#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9HAU4	uniprotkb:Q9HAU4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1397930|imex:IM-11951-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	wwpdb:2JQZ(primary-reference)	-	-	figure legend:1 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:744C8F2B8109403E|rigid:medk8PyMHaSgxit72qdNgb/e3ic	false	sufficient binding region:10-140	15n label:?-?|sufficient binding region:366-748	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAU4	uniprotkb:Q9HAU4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1397949|imex:IM-11951-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	wwpdb:2JQZ(primary-reference)	-	-	figure legend:1 C, S2 A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:2C8D4D663CD9F41E|rigid:medk8PyMHaSgxit72qdNgb/e3ic	false	sufficient binding region:10-140|15n label:?-?	sufficient binding region:366-748	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAU4	uniprotkb:Q9HAU4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1397961|imex:IM-11951-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	wwpdb:2JQZ(primary-reference)	-	-	figure legend:3 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:D598205966AE5FA3|rigid:medk8PyMHaSgxit72qdNgb/e3ic	false	sufficient binding region:366-748|13c label:?-?	sufficient binding region:10-140	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:46647"	uniprotkb:Q9HAU4	intact:EBI-1398107	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:myo-inositol 1,3,5-trisphosphate(display_short)|psi-mi:"CHEBI:46647"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398280|imex:IM-11951-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	standard inchi:"InChI=1/C6H15O15P3/c7-1-4(19-22(10,11)12)2(8)6(21-24(16,17)18)3(9)5(1)20-23(13,14)15/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2-,3-,4-,5+,6-/f/h10-11,13-14,16-17H"	-	figure legend:S2 C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	standard inchi key:"InChI=1/C6H15O15P3/c7-1-4(19-22(10,11)12)2(8)6(21-24(16,17)18)3(9)5(1)20-23(13,14)15/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18)/t1-,2-,3-,4-,5+,6-/f/h10-11,13-14,16-17H"	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:49361C2A007E76BD	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-140	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16851"	uniprotkb:Q9HAU4	intact:EBI-1257121	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate(display_short)|psi-mi:"CHEBI:16851"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1397990|imex:IM-11951-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:9873FBEBFBEB19BE	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-140	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:18348"	uniprotkb:Q9HAU4	intact:EBI-1257123	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate(display_short)|psi-mi:"CHEBI:18348"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398004|imex:IM-11951-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:539ADCDB08B9312D	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-140	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:18348"	uniprotkb:Q9HAU4	intact:EBI-1257123	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate(display_short)|psi-mi:"CHEBI:18348"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398011|imex:IM-11951-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:253275045F042518	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-140	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16618"	uniprotkb:Q9HAU4	intact:EBI-1257125	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:1-phosphatidyl-1d-myo-inositol 3,4,5-trisphosphate(display_short)|psi-mi:"CHEBI:16618"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398018|imex:IM-11951-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:A376D882280AF1A4	false	-	sufficient binding region:1-140|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:17283"	uniprotkb:Q9HAU4	intact:EBI-1257113	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:pi3p(display_short)|psi-mi:"CHEBI:17283"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398034|imex:IM-11951-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:CDD78007054E9811	false	-	sufficient binding region:1-140|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16500"	uniprotkb:Q9HAU4	intact:EBI-1257117	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:pi5p(display_short)|psi-mi:"CHEBI:16500"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398043|imex:IM-11951-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:ECAAF2623DFACE89	false	-	glutathione s tranferase tag:?-?|sufficient binding region:1-140	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16500"	uniprotkb:Q9HAU4	intact:EBI-1257117	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:pi5p(display_short)|psi-mi:"CHEBI:16500"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398052|imex:IM-11951-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:9A025BBD6A47DABC	false	-	sufficient binding region:1-140|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
