#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0DQD2 uniprotkb:P08581 intact:EBI-1379295|uniprotkb:Q9EXG1|uniprotkb:P25147|ensemblbacteria:CAC98513 intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860 psi-mi:inlb_lismo(display_long)|uniprotkb:inlB(gene name)|psi-mi:inlB(display_short)|uniprotkb:Invasion protein InlB(gene name synonym)|uniprotkb:lmo0434(locus name) psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Niemann et al. (2007) imex:IM-12053|pubmed:17662939 taxid:169963(lismo)|taxid:169963("Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379290|imex:IM-12053-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CIL|rcsb pdb:4AW4|interpro:IPR042229|rcsb pdb:1H6T|rcsb pdb:2UZX|rcsb pdb:2UZY|rcsb pdb:2WQU|rcsb pdb:2WQV|rcsb pdb:2WQW|rcsb pdb:2WQX|rcsb pdb:2Y5P|rcsb pdb:2Y5Q|rcsb pdb:6DBF|rcsb pdb:6DBG|refseq:NP_463963.1|refseq:WP_010989463.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR012569(Leucine-rich repeat, adjacent)|interpro:IPR013378(Listeria/Bacterioides repeat)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024634|interpro:IPR025875|interpro:IPR025987|interpro:IPR032675|interpro:IPR038200|reactome:R-HSA-8875360|ensemblbacteria:CAC98513(gene)|ensemblbacteria:CAC98513(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|interpro:IPR014755(Copper resistance protein CopC/internalin, immunoglobulin-like) refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N go:"GO:0051701"(biological process involved in interaction with host) - - figure legend:Figure 1E & 1F|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/07/31 2014/10/16 rogid:HDUmWzNu4ALiX1YiQ3vjqvUDStc169963 rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606 intact-crc:54B99AA0372EE477|rigid:Jg6X1fXCripGfU+KPiAvqJXmbJI false sufficient binding region:36-321(IPR001611)|glutathione s tranferase tag:?-? his tag:c-c|necessary binding region:567-741(IPR002909) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DQD2 uniprotkb:P08581 intact:EBI-1379295|uniprotkb:Q9EXG1|uniprotkb:P25147|ensemblbacteria:CAC98513 intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860 psi-mi:inlb_lismo(display_long)|uniprotkb:inlB(gene name)|psi-mi:inlB(display_short)|uniprotkb:Invasion protein InlB(gene name synonym)|uniprotkb:lmo0434(locus name) psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym) psi-mi:"MI:0411"(enzyme linked immunosorbent assay) Niemann et al. (2007) imex:IM-12053|pubmed:17662939 taxid:169963(lismo)|taxid:169963("Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379437|imex:IM-12053-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CIL|rcsb pdb:4AW4|interpro:IPR042229|rcsb pdb:1H6T|rcsb pdb:2UZX|rcsb pdb:2UZY|rcsb pdb:2WQU|rcsb pdb:2WQV|rcsb pdb:2WQW|rcsb pdb:2WQX|rcsb pdb:2Y5P|rcsb pdb:2Y5Q|rcsb pdb:6DBF|rcsb pdb:6DBG|refseq:NP_463963.1|refseq:WP_010989463.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR012569(Leucine-rich repeat, adjacent)|interpro:IPR013378(Listeria/Bacterioides repeat)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024634|interpro:IPR025875|interpro:IPR025987|interpro:IPR032675|interpro:IPR038200|reactome:R-HSA-8875360|ensemblbacteria:CAC98513(gene)|ensemblbacteria:CAC98513(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|interpro:IPR014755(Copper resistance protein CopC/internalin, immunoglobulin-like) refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N go:"GO:0051701"(biological process involved in interaction with host) - - figure legend:Figure 5A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/07/31 2014/10/16 rogid:HDUmWzNu4ALiX1YiQ3vjqvUDStc169963 rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606 intact-crc:E59B4CCCF6D51C40|rigid:Jg6X1fXCripGfU+KPiAvqJXmbJI false sufficient binding region:36-241(IPR001611)|glutathione s tranferase tag:?