#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P43235	uniprotkb:G5EFH4	intact:EBI-715344|ensembl:ENSP00000271651|ensembl:ENSP00000503723|ensembl:ENSP00000504176|uniprotkb:Q6FHS6	intact:EBI-1549936|ensemblmetazoa:C03G6.19.1	psi-mi:catk_human(display_long)|uniprotkb:Cathepsin O(gene name synonym)|uniprotkb:Cathepsin X(gene name synonym)|uniprotkb:Cathepsin O2(gene name synonym)|uniprotkb:CTSO(gene name synonym)|uniprotkb:CTSO2(gene name synonym)|uniprotkb:CTSK(gene name)|psi-mi:CTSK(display_short)	psi-mi:g5efh4_caeel(display_long)|uniprotkb:srp-6(gene name)|psi-mi:srp-6(display_short)|uniprotkb:CELE_C03G6.19(orf name)|uniprotkb:C03G6.19(orf name)	psi-mi:"MI:0415"(enzymatic study)	Luke et al. (2007)	imex:IM-11868|pubmed:17889653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1549962|imex:IM-11868-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000387.1|ensembl:ENSG00000143387(gene)|ensembl:ENST00000271651(transcript)|ensembl:ENST00000676824(transcript)|ensembl:ENST00000676966(transcript)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0006955"(immune response)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045453"(bone resorption)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0061037"(negative regulation of cartilage development)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR015644(Peptidase C1A, cathepsin K)|go:"GO:0000422"(autophagy of mitochondrion)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|rcsb pdb:1ATK|rcsb pdb:1AU0|interpro:IPR039417|rcsb pdb:1AU2|rcsb pdb:1AU3|rcsb pdb:1AU4|rcsb pdb:1AYU|rcsb pdb:1AYV|rcsb pdb:1AYW|rcsb pdb:1BGO|rcsb pdb:1BY8|rcsb pdb:1MEM|rcsb pdb:1NL6|rcsb pdb:1NLJ|rcsb pdb:1Q6K|rcsb pdb:1SNK|rcsb pdb:1TU6|rcsb pdb:1U9V|rcsb pdb:1U9W|rcsb pdb:1U9X|rcsb pdb:1VSN|rcsb pdb:1YK7|rcsb pdb:1YK8|rcsb pdb:1YT7|rcsb pdb:2ATO|rcsb pdb:2AUX|rcsb pdb:2AUZ|rcsb pdb:2BDL|rcsb pdb:2R6N|rcsb pdb:3C9E|rcsb pdb:3H7D|rcsb pdb:3KW9|rcsb pdb:3KWB|rcsb pdb:3KWZ|rcsb pdb:3KX1|rcsb pdb:3O0U|rcsb pdb:3O1G|rcsb pdb:3OVZ|rcsb pdb:4DMX|rcsb pdb:4DMY|rcsb pdb:4N79|rcsb pdb:4N8W|rcsb pdb:4X6H|rcsb pdb:4X6I|rcsb pdb:4X6J|rcsb pdb:4YV8|rcsb pdb:4YVA|rcsb pdb:5J94|rcsb pdb:5JA7|rcsb pdb:5JH3|rcsb pdb:5TDI|rcsb pdb:5TUN|rcsb pdb:5Z5O|rcsb pdb:6ASH|rcsb pdb:6HGY|rcsb pdb:6PXF|rcsb pdb:6QBS|rcsb pdb:6QL8|rcsb pdb:6QLM|rcsb pdb:6QLW|rcsb pdb:6QLX|rcsb pdb:6QM0|rcsb pdb:7PCK|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2132295|reactome:R-HSA-8939242|dip:DIP-39993N	uniprotkb:O01462(uniprot-removed-ac)|interpro:IPR042178|interpro:IPR042185|reactome:R-CEL-114608|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|refseq:NP_504890.1|wormbase:C03G6.19|reactome:R-CEL-381426|reactome:R-CEL-6798695|reactome:R-CEL-8957275|reactome:R-CEL-204005|reactome:R-CEL-416476|reactome:R-CEL-5694530|reactome:R-CEL-8939242|reactome:R-CEL-140837|reactome:R-CEL-1650814|reactome:R-CEL-194002|reactome:R-CEL-2022377|reactome:R-CEL-140875|interpro:IPR036186|ensemblmetazoa:C03G6.19.1(transcript)|ensemblmetazoa:WBGene00005647(gene)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table S1|kinetics:"Inhibition (%) = 94 ([I]0/[E]0 = 25)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/30	2014/10/16	rogid:C1kQxa3GinFgcXZsDLbrV8bn0FE9606	rogid:ubO/JMCHj8DOVXGPlIxwM+5xzlA6239	intact-crc:32991CE5B19F609E|rigid:bkUCBE/t/uw+GKjrVmKdAy4K28c	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:G5EFH4	uniprotkb:O60911	intact:EBI-1549936|ensemblmetazoa:C03G6.19.1	