#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P16599	uniprotkb:D4A4X6	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571392|ensembl:ENSRNOP00000030753	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:d4a4x6_rat(display_long)|uniprotkb:Adamtsl2(gene name)|psi-mi:Adamtsl2(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000027742(gene)|go:"GO:0031012"(extracellular matrix)|go:"GO:0050436"(microfibril binding)|go:"GO:0060481"(lobar bronchus epithelium development)|interpro:IPR000884(Thrombospondin, type I)|ensembl:ENSRNOT00000036995(transcript)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR010909(PLAC)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR036383|reactome:R-RNO-5173214|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|refseq:XP_001078833.1|refseq:XP_231125.3|rgd:1305459	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:R+GTg5SOsRWkGMK1VCDUNjXocTY10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:E9PTR4	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571381|ensembl:ENSRNOP00000024364	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:e9ptr4_rat(display_long)|uniprotkb:Ubap2l(gene name)|psi-mi:Ubap2l(display_short)|uniprotkb:rCG_62582(orf name)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000017990(gene)|ensembl:ENSRNOT00000024364(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0031519"(PcG protein complex)|go:"GO:0034063"(stress granule assembly)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001019969.2|rgd:1308707	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:tHMVedrztds3G1kh3UUUtahjqE010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572104	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00203773-rat-pro(display_short)|psi-mi:EBI-1572104(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00203773(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572083	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00768003-rat-pro(display_short)|psi-mi:EBI-1572083(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00768003(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572086	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00767360-rat-pro(display_short)|psi-mi:EBI-1572086(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00767360(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572101	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00763922-rat-pro(display_short)|psi-mi:EBI-1572101(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00763922(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1571388	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00365130-rat-pro(display_short)|psi-mi:EBI-1571388(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00365130(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1571384	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00365192-rat-pro(display_short)|psi-mi:EBI-1571384(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00365192(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q4KLH1	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571283	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q4klh1_rat(display_long)|uniprotkb:Ascc3l1(gene name)|psi-mi:Ascc3l1(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR035892|interpro:IPR004179(Sec63)|interpro:IPR014756(Immunoglobulin E-set)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:pjfzsjtGESkTOENT73Lec7Zu83Y10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P11507	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P63259	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-351310|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSRNOP00000051859|ensembl:ENSRNOP00000072273	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:actg_rat(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1304556|refseq:NP_001120921.1|ensembl:ENSRNOG00000036701(gene)|ensembl:ENSRNOG00000053452(gene)|ensembl:ENSRNOT00000054976(transcript)|ensembl:ENSRNOT00000079310(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-RNO-114608|reactome:R-RNO-190873|reactome:R-RNO-196025|reactome:R-RNO-2029482|reactome:R-RNO-3928662|reactome:R-RNO-418990|reactome:R-RNO-437239|reactome:R-RNO-4420097|reactome:R-RNO-445095|reactome:R-RNO-446353|reactome:R-RNO-5626467|reactome:R-RNO-5663213|reactome:R-RNO-5663220|reactome:R-RNO-5674135|reactome:R-RNO-8856828|reactome:R-RNO-9013418|refseq:XP_002729242.3|refseq:XP_017452655.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:G3V928	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571324|ensembl:ENSRNOP00000034210|intact:EBI-21232757|uniprotkb:Q5I0H1	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:lrp1_rat(display_long)|uniprotkb:Lrp1(gene name)|psi-mi:Lrp1(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0045177"(apical part of cell)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|reactome:R-RNO-2168880|reactome:R-RNO-975634|ensembl:ENSRNOG00000025053(gene)|ensembl:ENSRNOT00000031005(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0005768"(endosome)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|refseq:NP_001123962.1|rgd:1307535	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:vi8q0DhZdO50rCfk3KfkMFF65hs10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q62677	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571276|uniprotkb:O09065|uniprotkb:O09145	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q62677_rat(display_long)|uniprotkb:COL4A1(gene name)|psi-mi:COL4A1(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005581"(collagen trimer)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:P2SdkXpXWLArcAZ7LxXmS5tjBE410116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q63122	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571334	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q63122_rat(display_long)|uniprotkb:COL4A3(gene name)|psi-mi:COL4A3(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0016020"(membrane)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005604"(basement membrane)|interpro:IPR036954|interpro:IPR016187(C-type lectin fold)|interpro:IPR001442(Type 4 procollagen, C-terminal repeat)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:HxGB6xVOQ1l/ZI1WgarfuQaPjck10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q62772	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571357	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q62772_rat(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR036056|interpro:IPR002181(Fibrinogen, alpha/beta/gamma chain, C-terminal