#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05813-2	uniprotkb:P05813-2	intact:EBI-7519343|intact:MINT-3388168	intact:EBI-7519343|intact:MINT-3388168	psi-mi:p05813-2(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:p05813-2(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519336|mint:MINT-5161799|imex:IM-11125-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7043337(isoform-parent)|mint:MINT-5161800(identity)	intact:EBI-7043337(isoform-parent)|mint:MINT-5161803(identity)	-	comment:mint|isoform-comment:Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.	comment:mint|isoform-comment:Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:43B5dMWZcydxc0pj18ZsMagz5o89606	rogid:43B5dMWZcydxc0pj18ZsMagz5o89606	intact-crc:832D2527F4ED1C20|rigid:SSRhHXBr8jXtU6RuPaBDGhrPEww	false	tag:?-?(MINT-5161810)	tag:?-?(MINT-5161804)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53674	uniprotkb:P05813-2	intact:EBI-7519424|intact:MINT-8162887|intact:MINT-5161833|ensembl:ENSP00000497249	intact:EBI-7519343|intact:MINT-3388168	psi-mi:crbb1_human(display_long)|uniprotkb:CRYBB1(gene name)|psi-mi:CRYBB1(display_short)|uniprotkb:Beta-B1 crystallin(gene name synonym)	psi-mi:p05813-2(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519442|mint:MINT-5161819|imex:IM-11125-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011528201.1|refseq:NP_001878.1|ensembl:ENSG00000100122(gene)|ensembl:ENST00000647684(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033059|mint:P53674|rcsb pdb:1OKI|mint:MINT-5161820(identity)	intact:EBI-7043337(isoform-parent)|mint:MINT-5161826(identity)	-	function:"Defects in CRYBB1 are the cause of autosomal recessive congenital nuclear cataract type 3 (CATCN3) [MIM:611544]. CATCN3 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals"|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens	comment:mint|isoform-comment:Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:eJNGIH/zBV3wjYXqbKB5ftU9CVY9606	rogid:43B5dMWZcydxc0pj18ZsMagz5o89606	intact-crc:33B4FB1239EA302C|rigid:h7NzZxqmlEYvhnRcjgvUUEyOecc	false	tag:?-?(MINT-5161823)	tag:?-?(MINT-5161829)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05813-2	uniprotkb:P43320	intact:EBI-7519343|intact:MINT-3388168	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:p05813-2(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519491|mint:MINT-5161849|imex:IM-11125-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7043337(isoform-parent)|mint:MINT-5161850(identity)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1|mint:MINT-5161856(identity)	-	comment:mint|isoform-comment:Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:43B5dMWZcydxc0pj18ZsMagz5o89606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:2DA0775627705695|rigid:/pxsUd5+mTq5CtsqURHOGIpRH3A	false	tag:?-?(MINT-5161851)	tag:?-?(MINT-5161857)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05813-2	uniprotkb:P26998	intact:EBI-7519343|intact:MINT-3388168	intact:EBI-1965681|uniprotkb:Q3B7S9|uniprotkb:Q9UH09|uniprotkb:Q92965|uniprotkb:Q3T1B7|uniprotkb:Q6ISK6|ensembl:ENSP00000215855	psi-mi:p05813-2(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:crbb3_human(display_long)|uniprotkb:CRYB3(gene name synonym)|uniprotkb:Beta-B3 crystallin(gene name synonym)|uniprotkb:CRYBB3(gene name)|psi-mi:CRYBB3(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519545|mint:MINT-5161864|imex:IM-11125-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-7043337(isoform-parent)|mint:MINT-5161865(identity)	refseq:NP_004067.1|ensembl:ENSG00000100053(gene)|ensembl:ENST00000215855(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033115|mint:P26998|rcsb pdb:3QK3|mint:MINT-5161871(identity)	-	comment:mint|isoform-comment:Initiator Met-1 is removed. Contains a N-acetylalanine at position 2.	