intact:EBI-1549974|uniprotkb:O60233|uniprotkb:Q2TB86|uniprotkb:Q5T1U0|ensembl:ENSP00000259470|ensembl:ENSP00000505141|ensembl:ENSP00000505681|ensembl:ENSP00000506713	psi-mi:g5efh4_caeel(display_long)|uniprotkb:srp-6(gene name)|psi-mi:srp-6(display_short)|uniprotkb:CELE_C03G6.19(orf name)|uniprotkb:C03G6.19(orf name)	psi-mi:catl2_human(display_long)|uniprotkb:CTSV(gene name)|psi-mi:CTSV(display_short)|uniprotkb:CATL2(gene name synonym)|uniprotkb:CTSL2(gene name synonym)|uniprotkb:CTSU(gene name synonym)|uniprotkb:Cathepsin U(gene name synonym)|uniprotkb:Cathepsin V(gene name synonym)|uniprotkb:UNQ268/PRO305(orf name)	psi-mi:"MI:0415"(enzymatic study)	Luke et al. (2007)	imex:IM-11868|pubmed:17889653	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1550001|imex:IM-11868-2	-	-	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O01462(uniprot-removed-ac)|interpro:IPR042178|interpro:IPR042185|reactome:R-CEL-114608|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|refseq:NP_504890.1|wormbase:C03G6.19|reactome:R-CEL-381426|reactome:R-CEL-6798695|reactome:R-CEL-8957275|reactome:R-CEL-204005|reactome:R-CEL-416476|reactome:R-CEL-5694530|reactome:R-CEL-8939242|reactome:R-CEL-140837|reactome:R-CEL-1650814|reactome:R-CEL-194002|reactome:R-CEL-2022377|reactome:R-CEL-140875|interpro:IPR036186|ensemblmetazoa:C03G6.19.1(transcript)|ensemblmetazoa:WBGene00005647(gene)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)	refseq:NP_001188504.1|refseq:NP_001324.2|ensembl:ENSG00000136943(gene)|ensembl:ENST00000259470(transcript)|ensembl:ENST00000679661(transcript)|ensembl:ENST00000681737(transcript)|ensembl:ENST00000681927(transcript)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005902"(microvillus)|go:"GO:0006955"(immune response)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0021675"(nerve development)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030984"(kininogen binding)|go:"GO:0034698"(response to gonadotropin)|go:"GO:0042277"(peptide binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0046697"(decidualization)|go:"GO:0048102"(autophagic cell death)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060008"(Sertoli cell differentiation)|go:"GO:1990834"(response to odorant)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|mint:O60911|rcsb pdb:1FH0|rcsb pdb:3H6S|rcsb pdb:3KFQ|reactome:R-HSA-1236977|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242	psi-mi:"MI:0469"(intact)	-	-	figure legend:Table S1|kinetics:"Inhibition (%) = 99 ([I]0/[E]0 = 25)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/30	2014/10/16	rogid:ubO/JMCHj8DOVXGPlIxwM+5xzlA6239	rogid:gO9hGtUadglp9Zh7PRyZQJ2CN/89606	intact-crc:92901512EA7E0F71|rigid:CgyzuKnFiE69cbb6O+T5QqW3goY	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:G5EFH4	uniprotkb:P07711	intact:EBI-1549936|ensemblmetazoa:C03G6.19.1	intact:EBI-1220160|uniprotkb:Q6IAV1|uniprotkb:Q96QJ0|ensembl:ENSP00000345344|ensembl:ENSP00000365061|ensembl:ENSP00000502901|ensembl:ENSP00000502968|ensembl:ENSP00000503298|ensembl:ENSP00000503439|ensembl:ENSP00000503897|ensembl:ENSP00000503938|ensembl:ENSP00000504279|ensembl:ENSP00000504313|ensembl:ENSP00000503470|ensembl:ENSP00000503851	psi-mi:g5efh4_caeel(display_long)|uniprotkb:srp-6(gene name)|psi-mi:srp-6(display_short)|uniprotkb:CELE_C03G6.19(orf name)|uniprotkb:C03G6.19(orf name)	psi-mi:catl1_human(display_long)|uniprotkb:CTSL(gene name)|psi-mi:CTSL(display_short)|uniprotkb:CTSL1(gene name synonym)|uniprotkb:Major excreted