#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q8BX09 uniprotkb:Q91X20 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1556550|imex:IM-11982-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 psi-mi:"MI:0469"(intact) - - figure legend:6B|agonist:The interaction was observed in LPS stimulated cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2007/11/19 2014/10/16 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 intact-crc:30670B9ADBA9F29E|rigid:Y7FLYDT4iMhieYOWCPP9OtxR7GA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8BX09 uniprotkb:Q5NCY0 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 intact:EBI-1556564|uniprotkb:Q3UWY9|uniprotkb:Q4VC26|uniprotkb:Q6ZQD3|ensembl:ENSMUSP00000091620 psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:kdm6b_mouse(display_long)|uniprotkb:JmjC domain-containing protein 3(gene name synonym)|uniprotkb:Jumonji domain-containing protein 3(gene name synonym)|uniprotkb:Kdm6b(gene name)|psi-mi:Kdm6b(display_short)|uniprotkb:Kiaa0346(gene name synonym)|uniprotkb:Jmjd3(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6B"(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1556550|imex:IM-11982-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) refseq:NP_001017426.1|refseq:XP_011247221.1|refseq:XP_011247222.1|refseq:XP_011247223.1|refseq:XP_011247224.1|refseq:XP_011247225.1|refseq:XP_006532961.1|dip:DIP-39160N|ensembl:ENSMUSG00000018476(gene)|ensembl:ENSMUST00000094077(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0016577"(histone demethylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR029518|rcsb pdb:4EYU|rcsb pdb:4EZ4|rcsb pdb:4EZH|reactome:R-MMU-2559580|reactome:R-MMU-3214842|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding) psi-mi:"MI:0469"(intact) - - figure legend:6B|agonist:The interaction was observed in LPS stimulated cells.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2007/11/19 2014/10/16 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 rogid:EsQQ2ByEl/bLaegpLDb/n9Q0WIU10090 intact-crc:30670B9ADBA9F29E|rigid:Y7FLYDT4iMhieYOWCPP9OtxR7GA false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q91X20 uniprotkb:Q8BX09 intact:EBI-1556554|uniprotkb:Q3UIF9|uniprotkb:Q9Z2X4|ensembl:ENSMUSP00000070957 intact:EBI-1556543|uniprotkb:Q3TBL4|uniprotkb:Q6PAP0|uniprotkb:Q6PFC2|uniprotkb:Q3U3G1|ensembl:ENSMUSP00000141003 psi-mi:ash2l_mouse(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:Ash2l(gene name)|psi-mi:Ash2l(display_short) psi-mi:rbbp5_mouse(display_long)|uniprotkb:Rbbp5(gene name)|psi-mi:Rbbp5(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573302|imex:IM-11982-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_035921.2|dip:DIP-39161N|ensembl:ENSMUSG00000031575(gene)|ensembl:ENSMUST00000068892(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048096"|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q91X20|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459 refseq:NP_766105.2|dip:DIP-61809N|ensembl:ENSMUSG00000026439(gene)|ensembl:ENSMUST00000190997(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042800"("histone methyltransferase activity (H3-K4 specific)")|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR037850|mint:Q8BX09|rcsb pdb:2XL2|rcsb pdb:2XL3|reactome:R-MMU-201722|reactome:R-MMU-3214841|reactome:R-MMU-8936459|reactome:R-MMU-8951664|go:"GO:0035097"(histone methyltransferase complex) psi-mi:"MI:0469"(intact) - - figure legend:6B|comment:This interaction occured in the absence of LPS treatment.