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:43B5dMWZcydxc0pj18ZsMagz5o89606	rogid:jfDT8veqVpTWsOAULvGwRSL+NHk9606	intact-crc:F55A5ABFA3243607|rigid:nfYLBtAVhTl+129u5kaN+yDlE/4	false	tag:?-?(MINT-5161868)	tag:?-?(MINT-5161874)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P26998	uniprotkb:P26998	intact:EBI-1965681|uniprotkb:Q3B7S9|uniprotkb:Q9UH09|uniprotkb:Q92965|uniprotkb:Q3T1B7|uniprotkb:Q6ISK6|ensembl:ENSP00000215855	intact:EBI-1965681|uniprotkb:Q3B7S9|uniprotkb:Q9UH09|uniprotkb:Q92965|uniprotkb:Q3T1B7|uniprotkb:Q6ISK6|ensembl:ENSP00000215855	psi-mi:crbb3_human(display_long)|uniprotkb:CRYB3(gene name synonym)|uniprotkb:Beta-B3 crystallin(gene name synonym)|uniprotkb:CRYBB3(gene name)|psi-mi:CRYBB3(display_short)	psi-mi:crbb3_human(display_long)|uniprotkb:CRYB3(gene name synonym)|uniprotkb:Beta-B3 crystallin(gene name synonym)|uniprotkb:CRYBB3(gene name)|psi-mi:CRYBB3(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519579|mint:MINT-5161902|imex:IM-11125-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004067.1|ensembl:ENSG00000100053(gene)|ensembl:ENST00000215855(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033115|mint:P26998|rcsb pdb:3QK3|mint:MINT-5161903(identity)	refseq:NP_004067.1|ensembl:ENSG00000100053(gene)|ensembl:ENST00000215855(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033115|mint:P26998|rcsb pdb:3QK3|mint:MINT-5161909(identity)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:jfDT8veqVpTWsOAULvGwRSL+NHk9606	rogid:jfDT8veqVpTWsOAULvGwRSL+NHk9606	intact-crc:DB926738D5B2A1AB|rigid:IvaUjNxJN1HWs/h5D2wtez+uhPk	false	tag:?-?(MINT-5161904)	tag:?-?(MINT-5161910)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53672	uniprotkb:P26998	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	intact:EBI-1965681|uniprotkb:Q3B7S9|uniprotkb:Q9UH09|uniprotkb:Q92965|uniprotkb:Q3T1B7|uniprotkb:Q6ISK6|ensembl:ENSP00000215855	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:crbb3_human(display_long)|uniprotkb:CRYB3(gene name synonym)|uniprotkb:Beta-B3 crystallin(gene name synonym)|uniprotkb:CRYBB3(gene name)|psi-mi:CRYBB3(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519628|mint:MINT-5161919|imex:IM-11125-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|mint:MINT-5161926(identity)	refseq:NP_004067.1|ensembl:ENSG00000100053(gene)|ensembl:ENST00000215855(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033115|mint:P26998|rcsb pdb:3QK3|mint:MINT-5161920(identity)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	rogid:jfDT8veqVpTWsOAULvGwRSL+NHk9606	intact-crc:DA4666913BCAAAF9|rigid:pyzcfi/QAk9lkOqo/+caehAQIjI	false	tag:?-?(MINT-5161929)	tag:?-?(MINT-5161923)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05813-1	uniprotkb:P26998	intact:EBI-7519662|ensembl:ENSP00000225387|intact:MINT-3388165	intact:EBI-1965681|uniprotkb:Q3B7S9|uniprotkb:Q9UH09|uniprotkb:Q92965|uniprotkb:Q3T1B7|uniprotkb:Q6ISK6|ensembl:ENSP00000215855	psi-mi:p05813-1(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:crbb3_human(display_long)|uniprotkb:CRYB3(gene name synonym)|uniprotkb:Beta-B3 crystallin(gene name synonym)|uniprotkb:CRYBB3(gene name)|psi-mi:CRYBB3(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519670|mint:MINT-5161934|imex:IM-11125-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108255(gene)|ensembl:ENST00000225387(transcript)|intact:EBI-7043337(isoform-parent)|mint:MINT-5161941(identity)	refseq:NP_004067.1|ensembl:ENSG00000100053(gene)|ensembl:ENST00000215855(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033115|mint:P26998|rcsb pdb:3QK3|mint:MINT-5161935(identity)	-	comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:CqSFaF6cGoc2tpXQ60o5+HM10Tg9606	rogid:jfDT8veqVpTWsOAULvGwRSL+NHk9606	intact-crc:B0897775C967908E|rigid:JtOLGO1RFzS4ZOfZiL+217Kk3mo	false	tag:?-?(MINT-5161942)	tag:?-?