#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9XZK6 uniprotkb:P58154 intact:EBI-7516276|intact:MINT-5223670 intact:EBI-7516292|intact:MINT-5223682 psi-mi:ca11_conte(display_long) psi-mi:achp_lymst(display_long) psi-mi:"MI:0405"(competition binding) Dutertre et al. (2007) pubmed:17660751|imex:IM-10901|mint:MINT-5222754 taxid:6494(conte)|taxid:6494(Conus textile) taxid:6523(lymst)|taxid:6523(Lymnaea stagnalis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7516287|mint:MINT-5223703|imex:IM-10901-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q9XZK6|interpro:IPR009958(Conotoxin, alpha-type)|interpro:IPR018072|go:"GO:0005576"(extracellular region)|go:"GO:0030550"(acetylcholine receptor inhibitor activity)|go:"GO:0035792"(host cell postsynaptic membrane)|go:"GO:0090729"(toxin activity)|mint:MINT-5223705(identity) mint:P58154|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005230"(extracellular ligand-gated ion channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043083"(synaptic cleft)|go:"GO:0045202"(synapse)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036734|rcsb pdb:1I9B|rcsb pdb:1UV6|rcsb pdb:1UW6|rcsb pdb:1UX2|rcsb pdb:1YI5|rcsb pdb:2ZJU|rcsb pdb:2ZJV|rcsb pdb:3U8J|rcsb pdb:3U8K|rcsb pdb:3U8L|rcsb pdb:3U8M|rcsb pdb:3U8N|rcsb pdb:3WIP|rcsb pdb:3WTH|rcsb pdb:3WTI|rcsb pdb:3WTJ|rcsb pdb:3WTK|rcsb pdb:3WTL|rcsb pdb:3WTM|rcsb pdb:3WTN|rcsb pdb:3WTO|rcsb pdb:3ZDG|rcsb pdb:3ZDH|rcsb pdb:4ALX|rcsb pdb:4HQP|rcsb pdb:4NZB|rcsb pdb:4QAA|rcsb pdb:4QAB|rcsb pdb:4QAC|rcsb pdb:4UM1|rcsb pdb:4UM3|rcsb pdb:4ZJT|rcsb pdb:4ZK1|rcsb pdb:4ZR6|rcsb pdb:4ZRU|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFN|rcsb pdb:5BP0|rcsb pdb:5J5F|rcsb pdb:5J5G|rcsb pdb:5J5H|rcsb pdb:5J5I|rcsb pdb:5T90|rcsb pdb:5Y2Q|rcsb pdb:7NDP|rcsb pdb:7NDV|rcsb pdb:5AFM|dip:DIP-43985N|mint:MINT-5223706(identity) - comment:mint|function:"Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them" comment:mint|function:Binds to acetylcholine. Modulates neuronal synaptic transmission figure legend:f1d|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/23 2014/10/16 rogid:Z2U+LXLvrIB9KooK04/pu+Y7seA6494 rogid:tKf2LBq8RrKU2a89gKKrF4oWBzo6523 intact-crc:E863F2241EB69744|rigid:4H6dAi2uDGIwaYxgcsSnaYGJg8o false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P60615 uniprotkb:P58154 intact:EBI-7516391|uniprotkb:Q9PRI6|uniprotkb:Q9YI07|uniprotkb:P01378|uniprotkb:Q9YGD1|uniprotkb:Q9YI11|uniprotkb:Q9YI06|intact:MINT-5223718|uniprotkb:Q9YI09|uniprotkb:Q9YI10|uniprotkb:Q9YI13|uniprotkb:Q9YI12 intact:EBI-7516292|intact:MINT-5223682 psi-mi:3l21a_bunmu(display_long)|uniprotkb:Long neurotoxin 1(gene name synonym)|uniprotkb:Alpha-bungarotoxin, isoform A31(gene name synonym)|uniprotkb:Alpha-elapitoxin-Bm2a(gene