|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2007/11/19 2014/10/16 rogid:3ub+DLUG8tmHIoZHh9j8/bHHMWY10090 rogid:IfmUqzNWpYZzHDMDGeLiZqEcRK010090 intact-crc:FF60FDBE73C0DD24|rigid:SysKjps8PkRxx3K+fVRSMuBxbfk false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5NCY0 uniprotkb:P61964 intact:EBI-1556564|uniprotkb:Q3UWY9|uniprotkb:Q4VC26|uniprotkb:Q6ZQD3|ensembl:ENSMUSP00000091620 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:kdm6b_mouse(display_long)|uniprotkb:JmjC domain-containing protein 3(gene name synonym)|uniprotkb:Jumonji domain-containing protein 3(gene name synonym)|uniprotkb:Kdm6b(gene name)|psi-mi:Kdm6b(display_short)|uniprotkb:Kiaa0346(gene name synonym)|uniprotkb:Jmjd3(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6B"(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573361|imex:IM-11982-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001017426.1|refseq:XP_011247221.1|refseq:XP_011247222.1|refseq:XP_011247223.1|refseq:XP_011247224.1|refseq:XP_011247225.1|refseq:XP_006532961.1|dip:DIP-39160N|ensembl:ENSMUSG00000018476(gene)|ensembl:ENSMUST00000094077(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0016577"(histone demethylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR029518|rcsb pdb:4EYU|rcsb pdb:4EZ4|rcsb pdb:4EZH|reactome:R-MMU-2559580|reactome:R-MMU-3214842|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding) refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N psi-mi:"MI:0469"(intact) - - figure legend:6A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/11/19 2014/10/16 rogid:EsQQ2ByEl/bLaegpLDb/n9Q0WIU10090 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:5AC3CA49EB43CD19|rigid:JIiIW8QYIe8nhnH1BSvCZWr5hoE false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5NCY0 intact:EBI-1573643 intact:EBI-1556564|uniprotkb:Q3UWY9|uniprotkb:Q4VC26|uniprotkb:Q6ZQD3|ensembl:ENSMUSP00000091620 - psi-mi:kdm6b_mouse(display_long)|uniprotkb:JmjC domain-containing protein 3(gene name synonym)|uniprotkb:Jumonji domain-containing protein 3(gene name synonym)|uniprotkb:Kdm6b(gene name)|psi-mi:Kdm6b(display_short)|uniprotkb:Kiaa0346(gene name synonym)|uniprotkb:Jmjd3(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6B"(gene name synonym) psi-mi:a8mtg7_human(display_short)|psi-mi:EBI-1573643(display_long)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573361|imex:IM-11982-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001017426.1|refseq:XP_011247221.1|refseq:XP_011247222.1|refseq:XP_011247223.1|refseq:XP_011247224.1|refseq:XP_011247225.1|refseq:XP_006532961.1|dip:DIP-39160N|ensembl:ENSMUSG00000018476(gene)|ensembl:ENSMUST00000094077(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0016577"(histone demethylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR029518|rcsb pdb:4EYU|rcsb pdb:4EZ4|rcsb pdb:4EZH|reactome:R-MMU-2559580|reactome:R-MMU-3214842|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding) uniprotkb:A8MTG7(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:6A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/11/19 2014/10/16 rogid:EsQQ2ByEl/bLaegpLDb/n9Q0WIU10090 rogid:8sNPC98Omq8/zErCpvqlx1qq6Zo9606 intact-crc:5AC3CA49EB43CD19|rigid:JIiIW8QYIe8nhnH1BSvCZWr5hoE false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q5NCY0 uniprotkb:Q9UBL3 intact:EBI-1556564|uniprotkb:Q3UWY9|uniprotkb:Q4VC26|uniprotkb:Q6ZQD3|ensembl:ENSMUSP00000091620 