(MINT-5161936)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53673	uniprotkb:P53674	intact:EBI-7519711|intact:MINT-5161963|uniprotkb:Q4VB22|uniprotkb:Q6ICE4|ensembl:ENSP00000346805	intact:EBI-7519424|intact:MINT-8162887|intact:MINT-5161833|ensembl:ENSP00000497249	psi-mi:crba4_human(display_long)|uniprotkb:CRYBA4(gene name)|psi-mi:CRYBA4(display_short)|uniprotkb:Beta-A4 crystallin(gene name synonym)	psi-mi:crbb1_human(display_long)|uniprotkb:CRYBB1(gene name)|psi-mi:CRYBB1(display_short)|uniprotkb:Beta-B1 crystallin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519791|mint:MINT-5161990|imex:IM-11125-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001877.1|ensembl:ENSG00000196431(gene)|ensembl:ENST00000354760(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033342|mint:P53673|rcsb pdb:3LWK|refseq:XP_016884087.1|mint:MINT-5161991(identity)	refseq:XP_011528201.1|refseq:NP_001878.1|ensembl:ENSG00000100122(gene)|ensembl:ENST00000647684(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033059|mint:P53674|rcsb pdb:1OKI|mint:MINT-5161997(identity)	-	function:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens|function:"Defects in CRYBA4 are the cause of lamellar cataract 2 [MIM:610425]. Cataracts are a leading cause of blindness worldwide, affecting all societies. A significant proportion of cases are genetically determined. More than 15 genes for cataracts have been identified, of which the crystallin genes are the most commonly mutated. Lamellar cataract 2 is an autosomal dominant congenital cataract"|function:"Defects in CRYBA4 are a cause of isolated microphthalmia with cataract 4 (MCOPCT4) [MIM:610426]. Microphtalmia consists of a development defect causing moderate or severe reduction in size of the eye. Opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities like cataract may also be present"	function:"Defects in CRYBB1 are the cause of autosomal recessive congenital nuclear cataract type 3 (CATCN3) [MIM:611544]. CATCN3 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals"|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:C4fLOy1sz+QRnbjyIjkLP6ReyfY9606	rogid:eJNGIH/zBV3wjYXqbKB5ftU9CVY9606	intact-crc:E176938F297322FA|rigid:J6y3WEdVYdIVIZmHgKvPL2yjLpM	false	tag:?-?(MINT-5161992)	tag:?-?(MINT-5161998)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53673	uniprotkb:P43320	intact:EBI-7519711|intact:MINT-5161963|uniprotkb:Q4VB22|uniprotkb:Q6ICE4|ensembl:ENSP00000346805	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:crba4_human(display_long)|uniprotkb:CRYBA4(gene name)|psi-mi:CRYBA4(display_short)|uniprotkb:Beta-A4 crystallin(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519704|mint:MINT-5161949|imex:IM-11125-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001877.1|ensembl:ENSG00000196431(gene)|ensembl:ENST00000354760(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033342|mint:P53673|rcsb pdb:3LWK|refseq:XP_016884087.1|mint:MINT-5161956(identity)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1|mint:MINT-5161950(identity)	-	function:Crystallins do not turn over as the lens ages, providing ample opportunity for post-translational modifications or oxidations. These modifications may change crystallin solubility properties and favor senile cataract|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens|function:"Defects in CRYBA4 are the cause of lamellar cataract 2 [MIM:610425]. Cataracts are a leading cause of blindness worldwide, affecting all societies. A significant proportion of cases are genetically determined. More than 15 genes for cataracts have been identified, of which the crystallin genes are the most commonly mutated. Lamellar cataract 2 is an autosomal dominant congenital cataract"|function:"Defects in CRYBA4 are a cause of isolated microphthalmia with cataract 4 (MCOPCT4) [MIM:610426]. Microphtalmia consists of a development defect causing moderate or severe reduction in size of the eye. Opacities of the cornea and lens, scaring of the retina and choroid, and other abnormalities like cataract may also be present"	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:C4fLOy1sz+QRnbjyIjkLP6ReyfY9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:308077D57D963EC1|rigid:V/2LDQGEb+GHIjav/zymoT6ACR8	false	tag:?