#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7577677|mint:MINT-5207540|imex:IM-11414-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207541(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207542(identity)	-	-	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:9911B3C6EDE86731|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:434-527(MINT-5207548)	binding-associated region:1015-1020(MINT-5207553)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7577779|mint:MINT-5207558|imex:IM-11414-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207559(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207565(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:C7F09AFD10C5062B|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	mutation disrupting interaction:450-450(MINT-5207576)|binding-associated region:434-527(MINT-5207560)	binding-associated region:1007-1023(MINT-5207566)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96J92	uniprotkb:O95747	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7577837|mint:MINT-5207580|imex:IM-11414-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207590(identity)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207581(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	intact-crc:D35C5AC331FD7F82|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:1007-1023(MINT-5207592)	binding-associated region:434-527(MINT-5207586)|mutation disrupting interaction:459-459(MINT-5207582)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96J92	uniprotkb:O95747	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7577930|mint:MINT-5207597|imex:IM-11414-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207607(identity)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207598(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	intact-crc:E957AB6CF5CB90FC|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:1007-1023(MINT-5207608)	mutation disrupting interaction:467-467(MINT-5207603)|binding-associated region:434-527(MINT-5207599)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578059|mint:MINT-5207614|imex:IM-11414-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207615(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207624(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:6F8C4380F9FBD6AA|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:434-527(MINT-5207620)|mutation disrupting interaction:468-468(MINT-5207616)	binding-associated region:1007-1023(MINT-5207626)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578188|mint:MINT-5207648|imex:IM-11414-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207649(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207658(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:E3833695AAEC06B2|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:434-527(MINT-5207654)|mutation decreasing interaction:446-446(MINT-5207650)	binding-associated region:1007-1023(MINT-5207660)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96J92	uniprotkb:O95747	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578143|mint:MINT-5207631|imex:IM-11414-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207641(identity)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207632(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	intact-crc:643CA362848AF154|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:1007-1023(MINT-5207642)	binding-associated region:434-527(MINT-5207633)|mutation disrupting interaction:473-473(MINT-5207637)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96J92	uniprotkb:O95747	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578341|mint:MINT-5207682|imex:IM-11414-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207692(identity)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207683(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	intact-crc:6558DE79A6DC40E4|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:1007-1023(MINT-5207694)	binding-associated region:434-527(MINT-5207685)|mutation decreasing interaction:449-449(MINT-5207688)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578271|mint:MINT-5207665|imex:IM-11414-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207666(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207675(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:B383AAA70D26E627|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:434-527(MINT-5207670)|mutation