intact:EBI-540797|uniprotkb:O60659|uniprotkb:O60660|uniprotkb:Q96B62|ensembl:ENSP00000340896|uniprotkb:A8K7C3|uniprotkb:D3DSW9 psi-mi:kdm6b_mouse(display_long)|uniprotkb:JmjC domain-containing protein 3(gene name synonym)|uniprotkb:Jumonji domain-containing protein 3(gene name synonym)|uniprotkb:Kdm6b(gene name)|psi-mi:Kdm6b(display_short)|uniprotkb:Kiaa0346(gene name synonym)|uniprotkb:Jmjd3(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6B"(gene name synonym) psi-mi:ash2l_human(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573361|imex:IM-11982-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001017426.1|refseq:XP_011247221.1|refseq:XP_011247222.1|refseq:XP_011247223.1|refseq:XP_011247224.1|refseq:XP_011247225.1|refseq:XP_006532961.1|dip:DIP-39160N|ensembl:ENSMUSG00000018476(gene)|ensembl:ENSMUST00000094077(transcript)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014823"(response to activity)|go:"GO:0016577"(histone demethylation)|go:"GO:0021766"(hippocampus development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR029518|rcsb pdb:4EYU|rcsb pdb:4EZ4|rcsb pdb:4EZH|reactome:R-MMU-2559580|reactome:R-MMU-3214842|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding) refseq:NP_001098684.1|refseq:NP_004665.2|ensembl:ENSG00000129691(gene)|ensembl:ENST00000343823(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q9UBL3|rcsb pdb:3RSN|rcsb pdb:3S32|rcsb pdb:3TOJ|rcsb pdb:4RIQ|rcsb pdb:4X8P|rcsb pdb:5F6K|rcsb pdb:5F6L|rcsb pdb:6E2H|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:7BRE|reactome:R-HSA-201722|reactome:R-HSA-3214841|reactome:R-HSA-3769402|reactome:R-HSA-5617472|reactome:R-HSA-8936459|rcsb pdb:4X8N|refseq:NP_001248761.1|dip:DIP-29222N psi-mi:"MI:0469"(intact) - - figure legend:6A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/11/19 2014/10/16 rogid:EsQQ2ByEl/bLaegpLDb/n9Q0WIU10090 rogid:ZUYI3M78nGeeb8K2eIiDSw1uWeo9606 intact-crc:5AC3CA49EB43CD19|rigid:JIiIW8QYIe8nhnH1BSvCZWr5hoE false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O70546 intact:EBI-1573643 intact:EBI-1573712|uniprotkb:A2AID2|uniprotkb:Q6DI80|uniprotkb:Q7TSG4|ensembl:ENSMUSP00000045862 - psi-mi:kdm6a_mouse(display_long)|uniprotkb:Ubiquitously transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:Ubiquitously transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Kdm6a(gene name)|psi-mi:Kdm6a(display_short)|uniprotkb:Utx(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym) psi-mi:a8mtg7_human(display_short)|psi-mi:EBI-1573643(display_long)|uniprotkb:RBBP5(gene name)|psi-mi:RBBP5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573665|imex:IM-11982-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033509.1|refseq:NP_001297373.1|ensembl:ENSMUSG00000037369(gene)|ensembl:ENSMUST00000044484(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021915"(neural tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0072359"(circulatory system development)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-3214842|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060070"(canonical Wnt signaling pathway) uniprotkb:A8MTG7(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:6A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/11/19 2014/10/16 rogid:qMPUV3quo7aj9ipc9Abu2RWGX1M10090 rogid:8sNPC98Omq8/zErCpvqlx1qq6Zo9606 intact-crc:64E04003F1658B68|rigid:u088GpTOwtWnvvyusXQH6PeIjfU