chebi:"CHEBI:16337"	uniprotkb:Q9HAU4	intact:EBI-1263288	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:phosphatidic acids(display_short)|psi-mi:"CHEBI:16337"(display_long)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0049"(filter binding)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398072|imex:IM-11951-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	-	-	-	figure legend:S2 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	-	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:70A063B10726E6D4	false	-	sufficient binding region:1-140|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9HAU4	uniprotkb:P0CG47	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1398091|imex:IM-11951-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	psi-mi:"MI:0469"(intact)	-	-	figure legend:3 E, 4 A, B, S6, S7, S8 A|comment:The DeltaC2 -4 aa mutant readily formed thioester-, but not isopeptide-linked Ub adducts.|comment:Together with chemical shift mapping studies, these results suggest that the C2 domain inhibits Smurf2 activity by obstructing accessibility of the catalytic cysteine of the HECT domain, thus blucking Smurf2~Ub thioester formation.|comment:"When lysine-less (K0) ubiquitin, (cannot form polyUb chains), was used, Smurf2 DeltaC2 formed monoubiquitinated species conjugated with up to three K0 moieties, suggesting it contains three major ubiquitination sites."|inhibition:Smurf2 C2 domain - levels of autoubiquitinated DeltaC2 mutant decreased with increasing concentrations of isolated C2 domain.|resulting-ptm:Smurf2 undergoes autoubiquitination.|comment:It is not clear whether the autoubiquitination is intra-, inter-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:A2835FC63831EC64|rigid:MmhhYj34U+xzxSxGvslmjpKpe+g	false	sufficient binding region:141-744|mutation disrupting interaction:716-716	his tag:n-n|glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0CG47	uniprotkb:Q9HAU4	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1532772|imex:IM-11951-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 A, S6|comment:Deletion of the C2 domain enhances Smurf2 auto-ubiquitination in vitro.|comment:It is not proven whether the autoubiquitination is intra-, inter-molecular or both.|resulting-ptm:Smurf2 undergoes autoubiquitination.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:3AFBE91C8FB92175|rigid:MmhhYj34U+xzxSxGvslmjpKpe+g	false	-	sufficient binding region:366-748	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAU4	uniprotkb:Q9HAU4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1532786|imex:IM-11951-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 B|comment:"When lysine-less (K0) ubiquitin, (cannot form polyUb chains), was used, Smurf2 F29/30A formed monoubiquitinated species conjugated with up to three K0 moieties, suggesting it contains three major ubiquitination sites."|inhibition:Smurf2 C2 domain - levels of autoubiquitinated Smurf2 F29/30A mutant decreased with increasing concentrations of isolated C2 domain.|comment:The presence of increasing amounts of the CA mutant had no effect on the activity of F29/30A Smurf2.|comment:The results indicate that the interaction betweem the C2 and HECT domains serves an auto-inhibitory function, interacting in an intramolecular manner.|resulting-ptm:Smurf2 undergoes autoubiquitination.|comment:It is not proven whether autoubiquitination is inter-, intra-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:E93FD467DBA579F3|rigid:MmhhYj34U+xzxSxGvslmjpKpe+g	false	mutation decreasing interaction:88-88,87-87|mutation decreasing interaction:86-86|mutation increasing interaction:29-29,30-30|mutation increasing interaction:56-56,57-57	mutation decreasing interaction:87-87,88-88|mutation decreasing interaction:86-86|mutation increasing interaction:29-29,30-30|mutation increasing interaction:56-56,57-57	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAU4	uniprotkb:P0CG47	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1532786|imex:IM-11951-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 B|comment:"When lysine-less (K0) ubiquitin, (cannot form polyUb chains), was used, Smurf2 F29/30A formed monoubiquitinated species conjugated with up to three K0 moieties, suggesting it contains three major ubiquitination sites."