#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O14672	uniprotkb:P10275	intact:EBI-1536151|uniprotkb:Q10742|uniprotkb:Q92650|uniprotkb:B4DU28|ensembl:ENSP00000260408	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	psi-mi:ada10_human(display_long)|uniprotkb:ADAM10(gene name)|psi-mi:ADAM10(display_short)|uniprotkb:KUZ(gene name synonym)|uniprotkb:MADM(gene name synonym)|uniprotkb:Mammalian disintegrin-metalloprotease(gene name synonym)|uniprotkb:Kuzbanian protein homolog(gene name synonym)|uniprotkb:CDw156(gene name synonym)	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Arima et al. (2007)	pubmed:17727679|imex:IM-19335	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1536180|imex:IM-19335-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001101.1|dip:DIP-39889N|ensembl:ENSG00000137845(gene)|ensembl:ENST00000260408(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0034205"(amyloid-beta formation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042117"(monocyte activation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042987"(amyloid precursor protein catabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0051089"(constitutive protein ectodomain proteolysis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090102"(cochlea development)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097197"(tetraspanin-enriched microdomain)|go:"GO:0097327"(response to antineoplastic agent)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099173"(postsynapse organization)|go:"GO:1901342"(regulation of vasculature development)|go:"GO:1901998"(toxin transport)|go:"GO:1902945"(metalloendopeptidase activity involved in amyloid precursor protein catabolic process)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR001762(Blood coagulation inhibitor, Disintegrin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR024079|interpro:IPR027053|interpro:IPR034025|interpro:IPR036436|mint:O14672|rcsb pdb:1M1I|rcsb pdb:6BDZ|rcsb pdb:6BE6|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-177929|reactome:R-HSA-2122948|reactome:R-HSA-2644606|reactome:R-HSA-2660826|reactome:R-HSA-2691232|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9013507|reactome:R-HSA-9013700|reactome:R-HSA-977225	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N	omim:176807(primary-reference)|go:"GO:0005634"(nucleus)	-	-	figure legend:3|comment:This interaction was detected in the nuclear fraction but not the cell membrane or cytoplasmic fraction.|agonist:"DHT (dihydrotestoterone) - coimmunoprecipitated AR protein in the nuclear fractions tended to increase with the DHT dose."|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lncap)|taxid:9606(Human caucasian prostate carcinoma)	-	2007/09/23	2016/03/30	rogid:oaWIe6XWClYEFZKUARbeLsWRsu49606	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	intact-crc:FADE5BC524F4DAE1|rigid:EFr6bNXaPYGgbn3JWQA9+Y8rDXA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)