protein(gene name synonym)|uniprotkb:Cathepsin L1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Luke et al. (2007)	imex:IM-11868|pubmed:17889653	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1550006|imex:IM-11868-1	-	-	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O01462(uniprot-removed-ac)|interpro:IPR042178|interpro:IPR042185|reactome:R-CEL-114608|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|refseq:NP_504890.1|wormbase:C03G6.19|reactome:R-CEL-381426|reactome:R-CEL-6798695|reactome:R-CEL-8957275|reactome:R-CEL-204005|reactome:R-CEL-416476|reactome:R-CEL-5694530|reactome:R-CEL-8939242|reactome:R-CEL-140837|reactome:R-CEL-1650814|reactome:R-CEL-194002|reactome:R-CEL-2022377|reactome:R-CEL-140875|interpro:IPR036186|ensemblmetazoa:C03G6.19.1(transcript)|ensemblmetazoa:WBGene00005647(gene)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)	refseq:NP_001244900.1|refseq:NP_001244901.1|refseq:NP_001903.1|refseq:NP_666023.1|refseq:XP_005251773.1|ensembl:ENSG00000135047(gene)|ensembl:ENST00000340342(transcript)|ensembl:ENST00000343150(transcript)|ensembl:ENST00000676480(transcript)|ensembl:ENST00000676531(transcript)|ensembl:ENST00000676881(transcript)|ensembl:ENST00000676946(transcript)|ensembl:ENST00000677262(transcript)|ensembl:ENST00000677761(transcript)|ensembl:ENST00000677821(transcript)|ensembl:ENST00000678442(transcript)|ensembl:ENST00000679149(transcript)|ensembl:ENST00000679157(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031638"(zymogen activation)|go:"GO:0034230"(enkephalin processing)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042583"(chromaffin granule)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043373"(CD4-positive, alpha-beta T cell lineage commitment)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060309"(elastin catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097655"(serpin family protein binding)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|rcsb pdb:1CJL|rcsb pdb:1CS8|rcsb pdb:1ICF|rcsb pdb:1MHW|rcsb pdb:2NQD|rcsb pdb:2VHS|rcsb pdb:2XU1|rcsb pdb:2XU3|rcsb pdb:2XU4|rcsb pdb:2XU5|rcsb pdb:2YJ2|rcsb pdb:2YJ8|rcsb pdb:2YJ9|rcsb pdb:2YJB|rcsb pdb:2YJC|rcsb pdb:3H89|rcsb pdb:3H8B|rcsb pdb:3H8C|rcsb pdb:3HHA|rcsb pdb:3HWN|rcsb pdb:3IV2|rcsb pdb:3K24|rcsb pdb:3KSE|rcsb pdb:3OF8|rcsb pdb:3OF9|rcsb pdb:4AXL|rcsb pdb:4AXM|rcsb pdb:5F02|rcsb pdb:5I4H|rcsb pdb:5MAE|rcsb pdb:5MAJ|rcsb pdb:5MQY|rcsb pdb:6EZP|rcsb pdb:6EZX|rcsb pdb:6F06|rcsb pdb:6JD0|rcsb pdb:6JD8|reactome:R-HSA-1236977|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:3BC3	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 A, C, Table S1|kinetics:"Inhibition (%) = 99 ([I]0/[E]0 = 25); complete inhibition at inhibitor:enzyme ratio of approx. 1:1; second-order rate constant ka = 10 E4 +- 0.1 M-1 s-1 (mean ka +- SD from 3-4 experiments)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/30	2014/10/16	rogid:ubO/JMCHj8DOVXGPlIxwM+5xzlA6239	rogid:4ASJZ/S9LTLUCO4cGa+6q3vMyEE9606	intact-crc:14A6F32E139D3357|rigid:jwRo8q1gr47F5QiPe2SWmgv+vPk	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:G5EFH4	uniprotkb:Q07009	intact:EBI-1549936|ensemblmetazoa:C03G6.19.1	intact:EBI-1040438|ensembl:ENSRNOP00000046509	psi-mi:g5efh4_caeel(display_long)|uniprotkb:srp-6(gene name)|psi-mi:srp-6(display_short)|uniprotkb:CELE_C03G6.19(orf name)|uniprotkb:C03G6.19(orf name)	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Luke et al. (2007)	imex:IM-11868|pubmed:17889653	