name synonym) psi-mi:achp_lymst(display_long) psi-mi:"MI:0440"(saturation binding) Dutertre et al. (2007) pubmed:17660751|imex:IM-10901|mint:MINT-5222754 taxid:8616(bunmu)|taxid:8616(Bungarus multicinctus) taxid:6523(lymst)|taxid:6523(Lymnaea stagnalis) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7516385|mint:MINT-5223755|imex:IM-10901-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:P60615|interpro:IPR035076|interpro:IPR018354|interpro:IPR003571(Snake toxin)|go:"GO:0005576"(extracellular region)|go:"GO:0090729"(toxin activity)|rcsb pdb:1ABT|rcsb pdb:1BXP|rcsb pdb:1HAA|rcsb pdb:1HAJ|rcsb pdb:1HC9|rcsb pdb:1HOY|rcsb pdb:1IDG|rcsb pdb:1IDH|rcsb pdb:1IDI|rcsb pdb:1IDL|rcsb pdb:1IK8|rcsb pdb:1IKC|rcsb pdb:1JBD|rcsb pdb:1KC4|rcsb pdb:1KFH|rcsb pdb:1KL8|rcsb pdb:1L4W|rcsb pdb:1LJZ|rcsb pdb:1LK1|rcsb pdb:1RGJ|rcsb pdb:2ABX|rcsb pdb:2BTX|rcsb pdb:6UWZ|mint:MINT-5223758(identity) mint:P58154|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005230"(extracellular ligand-gated ion channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043083"(synaptic cleft)|go:"GO:0045202"(synapse)|interpro:IPR006201(Neurotransmitter-gated ion-channel)|interpro:IPR006202(Neurotransmitter-gated ion-channel ligand-binding)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR036734|rcsb pdb:1I9B|rcsb pdb:1UV6|rcsb pdb:1UW6|rcsb pdb:1UX2|rcsb pdb:1YI5|rcsb pdb:2ZJU|rcsb pdb:2ZJV|rcsb pdb:3U8J|rcsb pdb:3U8K|rcsb pdb:3U8L|rcsb pdb:3U8M|rcsb pdb:3U8N|rcsb pdb:3WIP|rcsb pdb:3WTH|rcsb pdb:3WTI|rcsb pdb:3WTJ|rcsb pdb:3WTK|rcsb pdb:3WTL|rcsb pdb:3WTM|rcsb pdb:3WTN|rcsb pdb:3WTO|rcsb pdb:3ZDG|rcsb pdb:3ZDH|rcsb pdb:4ALX|rcsb pdb:4HQP|rcsb pdb:4NZB|rcsb pdb:4QAA|rcsb pdb:4QAB|rcsb pdb:4QAC|rcsb pdb:4UM1|rcsb pdb:4UM3|rcsb pdb:4ZJT|rcsb pdb:4ZK1|rcsb pdb:4ZR6|rcsb pdb:4ZRU|rcsb pdb:5AFH|rcsb pdb:5AFJ|rcsb pdb:5AFK|rcsb pdb:5AFL|rcsb pdb:5AFN|rcsb pdb:5BP0|rcsb pdb:5J5F|rcsb pdb:5J5G|rcsb pdb:5J5H|rcsb pdb:5J5I|rcsb pdb:5T90|rcsb pdb:5Y2Q|rcsb pdb:7NDP|rcsb pdb:7NDV|rcsb pdb:5AFM|dip:DIP-43985N|mint:MINT-5223757(identity) - comment:mint|function:"Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to muscular and neuronal (alpha-7, alpha-8, and alpha-9) nicotinic acetylcholine receptors. Blocks the extracellular increase of dopamine evoked by nicotine only at the higher dose (4.2 uM)" comment:mint|function:Binds to acetylcholine. Modulates neuronal synaptic transmission figure legend:f1c|kinetics:kd 3.5 nanomolar|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/11/23 2014/10/16 rogid:H8HmrCO0Ummh3xuVj5FOUmoCcN08616 rogid:tKf2LBq8RrKU2a89gKKrF4oWBzo6523 intact-crc:4A9206150AA7F7F9|rigid:Mc8msxUWH0PbaPHarWFmMHNxvjw false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)