globular)|interpro:IPR020837|interpro:IPR014716(Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:jvHw9mi/o7HpMANbOdThdUs1n8Q10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q99PU6	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571290	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q99pu6_rat(display_long)|uniprotkb:Dbt(gene name)|psi-mi:Dbt(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR036625|rgd:68403|refseq:NP_445764.1|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:uIcZqKixsvqv10OqNWN4SvZ/FbI10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q9QYP0	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571307	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:megf8_rat(display_long)|uniprotkb:Epidermal growth factor-like protein 4(gene name synonym)|uniprotkb:Megf8(gene name)|psi-mi:Megf8(display_short)|uniprotkb:Egfl4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0055113"(epiboly involved in gastrulation with mouth forming second)|go:"GO:0060971"(embryonic heart tube left/right pattern formation)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0060972"(left/right pattern formation)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0071907"(determination of digestive tract left/right asymmetry)|go:"GO:0097094"(craniofacial suture morphogenesis)|go:"GO:0097155"(fasciculation of sensory neuron axon)|interpro:IPR035914|rgd:621190|interpro:IPR000859(CUB)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR002049(EGF-like, laminin)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR002165(Plexin)|interpro:IPR024731|interpro:IPR016201(Plexin-like fold)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:+Wp2qb6ByRBNhFiYxj32ePzt1FQ10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q63075	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1571350	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q63075_rat(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|interpro:IPR000885(Fibrillar collagen, C-terminal)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:Dhf/fp0F2prRU0VigGM9otYAFb410116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572050	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00767320-rat-pro(display_short)|psi-mi:EBI-1572050(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00767320(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572059	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00368082-rat-pro(display_short)|psi-mi:EBI-1572059(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00368082(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572056	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00361486-rat-pro(display_short)|psi-mi:EBI-1572056(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00361486(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572074	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00768298-rat-pro(display_short)|psi-mi:EBI-1572074(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00768298(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572089	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00767825-rat-pro(display_short)|psi-mi:EBI-1572089(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00767825(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572077	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00768616-rat-pro(display_short)|psi-mi:EBI-1572077(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00768616(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572068	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00767314-rat-pro(display_short)|psi-mi:EBI-1572068(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00767314(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572098	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00368692-rat-pro(display_short)|psi-mi:EBI-1572098(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00368692(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572092	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00764166-rat-pro(display_short)|psi-mi:EBI-1572092(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00764166(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572065	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00766216-rat-pro(display_short)|psi-mi:EBI-1572065(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00766216(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:D3ZW60	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1572054|ensembl:ENSRNOP00000056038	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:d3zw60_rat(display_long)|uniprotkb:Togaram1(gene name)|psi-mi:Togaram1(display_short)|uniprotkb:Fam179b(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000004415(gene)|ensembl:ENSRNOT00000059271(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005929"(cilium)|go:"GO:0008017"(microtubule binding)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028401|interpro:IPR034085|refseq:XP_002726789.1|refseq:XP_234236.4|rgd:1310474	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:Lozexof7f05AdeDiE8rh7kcK6m010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572080	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00391468-rat-pro(display_short)|psi-mi:EBI-1572080(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00391468(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572095	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00188079-rat-pro(display_short)|psi-mi:EBI-1572095(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00188079(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572062	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00370353-rat-pro(display_short)|psi-mi:EBI-1572062(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00370353(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	intact:EBI-1572071	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	-	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ipi00360086-rat-pro(display_short)|psi-mi:EBI-1572071(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ipi:IPI00360086(primary-reference)	psi-mi:"MI:0469"(intact)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	-	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P37361	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374524|ensembl:ENSRNOP00000025669	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:mt3_rat(display_long)|uniprotkb:Mt3(gene name)|psi-mi:Mt3(display_short)|uniprotkb:Metallothionein-III(gene name synonym)|uniprotkb:Growth inhibitory factor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:621252|refseq:NP_446420.1|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0055073"(cadmium ion homeostasis)|go:"GO:0060049"(regulation