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1550011|imex:IM-11868-3	-	-	psi-mi:"MI:0586"(inhibitor)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:O01462(uniprot-removed-ac)|interpro:IPR042178|interpro:IPR042185|reactome:R-CEL-114608|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|refseq:NP_504890.1|wormbase:C03G6.19|reactome:R-CEL-381426|reactome:R-CEL-6798695|reactome:R-CEL-8957275|reactome:R-CEL-204005|reactome:R-CEL-416476|reactome:R-CEL-5694530|reactome:R-CEL-8939242|reactome:R-CEL-140837|reactome:R-CEL-1650814|reactome:R-CEL-194002|reactome:R-CEL-2022377|reactome:R-CEL-140875|interpro:IPR036186|ensemblmetazoa:C03G6.19.1(transcript)|ensemblmetazoa:WBGene00005647(gene)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 B, D, Table S1|kinetics:"Inhibition (%) = 96 ([I]0/[E]0 = 5); complete inhibition at inhibitor:enzyme ratio of approx. 1:1.5; second-order rate constant ka = 2.3 E4 +- O.4 M-1 s-1 (mean ka +- SD from 3-4 experiments)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/30	2014/10/16	rogid:ubO/JMCHj8DOVXGPlIxwM+5xzlA6239	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	intact-crc:BF4233AB1786E41A|rigid:Wd1YZrcGnZNlSZAFQAbjFq1NKKo	false	-	-	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:P07711	uniprotkb:G5EFH4	intact:EBI-1220160|uniprotkb:Q6IAV1|uniprotkb:Q96QJ0|ensembl:ENSP00000345344|ensembl:ENSP00000365061|ensembl:ENSP00000502901|ensembl:ENSP00000502968|ensembl:ENSP00000503298|ensembl:ENSP00000503439|ensembl:ENSP00000503897|ensembl:ENSP00000503938|ensembl:ENSP00000504279|ensembl:ENSP00000504313|ensembl:ENSP00000503470|ensembl:ENSP00000503851	intact:EBI-1549936|ensemblmetazoa:C03G6.19.1	psi-mi:catl1_human(display_long)|uniprotkb:CTSL(gene name)|psi-mi:CTSL(display_short)|uniprotkb:CTSL1(gene name synonym)|uniprotkb:Major excreted protein(gene name synonym)|uniprotkb:Cathepsin L1(gene name synonym)	psi-mi:g5efh4_caeel(display_long)|uniprotkb:srp-6(gene name)|psi-mi:srp-6(display_short)|uniprotkb:CELE_C03G6.19(orf name)|uniprotkb:C03G6.19(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Luke et al. (2007)	imex:IM-11868|pubmed:17889653	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1550124|imex:IM-11868-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001244900.1|refseq:NP_001244901.1|refseq:NP_001903.1|refseq:NP_666023.1|refseq:XP_005251773.1|ensembl:ENSG00000135047(gene)|ensembl:ENST00000340342(transcript)|ensembl:ENST00000343150(transcript)|ensembl:ENST00000676480(transcript)|ensembl:ENST00000676531(transcript)|ensembl:ENST00000676881(transcript)|ensembl:ENST00000676946(transcript)|ensembl:ENST00000677262(transcript)|ensembl:ENST00000677761(transcript)|ensembl:ENST00000677821(transcript)|ensembl:ENST00000678442(transcript)|ensembl:ENST00000679149(transcript)|ensembl:ENST00000679157(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006955"(immune response)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019064"(fusion of virus membrane with host plasma membrane)|go:"GO:0019065"(receptor-mediated endocytosis of virus by host cell)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0031638"(zymogen activation)|go:"GO:0034230"(enkephalin processing)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0042393"(histone binding)|go:"GO:0042583"(chromaffin granule)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043373"(CD4-positive, alpha-beta T cell lineage commitment)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048002"(antigen