#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P02741 uniprotkb:P12318 intact:EBI-1395983|uniprotkb:A8K078|uniprotkb:Q08AK3|uniprotkb:Q8WW75|uniprotkb:D3DVD9|uniprotkb:D3DVE0|ensembl:ENSP00000255030 intact:EBI-1395970|uniprotkb:Q8WUN1|uniprotkb:Q8WW64|ensembl:ENSP00000271450 psi-mi:crp_human(display_long)|uniprotkb:CRP(gene name)|psi-mi:CRP(display_short)|uniprotkb:PTX1(gene name synonym) psi-mi:fcg2a_human(display_long)|uniprotkb:FCGR2A(gene name)|psi-mi:FCGR2A(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:FCGR2A1(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-a(gene name synonym)|uniprotkb:CDw32(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yang et al. (2007) imex:IM-11881|pubmed:17785206 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1396031|imex:IM-11881-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000558.2|refseq:NP_001315986.1|refseq:NP_001315987.1|dip:DIP-39125N|ensembl:ENSG00000132693(gene)|ensembl:ENST00000255030(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008228"(opsonization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0033265"(choline binding)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:P02741|rcsb pdb:1B09|rcsb pdb:1CRV|rcsb pdb:1GNH|rcsb pdb:1LJ7|rcsb pdb:3L2Y|rcsb pdb:3PVN|rcsb pdb:3PVO|reactome:R-HSA-173623 refseq:NP_001129691.1|refseq:NP_067674.2|ensembl:ENSG00000143226(gene)|ensembl:ENST00000271450(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0019864"(IgG binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0050776"(regulation of immune response)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1FCG|rcsb pdb:1H9V|rcsb pdb:3D5O|rcsb pdb:3RY4|rcsb pdb:3RY5|rcsb pdb:3RY6|reactome:R-HSA-2029481|reactome:R-HSA-2029482|reactome:R-HSA-2029485|reactome:R-HSA-6798695|reactome:R-HSA-9664323 psi-mi:"MI:0469"(intact) - - figure legend:4 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/13 2014/10/16 rogid:R7vKMSGKD4ETbUKVGL9IiL8jzjE9606 rogid:nLZVU54CX2WcrlhLnD3LQ8Sabgc9606 intact-crc:8A2E7EDFC2D3D1F3|rigid:B+NXHjZcy2ewiGUtOAvrlcyxsUQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P02741 uniprotkb:P31995 intact:EBI-1395983|uniprotkb:A8K078|uniprotkb:Q08AK3|uniprotkb:Q8WW75|uniprotkb:D3DVD9|uniprotkb:D3DVE0|ensembl:ENSP00000255030 intact:EBI-1396036|uniprotkb:O00523|uniprotkb:O00524|uniprotkb:O00525 psi-mi:crp_human(display_long)|uniprotkb:CRP(gene name)|psi-mi:CRP(display_short)|uniprotkb:PTX1(gene name synonym) psi-mi:fcg2c_human(display_long)|uniprotkb:FCGR2C(gene name)|psi-mi:FCGR2C(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-c(gene name synonym)|uniprotkb:CDw32(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yang et al. (2007) imex:IM-11881|pubmed:17785206 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1396070|imex:IM-11881-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000558.2|refseq:NP_001315986.1|refseq:NP_001315987.1|dip:DIP-39125N|ensembl:ENSG00000132693(gene)|ensembl:ENST00000255030(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008228"(opsonization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0033265"(choline binding)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:P02741|rcsb pdb:1B09|rcsb pdb:1CRV|rcsb pdb:1GNH|rcsb pdb:1LJ7|rcsb pdb:3L2Y|rcsb pdb:3PVN|rcsb pdb:3PVO|reactome:R-HSA-173623 refseq:NP_963857.3|rcsb pdb:3WJL|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:XP_011507594.1|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR036179|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019864"(IgG binding)|go:"GO:0050776"(regulation of immune response) psi-mi:"MI:0469"(intact) - - figure legend:4 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/09/13 2014/10/16 rogid:R7vKMSGKD4ETbUKVGL9IiL8jzjE9606 rogid:Zkg59SJLVS7Nuhzbqw526n6Jk/g9606 intact-crc:7A2A2B5F65D3C904|rigid:fOq0zE6Dk1cP3Fqfff5eapsQ7PE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P31995 uniprotkb:P02741 intact:EBI-1396036|uniprotkb:O00523|uniprotkb:O00524|uniprotkb:O00525 intact:EBI-1395983|uniprotkb:A8K078|uniprotkb:Q08AK3|uniprotkb:Q8WW75|uniprotkb:D3DVD9|uniprotkb:D3DVE0|ensembl:ENSP00000255030 psi-mi:fcg2c_human(display_long)|uniprotkb:FCGR2C(gene name)|psi-mi:FCGR2C(display_short)|uniprotkb:CD32(gene name synonym)|uniprotkb:FCG2(gene name synonym)|uniprotkb:IGFR2(gene name synonym)|uniprotkb:Fc-gamma RII-c(gene name synonym)|uniprotkb:CDw32(gene name synonym) psi-mi:crp_human(display_long)|uniprotkb:CRP(gene name)|psi-mi:CRP(display_short)|uniprotkb:PTX1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Yang et al. (2007) imex:IM-11881|pubmed:17785206 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1396092|imex:IM-11881-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_963857.3|rcsb pdb:3WJL|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|refseq:XP_011507594.1|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR036179|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019864"(IgG binding)|go:"GO:0050776"(regulation of immune response) refseq:NP_000558.2|refseq:NP_001315986.1|refseq:NP_001315987.1|dip:DIP-39125N|ensembl:ENSG00000132693(gene)|ensembl:ENST00000255030(transcript)|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008228"(opsonization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030169"(low-density lipoprotein particle binding)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032945"(negative regulation of mononuclear cell proliferation)|go:"GO:0033265"(choline binding)|go:"GO:0042310"(vasoconstriction)|go:"GO:0042802"(identical protein binding)|go:"GO:0044793"(negative regulation by host of viral process)|go:"GO:0045087"(innate immune response)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|interpro:IPR001759(Pentaxin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030476|mint:P02741|rcsb pdb:1B09|rcsb pdb:1CRV|rcsb pdb:1GNH|rcsb pdb:1LJ7|rcsb pdb:3L2Y|rcsb pdb:3PVN|rcsb pdb:3PVO|reactome:R-HSA-173623 psi-mi:"MI:0469"(intact) - - figure legend:4 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-mm1_144)|taxid:9606(Homo sapiens myeloma cell line MM1-144) - 2007/09/13 2014/10/16 rogid:Zkg59SJLVS7Nuhzbqw526n6Jk/g9606 rogid:R7vKMSGKD4ETbUKVGL9IiL8jzjE9606 intact-crc:FE32A668C35A86AA|rigid:fOq0zE6Dk1cP3Fqfff5eapsQ7PE false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)