#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q63666 uniprotkb:Q9JI51 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-7573650|intact:MINT-5225883|uniprotkb:Q9JI52 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:vti1a_rat(display_long)|uniprotkb:Vti1a(gene name)|psi-mi:Vti1a(display_short)|uniprotkb:Vti1l2(gene name synonym)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573643|mint:MINT-5225940|imex:IM-10817-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5225947(identity) mint:Q9JI51|interpro:IPR027027|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|refseq:NP_075589.1|interpro:IPR000727(Target SNARE coiled-coil region)|rgd:621490|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|rcsb pdb:2NPS|reactome:R-RNO-6811438|reactome:R-RNO-6811440|interpro:IPR038407|mint:MINT-5225944(identity) go:"GO:0005769"(early endosome) - comment:mint|function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be required for a fusion step during synaptic vesicle Recycling in the nerve terminal figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:MOylCkFQJsOJ8a/WTTU197k386I10116 intact-crc:C57163E8FA975E9B|rigid:JJvkXsFOQv8nnSf2nkqmK+NRTBI false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:Q63635 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-398854|ensembl:ENSRNOP00000037536 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx6_rat(display_long)|uniprotkb:Stx6(gene name)|psi-mi:Stx6(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573643|mint:MINT-5225940|imex:IM-10817-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5225947(identity) rgd:61915|refseq:NP_113853.1|ensembl:ENSRNOG00000003402(gene)|ensembl:ENSRNOT00000035145(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:Q63635|rcsb pdb:1LVF|reactome:R-RNO-6811438|reactome:R-RNO-6811440|mint:MINT-5225942(identity) go:"GO:0005769"(early endosome) - - figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:mxWw+8l//wW59ZQonfoo/lPa3Ts10116 intact-crc:C57163E8FA975E9B|rigid:JJvkXsFOQv8nnSf2nkqmK+NRTBI false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:G3V7P1 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-915654|uniprotkb:O70319|uniprotkb:O88385|ensembl:ENSRNOP00000017227 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx12_rat(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)|uniprotkb:Stx13(gene name synonym)|uniprotkb:Syntaxin-13(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573643|mint:MINT-5225940|imex:IM-10817-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5225947(identity) rgd:620977|refseq:NP_075228.2|ensembl:ENSRNOG00000011804(gene)|ensembl:ENSRNOT00000017227(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:G3V7P1|rcsb pdb:2NPS|mint:MINT-5225943(identity) go:"GO:0005769"(early endosome) - - figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:HrZ1eN7bur9OxIkSP7hIfIugdOs10116 intact-crc:C57163E8FA975E9B|rigid:JJvkXsFOQv8nnSf2nkqmK+NRTBI false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:P60881 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-1027214|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|intact:EBI-11701410 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:snp25_rat(display_long)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573643|mint:MINT-5225940|imex:IM-10817-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5225947(identity) go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|rcsb pdb:1JTH|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5LOB|rcsb pdb:5LOW|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MDO|rcsb pdb:6MDP|go:"GO:0060291"(long-term synaptic potentiation)|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-6798695|reactome:R-RNO-888590|rgd:3728|refseq:NP_112253.1|refseq:NP_001257504.1|refseq:NP_001257505.1|mint:P60881|dip:DIP-29205N|mint:MINT-5225946(identity) go:"GO:0005769"(early endosome) - - figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10116 intact-crc:C57163E8FA975E9B|rigid:JJvkXsFOQv8nnSf2nkqmK+NRTBI false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:P32851 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-539720|ensembl:ENSRNOP00000040699 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx1a_rat(display_long)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Sap(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573643|mint:MINT-5225940|imex:IM-10817-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5225947(identity) rgd:69430|refseq:NP_446240.2|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-5682910|reactome:R-RNO-888590|reactome:R-RNO-9609523|ensembl:ENSRNOG00000029165(gene)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|ensembl:ENSRNOT00000049601(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0000149"(SNARE binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:1BR0|rcsb pdb:1EZ3|rcsb pdb:1HVV|rcsb pdb:1JTH|rcsb pdb:1KIL|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:2BU0|rcsb pdb:2M8R|rcsb pdb:2N1T|rcsb pdb:3C98|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:4JEH|rcsb pdb:4JEU|rcsb pdb:5CCG|rcsb pdb:5CCH|mint:P32851|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|dip:DIP-108N|mint:MINT-5225945(identity) go:"GO:0005769"(early endosome) - - figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:2YT66D4HEHmgdiM1iy3NvlTJpVo10116 intact-crc:C57163E8FA975E9B|rigid:JJvkXsFOQv8nnSf2nkqmK+NRTBI false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0113"(western blot) uniprotkb:P60881 uniprotkb:Q63635 intact:EBI-1027214|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|intact:EBI-11701410 intact:EBI-398854|ensembl:ENSRNOP00000037536 psi-mi:snp25_rat(display_long)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym) psi-mi:stx6_rat(display_long)|uniprotkb:Stx6(gene name)|psi-mi:Stx6(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7573728|mint:MINT-5225999|imex:IM-10817-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|rcsb pdb:1JTH|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5LOB|rcsb pdb:5LOW|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MDO|rcsb pdb:6MDP|go:"GO:0060291"(long-term synaptic potentiation)|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-6798695|reactome:R-RNO-888590|rgd:3728|refseq:NP_112253.1|refseq:NP_001257504.1|refseq:NP_001257505.1|mint:P60881|dip:DIP-29205N|mint:MINT-5226027(identity) rgd:61915|refseq:NP_113853.1|ensembl:ENSRNOG00000003402(gene)|ensembl:ENSRNOT00000035145(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:Q63635|rcsb pdb:1LVF|reactome:R-RNO-6811438|reactome:R-RNO-6811440|mint:MINT-5226007(identity) go:"GO:0005769"(early endosome) - - figure legend:F2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10116 rogid:mxWw+8l//wW59ZQonfoo/lPa3Ts10116 intact-crc:4F71D190D34ED9B0|rigid:+G0o6YtttmYnI6TQZ0yl/TAivwo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:G3V7P1 uniprotkb:P60881 intact:EBI-915654|uniprotkb:O70319|uniprotkb:O88385|ensembl:ENSRNOP00000017227 intact:EBI-1027214|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|intact:EBI-11701410 psi-mi:stx12_rat(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)|uniprotkb:Stx13(gene name synonym)|uniprotkb:Syntaxin-13(gene name synonym) psi-mi:snp25_rat(display_long)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7573698|mint:MINT-5225978|imex:IM-10817-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:620977|refseq:NP_075228.2|ensembl:ENSRNOG00000011804(gene)|ensembl:ENSRNOT00000017227(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:G3V7P1|rcsb pdb:2NPS|mint:MINT-5225987(identity) go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|rcsb pdb:1JTH|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5LOB|rcsb pdb:5LOW|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MDO|rcsb pdb:6MDP|go:"GO:0060291"(long-term synaptic potentiation)|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-6798695|reactome:R-RNO-888590|rgd:3728|refseq:NP_112253.1|refseq:NP_001257504.1|refseq:NP_001257505.1|mint:P60881|dip:DIP-29205N|mint:MINT-5225996(identity) go:"GO:0005769"(early endosome) - - figure legend:F2d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:HrZ1eN7bur9OxIkSP7hIfIugdOs10116 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10116 intact-crc:71CAC92948342025|rigid:cK3FtGy89pzIOnzVAFItH8Agwf4 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P60881 uniprotkb:P32851 intact:EBI-1027214|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|intact:EBI-11701410 intact:EBI-539720|ensembl:ENSRNOP00000040699 psi-mi:snp25_rat(display_long)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym) psi-mi:stx1a_rat(display_long)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Sap(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7573754|mint:MINT-5226108|imex:IM-10817-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|rcsb pdb:1JTH|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5LOB|rcsb pdb:5LOW|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MDO|rcsb pdb:6MDP|go:"GO:0060291"(long-term synaptic potentiation)|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-6798695|reactome:R-RNO-888590|rgd:3728|refseq:NP_112253.1|refseq:NP_001257504.1|refseq:NP_001257505.1|mint:P60881|dip:DIP-29205N|mint:MINT-5226120(identity) rgd:69430|refseq:NP_446240.2|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-5682910|reactome:R-RNO-888590|reactome:R-RNO-9609523|ensembl:ENSRNOG00000029165(gene)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|ensembl:ENSRNOT00000049601(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0000149"(SNARE binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:1BR0|rcsb pdb:1EZ3|rcsb pdb:1HVV|rcsb pdb:1JTH|rcsb pdb:1KIL|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:2BU0|rcsb pdb:2M8R|rcsb pdb:2N1T|rcsb pdb:3C98|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:4JEH|rcsb pdb:4JEU|rcsb pdb:5CCG|rcsb pdb:5CCH|mint:P32851|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|dip:DIP-108N|mint:MINT-5226111(identity) go:"GO:0005769"(early endosome) - - figure legend:F2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10116 rogid:2YT66D4HEHmgdiM1iy3NvlTJpVo10116 intact-crc:601905DDA55E528C|rigid:zDdf9bh9MTGsKJ/KHq7dEKhX1LU false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9JI51 uniprotkb:Q63635 intact:EBI-7573650|intact:MINT-5225883|uniprotkb:Q9JI52 intact:EBI-398854|ensembl:ENSRNOP00000037536 psi-mi:vti1a_rat(display_long)|uniprotkb:Vti1a(gene name)|psi-mi:Vti1a(display_short)|uniprotkb:Vti1l2(gene name synonym)|uniprotkb:Vesicle transport v-SNARE protein Vti1-like 2(gene name synonym)|uniprotkb:Vti1-rp2(gene name synonym) psi-mi:stx6_rat(display_long)|uniprotkb:Stx6(gene name)|psi-mi:Stx6(display_short) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7573741|mint:MINT-5226032|imex:IM-10817-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9JI51|interpro:IPR027027|interpro:IPR007705(Vesicle transport v-SNARE)|interpro:IPR010989(t-SNARE)|refseq:NP_075589.1|interpro:IPR000727(Target SNARE coiled-coil region)|rgd:621490|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0006914"(autophagy)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048280"(vesicle fusion with Golgi apparatus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0090161"(Golgi ribbon formation)|rcsb pdb:2NPS|reactome:R-RNO-6811438|reactome:R-RNO-6811440|interpro:IPR038407|mint:MINT-5226062(identity) rgd:61915|refseq:NP_113853.1|ensembl:ENSRNOG00000003402(gene)|ensembl:ENSRNOT00000035145(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:Q63635|rcsb pdb:1LVF|reactome:R-RNO-6811438|reactome:R-RNO-6811440|mint:MINT-5226044(identity) go:"GO:0005769"(early endosome) comment:mint|function:V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be required for a fusion step during synaptic vesicle Recycling in the nerve terminal - figure legend:F2d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-pc12)|taxid:10116(Rattus norvegicus PC12 cells) - 2007/11/27 2014/10/16 rogid:MOylCkFQJsOJ8a/WTTU197k386I10116 rogid:mxWw+8l//wW59ZQonfoo/lPa3Ts10116 intact-crc:630E01BF15E635CC|rigid:nWinsJIpebd+oIl+Ne+Eqm6rkNY false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:P32851 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-539720|ensembl:ENSRNOP00000040699 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx1a_rat(display_long)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Sap(gene name synonym) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573845|mint:MINT-5226186|imex:IM-10817-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5226189(identity) rgd:69430|refseq:NP_446240.2|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-5682910|reactome:R-RNO-888590|reactome:R-RNO-9609523|ensembl:ENSRNOG00000029165(gene)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|ensembl:ENSRNOT00000049601(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0000149"(SNARE binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:1BR0|rcsb pdb:1EZ3|rcsb pdb:1HVV|rcsb pdb:1JTH|rcsb pdb:1KIL|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:2BU0|rcsb pdb:2M8R|rcsb pdb:2N1T|rcsb pdb:3C98|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:4JEH|rcsb pdb:4JEU|rcsb pdb:5CCG|rcsb pdb:5CCH|mint:P32851|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|dip:DIP-108N|mint:MINT-5226201(identity) - - - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:2YT66D4HEHmgdiM1iy3NvlTJpVo10116 intact-crc:29F41B5DF7C57117|rigid:0gT32o4rpL+ly0u0kFOu+LWDRBk false myc tag:?-?(MINT-5226247) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:G3V7P1 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-915654|uniprotkb:O70319|uniprotkb:O88385|ensembl:ENSRNOP00000017227 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx12_rat(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)|uniprotkb:Stx13(gene name synonym)|uniprotkb:Syntaxin-13(gene name synonym) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573845|mint:MINT-5226186|imex:IM-10817-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5226189(identity) rgd:620977|refseq:NP_075228.2|ensembl:ENSRNOG00000011804(gene)|ensembl:ENSRNOT00000017227(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:G3V7P1|rcsb pdb:2NPS|mint:MINT-5226195(identity) - - - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:HrZ1eN7bur9OxIkSP7hIfIugdOs10116 intact-crc:29F41B5DF7C57117|rigid:0gT32o4rpL+ly0u0kFOu+LWDRBk false myc tag:?