#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P21583	uniprotkb:P10721	intact:EBI-1379527|uniprotkb:A8K2Q4|uniprotkb:Q68DZ2|uniprotkb:Q7M4N8|uniprotkb:B7ZLM4|uniprotkb:A0AV09|uniprotkb:Q16487|uniprotkb:Q9UQK7|ensembl:ENSP00000495951	intact:EBI-1379503|uniprotkb:Q6IQ28|uniprotkb:B5A956|uniprotkb:D5LXN2|uniprotkb:D5M931|uniprotkb:F5H8F8|uniprotkb:Q9UM99|uniprotkb:Q99662|ensembl:ENSP00000288135	psi-mi:scf_human(display_long)|uniprotkb:c-Kit ligand(gene name synonym)|uniprotkb:Stem cell factor(gene name synonym)|uniprotkb:Mast cell growth factor(gene name synonym)|uniprotkb:KITLG(gene name)|psi-mi:KITLG(display_short)|uniprotkb:MGF(gene name synonym)|uniprotkb:SCF(gene name synonym)	psi-mi:kit_human(display_long)|uniprotkb:Tyrosine-protein kinase Kit(gene name synonym)|uniprotkb:KIT(gene name)|psi-mi:KIT(display_short)|uniprotkb:Proto-oncogene c-Kit(gene name synonym)|uniprotkb:SCFR(gene name synonym)|uniprotkb:Piebald trait protein(gene name synonym)|uniprotkb:p145 c-kit(gene name synonym)|uniprotkb:v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Yuzawa et al. (2007)	imex:IM-12054|pubmed:17662946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379520|wwpdb:2E9W|imex:IM-12054-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000890.1|refseq:NP_003985.2|ensembl:ENSG00000049130(gene)|ensembl:ENST00000644744(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002763"(positive regulation of myeloid leukocyte differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005173"(stem cell factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR003452(Stem cell factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1EXZ|rcsb pdb:1SCF|rcsb pdb:2E9W|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558	refseq:NP_000213.1|refseq:NP_001087241.1|dip:DIP-1055N|ensembl:ENSG00000157404(gene)|ensembl:ENST00000288135(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001650"(fibrillar center)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002020"(protease binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005020"(stem cell factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008542"(visual learning)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0038093"(Fc receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043235"(receptor complex)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0070662"(mast cell proliferation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097324"(melanocyte migration)|go:"GO:0097326"(melanocyte adhesion)|go:"GO:0120072"(positive regulation of pyloric antrum smooth muscle contraction)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904343"(positive regulation of colon smooth muscle contraction)|go:"GO:1904349"(positive regulation of small intestine smooth muscle contraction)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027263|interpro:IPR036179|mint:P10721|rcsb pdb:1PKG|rcsb pdb:1QZJ|rcsb pdb:1QZK|rcsb pdb:1R01|rcsb pdb:1T45|rcsb pdb:1T46|rcsb pdb:2E9W|rcsb pdb:2EC8|rcsb pdb:2IUH|rcsb pdb:2VIF|rcsb pdb:3G0E|rcsb pdb:3G0F|rcsb pdb:4HVS|rcsb pdb:4K94|rcsb pdb:4K9E|rcsb pdb:4PGZ|rcsb pdb:4U0I|rcsb pdb:6GQJ|rcsb pdb:6GQK|rcsb pdb:6GQL|rcsb pdb:6GQM|rcsb pdb:6HH1|rcsb pdb:6ITT|rcsb pdb:6ITV|rcsb pdb:6KLA|rcsb pdb:6MOB|rcsb pdb:6XV9|rcsb pdb:6XVA|rcsb pdb:6XVB|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-9669914|reactome:R-HSA-9669917|reactome:R-HSA-9669921|reactome:R-HSA-9669924|reactome:R-HSA-9669926|reactome:R-HSA-9669929|reactome:R-HSA-9669933|reactome:R-HSA-9669934|reactome:R-HSA-9669935|reactome:R-HSA-9669936|reactome:R-HSA-9670439|reactome:R-HSA-9680187	-	-	-	comment:KIT was partially deglycosylated prior to crystallization|figure legend:3|3d-resolution:3.5A|3d-r-factors:24.9% bound and 29.5% free|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/08/01	2014/10/16	rogid:lVHI+urdBzgi2jew8H1xhCNe7mg9606	rogid:FZGJcek6hOsn4AKqu7bBMmfuGKU9606	intact-crc:2C04BF36126BDEA7|rigid:yXA/0HfP6bY5erNQa0pj2D0aC5k	false	sufficient binding region:1-141	his tag:c-c|sufficient binding region:1-519	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10721	uniprotkb:P21583	intact:EBI-1379503|uniprotkb:Q6IQ28|uniprotkb:B5A956|uniprotkb:D5LXN2|uniprotkb:D5M931|uniprotkb:F5H8F8|uniprotkb:Q9UM99|uniprotkb:Q99662|ensembl:ENSP00000288135	intact:EBI-1379527|uniprotkb:A8K2Q4|uniprotkb:Q68DZ2|uniprotkb:Q7M4N8|uniprotkb:B7ZLM4|uniprotkb:A0AV09|uniprotkb:Q16487|uniprotkb:Q9UQK7|ensembl:ENSP00000495951	psi-mi:kit_human(display_long)|uniprotkb:Tyrosine-protein kinase Kit(gene name synonym)|uniprotkb:KIT(gene name)|psi-mi:KIT(display_short)|uniprotkb:Proto-oncogene c-Kit(gene name synonym)|uniprotkb:SCFR(gene name synonym)|uniprotkb:Piebald trait protein(gene name synonym)|uniprotkb:p145 c-kit(gene name synonym)|uniprotkb:v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog(gene name synonym)	psi-mi:scf_human(display_long)|uniprotkb:c-Kit ligand(gene