-?(MINT-5161959)	tag:?-?(MINT-5161953)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05813-1	uniprotkb:P43320	intact:EBI-7519662|ensembl:ENSP00000225387|intact:MINT-3388165	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:p05813-1(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519860|mint:MINT-5162021|imex:IM-11125-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108255(gene)|ensembl:ENST00000225387(transcript)|intact:EBI-7043337(isoform-parent)|mint:MINT-5162028(identity)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1|mint:MINT-5162022(identity)	-	comment:mint	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:CqSFaF6cGoc2tpXQ60o5+HM10Tg9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:A850CF83E03E99D5|rigid:EzI8T334OU6q9ieKo/mnC0OLnzI	false	tag:?-?(MINT-5162029)	tag:?-?(MINT-5162023)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05813-1	uniprotkb:P05813-1	intact:EBI-7519662|ensembl:ENSP00000225387|intact:MINT-3388165	intact:EBI-7519662|ensembl:ENSP00000225387|intact:MINT-3388165	psi-mi:p05813-1(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:p05813-1(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519826|mint:MINT-5162005|imex:IM-11125-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108255(gene)|ensembl:ENST00000225387(transcript)|intact:EBI-7043337(isoform-parent)|mint:MINT-5162006(identity)	ensembl:ENSG00000108255(gene)|ensembl:ENST00000225387(transcript)|intact:EBI-7043337(isoform-parent)|mint:MINT-5162012(identity)	-	comment:mint	comment:mint	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:CqSFaF6cGoc2tpXQ60o5+HM10Tg9606	rogid:CqSFaF6cGoc2tpXQ60o5+HM10Tg9606	intact-crc:043F9623EBE7FE22|rigid:iIFRR/+wJFGnZNDVJMOY5Uw79kM	false	tag:?-?(MINT-5162009)	tag:?-?(MINT-5162015)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P05813-1	uniprotkb:P53674	intact:EBI-7519662|ensembl:ENSP00000225387|intact:MINT-3388165	intact:EBI-7519424|intact:MINT-8162887|intact:MINT-5161833|ensembl:ENSP00000497249	psi-mi:p05813-1(display_long)|uniprotkb:CRYBA1(gene name)|psi-mi:CRYBA1(display_short)|uniprotkb:CRYB1(gene name synonym)	psi-mi:crbb1_human(display_long)|uniprotkb:CRYBB1(gene name)|psi-mi:CRYBB1(display_short)|uniprotkb:Beta-B1 crystallin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519901|mint:MINT-5162036|imex:IM-11125-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000108255(gene)|ensembl:ENST00000225387(transcript)|intact:EBI-7043337(isoform-parent)|mint:MINT-5162037(identity)	refseq:XP_011528201.1|refseq:NP_001878.1|ensembl:ENSG00000100122(gene)|ensembl:ENST00000647684(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033059|mint:P53674|rcsb pdb:1OKI|mint:MINT-5162043(identity)	-	comment:mint	function:"Defects in CRYBB1 are the cause of autosomal recessive congenital nuclear cataract type 3 (CATCN3) [MIM:611544]. CATCN3 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals"|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:CqSFaF6cGoc2tpXQ60o5+HM10Tg9606	rogid:eJNGIH/zBV3wjYXqbKB5ftU9CVY9606	intact-crc:7667D6D853A996A5|rigid:xenl8JwctJBLiZmOMUu3/Tx3b/M	false	tag:?-?(MINT-5162040)	tag:?-?