of protein glycosylation)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097450"(astrocyte end-foot)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000117"(negative regulation of cysteine-type endopeptidase activity)|go:"GO:2000296"(negative regulation of hydrogen peroxide catabolic process)|go:"GO:2000376"(positive regulation of oxygen metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|mint:P37361|reactome:R-RNO-5661231|ensembl:ENSRNOG00000018958(gene)|ensembl:ENSRNOT00000025669(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0006707"(cholesterol catabolic process)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006875"(cellular metal ion homeostasis)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010940"(positive regulation of necrotic cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0014002"(astrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016234"(inclusion body)|go:"GO:0016570"(histone modification)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032095"(regulation of response to food)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:CQUNi1gLHk512lc0gQl6i/7pft010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P42123	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374493|ensembl:ENSRNOP00000017965	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ldhb_rat(display_long)|uniprotkb:Ldhb(gene name)|psi-mi:Ldhb(display_short)|uniprotkb:Ldh2(gene name synonym)|uniprotkb:Ldh-2(gene name synonym)|uniprotkb:LDH heart subunit(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:2997|refseq:NP_036727.1|refseq:NP_001303262.1|refseq:NP_001303263.1|ensembl:ENSRNOG00000013000(gene)|ensembl:ENSRNOT00000017965(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0019674"(NAD metabolic process)|go:"GO:0019900"(kinase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051287"(NAD binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P42123|reactome:R-RNO-70268	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:Mbwe4KveGEoCqcAZ88WOIe1c1pQ10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q6MG72	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374427|uniprotkb:F1M7S8|ensembl:ENSRNOP00000042145	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q6mg72_rat(display_long)|uniprotkb:Ehmt2(gene name)|psi-mi:Ehmt2(display_short)|uniprotkb:Apom(gene name synonym)|uniprotkb:Bat4(gene name synonym)|uniprotkb:Bat8(gene name synonym)|uniprotkb:C2(gene name synonym)|uniprotkb:C4a(gene name synonym)|uniprotkb:Cfb(gene name synonym)|uniprotkb:Csnk2b(gene name synonym)|uniprotkb:G7e(gene name synonym)|uniprotkb:Hspa1a(gene name synonym)|uniprotkb:Hspa1b(gene name synonym)|uniprotkb:Ly6g5c(gene name synonym)|uniprotkb:Ly6g6c(gene name synonym)|uniprotkb:Neu1(gene name synonym)|uniprotkb:Ng35(gene name synonym)|uniprotkb:Rps25-ps2(gene name synonym)|uniprotkb:Stk19(gene name synonym)|uniprotkb:Hspa1l(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1302972|refseq:NP_997628.1|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009566"(fertilization)|go:"GO:0006306"(DNA methylation)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010424"(DNA methylation on cytosine within a CG sequence)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007281"(germ cell development)|go:"GO:0007286"(spermatid development)|go:"GO:0007616"(long-term memory)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016279"(protein-lysine N-methyltransferase activity)|go:"GO:0016571"(histone methylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0018027"(peptidyl-lysine dimethylation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0034968"(histone lysine methylation)|go:"GO:0035265"(organ growth)|go:"GO:0035690"|go:"GO:0036166"(phenotypic switching)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045471"(response to ethanol)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0046976"("histone methyltransferase activity (H3-K27 specific)")|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048665"(neuron fate specification)|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051570"(regulation of histone H3-K9 methylation)|go:"GO:0060992"(response to fungicide)|go:"GO:0070734"(histone H3-K27 methylation)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001214(SET)|interpro:IPR002110(Ankyrin)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR020683|interpro:IPR036770|interpro:IPR038034|interpro:IPR043550|reactome:R-RNO-2559582|reactome:R-RNO-3214841|reactome:R-RNO-6804760|reactome:R-RNO-73762|reactome:R-RNO-8953750|ensembl:ENSRNOG00000030630(gene)|ensembl:ENSRNOT00000047370(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0006275"(regulation of DNA replication)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:pkDnF0nVSrBxzvmGSFPmHzolnZo10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q6AY44	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374540	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q6ay44_rat(display_long)|uniprotkb:Mcoln3(gene name)|psi-mi:Mcoln3(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR013122(Polycystin cation channel, PKD1/PKD2)|rgd:1308420|refseq:NP_001012059.1|interpro:IPR039031|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0072345"(NAADP-sensitive calcium-release channel activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:9rqO2I842LHHq+nn3IE4q+nG90A10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P35565	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-917363|ensembl:ENSRNOP00000040859	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:calx_rat(display_long)|uniprotkb:Canx(gene name)|psi-mi:Canx(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:2266|refseq:NP_742005.1|refseq:XP_008765901.1|refseq:XP_008765902.1|ensembl:ENSRNOG00000003343(gene)|ensembl:ENSRNOT00000049942(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P35565|reactome:R-RNO-2132295|reactome:R-RNO-901042|reactome:R-RNO-9020956|reactome:R-RNO-983170	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:OA7gJ6oMBN6zraU38Xg856XebR810116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q6UN82	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374486	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q6un82_rat(display_long)|uniprotkb:Setsip(gene name)|psi-mi:Setsip(display_short)|uniprotkb:Set(gene name synonym)|uniprotkb:Setl1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR002164("Nucleosome assembly protein (NAP)")|rgd:727855|refseq:NP_919334.1|interpro:IPR037231|go:"GO:0005634"(nucleus)|go:"GO:0006334"(nucleosome assembly)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:H325wl+duDWuXwPj5KQGUwsRsjg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q3KR98	