln(gene name)|psi-mi:Pln(display_short)	psi-mi:aka7g_rat(display_long)|uniprotkb:Akap7(gene name)|psi-mi:Akap7(display_short)|uniprotkb:A-kinase anchor protein 18(gene name synonym)|uniprotkb:AKAP-18(gene name synonym)|uniprotkb:Akap18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoforms delta and gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lygren et al. (2007)	pubmed:17901878|imex:IM-11139|mint:MINT-5227054	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7620719|mint:MINT-5227079|imex:IM-11139-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619894|refseq:NP_073198.1|ensembl:ENSRNOG00000000413(gene)|ensembl:ENSRNOT00000000469(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|mint:P61016|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0033574"(response to testosterone)|mint:MINT-5227082(identity)	mint:Q6JP77|rgd:1303071|refseq:NP_001001801.1|interpro:IPR019510|interpro:IPR019511|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|rcsb pdb:2VFK|rcsb pdb:2VFL|rcsb pdb:2VFY|rcsb pdb:3J4Q|rcsb pdb:3J4R|mint:MINT-5227081(identity)	go:"GO:0016529"(sarcoplasmic reticulum)	comment:mint|function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum	-	figure legend:f3b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/11/29	2014/10/16	rogid:/rJRfpGBnSyV37L7wJcTtmVsrRc10116	rogid:sSbqSwGJRZSWKrpe4GgdME6TVNU10116	intact-crc:DEDDF1DCF235A8F5|rigid:NUf/jIOJUzWMK44Ow8s+O+WSr5g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61016	uniprotkb:Q6JP77	intact:EBI-7620725|intact:MINT-5227067|uniprotkb:P20006|ensembl:ENSRNOP00000000469	intact:EBI-6096191|uniprotkb:D3ZMQ5	psi-mi:ppla_rat(display_long)|uniprotkb:Pln(gene name)|psi-mi:Pln(display_short)	psi-mi:aka7g_rat(display_long)|uniprotkb:Akap7(gene name)|psi-mi:Akap7(display_short)|uniprotkb:A-kinase anchor protein 18(gene name synonym)|uniprotkb:AKAP-18(gene name synonym)|uniprotkb:Akap18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoforms delta and gamma(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Lygren et al. (2007)	pubmed:17901878|imex:IM-11139|mint:MINT-5227054	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7620891|mint:MINT-5227112|imex:IM-11139-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619894|refseq:NP_073198.1|ensembl:ENSRNOG00000000413(gene)|ensembl:ENSRNOT00000000469(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|mint:P61016|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0033574"(response to testosterone)|mint:MINT-5227114(identity)	mint:Q6JP77|rgd:1303071|refseq:NP_001001801.1|interpro:IPR019510|interpro:IPR019511|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|rcsb pdb:2VFK|rcsb pdb:2VFL|rcsb pdb:2VFY|rcsb pdb:3J4Q|rcsb pdb:3J4R|mint:MINT-5227117(identity)	-	comment:mint|function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum	-	figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/11/29	2014/10/16	rogid:/rJRfpGBnSyV37L7wJcTtmVsrRc10116	rogid:sSbqSwGJRZSWKrpe4GgdME6TVNU10116	intact-crc:E52FB6BC63354741|rigid:NUf/jIOJUzWMK44Ow8s+O+WSr5g	false	green fluorescent protein tag:?-?(MINT-5227115)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61016	uniprotkb:Q6JP77	intact:EBI-7620725|intact:MINT-5227067|uniprotkb:P20006|ensembl:ENSRNOP00000000469	intact:EBI-6096191|uniprotkb:D3ZMQ5	psi-mi:ppla_rat(display_long)|uniprotkb:Pln(gene name)|psi-mi:Pln(display_short)	psi-mi:aka7g_rat(display_long)|uniprotkb:Akap7(gene name)|psi-mi:Akap7(display_short)|uniprotkb:A-kinase anchor protein 18(gene name synonym)|uniprotkb:AKAP-18(gene name synonym)|uniprotkb:Akap18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoforms delta and gamma(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Lygren et al. (2007)	pubmed:17901878|imex:IM-11139|mint:MINT-5227054	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7620961|mint:MINT-5227127|imex:IM-11139-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619894|refseq:NP_073198.1|ensembl:ENSRNOG00000000413(gene)|ensembl:ENSRNOT00000000469(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|mint:P61016|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0033574"(response to testosterone)|mint:MINT-5227130(identity)	mint:Q6JP77|rgd:1303071|refseq:NP_001001801.1|interpro:IPR019510|interpro:IPR019511|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|rcsb pdb:2VFK|rcsb pdb:2VFL|rcsb pdb:2VFY|rcsb pdb:3J4Q|rcsb pdb:3J4R|mint:MINT-5227129(identity)	-	comment:mint|function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum	-	figure legend:F3D|comment:Interaction is distroyed whe PLN ser16 is phosphorylated.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/29	2014/10/16	rogid:/rJRfpGBnSyV37L7wJcTtmVsrRc10116	rogid:sSbqSwGJRZSWKrpe4GgdME6TVNU10116	intact-crc:A66A66696951BE7C|rigid:NUf/jIOJUzWMK44Ow8s+O+WSr5g	false	binding-associated region:13-20(MINT-5227145)	glutathione s tranferase tag:?-?