false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O70546 uniprotkb:Q9UBL3 intact:EBI-1573712|uniprotkb:A2AID2|uniprotkb:Q6DI80|uniprotkb:Q7TSG4|ensembl:ENSMUSP00000045862 intact:EBI-540797|uniprotkb:O60659|uniprotkb:O60660|uniprotkb:Q96B62|ensembl:ENSP00000340896|uniprotkb:A8K7C3|uniprotkb:D3DSW9 psi-mi:kdm6a_mouse(display_long)|uniprotkb:Ubiquitously transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:Ubiquitously transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Kdm6a(gene name)|psi-mi:Kdm6a(display_short)|uniprotkb:Utx(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym) psi-mi:ash2l_human(display_long)|uniprotkb:ASH2-like protein(gene name synonym)|uniprotkb:ASH2L(gene name)|psi-mi:ASH2L(display_short)|uniprotkb:ASH2L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573665|imex:IM-11982-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033509.1|refseq:NP_001297373.1|ensembl:ENSMUSG00000037369(gene)|ensembl:ENSMUST00000044484(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021915"(neural tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0072359"(circulatory system development)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-3214842|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060070"(canonical Wnt signaling pathway) refseq:NP_001098684.1|refseq:NP_004665.2|ensembl:ENSG00000129691(gene)|ensembl:ENST00000343823(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0043627"(response to estrogen)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037353|mint:Q9UBL3|rcsb pdb:3RSN|rcsb pdb:3S32|rcsb pdb:3TOJ|rcsb pdb:4RIQ|rcsb pdb:4X8P|rcsb pdb:5F6K|rcsb pdb:5F6L|rcsb pdb:6E2H|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6PWV|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:7BRE|reactome:R-HSA-201722|reactome:R-HSA-3214841|reactome:R-HSA-3769402|reactome:R-HSA-5617472|reactome:R-HSA-8936459|rcsb pdb:4X8N|refseq:NP_001248761.1|dip:DIP-29222N psi-mi:"MI:0469"(intact) - - figure legend:6A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/11/19 2014/10/16 rogid:qMPUV3quo7aj9ipc9Abu2RWGX1M10090 rogid:ZUYI3M78nGeeb8K2eIiDSw1uWeo9606 intact-crc:64E04003F1658B68|rigid:u088GpTOwtWnvvyusXQH6PeIjfU false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O70546 uniprotkb:P61964 intact:EBI-1573712|uniprotkb:A2AID2|uniprotkb:Q6DI80|uniprotkb:Q7TSG4|ensembl:ENSMUSP00000045862 intact:EBI-540834|uniprotkb:Q91VA5|uniprotkb:Q9NWX7|uniprotkb:Q9UGP9|intact:EBI-28992503|ensembl:ENSP00000351446|intact:EBI-5774097 psi-mi:kdm6a_mouse(display_long)|uniprotkb:Ubiquitously transcribed X chromosome tetratricopeptide repeat protein(gene name synonym)|uniprotkb:Ubiquitously transcribed TPR protein on the X chromosome(gene name synonym)|uniprotkb:Kdm6a(gene name)|psi-mi:Kdm6a(display_short)|uniprotkb:Utx(gene name synonym)|uniprotkb:Histone demethylase UTX(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(27) demethylase 6A"(gene name synonym) psi-mi:wdr5_human(display_long)|uniprotkb:BMP2-induced 3-kb gene protein(gene name synonym)|uniprotkb:WDR5(gene name)|psi-mi:WDR5(display_short)|uniprotkb:BIG3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) De et al. (2007) imex:IM-11982|pubmed:17825402 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:0469"(IntAct) intact:EBI-1573665|imex:IM-11982-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_033509.1|refseq:NP_001297373.1|ensembl:ENSMUSG00000037369(gene)|ensembl:ENSMUST00000044484(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001843"(neural