decreasing interaction:448-448(MINT-5207667)	binding-associated region:1007-1023(MINT-5207676)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578411|mint:MINT-5207699|imex:IM-11414-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207700(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207709(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:A585A3F827A28C5E|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	mutation decreasing interaction:451-451(MINT-5207701)|binding-associated region:434-527(MINT-5207704)	binding-associated region:1007-1023(MINT-5207710)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q96J92	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-766352|uniprotkb:Q8N8X3|uniprotkb:Q8N8Z2|uniprotkb:Q96DT8|uniprotkb:Q9BYS5|uniprotkb:B0LPI0|intact:EBI-28967389|ensembl:ENSP00000246914	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk4_human(display_long)|uniprotkb:Protein kinase with no lysine 4(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 4(gene name synonym)|uniprotkb:WNK4(gene name)|psi-mi:WNK4(display_short)|uniprotkb:PRKWNK4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578508|mint:MINT-5207716|imex:IM-11414-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207717(identity)	refseq:NP_115763.2|ensembl:ENSP00000246914|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0070294"(renal sodium ion absorption)|go:"GO:0072156"(distal tubule morphogenesis)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0019869"(chloride channel inhibitor activity)|ensembl:ENSG00000126562(gene)|ensembl:ENST00000246914(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0006821"(chloride transport)|go:"GO:0008104"(protein localization)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0016020"(membrane)|interpro:IPR024678|mint:Q96J92|rcsb pdb:2V3S|rcsb pdb:4CH9|rcsb pdb:4CHB|reactome:R-HSA-2672351|mint:MINT-5207726(identity)	-	-	-	figure legend:F4A|figure legend:F4D|comment:The binding has lower affinity when WNK4 threonin 1020 is phosphorylated|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:RiSrW6NfbbSbmUZixfxAvv+QnEU9606	intact-crc:798815119AF57913|rigid:hscJF9E0Ln2sinja8Gg37d3DSOM	false	binding-associated region:434-527(MINT-5207719)|mutation decreasing interaction:471-471(MINT-5207722)	binding-associated region:1007-1023(MINT-5207728)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95747	uniprotkb:Q9H4A3	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-457907|uniprotkb:O15052|uniprotkb:P54963|uniprotkb:Q86WL5|uniprotkb:Q8N673|uniprotkb:Q9P1S9|uniprotkb:Q4VBX9|intact:EBI-948424|uniprotkb:A1L4B0|uniprotkb:Q6IFS5|uniprotkb:C5HTZ5|uniprotkb:C5HTZ6|uniprotkb:C5HTZ7|uniprotkb:H6WZW3|uniprotkb:Q96CZ6|ensembl:ENSP00000313059	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk1_human(display_long)|uniprotkb:WNK1(gene name)|psi-mi:WNK1(display_short)|uniprotkb:KDP(gene name synonym)|uniprotkb:KIAA0344(gene name synonym)|uniprotkb:PRKWNK1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Erythrocyte 65 kDa protein(gene name synonym)|uniprotkb:Kinase deficient protein(gene name synonym)|uniprotkb:HSN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578637|mint:MINT-5207758|imex:IM-11414-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207759(identity)	ensembl:ENSP00000313059|ensembl:ENST00000340908|ensembl:ENSP00000341292|ensembl:ENST00000530271|ensembl:ENSP00000433548|ensembl:ENST00000537687|ensembl:ENSP00000444465|ensembl:ENST00000675631|ensembl:ENSP00000502415|refseq:NP_001171914.1|refseq:NP_055638.2|refseq:NP_061852.3|refseq:NP_998820.3|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q9H4A3|rcsb pdb:4PWN|rcsb pdb:5TF9|rcsb pdb:5WDY|rcsb pdb:5WE8|rcsb pdb:6FBK|reactome:R-HSA-2672351|go:"GO:0097022"(lymphocyte migration into lymph node)|ensembl:ENSG00000060237(gene)|ensembl:ENST00000315939(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|refseq:XP_016875326.1|refseq:XP_016875327.1|dip:DIP-32648N|mint:MINT-5207767(identity)	-	-	-	figure legend:F4B|figure legend:F4F|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:Jt4cvhSumyRRIZDmWgj4GsG7wjQ9606	intact-crc:4AF557913EC30A23|rigid:Wu7POKviQbOQIYBdlXlTF+qka6Q	false	mutation disrupting interaction:473-473(MINT-5207762)|glutathione s tranferase tag:?-?