|inhibition:Smurf2 C2 domain - levels of autoubiquitinated Smurf2 F29/30A mutant decreased with increasing concentrations of isolated C2 domain.|comment:The presence of increasing amounts of the CA mutant had no effect on the activity of F29/30A Smurf2.|comment:The results indicate that the interaction betweem the C2 and HECT domains serves an auto-inhibitory function, interacting in an intramolecular manner.|resulting-ptm:Smurf2 undergoes autoubiquitination.|comment:It is not proven whether autoubiquitination is inter-, intra-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:E93FD467DBA579F3|rigid:MmhhYj34U+xzxSxGvslmjpKpe+g	false	mutation decreasing interaction:88-88,87-87|mutation decreasing interaction:86-86|mutation increasing interaction:29-29,30-30|mutation increasing interaction:56-56,57-57	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61586	uniprotkb:Q9HAU4	intact:EBI-446668|uniprotkb:P06749|uniprotkb:Q5U024|uniprotkb:Q9UEJ4|uniprotkb:Q53HM4|uniprotkb:Q9UDJ0|ensembl:ENSP00000400175|ensembl:ENSP00000408402|ensembl:ENSP00000503282|ensembl:ENSP00000504180	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:rhoa_human(display_long)|uniprotkb:Rho cDNA clone 12(gene name synonym)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARH12(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1532826|imex:IM-11951-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001655.1|refseq:NP_001300870.1|dip:DIP-29642N|rcsb pdb:3LWN|rcsb pdb:3LXR|rcsb pdb:3MSX|rcsb pdb:3T06|rcsb pdb:4D0N|rcsb pdb:4XH9|rcsb pdb:4XOI|rcsb pdb:4XSG|rcsb pdb:4XSH|rcsb pdb:5A0F|rcsb pdb:5BWM|rcsb pdb:5C2K|rcsb pdb:5C4M|rcsb pdb:5EZ6|rcsb pdb:5FR1|rcsb pdb:5FR2|rcsb pdb:5HPY|rcsb pdb:5IRC|rcsb pdb:5JCP|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:5ZHX|rcsb pdb:6BC0|rcsb pdb:6BCA|rcsb pdb:6BCB|rcsb pdb:6KX2|rcsb pdb:6KX3|rcsb pdb:6R3V|rcsb pdb:6V6M|rcsb pdb:6V6U|rcsb pdb:6V6V|reactome:R-HSA-114604|reactome:R-HSA-193634|reactome:R-HSA-198203|reactome:R-HSA-209563|reactome:R-HSA-2173791|reactome:R-HSA-392451|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-4086400|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-5689896|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-8985586|reactome:R-HSA-9013106|rcsb pdb:3LW8|ensembl:ENSG00000067560(gene)|ensembl:ENST00000418115(transcript)|ensembl:ENST00000445425(transcript)|ensembl:ENST00000678200(transcript)|ensembl:ENST00000679208(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61586|rcsb pdb:1A2B|rcsb pdb:1CC0|rcsb pdb:1CXZ|rcsb pdb:1DPF|rcsb pdb:1FTN|rcsb pdb:1KMQ|rcsb pdb:1LB1|rcsb pdb:1OW3|rcsb pdb:1S1C|rcsb pdb:1TX4|rcsb pdb:1X86|rcsb pdb:1XCG|rcsb pdb:2RGN|rcsb pdb:3KZ1|go:"GO:0050919"(negative chemotaxis)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 D|comment:Interfering with the Smurf2 C2 domain and HECT domain interface enhances Smurf2 ubiquitination of RhoA.|resulting-ptm:RhoA becomes ubiquitinated.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:3E8F9FD43CFB2E59|rigid:3tNGxQymcqRGSZrqf28trw32EK8	false	-	mutation increasing interaction:29-29,30-30	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61586	uniprotkb:P0CG47	intact:EBI-446668|uniprotkb:P06749|uniprotkb:Q5U024|uniprotkb:Q9UEJ4|uniprotkb:Q53HM4|uniprotkb:Q9UDJ0|ensembl:ENSP00000400175|ensembl:ENSP00000408402|ensembl:ENSP00000503282|ensembl:ENSP00000504180	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:rhoa_human(display_long)|uniprotkb:Rho cDNA clone 12(gene name synonym)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARH12(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1532826|imex:IM-11951-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001655.1|refseq:NP_001300870.1|dip:DIP-29642N|rcsb pdb:3LWN|rcsb pdb:3LXR|rcsb pdb:3MSX|rcsb pdb:3T06|rcsb pdb:4D0N|rcsb pdb:4XH9|rcsb pdb:4XOI|rcsb pdb:4XSG|rcsb pdb:4XSH|rcsb pdb:5A0F|rcsb pdb:5BWM|rcsb pdb:5C2K|rcsb pdb:5C4M|rcsb pdb:5EZ6|rcsb pdb:5FR1|rcsb pdb:5FR2|rcsb pdb:5HPY|rcsb pdb:5IRC|rcsb pdb:5JCP|rcsb pdb:5JHG|rcsb pdb:5JHH|rcsb pdb:5M6X|rcsb pdb:5M70|rcsb pdb:5ZHX|rcsb pdb:6BC0|rcsb pdb:6BCA|rcsb