-?(MINT-5226247) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:P60881 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-1027214|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|intact:EBI-11701410 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:snp25_rat(display_long)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573845|mint:MINT-5226186|imex:IM-10817-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5226189(identity) go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|rcsb pdb:1JTH|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5LOB|rcsb pdb:5LOW|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MDO|rcsb pdb:6MDP|go:"GO:0060291"(long-term synaptic potentiation)|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-6798695|reactome:R-RNO-888590|rgd:3728|refseq:NP_112253.1|refseq:NP_001257504.1|refseq:NP_001257505.1|mint:P60881|dip:DIP-29205N|mint:MINT-5226204(identity) - - - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10116 intact-crc:29F41B5DF7C57117|rigid:0gT32o4rpL+ly0u0kFOu+LWDRBk false myc tag:?-?(MINT-5226247) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:Q63635 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-398854|ensembl:ENSRNOP00000037536 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx6_rat(display_long)|uniprotkb:Stx6(gene name)|psi-mi:Stx6(display_short) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573845|mint:MINT-5226186|imex:IM-10817-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5226189(identity) rgd:61915|refseq:NP_113853.1|ensembl:ENSRNOG00000003402(gene)|ensembl:ENSRNOT00000035145(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:Q63635|rcsb pdb:1LVF|reactome:R-RNO-6811438|reactome:R-RNO-6811440|mint:MINT-5226192(identity) - - - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:mxWw+8l//wW59ZQonfoo/lPa3Ts10116 intact-crc:29F41B5DF7C57117|rigid:0gT32o4rpL+ly0u0kFOu+LWDRBk false myc tag:?-?(MINT-5226247) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WUF4 uniprotkb:G3V7P1 intact:EBI-7573869|intact:MINT-4570149 intact:EBI-915654|uniprotkb:O70319|uniprotkb:O88385|ensembl:ENSRNOP00000017227 psi-mi:vamp8_rat(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym) psi-mi:stx12_rat(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)|uniprotkb:Stx13(gene name synonym)|uniprotkb:Syntaxin-13(gene name synonym) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573895|mint:MINT-5226214|imex:IM-10817-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9WUF4|rgd:620421|refseq:NP_114015.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|rcsb pdb:1GL2|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-6798695|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031201"(SNARE complex)|dip:DIP-43964N|mint:MINT-5226216(identity) rgd:620977|refseq:NP_075228.2|ensembl:ENSRNOG00000011804(gene)|ensembl:ENSRNOT00000017227(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:G3V7P1|rcsb pdb:2NPS|mint:MINT-5226226(identity) - comment:mint|function:Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:pO8yEcv/WFSQw1+K9p/bBtwDqEo10116 rogid:HrZ1eN7bur9OxIkSP7hIfIugdOs10116 intact-crc:6ADE70839621C705|rigid:lk6mFEWroJLbmKq3YJiUlGJ6R94 false myc tag:?-?(MINT-5226244) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WUF4 uniprotkb:P60881 intact:EBI-7573869|intact:MINT-4570149 intact:EBI-1027214|uniprotkb:P13795|uniprotkb:P36974|uniprotkb:P70557|uniprotkb:P70558|uniprotkb:Q8IXK3|uniprotkb:Q96FM2|uniprotkb:Q9BR45|intact:EBI-11701410 psi-mi:vamp8_rat(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym) psi-mi:snp25_rat(display_long)|uniprotkb:Snap25(gene name)|psi-mi:Snap25(display_short)|uniprotkb:Snap(gene name synonym)|uniprotkb:Synaptosomal-associated 25 kDa protein(gene name synonym)|uniprotkb:Super protein(gene name synonym) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573895|mint:MINT-5226214|imex:IM-10817-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9WUF4|rgd:620421|refseq:NP_114015.