-? his tag:c-c|necessary binding region:25-928(IPR002909) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P08581 uniprotkb:P0DQD2 intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860 intact:EBI-1379295|uniprotkb:Q9EXG1|uniprotkb:P25147|ensemblbacteria:CAC98513 psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym) psi-mi:inlb_lismo(display_long)|uniprotkb:inlB(gene name)|psi-mi:inlB(display_short)|uniprotkb:Invasion protein InlB(gene name synonym)|uniprotkb:lmo0434(locus name) psi-mi:"MI:0114"(x-ray crystallography) Niemann et al. (2007) imex:IM-12053|pubmed:17662939 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:169963(lismo)|taxid:169963("Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379320|wwpdb:2uzx|wwpdb:2uzy|imex:IM-12053-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N rcsb pdb:4CIL|rcsb pdb:4AW4|interpro:IPR042229|rcsb pdb:1H6T|rcsb pdb:2UZX|rcsb pdb:2UZY|rcsb pdb:2WQU|rcsb pdb:2WQV|rcsb pdb:2WQW|rcsb pdb:2WQX|rcsb pdb:2Y5P|rcsb pdb:2Y5Q|rcsb pdb:6DBF|rcsb pdb:6DBG|refseq:NP_463963.1|refseq:WP_010989463.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR012569(Leucine-rich repeat, adjacent)|interpro:IPR013378(Listeria/Bacterioides repeat)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024634|interpro:IPR025875|interpro:IPR025987|interpro:IPR032675|interpro:IPR038200|reactome:R-HSA-8875360|ensemblbacteria:CAC98513(gene)|ensemblbacteria:CAC98513(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|interpro:IPR014755(Copper resistance protein CopC/internalin, immunoglobulin-like) go:"GO:0051701"(biological process involved in interaction with host) - - figure legend:Figure 2 & Supp. Table 1|3d-resolution:"2.8A (Deglycosylated), 4.0 (glycosylated)"|3d-structure:A contact between the concave face of the InlB LRR region and Met Ig1 forms the primary interface, the secondary, less extensive contact involves the InlB IR region and the Sema domain of Met.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/07/31 2014/10/16 rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606 rogid:HDUmWzNu4ALiX1YiQ3vjqvUDStc169963 intact-crc:F4265D844751BDE6|rigid:Jg6X1fXCripGfU+KPiAvqJXmbJI false his tag:c-c|necessary binding region:25-741(IPR002909)|binding-associated region:600-600|binding-associated region:599-599 sufficient binding region:36-321(IPR001611)|binding-associated region:170-170|binding-associated region:170-170 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0DQD2 uniprotkb:P08581 intact:EBI-1379295|uniprotkb:Q9EXG1|uniprotkb:P25147|ensemblbacteria:CAC98513 intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860 psi-mi:inlb_lismo(display_long)|uniprotkb:inlB(gene name)|psi-mi:inlB(display_short)|uniprotkb:Invasion protein InlB(gene name synonym)|uniprotkb:lmo0434(locus name) psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Niemann et al. (2007) imex:IM-12053|pubmed:17662939 taxid:169963(lismo)|taxid:169963("Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379353|imex:IM-12053-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4CIL|rcsb pdb:4AW4|interpro:IPR042229|rcsb pdb:1H6T|rcsb pdb:2UZX|rcsb pdb:2UZY|rcsb pdb:2WQU|rcsb pdb:2WQV|rcsb pdb:2WQW|rcsb pdb:2WQX|rcsb pdb:2Y5P|rcsb pdb:2Y5Q|rcsb pdb:6DBF|rcsb pdb:6DBG|refseq:NP_463963.1|refseq:WP_010989463.