name synonym)|uniprotkb:Stem cell factor(gene name synonym)|uniprotkb:Mast cell growth factor(gene name synonym)|uniprotkb:KITLG(gene name)|psi-mi:KITLG(display_short)|uniprotkb:MGF(gene name synonym)|uniprotkb:SCF(gene name synonym)	psi-mi:"MI:0405"(competition binding)	Yuzawa et al. (2007)	imex:IM-12054|pubmed:17662946	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1379609|wwpdb:2E9W|imex:IM-12054-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000213.1|refseq:NP_001087241.1|dip:DIP-1055N|ensembl:ENSG00000157404(gene)|ensembl:ENST00000288135(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001650"(fibrillar center)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002020"(protease binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002318"(myeloid progenitor cell differentiation)|go:"GO:0002320"(lymphoid progenitor cell differentiation)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005020"(stem cell factor receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006687"(glycosphingolipid metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008542"(visual learning)|go:"GO:0008584"(male gonad development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019955"(cytokine binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032765"(positive regulation of mast cell cytokine production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035701"(hematopoietic stem cell migration)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0038093"(Fc receptor signaling pathway)|go:"GO:0038109"(Kit signaling pathway)|go:"GO:0038162"(erythropoietin-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043235"(receptor complex)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043473"(pigmentation)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043586"(tongue development)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048565"(digestive tract development)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050673"(epithelial cell proliferation)|go:"GO:0050910"(detection of mechanical stimulus involved in sensory perception of sound)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060374"(mast cell differentiation)|go:"GO:0070662"(mast cell proliferation)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:0097324"(melanocyte migration)|go:"GO:0097326"(melanocyte adhesion)|go:"GO:0120072"(positive regulation of pyloric antrum smooth muscle contraction)|go:"GO:1904251"(regulation of bile acid metabolic process)|go:"GO:1904343"(positive regulation of colon smooth muscle contraction)|go:"GO:1904349"(positive regulation of small intestine smooth muscle contraction)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027263|interpro:IPR036179|mint:P10721|rcsb pdb:1PKG|rcsb pdb:1QZJ|rcsb pdb:1QZK|rcsb pdb:1R01|rcsb pdb:1T45|rcsb pdb:1T46|rcsb pdb:2E9W|rcsb pdb:2EC8|rcsb pdb:2IUH|rcsb pdb:2VIF|rcsb pdb:3G0E|rcsb pdb:3G0F|rcsb pdb:4HVS|rcsb pdb:4K94|rcsb pdb:4K9E|rcsb pdb:4PGZ|rcsb pdb:4U0I|rcsb pdb:6GQJ|rcsb pdb:6GQK|rcsb pdb:6GQL|rcsb pdb:6GQM|rcsb pdb:6HH1|rcsb pdb:6ITT|rcsb pdb:6ITV|rcsb pdb:6KLA|rcsb pdb:6MOB|rcsb pdb:6XV9|rcsb pdb:6XVA|rcsb pdb:6XVB|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-9669914|reactome:R-HSA-9669917|reactome:R-HSA-9669921|reactome:R-HSA-9669924|reactome:R-HSA-9669926|reactome:R-HSA-9669929|reactome:R-HSA-9669933|reactome:R-HSA-9669934|reactome:R-HSA-9669935|reactome:R-HSA-9669936|reactome:R-HSA-9670439|reactome:R-HSA-9680187	refseq:NP_000890.1|refseq:NP_003985.2|ensembl:ENSG00000049130(gene)|ensembl:ENST00000644744(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002763"(positive regulation of myeloid leukocyte differentiation)|go:"GO:0005125"(cytokine activity)|go:"GO:0005173"(stem cell factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0033026"(negative regulation of mast cell apoptotic process)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045636"(positive regulation of melanocyte differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901534"(positive regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR003452(Stem cell factor)|interpro:IPR009079(Four-helical cytokine-like, core)|rcsb pdb:1EXZ|rcsb pdb:1SCF|rcsb pdb:2E9W|reactome:R-HSA-1257604|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-2219530|reactome:R-HSA-5673001|reactome:R-HSA-6811558	-	-	-	kinetics:"The EC50 (ligand concentration that displaces 50% of 125I-SCF bound to c-KIT) of SCF toward wild type KIT = 1.1 nM. Mutations in KIT (R381A, E386A0) which prevent dimerization or kinase activity (K263A) do not alter this value."|figure legend:Fig. 7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/08/01	2014/10/16	rogid:FZGJcek6hOsn4AKqu7bBMmfuGKU9606	rogid:lVHI+urdBzgi2jew8H1xhCNe7mg9606	intact-crc:59312AE985445E13|rigid:yXA/0HfP6bY5erNQa0pj2D0aC5k	false	sufficient binding region:1-524	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)