processing and presentation of peptide antigen)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060309"(elastin catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0071888"(macrophage apoptotic process)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097655"(serpin family protein binding)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR013201(Proteinase inhibitor I29, cathepsin propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|interpro:IPR039417|rcsb pdb:1CJL|rcsb pdb:1CS8|rcsb pdb:1ICF|rcsb pdb:1MHW|rcsb pdb:2NQD|rcsb pdb:2VHS|rcsb pdb:2XU1|rcsb pdb:2XU3|rcsb pdb:2XU4|rcsb pdb:2XU5|rcsb pdb:2YJ2|rcsb pdb:2YJ8|rcsb pdb:2YJ9|rcsb pdb:2YJB|rcsb pdb:2YJC|rcsb pdb:3H89|rcsb pdb:3H8B|rcsb pdb:3H8C|rcsb pdb:3HHA|rcsb pdb:3HWN|rcsb pdb:3IV2|rcsb pdb:3K24|rcsb pdb:3KSE|rcsb pdb:3OF8|rcsb pdb:3OF9|rcsb pdb:4AXL|rcsb pdb:4AXM|rcsb pdb:5F02|rcsb pdb:5I4H|rcsb pdb:5MAE|rcsb pdb:5MAJ|rcsb pdb:5MQY|rcsb pdb:6EZP|rcsb pdb:6EZX|rcsb pdb:6F06|rcsb pdb:6JD0|rcsb pdb:6JD8|reactome:R-HSA-1236977|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-8939242|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:3BC3	uniprotkb:O01462(uniprot-removed-ac)|interpro:IPR042178|interpro:IPR042185|reactome:R-CEL-114608|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|refseq:NP_504890.1|wormbase:C03G6.19|reactome:R-CEL-381426|reactome:R-CEL-6798695|reactome:R-CEL-8957275|reactome:R-CEL-204005|reactome:R-CEL-416476|reactome:R-CEL-5694530|reactome:R-CEL-8939242|reactome:R-CEL-140837|reactome:R-CEL-1650814|reactome:R-CEL-194002|reactome:R-CEL-2022377|reactome:R-CEL-140875|interpro:IPR036186|ensemblmetazoa:C03G6.19.1(transcript)|ensemblmetazoa:WBGene00005647(gene)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/30	2014/10/16	rogid:4ASJZ/S9LTLUCO4cGa+6q3vMyEE9606	rogid:ubO/JMCHj8DOVXGPlIxwM+5xzlA6239	intact-crc:C05F30A692361D68|rigid:jwRo8q1gr47F5QiPe2SWmgv+vPk	false	-	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q07009	uniprotkb:G5EFH4	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-1549936|ensemblmetazoa:C03G6.19.1	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:g5efh4_caeel(display_long)|uniprotkb:srp-6(gene name)|psi-mi:srp-6(display_short)|uniprotkb:CELE_C03G6.19(orf name)|uniprotkb:C03G6.19(orf name)	psi-mi:"MI:0808"(comigration in sds page)	Luke et al. (2007)	imex:IM-11868|pubmed:17889653	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1550213|imex:IM-11868-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	uniprotkb:O01462(uniprot-removed-ac)|interpro:IPR042178|interpro:IPR042185|reactome:R-CEL-114608|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|refseq:NP_504890.1|wormbase:C03G6.19|reactome:R-CEL-381426|reactome:R-CEL-6798695|reactome:R-CEL-8957275|reactome:R-CEL-204005|reactome:R-CEL-416476|reactome:R-CEL-5694530|reactome:R-CEL-8939242|reactome:R-CEL-140837|reactome:R-CEL-1650814|reactome:R-CEL-194002|reactome:R-CEL-2022377|reactome:R-CEL-140875|interpro:IPR036186|ensemblmetazoa:C03G6.19.1(transcript)|ensemblmetazoa:WBGene00005647(gene)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0008233"(peptidase activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 F|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/30	2014/10/16	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:ubO/JMCHj8DOVXGPlIxwM+5xzlA6239	intact-crc:C5135B6335CFCD5C|rigid:Wd1YZrcGnZNlSZAFQAbjFq1NKKo	false	-	35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)