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR012569(Leucine-rich repeat, adjacent)|interpro:IPR013378(Listeria/Bacterioides repeat)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024634|interpro:IPR025875|interpro:IPR025987|interpro:IPR032675|interpro:IPR038200|reactome:R-HSA-8875360|ensemblbacteria:CAC98513(gene)|ensemblbacteria:CAC98513(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|interpro:IPR014755(Copper resistance protein CopC/internalin, immunoglobulin-like) refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N go:"GO:0051701"(biological process involved in interaction with host) - - figure legend:Figure 6|comment:"Equimolar mixtures of InlB321 and Met928 produced a 1:1 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/07/31 2014/10/16 rogid:HDUmWzNu4ALiX1YiQ3vjqvUDStc169963 rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606 intact-crc:594362369FD276A5|rigid:Jg6X1fXCripGfU+KPiAvqJXmbJI false sufficient binding region:36-321(IPR001611)|glutathione s tranferase tag:?-? his tag:c-c|necessary binding region:25-928 1 1 psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28304" uniprotkb:P0DQD2 intact:EBI-1379423 intact:EBI-1379295|uniprotkb:Q9EXG1|uniprotkb:P25147|ensemblbacteria:CAC98513 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:inlb_lismo(display_long)|uniprotkb:inlB(gene name)|psi-mi:inlB(display_short)|uniprotkb:Invasion protein InlB(gene name synonym)|uniprotkb:lmo0434(locus name) psi-mi:"MI:0028"(cosedimentation in solution) Niemann et al. (2007) imex:IM-12053|pubmed:17662939 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:169963(lismo)|taxid:169963("Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379407|imex:IM-12053-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - rcsb pdb:4CIL|rcsb pdb:4AW4|interpro:IPR042229|rcsb pdb:1H6T|rcsb pdb:2UZX|rcsb pdb:2UZY|rcsb pdb:2WQU|rcsb pdb:2WQV|rcsb pdb:2WQW|rcsb pdb:2WQX|rcsb pdb:2Y5P|rcsb pdb:2Y5Q|rcsb pdb:6DBF|rcsb pdb:6DBG|refseq:NP_463963.1|refseq:WP_010989463.1|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR012569(Leucine-rich repeat, adjacent)|interpro:IPR013378(Listeria/Bacterioides repeat)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024634|interpro:IPR025875|interpro:IPR025987|interpro:IPR032675|interpro:IPR038200|reactome:R-HSA-8875360|ensemblbacteria:CAC98513(gene)|ensemblbacteria:CAC98513(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005618"(cell wall)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008201"(heparin binding)|go:"GO:0008289"(lipid binding)|interpro:IPR014755(Copper resistance protein CopC/internalin, immunoglobulin-like) go:"GO:0051701"(biological process involved in interaction with host) - - figure legend:Figure 6|comment:Heparin induced massive clustering of the Met-InlBfl complex, which shifted to large sedimentation coefficients.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/07/31 2014/10/16 - rogid:HDUmWzNu4ALiX1YiQ3vjqvUDStc169963 intact-crc:AF8D6F18190F175A false - sufficient binding region:36-321(IPR001611)|glutathione s tranferase tag:?-? - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) chebi:"CHEBI:28304" uniprotkb:P08581 intact:EBI-1379423 intact:EBI-1039152|uniprotkb:O60366|uniprotkb:Q12875|uniprotkb:Q9UDX7|uniprotkb:Q9UPL8|uniprotkb:A1L467|uniprotkb:B5A932|uniprotkb:E7EQ94|ensembl:ENSP00000380860 psi-mi:heparin(display_short)|psi-mi:"CHEBI:28304"(display_long) psi-mi:met_human(display_long)|uniprotkb:MET(gene name)|psi-mi:MET(display_short)|uniprotkb:Scatter factor receptor(gene name synonym)|uniprotkb:HGF/SF receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase Met(gene name synonym)|uniprotkb:Proto-oncogene c-Met(gene name synonym) psi-mi:"MI:0028"(cosedimentation in solution) Niemann et al. (2007) imex:IM-12053|pubmed:17662939 taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1379407|imex:IM-12053-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0328"(small molecule) psi-mi:"MI:0326"(protein) - refseq:NP_000236.2|refseq:NP_001120972.1|rcsb pdb:2UZY|rcsb pdb:2WD1|rcsb