(MINT-5162046)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53674	uniprotkb:P53674	intact:EBI-7519424|intact:MINT-8162887|intact:MINT-5161833|ensembl:ENSP00000497249	intact:EBI-7519424|intact:MINT-8162887|intact:MINT-5161833|ensembl:ENSP00000497249	psi-mi:crbb1_human(display_long)|uniprotkb:CRYBB1(gene name)|psi-mi:CRYBB1(display_short)|uniprotkb:Beta-B1 crystallin(gene name synonym)	psi-mi:crbb1_human(display_long)|uniprotkb:CRYBB1(gene name)|psi-mi:CRYBB1(display_short)|uniprotkb:Beta-B1 crystallin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519929|mint:MINT-5162051|imex:IM-11125-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011528201.1|refseq:NP_001878.1|ensembl:ENSG00000100122(gene)|ensembl:ENST00000647684(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033059|mint:P53674|rcsb pdb:1OKI|mint:MINT-5162058(identity)	refseq:XP_011528201.1|refseq:NP_001878.1|ensembl:ENSG00000100122(gene)|ensembl:ENST00000647684(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033059|mint:P53674|rcsb pdb:1OKI|mint:MINT-5162052(identity)	-	function:"Defects in CRYBB1 are the cause of autosomal recessive congenital nuclear cataract type 3 (CATCN3) [MIM:611544]. CATCN3 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals"|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens	function:"Defects in CRYBB1 are the cause of autosomal recessive congenital nuclear cataract type 3 (CATCN3) [MIM:611544]. CATCN3 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals"|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:eJNGIH/zBV3wjYXqbKB5ftU9CVY9606	rogid:eJNGIH/zBV3wjYXqbKB5ftU9CVY9606	intact-crc:7D6D8AD8FE61397D|rigid:TX+D4k3Diqlu5aJKR/RHHaYQqjA	false	tag:?-?(MINT-5162059)	tag:?-?(MINT-5162053)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53674	uniprotkb:P53672	intact:EBI-7519424|intact:MINT-8162887|intact:MINT-5161833|ensembl:ENSP00000497249	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	psi-mi:crbb1_human(display_long)|uniprotkb:CRYBB1(gene name)|psi-mi:CRYBB1(display_short)|uniprotkb:Beta-B1 crystallin(gene name synonym)	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519963|mint:MINT-5162066|imex:IM-11125-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011528201.1|refseq:NP_001878.1|ensembl:ENSG00000100122(gene)|ensembl:ENST00000647684(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033059|mint:P53674|rcsb pdb:1OKI|mint:MINT-5162067(identity)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|mint:MINT-5162073(identity)	-	function:"Defects in CRYBB1 are the cause of autosomal recessive congenital nuclear cataract type 3 (CATCN3) [MIM:611544]. CATCN3 is a form of non-syndromic congenital cataract. Non-syndromic congenital cataracts vary markedly in severity and morphology, affecting the nuclear, cortical, polar, or subcapsular parts of the lens or, in severe cases, the entire lens, with a variety of types of opacity. They are one of the major causes of vision loss in children worldwide and are responsible for approximately one third of blindness in infants. Congenital cataracts can lead to permanent blindness by interfering with the sharp focus of light on the retina during critical developmental intervals"|comment:mint|function:Crystallins are the dominant structural components of the vertebrate eye lens	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:eJNGIH/zBV3wjYXqbKB5ftU9CVY9606	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	intact-crc:1CA8C73CA104ACD2|rigid:CfgKIiSxaQ3IyvwogjAI3I+STVE	false	tag:?-?(MINT-5162070)	tag:?-?(MINT-5162076)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43320	uniprotkb:P53672	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	intact:EBI-750444|uniprotkb:Q9Y562|uniprotkb:Q4ZFX0|ensembl:ENSP00000295728|ensembl:ENSP00000375946	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:crba2_human(display_long)|uniprotkb:Beta-A2 crystallin(gene name synonym)|uniprotkb:CRYBA2(gene name)|psi-mi:CRYBA2(display_short)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7519998|mint:MINT-5162081|imex:IM-11125-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1|mint:MINT-5162082(identity)	refseq:NP_476434.1|refseq:NP_476435.1|ensembl:ENSG00000163499(gene)|ensembl:ENST00000295728(transcript)|ensembl:ENST00000392096(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|mint:P53672|mint:MINT-5162088(identity)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	rogid:/WkdaQ4LTxa9mpIiOwVuhd375mE9606	intact-crc:9947A9AEF172E71E|rigid:4dE42ZPXq+PbeKj0SKNIPy30hiI	false	tag:?