(MINT-5207760)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95747	uniprotkb:Q9H4A3	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-457907|uniprotkb:O15052|uniprotkb:P54963|uniprotkb:Q86WL5|uniprotkb:Q8N673|uniprotkb:Q9P1S9|uniprotkb:Q4VBX9|intact:EBI-948424|uniprotkb:A1L4B0|uniprotkb:Q6IFS5|uniprotkb:C5HTZ5|uniprotkb:C5HTZ6|uniprotkb:C5HTZ7|uniprotkb:H6WZW3|uniprotkb:Q96CZ6|ensembl:ENSP00000313059	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:wnk1_human(display_long)|uniprotkb:WNK1(gene name)|psi-mi:WNK1(display_short)|uniprotkb:KDP(gene name synonym)|uniprotkb:KIAA0344(gene name synonym)|uniprotkb:PRKWNK1(gene name synonym)|uniprotkb:Protein kinase with no lysine 1(gene name synonym)|uniprotkb:Protein kinase lysine-deficient 1(gene name synonym)|uniprotkb:Erythrocyte 65 kDa protein(gene name synonym)|uniprotkb:Kinase deficient protein(gene name synonym)|uniprotkb:HSN2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578592|mint:MINT-5207733|imex:IM-11414-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207734(identity)	ensembl:ENSP00000313059|ensembl:ENST00000340908|ensembl:ENSP00000341292|ensembl:ENST00000530271|ensembl:ENSP00000433548|ensembl:ENST00000537687|ensembl:ENSP00000444465|ensembl:ENST00000675631|ensembl:ENSP00000502415|refseq:NP_001171914.1|refseq:NP_055638.2|refseq:NP_061852.3|refseq:NP_998820.3|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903288"(positive regulation of potassium ion import across plasma membrane)|go:"GO:1904062"(regulation of cation transmembrane transport)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000651"(positive regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR024678|mint:Q9H4A3|rcsb pdb:4PWN|rcsb pdb:5TF9|rcsb pdb:5WDY|rcsb pdb:5WE8|rcsb pdb:6FBK|reactome:R-HSA-2672351|go:"GO:0097022"(lymphocyte migration into lymph node)|ensembl:ENSG00000060237(gene)|ensembl:ENST00000315939(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006811"(ion transport)|go:"GO:0007165"(signal transduction)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030291"(protein serine/threonine kinase inhibitor activity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0033633"(negative regulation of cell-cell adhesion mediated by integrin)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048666"(neuron development)|go:"GO:0050794"(regulation of cellular process)|go:"GO:0050801"(ion homeostasis)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090188"(negative regulation of pancreatic juice secretion)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|refseq:XP_016875326.1|refseq:XP_016875327.1|dip:DIP-32648N|mint:MINT-5207743(identity)	-	-	-	figure legend:F4B|figure legend:F4F|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:Jt4cvhSumyRRIZDmWgj4GsG7wjQ9606	intact-crc:0BBDB7397C9EC6EE|rigid:Wu7POKviQbOQIYBdlXlTF+qka6Q	false	glutathione s tranferase tag:?-?(MINT-5207752)|mutation disrupting interaction:459-459(MINT-5207739)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O95747	uniprotkb:P55011	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	intact:EBI-2801449|uniprotkb:Q8WWH7|uniprotkb:Q8N713|intact:EBI-28983018|ensembl:ENSP00000262461	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:s12a2_human(display_long)|uniprotkb:NKCC1(gene name synonym)|uniprotkb:Basolateral Na-K-Cl symporter(gene name synonym)|uniprotkb:SLC12A2(gene name)|psi-mi:SLC12A2(display_short)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym)	psi-mi:"MI:0096"(pull down)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578750|mint:MINT-5207788|imex:IM-11414-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207789(identity)	ensembl:ENSP00000262461|ensembl:ENST00000343225|ensembl:ENSP00000340878|refseq:NP_001037.1|ensembl:ENSG00000064651(gene)|ensembl:ENST00000262461(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031253"(cell projection membrane)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0044298"(cell body membrane)|go:"GO:0045795"(positive regulation of cell volume)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070634"(transepithelial ammonium transport)|go:"GO:0071944"(cell periphery)|go:"GO:0098658"(inorganic anion import across plasma membrane)|go:"GO:0098659"(inorganic cation import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904450"(positive regulation of aspartate secretion)|go:"GO:1904464"(regulation of matrix metallopeptidase secretion)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0042995"(cell projection)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P55011|rcsb pdb:6PZT|rcsb pdb:7D10|reactome:R-HSA-426117|interpro:IPR002443(Na-K-Cl co-transporter)|dip:DIP-43979N|mint:MINT-5207797(identity)	-	-	-	figure legend:F4B|figure legend:F4F|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	rogid:DJ/f5e8b/aBlnCcWYxYUa/mcoFY9606	intact-crc:E32E25DA96C3ED45|rigid:SytymyqDKxAS6jPQvSzJuFGYGyI	false	glutathione s tranferase tag:?