pdb:2WGJ|rcsb pdb:2WKM|rcsb pdb:3A4P|rcsb pdb:3BUX|rcsb pdb:3C1X|rcsb pdb:3CCN|rcsb pdb:3CD8|rcsb pdb:3CE3|rcsb pdb:3CTH|rcsb pdb:3CTJ|rcsb pdb:3DKC|rcsb pdb:3DKF|rcsb pdb:3DKG|rcsb pdb:3EFJ|rcsb pdb:3EFK|rcsb pdb:3F66|rcsb pdb:3F82|rcsb pdb:3U6H|rcsb pdb:3I5N|rcsb pdb:3L8V|rcsb pdb:3LQ8|rcsb pdb:3Q6U|rcsb pdb:3Q6W|rcsb pdb:3QTI|rcsb pdb:3R7O|rcsb pdb:3RHK|go:"GO:0043235"(receptor complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000105976(gene)|ensembl:ENST00000397752(transcript)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001889"(liver development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0005008"(hepatocyte growth factor-activated receptor activity)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0005524"(ATP binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:1901299"(negative regulation of hydrogen peroxide-mediated programmed cell death)|go:"GO:1905098"(negative regulation of guanyl-nucleotide exchange factor activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001627(Semaphorin/CD100 antigen)|interpro:IPR002165(Plexin)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0006909"(phagocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010507"(negative regulation of autophagy)|interpro:IPR011009(Protein kinase-like)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017154"(semaphorin receptor activity)|go:"GO:0019903"(protein phosphatase binding)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0030182"(neuron differentiation)|go:"GO:0031016"(pancreas development)|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0031116"(positive regulation of microtubule polymerization)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|interpro:IPR016201(Plexin-like fold)|interpro:IPR016244(Tyrosine-protein kinase, HGF/MSP receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR031148|interpro:IPR036352|mint:P08581|rcsb pdb:1FYR|rcsb pdb:1R0P|rcsb pdb:1R1W|rcsb pdb:1SHY|rcsb pdb:1SSL|rcsb pdb:1UX3|rcsb pdb:2G15|rcsb pdb:2RFN|rcsb pdb:2RFS|rcsb pdb:2UZX|rcsb pdb:3VW8|rcsb pdb:3ZBX|rcsb pdb:3ZC5|rcsb pdb:3ZCL|rcsb pdb:3U6I|rcsb pdb:3ZXZ|rcsb pdb:3ZZE|rcsb pdb:4AOI|rcsb pdb:4AP7|rcsb pdb:4DEG|rcsb pdb:4DEH|rcsb pdb:4DEI|rcsb pdb:4EEV|rcsb pdb:4GG5|rcsb pdb:4GG7|rcsb pdb:4IWD|rcsb pdb:4K3J|rcsb pdb:4KNB|rcsb pdb:4MXC|rcsb pdb:4O3T|rcsb pdb:4O3U|rcsb pdb:4R1V|rcsb pdb:4R1Y|rcsb pdb:4XMO|rcsb pdb:4XYF|rcsb pdb:5DG5|rcsb pdb:5EOB|rcsb pdb:5EYC|rcsb pdb:5EYD|rcsb pdb:5HLW|rcsb pdb:5HNI|rcsb pdb:5HO6|rcsb pdb:5HOA|rcsb pdb:5HOR|rcsb pdb:5HTI|rcsb pdb:5LSP|rcsb pdb:5T3Q|rcsb pdb:5UAB|rcsb pdb:5UAD|rcsb pdb:5YA5|rcsb pdb:6GCU|rcsb pdb:6I04|rcsb pdb:6SD9|rcsb pdb:6SDC|rcsb pdb:6SDD|rcsb pdb:6SDE|rcsb pdb:6UBW|rcsb pdb:6WVZ|rcsb pdb:7B3Q|rcsb pdb:7B3T|rcsb pdb:7B3V|rcsb pdb:7B3W|rcsb pdb:7B3Z|rcsb pdb:7B40|rcsb pdb:7B41|rcsb pdb:7B42|rcsb pdb:7B43|rcsb pdb:7B44|rcsb pdb:7MO8|rcsb pdb:7MO9|rcsb pdb:7MOA|rcsb pdb:7MOB|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-416550|reactome:R-HSA-5673001|reactome:R-HSA-6806942|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8865999|reactome:R-HSA-8874081|reactome:R-HSA-8875360|rcsb pdb:7MO7|reactome:R-HSA-8875513|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8875791|reactome:R-HSA-9022699|dip:DIP-6023N go:"GO:0051701"(biological process involved in interaction with host) - - figure legend:Figure 6|comment:Heparin induced massive clustering of the Met-InlBfl complex, which shifted to large sedimentation coefficients.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/07/31 2014/10/16 - rogid:Xhr+H4h5JjKYOhEqtgK7PNh1brs9606 intact-crc:AF8D6F18190F175A false - necessary binding region:25-928|his tag:c-c - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)