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|rcsb pdb:1GL2|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-6798695|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031201"(SNARE complex)|dip:DIP-43964N|mint:MINT-5226216(identity) go:"GO:0000149"(SNARE binding)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007616"(long-term memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0008306"(associative learning)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0016197"(endosomal transport)|go:"GO:0017022"(myosin binding)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030252"(growth hormone secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030431"(sleep)|go:"GO:0031201"(SNARE complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0048791"(calcium ion-regulated exocytosis of neurotransmitter)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099026"(anchored component of presynaptic membrane)|go:"GO:0099590"(neurotransmitter receptor internalization)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR000928(SNAP-25)|interpro:IPR039077|rcsb pdb:1JTH|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:5CCG|rcsb pdb:5CCH|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|rcsb pdb:5LOB|rcsb pdb:5LOW|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MDO|rcsb pdb:6MDP|go:"GO:0060291"(long-term synaptic potentiation)|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-6798695|reactome:R-RNO-888590|rgd:3728|refseq:NP_112253.1|refseq:NP_001257504.1|refseq:NP_001257505.1|mint:P60881|dip:DIP-29205N|mint:MINT-5226236(identity) - comment:mint|function:Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:pO8yEcv/WFSQw1+K9p/bBtwDqEo10116 rogid:/Z7IJEKvHKJbZS4f4oDDyluztHs10116 intact-crc:6ADE70839621C705|rigid:lk6mFEWroJLbmKq3YJiUlGJ6R94 false myc tag:?-?(MINT-5226244) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WUF4 uniprotkb:P32851 intact:EBI-7573869|intact:MINT-4570149 intact:EBI-539720|ensembl:ENSRNOP00000040699 psi-mi:vamp8_rat(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym) psi-mi:stx1a_rat(display_long)|uniprotkb:Synaptotagmin-associated 35 kDa protein(gene name synonym)|uniprotkb:Neuron-specific antigen HPC-1(gene name synonym)|uniprotkb:Stx1a(gene name)|psi-mi:Stx1a(display_short)|uniprotkb:Sap(gene name synonym) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573895|mint:MINT-5226214|imex:IM-10817-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9WUF4|rgd:620421|refseq:NP_114015.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|rcsb pdb:1GL2|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-6798695|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031201"(SNARE complex)|dip:DIP-43964N|mint:MINT-5226216(identity) rgd:69430|refseq:NP_446240.2|rcsb pdb:5W5C|rcsb pdb:5W5D|rcsb pdb:6IP1|rcsb pdb:6MDM|rcsb pdb:6MDN|rcsb pdb:6MTI|rcsb pdb:6WVW|reactome:R-RNO-181429|reactome:R-RNO-181430|reactome:R-RNO-210500|reactome:R-RNO-212676|reactome:R-RNO-264642|reactome:R-RNO-449836|reactome:R-RNO-5682910|reactome:R-RNO-888590|reactome:R-RNO-9609523|ensembl:ENSRNOG00000029165(gene)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|ensembl:ENSRNOT00000049601(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006836"(neurotransmitter transport)|go:"GO:0000149"(SNARE binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009629"(response to gravity)|go:"GO:0010701"(positive regulation of norepinephrine secretion)|go:"GO:0010807"(regulation of synaptic vesicle priming)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016925"(protein sumoylation)|go:"GO:0017022"(myosin binding)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030141"(secretory granule)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031201"(SNARE complex)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032028"(myosin head/neck binding)|go:"GO:0032940"(secretion by cell)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033605"(positive regulation of catecholamine secretion)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0042641"(actomyosin)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0046879"(hormone secretion)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048278"(vesicle docking)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0070032"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex)|go:"GO:0070033"(synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex)|go:"GO:0070044"(synaptobrevin 2-SNAP-25-syntaxin-1a complex)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR028669|go:"GO:0044325"(transmembrane transporter binding)|rcsb pdb:1BR0|rcsb pdb:1EZ3|rcsb pdb:1HVV|rcsb pdb:1JTH|rcsb pdb:1KIL|rcsb pdb:1N7S|rcsb pdb:1SFC|rcsb pdb:1URQ|rcsb pdb:2BU0|rcsb pdb:2M8R|rcsb pdb:2N1T|rcsb pdb:3C98|rcsb pdb:3HD7|rcsb pdb:3IPD|rcsb pdb:3J96|rcsb pdb:3J97|rcsb pdb:3J98|rcsb pdb:3J99|rcsb pdb:3RK2|rcsb pdb:3RK3|rcsb pdb:3RL0|rcsb pdb:4JEH|rcsb pdb:4JEU|rcsb pdb:5CCG|rcsb pdb:5CCH|mint:P32851|rcsb pdb:5CCI|rcsb pdb:5KJ7|rcsb pdb:5KJ8|dip:DIP-108N|mint:MINT-5226231(identity) - comment:mint|function:Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:pO8yEcv/WFSQw1+K9p/bBtwDqEo10116 rogid:2YT66D4HEHmgdiM1iy3NvlTJpVo10116 intact-crc:6ADE70839621C705|rigid:lk6mFEWroJLbmKq3YJiUlGJ6R94 false myc tag:?