pdb:6BCB|rcsb pdb:6KX2|rcsb pdb:6KX3|rcsb pdb:6R3V|rcsb pdb:6V6M|rcsb pdb:6V6U|rcsb pdb:6V6V|reactome:R-HSA-114604|reactome:R-HSA-193634|reactome:R-HSA-198203|reactome:R-HSA-209563|reactome:R-HSA-2173791|reactome:R-HSA-392451|reactome:R-HSA-3928662|reactome:R-HSA-3928663|reactome:R-HSA-4086400|reactome:R-HSA-416482|reactome:R-HSA-416550|reactome:R-HSA-416572|reactome:R-HSA-4420097|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5625970|reactome:R-HSA-5627117|reactome:R-HSA-5663220|reactome:R-HSA-5666185|reactome:R-HSA-5689896|reactome:R-HSA-6785631|reactome:R-HSA-6798695|reactome:R-HSA-8849471|reactome:R-HSA-8980692|reactome:R-HSA-8985586|reactome:R-HSA-9013106|rcsb pdb:3LW8|ensembl:ENSG00000067560(gene)|ensembl:ENST00000418115(transcript)|ensembl:ENST00000445425(transcript)|ensembl:ENST00000678200(transcript)|ensembl:ENST00000679208(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009749"(response to glucose)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61586|rcsb pdb:1A2B|rcsb pdb:1CC0|rcsb pdb:1CXZ|rcsb pdb:1DPF|rcsb pdb:1FTN|rcsb pdb:1KMQ|rcsb pdb:1LB1|rcsb pdb:1OW3|rcsb pdb:1S1C|rcsb pdb:1TX4|rcsb pdb:1X86|rcsb pdb:1XCG|rcsb pdb:2RGN|rcsb pdb:3KZ1|go:"GO:0050919"(negative chemotaxis)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 D|comment:Interfering with the Smurf2 C2 domain and HECT domain interface enhances Smurf2 ubiquitination of RhoA.|resulting-ptm:RhoA becomes ubiquitinated.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:3E8F9FD43CFB2E59|rigid:3tNGxQymcqRGSZrqf28trw32EK8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0CG47	uniprotkb:P48524	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-3881|uniprotkb:D6W0A2|ensemblfungi:YMR275C	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:bul1_yeast(display_long)|uniprotkb:BUL1(gene name)|psi-mi:BUL1(display_short)|uniprotkb:DAG1(gene name synonym)|uniprotkb:RDS1(gene name synonym)|uniprotkb:YMR275C(locus name)|uniprotkb:YM8021.01C(orf name)|uniprotkb:YM8156.17C(orf name)|uniprotkb:SMM2(gene name synonym)|uniprotkb:Respiration deficiency suppressor 1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564353|imex:IM-11951-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	sgd:S000004888|refseq:NP_014002.1|dip:DIP-2502N|mint:P48524|ensemblfungi:YMR275C(gene)|ensemblfungi:YMR275C_mRNA(transcript)|go:"GO:0000001"(mitochondrion inheritance)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005737"(cytoplasm)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904669"(ATP export)|interpro:IPR007519(Bul1, N-terminal)|interpro:IPR022794|interpro:IPR039634	psi-mi:"MI:0469"(intact)	-	crc64:9253D207B894CE44	figure legend:5|comment:Deletion of the C2 domain of Rsp5p had little effect on its autoubiquitination efficiency.|resulting-ptm:Rsp5p undergoes autoubiquitination.|comment:It is not clear whether the autoubiquitination is intra- or inter-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:RKJqBKVm6Mgxmfj/JCXuW0hV1jc559292	intact-crc:7B8A03F868A9E796|rigid:NW2N0niQlrzxCNOs26KS0mFpxaE	false	-	sufficient binding region:1-19..19,101..101-976	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46934	uniprotkb:P0CG47	intact:EBI-726944|ensembl:ENSP00000424827|uniprotkb:A1KY35|uniprotkb:A6ND72|uniprotkb:A7MD29|uniprotkb:B4E2R7|uniprotkb:B7ZM59|uniprotkb:B7ZM60|uniprotkb:B9EGN5|uniprotkb:D6RF89|intact:EBI-28969445	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:nedd4_human(display_long)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 4(gene name synonym)|uniprotkb:NEDD4(gene name)|psi-mi:NEDD4(display_short)|uniprotkb:KIAA0093(gene name synonym)|uniprotkb:NEDD4-1(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 53 protein(gene name synonym)|uniprotkb:PIG53(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase NEDD4(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564670|imex:IM-11951-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001271267.1|refseq:NP_001271268.1|refseq:NP_001271269.1|ensembl:ENSG00000069869(gene)|ensembl:ENST00000508342(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0010766"(negative regulation of sodium ion transport)|go:"GO:0010768"(negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043197"(dendritic spine)|go:"GO:0044111"(formation of structure involved in a symbiotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046755"(viral budding)|go:"GO:0046824"(positive regulation of nucleocytoplasmic transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0050816"(phosphothreonine