(MINT-5227140)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61016	uniprotkb:Q6JP77	intact:EBI-7620725|intact:MINT-5227067|uniprotkb:P20006|ensembl:ENSRNOP00000000469	intact:EBI-6096191|uniprotkb:D3ZMQ5	psi-mi:ppla_rat(display_long)|uniprotkb:Pln(gene name)|psi-mi:Pln(display_short)	psi-mi:aka7g_rat(display_long)|uniprotkb:Akap7(gene name)|psi-mi:Akap7(display_short)|uniprotkb:A-kinase anchor protein 18(gene name synonym)|uniprotkb:AKAP-18(gene name synonym)|uniprotkb:Akap18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoforms delta and gamma(gene name synonym)	psi-mi:"MI:0081"(peptide array)	Lygren et al. (2007)	pubmed:17901878|imex:IM-11139|mint:MINT-5227054	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7621019|mint:MINT-5227148|imex:IM-11139-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619894|refseq:NP_073198.1|ensembl:ENSRNOG00000000413(gene)|ensembl:ENSRNOT00000000469(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|mint:P61016|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0033574"(response to testosterone)|mint:MINT-5227150(identity)	mint:Q6JP77|rgd:1303071|refseq:NP_001001801.1|interpro:IPR019510|interpro:IPR019511|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|rcsb pdb:2VFK|rcsb pdb:2VFL|rcsb pdb:2VFY|rcsb pdb:3J4Q|rcsb pdb:3J4R|mint:MINT-5227153(identity)	-	comment:mint|function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum	-	figure legend:SF2|comment:When PLN residues R13, R14 and R21 are mutated,  interaction is almost abolished.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/11/29	2014/10/16	rogid:/rJRfpGBnSyV37L7wJcTtmVsrRc10116	rogid:sSbqSwGJRZSWKrpe4GgdME6TVNU10116	intact-crc:B032C3FCD16834FE|rigid:NUf/jIOJUzWMK44Ow8s+O+WSr5g	false	binding-associated region:13-23(MINT-5227151)	glutathione s tranferase tag:?-?(MINT-5227154)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61016	uniprotkb:Q6JP77	intact:EBI-7620725|intact:MINT-5227067|uniprotkb:P20006|ensembl:ENSRNOP00000000469	intact:EBI-6096191|uniprotkb:D3ZMQ5	psi-mi:ppla_rat(display_long)|uniprotkb:Pln(gene name)|psi-mi:Pln(display_short)	psi-mi:aka7g_rat(display_long)|uniprotkb:Akap7(gene name)|psi-mi:Akap7(display_short)|uniprotkb:A-kinase anchor protein 18(gene name synonym)|uniprotkb:AKAP-18(gene name synonym)|uniprotkb:Akap18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoforms delta and gamma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lygren et al. (2007)	pubmed:17901878|imex:IM-11139|mint:MINT-5227054	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7621062|mint:MINT-5227093|imex:IM-11139-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619894|refseq:NP_073198.1|ensembl:ENSRNOG00000000413(gene)|ensembl:ENSRNOT00000000469(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|mint:P61016|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0033574"(response to testosterone)|mint:MINT-5227097(identity)	mint:Q6JP77|rgd:1303071|refseq:NP_001001801.1|interpro:IPR019510|interpro:IPR019511|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|rcsb pdb:2VFK|rcsb pdb:2VFL|rcsb pdb:2VFY|rcsb pdb:3J4Q|rcsb pdb:3J4R|mint:MINT-5227096(identity)	-	comment:mint|function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum	-	figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/11/29	2014/10/16	rogid:/rJRfpGBnSyV37L7wJcTtmVsrRc10116	rogid:sSbqSwGJRZSWKrpe4GgdME6TVNU10116	intact-crc:82D15E18D2481D70|rigid:NUf/jIOJUzWMK44Ow8s+O+WSr5g	false	green fluorescent protein tag:?-?(MINT-5227101)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61016	uniprotkb:Q6JP77	intact:EBI-7620725|intact:MINT-5227067|uniprotkb:P20006|ensembl:ENSRNOP00000000469	intact:EBI-6096191|uniprotkb:D3ZMQ5	psi-mi:ppla_rat(display_long)|uniprotkb:Pln(gene name)|psi-mi:Pln(display_short)	psi-mi:aka7g_rat(display_long)|uniprotkb:Akap7(gene name)|psi-mi:Akap7(display_short)|uniprotkb:A-kinase anchor protein 18(gene name synonym)|uniprotkb:AKAP-18(gene name synonym)|uniprotkb:Akap18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoforms delta and gamma(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Lygren et al. (2007)	pubmed:17901878|imex:IM-11139|mint:MINT-5227054	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7621094|mint:MINT-5227166|imex:IM-11139-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619894|refseq:NP_073198.1|ensembl:ENSRNOG00000000413(gene)|ensembl:ENSRNOT00000000469(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042030"(ATPase inhibitor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:0086023"(adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1901077"(regulation of relaxation of muscle)|go:"GO:1901877"(negative regulation of calcium ion binding)|go:"GO:1901894"(regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902081"(negative regulation of calcium ion import into sarcoplasmic reticulum)|interpro:IPR005984(Phospholamban)|mint:P61016|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0033574"(response to testosterone)|mint:MINT-5227168(identity)	mint:Q6JP77|rgd:1303071|refseq:NP_001001801.1|interpro:IPR019510|interpro:IPR019511|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|rcsb pdb:2VFK|rcsb pdb:2VFL|rcsb pdb:2VFY|rcsb pdb:3J4Q|rcsb pdb:3J4R|mint:MINT-5227171(identity)	-	comment:mint|function:Phospholamban has been postulated to regulate the activity of the calcium pump of cardiac sarcoplasmic reticulum	-	figure legend:SF3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/11/29	2014/10/16	rogid:/rJRfpGBnSyV37L7wJcTtmVsrRc10116	rogid:sSbqSwGJRZSWKrpe4GgdME6TVNU10116	intact-crc:D8222A81500DFC8F|rigid:NUf/jIOJUzWMK44Ow8s+O+WSr5g	false	green fluorescent protein tag:?-?(MINT-5227169)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)