-?(MINT-5226244) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q9WUF4 uniprotkb:Q63635 intact:EBI-7573869|intact:MINT-4570149 intact:EBI-398854|ensembl:ENSRNOP00000037536 psi-mi:vamp8_rat(display_long)|uniprotkb:Vamp8(gene name)|psi-mi:Vamp8(display_short)|uniprotkb:Endobrevin(gene name synonym) psi-mi:stx6_rat(display_long)|uniprotkb:Stx6(gene name)|psi-mi:Stx6(display_short) psi-mi:"MI:0096"(pull down) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7573895|mint:MINT-5226214|imex:IM-10817-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9WUF4|rgd:620421|refseq:NP_114015.1|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0009986"(cell surface)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019869"(chloride channel inhibitor activity)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030141"(secretory granule)|go:"GO:0030496"(midbody)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042588"(zymogen granule)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051607"(defense response to virus)|go:"GO:0055037"(recycling endosome)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070254"(mucus secretion)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098594"(mucin granule)|go:"GO:1902278"(positive regulation of pancreatic amylase secretion)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903531"(negative regulation of secretion by cell)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|rcsb pdb:1GL2|reactome:R-RNO-432720|reactome:R-RNO-432722|reactome:R-RNO-6798695|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0031201"(SNARE complex)|dip:DIP-43964N|mint:MINT-5226216(identity) rgd:61915|refseq:NP_113853.1|ensembl:ENSRNOG00000003402(gene)|ensembl:ENSRNOT00000035145(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007032"(endosome organization)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043195"(terminal bouton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0048278"(vesicle docking)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1903827"|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|interpro:IPR015260(Syntaxin 6, N-terminal)|mint:Q63635|rcsb pdb:1LVF|reactome:R-RNO-6811438|reactome:R-RNO-6811440|mint:MINT-5226221(identity) - comment:mint|function:Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells - figure legend:F6A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/27 2014/10/16 rogid:pO8yEcv/WFSQw1+K9p/bBtwDqEo10116 rogid:mxWw+8l//wW59ZQonfoo/lPa3Ts10116 intact-crc:6ADE70839621C705|rigid:lk6mFEWroJLbmKq3YJiUlGJ6R94 false myc tag:?-?(MINT-5226244) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0113"(western blot) uniprotkb:Q63666 uniprotkb:G3V7P1 intact:EBI-2029956|uniprotkb:A6YSN3|uniprotkb:O09025|uniprotkb:Q56A22|uniprotkb:Q8CH14|ensembl:ENSRNOP00000025081 intact:EBI-915654|uniprotkb:O70319|uniprotkb:O88385|ensembl:ENSRNOP00000017227 psi-mi:vamp1_rat(display_long)|uniprotkb:Vamp1(gene name)|psi-mi:Vamp1(display_short)|uniprotkb:Syb1(gene name synonym)|uniprotkb:Synaptobrevin-1(gene name synonym) psi-mi:stx12_rat(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)|uniprotkb:Stx13(gene name synonym)|uniprotkb:Syntaxin-13(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Bethani et al. (2007) pubmed:17717530|imex:IM-10817|mint:MINT-5225865 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7573930|mint:MINT-5226131|imex:IM-10817-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:3948|refseq:NP_037222.2|ensembl:ENSRNOG00000019219(gene)|ensembl:ENSRNOT00000025081(transcript)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043195"(terminal bouton)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0098793"(presynapse)|interpro:IPR001388(Synaptobrevin)|interpro:IPR016444(Synaptobrevin, metazoa/fungi)|interpro:IPR042855|mint:Q63666|mint:MINT-5226134(identity) rgd:620977|refseq:NP_075228.2|ensembl:ENSRNOG00000011804(gene)|ensembl:ENSRNOT00000017227(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:G3V7P1|rcsb pdb:2NPS|mint:MINT-5226140(identity) - - - figure legend:F3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") - 2007/11/27 2014/10/16 rogid:XGwIWepyYnUkrB97k7IAoIbbipY10116 rogid:HrZ1eN7bur9OxIkSP7hIfIugdOs10116 intact-crc:F1E639AFE829D3B8|rigid:FpI8zTGYh9t7clZrR5MlWP5qsJY false - - - - psi-mi:"MI:0708"(monoclonal antibody immunostaining) psi-mi:"MI:0113"(western blot)