residue binding)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051592"(response to calcium ion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:P46934|rcsb pdb:2KPZ|rcsb pdb:2KQ0|go:"GO:0050815"(phosphoserine residue binding)|rcsb pdb:2M3O|rcsb pdb:2XBB|rcsb pdb:2XBF|rcsb pdb:3B7Y|rcsb pdb:4BBN|rcsb pdb:4BE8|rcsb pdb:4N7F|rcsb pdb:4N7H|rcsb pdb:5AHT|rcsb pdb:5C7J|rcsb pdb:5C91|reactome:R-HSA-1169408|reactome:R-HSA-1253288|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-983168|refseq:NP_006145.2|refseq:NP_940682.2|ensembl:ENST00000338963|ensembl:ENSP00000345530|ensembl:ENST00000435532|ensembl:ENSP00000410613|ensembl:ENST00000506154|ensembl:ENSP00000422705|ensembl:ENSP00000424827|refseq:NP_001316141.1|dip:DIP-29815N	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	psi-mi:"MI:0469"(intact)	-	-	figure legend:5|comment:Deletion of the C2 domain of Nedd4-1 significantly enhanced autoubiquitination.|resulting-ptm:Nedd4-1 undergoes autoubiquitination.|comment:It is not clear whether the autoubiquitination is intra- or inter-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:R0IvurHHFLE8EYZK1hRLsSwbs5I9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:CD799807F932D65A|rigid:yJzZvEC2c2KcaLlD+UBxI2XYLNw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0CG47	uniprotkb:Q96J02	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564716|imex:IM-11951-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:5|comment:Deletion of the C2 domain of AIP4 had little effect on its  autoubiquitination.|resulting-ptm:AIP4 undergoes autoubiquitination.|comment:It is not clear whether the autoubiquitination is intra- or inter-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606	intact-crc:A681E3F8232D90BE|rigid:HuBKakrcTr9UzlribgPyZCwfD9w	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00308	uniprotkb:P0CG47	intact:EBI-743923|uniprotkb:H3BRF3|uniprotkb:Q6ZTQ5|uniprotkb:A6NEP1|uniprotkb:Q96CZ2|uniprotkb:Q9BWN6|uniprotkb:B2R706|uniprotkb:B4DTL5|uniprotkb:F5H213|uniprotkb:I3RSG8|ensembl:ENSP00000352069	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:wwp2_human(display_long)|uniprotkb:WW domain-containing protein 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 2(gene name synonym)|uniprotkb:WWP2(gene name)|psi-mi:WWP2(display_short)|uniprotkb:HECT-type E3 ubiquitin transferase WWP2(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1564724|imex:IM-11951-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_008945.2|refseq:NP_001257383.1|refseq:NP_001257384.1|refseq:XP_011521125.1|refseq:XP_011521127.1|refseq:XP_011521128.1|refseq:NP_001257382.1|refseq:NP_955456.1|refseq:XP_016878368.1|refseq:XP_016878369.1|refseq:XP_016878370.1|ensembl:ENSG00000198373(gene)|ensembl:ENST00000359154(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006858"(extracellular transport)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0051224"(negative regulation of protein transport)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:O00308|rcsb pdb:4Y07|rcsb pdb:5TJ7|rcsb pdb:5TJ8|rcsb pdb:5TJQ|rcsb pdb:6J1Z|rcsb pdb:6RSS|reactome:R-HSA-8948751|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013420|reactome:R-HSA-9013507	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	psi-mi:"MI:0469"(intact)	-	-	figure legend:5|comment:Deletion of the C2 domain of WWP2 significantly enhanced autoubiquitination.|resulting-ptm:WWP2 undergoes autoubiquitination.|comment:It is not clear whether the autoubiquitination is intra- or inter-molecular or both.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Xj0Xssn75HP9sp/tHNe4n83eHPE9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:631D9A13DCB12F23|rigid:D+L4lqiodcaVXWC67ofMzvrtFb0	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAU4	uniprotkb:Q9HAU4	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Wiesner et al. (2007)	imex:IM-11951|pubmed:17719543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1532844|imex:IM-11951-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	psi-mi:"MI:0469"(intact)	-	-	figure legend:4 F|inhibition:"Smad7 N-terminal domain (NTD) - Increasing concentrations of Smad7 NTD interfered with HECT domain binding to the C2 domain."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:27B362BA711BCFAC|rigid:medk8PyMHaSgxit72qdNgb/e3ic	false	sufficient binding region:366-748(IPR000569)|his tag:?-?	sufficient binding region:10-140(IPR000008)|glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)