tube closure)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003016"(respiratory system process)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007507"(heart development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0021915"(neural tube development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0071557"(histone H3-K27 demethylation)|go:"GO:0071558"(histone H3-tri/di-methyl-lysine-27 demethylase activity)|go:"GO:0072359"(circulatory system development)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-3214842|go:"GO:0046872"(metal ion binding)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048570"(notochord morphogenesis)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060070"(canonical Wnt signaling pathway) refseq:NP_060058.1|refseq:NP_438172.1|rcsb pdb:4GMB|rcsb pdb:4IA9|rcsb pdb:4O45|rcsb pdb:4QL1|rcsb pdb:4Y7R|rcsb pdb:5EAL|rcsb pdb:5EAM|rcsb pdb:5EAP|rcsb pdb:5EAR|rcsb pdb:5M23|rcsb pdb:5M25|rcsb pdb:5SXM|rcsb pdb:5VFC|rcsb pdb:6BYN|rcsb pdb:6D9X|rcsb pdb:6DAI|rcsb pdb:6DAK|rcsb pdb:6DAR|rcsb pdb:6DAS|rcsb pdb:6DY7|rcsb pdb:6DYA|rcsb pdb:6E1Y|rcsb pdb:6E1Z|rcsb pdb:6E22|rcsb pdb:6E23|rcsb pdb:6IAM|rcsb pdb:6KIU|rcsb pdb:6KIV|rcsb pdb:6KIW|rcsb pdb:6KIX|rcsb pdb:6KIZ|rcsb pdb:6OFZ|rcsb pdb:6OI0|rcsb pdb:6OI1|rcsb pdb:6OI2|rcsb pdb:6OI3|rcsb pdb:6PG3|rcsb pdb:6PG4|rcsb pdb:6PG5|rcsb pdb:6PG6|rcsb pdb:6PG7|rcsb pdb:6PG8|rcsb pdb:6PG9|rcsb pdb:6PGA|rcsb pdb:6PGB|rcsb pdb:6PGC|rcsb pdb:6PGD|rcsb pdb:6PGE|rcsb pdb:6PGF|rcsb pdb:6PWV|rcsb pdb:6PWW|rcsb pdb:6U5M|rcsb pdb:6U5Y|rcsb pdb:6U6W|rcsb pdb:6U80|rcsb pdb:6U8B|rcsb pdb:6U8L|rcsb pdb:6U8O|rcsb pdb:6UCS|rcsb pdb:6UFX|rcsb pdb:6UHY|rcsb pdb:6UHZ|rcsb pdb:6UIF|rcsb pdb:6UIK|rcsb pdb:6UJ4|rcsb pdb:6UJH|rcsb pdb:6UJJ|rcsb pdb:6UJL|rcsb pdb:6UOZ|rcsb pdb:6W5I|rcsb pdb:6W5M|rcsb pdb:6W5N|rcsb pdb:6WJQ|rcsb pdb:7DNO|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5617472|reactome:R-HSA-8936459|reactome:R-HSA-8951664|ensembl:ENSG00000196363(gene)|ensembl:ENST00000358625(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0001501"(skeletal system development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042393"(histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051572"(negative regulation of histone H3-K4 methylation)|go:"GO:0071339"(MLL1 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P61964|rcsb pdb:2CNX|rcsb pdb:2CO0|rcsb pdb:2G99|rcsb pdb:2G9A|rcsb pdb:2GNQ|rcsb pdb:2H13|rcsb pdb:2H14|rcsb pdb:2H68|rcsb pdb:2H6K|rcsb pdb:2H6N|rcsb pdb:2H6Q|rcsb pdb:2H9L|rcsb pdb:2H9M|rcsb pdb:2H9N|rcsb pdb:2H9P|rcsb pdb:2O9K|rcsb pdb:3EG6|rcsb pdb:3EMH|rcsb pdb:3MXX|rcsb pdb:3N0D|rcsb pdb:3N0E|rcsb pdb:3P4F|rcsb pdb:3PSL|rcsb pdb:3SMR|rcsb pdb:3UR4|rcsb pdb:3UVK|rcsb pdb:3UVL|rcsb pdb:3UVM|rcsb pdb:3UVN|rcsb pdb:3UVO|rcsb pdb:4A7J|rcsb pdb:4CY1|rcsb pdb:4CY2|rcsb pdb:4ERQ|rcsb pdb:4ERY|rcsb pdb:4ERZ|rcsb pdb:4ES0|rcsb pdb:4ESG|rcsb pdb:4EWR|rcsb pdb:4GM3|rcsb pdb:4GM8|rcsb pdb:4GM9|ensembl:ENSP00000351446|refseq:XP_005272220.1|dip:DIP-29223N psi-mi:"MI:0469"(intact) - - figure legend:6A|dataset:Chromatin - Epigenetic interactions resulting in chromatin modulation|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2007/11/19 2014/10/16 rogid:qMPUV3quo7aj9ipc9Abu2RWGX1M10090 rogid:MNq7yCtkHPFRGiq1fP5TAwcGUAU9606 intact-crc:64E04003F1658B68|rigid:u088GpTOwtWnvvyusXQH6PeIjfU false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)