-?(MINT-5207790)|mutation disrupting interaction:459-459(MINT-5207792)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P55011	uniprotkb:O95747	intact:EBI-2801449|uniprotkb:Q8WWH7|uniprotkb:Q8N713|intact:EBI-28983018|ensembl:ENSP00000262461	intact:EBI-620853|intact:EBI-28983016|ensembl:ENSP00000311713|uniprotkb:Q3LR53|uniprotkb:Q7Z501|uniprotkb:Q9UPQ1|intact:EBI-21354189	psi-mi:s12a2_human(display_long)|uniprotkb:NKCC1(gene name synonym)|uniprotkb:Basolateral Na-K-Cl symporter(gene name synonym)|uniprotkb:SLC12A2(gene name)|psi-mi:SLC12A2(display_short)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym)	psi-mi:oxsr1_human(display_long)|uniprotkb:Oxidative stress-responsive 1 protein(gene name synonym)|uniprotkb:OXSR1(gene name)|psi-mi:OXSR1(display_short)|uniprotkb:OSR1(gene name synonym)|uniprotkb:KIAA1101(gene name synonym)	psi-mi:"MI:0096"(pull down)	Villa et al. (2007)	pubmed:17721439|imex:IM-11414|mint:MINT-5220132	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7578682|mint:MINT-5207773|imex:IM-11414-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000262461|ensembl:ENST00000343225|ensembl:ENSP00000340878|refseq:NP_001037.1|ensembl:ENSG00000064651(gene)|ensembl:ENST00000262461(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006811"(ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007214"(gamma-aminobutyric acid signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0008519"(ammonium transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0015079"(potassium ion transmembrane transporter activity)|go:"GO:0015377"("cation:chloride symporter activity")|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0015696"|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0030321"(transepithelial chloride transport)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031253"(cell projection membrane)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044297"(cell body)|go:"GO:0044298"(cell body membrane)|go:"GO:0045795"(positive regulation of cell volume)|go:"GO:0046873"(metal ion transmembrane transporter activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070634"(transepithelial ammonium transport)|go:"GO:0071944"(cell periphery)|go:"GO:0098658"(inorganic anion import across plasma membrane)|go:"GO:0098659"(inorganic cation import across plasma membrane)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1903561"(extracellular vesicle)|go:"GO:1904450"(positive regulation of aspartate secretion)|go:"GO:1904464"(regulation of matrix metallopeptidase secretion)|go:"GO:1990573"(potassium ion import across plasma membrane)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:0042995"(cell projection)|interpro:IPR002444(Na-K-Cl co-transporter 1)|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR018491|mint:P55011|rcsb pdb:6PZT|rcsb pdb:7D10|reactome:R-HSA-426117|interpro:IPR002443(Na-K-Cl co-transporter)|dip:DIP-43979N|mint:MINT-5207782(identity)	ensembl:ENSG00000172939(gene)|ensembl:ENST00000311806(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0010820"(positive regulation of T cell chemotaxis)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038116"("chemokine (C-C motif) ligand 21 signaling pathway")|go:"GO:0038146"("chemokine (C-X-C motif) ligand 12 signaling pathway")|go:"GO:0042802"(identical protein binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1990869"(cellular response to chemokine)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024678|interpro:IPR028749|mint:O95747|rcsb pdb:2V3S|rcsb pdb:2VWI|rcsb pdb:3DAK|ensembl:ENSP00000311713|refseq:NP_005100.1|dip:DIP-34977N|mint:MINT-5207774(identity)	-	-	-	figure legend:F4B|figure legend:F4F|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/10/15	2014/10/16	rogid:DJ/f5e8b/aBlnCcWYxYUa/mcoFY9606	rogid:B/vq09Ygsvo5paZdMXlX9tyo7aE9606	intact-crc:7C4A985BE057C6AE|rigid:SytymyqDKxAS6jPQvSzJuFGYGyI	false	-	glutathione s tranferase tag:?-?(MINT-5207779)|mutation disrupting interaction:473-473(MINT-5207776)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)