-?(MINT-5162083)	tag:?-?(MINT-5162089)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43320	uniprotkb:P43320	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	intact:EBI-974082|ensembl:ENSP00000381273|ensembl:ENSP00000498905|uniprotkb:Q9UCM8	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:crbb2_human(display_long)|uniprotkb:Beta-B2 crystallin(gene name synonym)|uniprotkb:Beta-crystallin Bp(gene name synonym)|uniprotkb:CRYBB2(gene name)|psi-mi:CRYBB2(display_short)|uniprotkb:CRYB2(gene name synonym)|uniprotkb:CRYB2A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7520047|mint:MINT-5162096|imex:IM-11125-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1|mint:MINT-5162097(identity)	ensembl:ENSG00000244752(gene)|ensembl:ENST00000398215(transcript)|ensembl:ENST00000651629(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0007601"(visual perception)|go:"GO:0042802"(identical protein binding)|go:"GO:0050896"(response to stimulus)|interpro:IPR001064(Beta and gamma crystallin)|interpro:IPR011024(Gamma-crystallin related)|interpro:IPR033058|mint:P43320|rcsb pdb:1YTQ|refseq:NP_000487.1|refseq:XP_011528202.1|refseq:XP_006724204.1|mint:MINT-5162103(identity)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2014/10/16	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	rogid:CXsf29udifdbWRxtboJe4mnZAgM9606	intact-crc:BAEE17A571FB73D9|rigid:5PhS6Y0gOEcYqpgSlMvbhvck7io	false	tag:?-?(MINT-5162100)	tag:?-?(MINT-5162106)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03070	uniprotkb:P04637	intact:EBI-617698	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	psi-mi:lt_sv40(display_long)	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Liu et al. (2007)	pubmed:17662718|imex:IM-11125|mint:MINT-5220110	taxid:1891767(sv40)|taxid:1891767(sv40)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7520124|mint:MINT-5162111|imex:IM-11125-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0016787"(hydrolase activity)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039576"(suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039648"(modulation by virus of host protein ubiquitination)|go:"GO:0039649"(modulation by virus of host ubiquitin-protein ligase activity)|go:"GO:0039686"(bidirectional double-stranded viral DNA replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR003133(T antigen, Ori-binding)|interpro:IPR010932(Large T antigen, polyomavirus,  C-terminus)|interpro:IPR016392(Large T antigen, polyomaviridae)|interpro:IPR017910|interpro:IPR027417|interpro:IPR036869|rcsb pdb:1EJL|rcsb pdb:1GH6|rcsb pdb:1N25|rcsb pdb:1Q1S|rcsb pdb:1Q1T|rcsb pdb:1SVL|rcsb pdb:1SVM|rcsb pdb:1SVO|rcsb pdb:1TBD|rcsb pdb:1Z1D|rcsb pdb:2FUF|rcsb pdb:2H1L|rcsb pdb:2IF9|rcsb pdb:2IPR|rcsb pdb:2ITJ|rcsb pdb:2ITL|rcsb pdb:2NL8|rcsb pdb:2NTC|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|rcsb pdb:2TBD|rcsb pdb:3QK2|rcsb pdb:3QN2|rcsb pdb:4E2I|rcsb pdb:4FGN|rcsb pdb:4GDF|rcsb pdb:4RXH|rcsb pdb:5D9I|refseq:YP_003708382.1|mint:P03070|dip:DIP-24251N|mint:MINT-5162112(identity)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N|mint:MINT-5162118(identity)	-	-	-	figure legend:F1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2007/09/21	2019/10/18	rogid:IMcAp2PRxZXkbJ1eiXhJU9rD2JM1891767	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	intact-crc:C01CD62946BE1E35|rigid:VZOTDTO282G04bb2R4V1QRGy4IU	false	tag:?-?(MINT-5162113)	tag:?-?(MINT-5162119)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)