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374466	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q3kr98_rat(display_long)|uniprotkb:Kpna6(gene name)|psi-mi:Kpna6(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR032413|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|refseq:NP_001015029.2|rgd:1306570|interpro:IPR024931|interpro:IPR036975|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0019079"(viral genome replication)|go:"GO:0030682"(mitigation of host defenses by symbiont)|go:"GO:0043657"(host cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0075506"(entry of viral genome into host nucleus through nuclear pore complex via importin)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:0061608"(nuclear import signal receptor activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:+w2+S9nK+zy+7rwV2Cb3fd0uvzU10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q9WUH9	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374386	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q9wuh9_rat(display_long)|uniprotkb:Fbn2(gene name)|psi-mi:Fbn2(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR040872|rgd:620910|refseq:NP_114014.1|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR026823|interpro:IPR036773|go:"GO:0001527"(microfibril)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR011398(Fibrillin)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:N9YYLM056bTahI877wbTkfb05cM10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:O35359	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374598	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:o35359_rat(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR015898(G-protein, gamma-like subunit)|interpro:IPR001770(G-protein, gamma subunit)|interpro:IPR036284|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031681"(G-protein beta-subunit binding)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:pbPTIdRdkrEHmYJ/nzhqFAuDwpg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:C0H5Y5	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374286|ensembl:ENSRNOP00000016730	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:c0h5y5_rat(display_long)|uniprotkb:Cflar(gene name)|psi-mi:Cflar(display_short)|uniprotkb:rCG_22405(orf name)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_001029036.1|refseq:NP_476479.1|refseq:XP_006245011.1|refseq:XP_006245008.1|refseq:XP_006245009.1|refseq:XP_006245010.1|rgd:620847|ensembl:ENSRNOG00000012473(gene)|ensembl:ENSRNOT00000016730(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|reactome:R-RNO-3371378|reactome:R-RNO-5218900|reactome:R-RNO-5357905|reactome:R-RNO-69416|reactome:R-RNO-75158	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:WctJbOwUNe8rg8sRl6RrgJc1dFs10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q99M88	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374348	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q99m88_rat(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR042147|interpro:IPR029030|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR033139|interpro:IPR033171|interpro:IPR002398(Peptidase C14, caspase precursor p45)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0042981"(regulation of apoptotic process)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:fSdhm5YAmu10TTMO3Veh4Wm3KME10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q5XIC5	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374592	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q5xic5_rat(display_long)|uniprotkb:Plekha3(gene name)|psi-mi:Plekha3(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|rgd:1305244|refseq:NP_001013095.1|go:"GO:0042802"(identical protein binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR000648(Oxysterol-binding protein)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:aA37MUBJJaYP1h4FXMP6iUR+kN810116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P04355	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374516|ensembl:ENSRNOP00000062585	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:mt2_rat(display_long)|uniprotkb:Metallothionein-II(gene name synonym)|uniprotkb:Mt2(gene name)|psi-mi:Mt2(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_001131036.1|ensembl:ENSRNOG00000043098(gene)|ensembl:ENSRNOT00000067391(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0046872"(metal ion binding)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071294"(cellular response to zinc ion)|interpro:IPR000006(Metallothionein, vertebrate)|interpro:IPR003019(Metallothionein superfamily, eukaryotic)|interpro:IPR017854(Metallothionein superfamily)|interpro:IPR018064|interpro:IPR023587|rcsb pdb:1MRT|rcsb pdb:2MRT|rcsb pdb:4MT2|reactome:R-RNO-5661231	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:mInDxJ7OrGYVF//nCGF2suV1ow810116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:O70513	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374506|uniprotkb:Q66HR4|uniprotkb:Q6Q8R9|ensembl:ENSRNOP00000004320	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:lg3bp_rat(display_long)|uniprotkb:Mac-2-binding protein(gene name synonym)|uniprotkb:Cyp-C-associated protein(gene name synonym)|uniprotkb:Protein 90K(gene name synonym)|uniprotkb:Lectin galactoside-binding soluble 3-binding protein(gene name synonym)|uniprotkb:Lgals3bp(gene name)|psi-mi:Lgals3bp(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:620837|refseq:NP_620796.1|ensembl:ENSRNOG00000003217(gene)|ensembl:ENSRNOT00000004320(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007155"(cell adhesion)|go:"GO:0016020"(membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR036772|reactome:R-RNO-114608	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:eNbx920wWCU5fCR4M6vZGNq52rg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q99P84	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374566	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:plce1_rat(display_long)|uniprotkb:Plce1(gene name)|psi-mi:Plce1(display_short)|uniprotkb:Plce(gene name synonym)|uniprotkb:Phospholipase C-epsilon-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-epsilon-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR028398|interpro:IPR000159(Ras-association)|interpro:IPR023578|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|rgd:69424|refseq:NP_446210.1|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR011992(EF-Hand type)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR017946|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR029071|rcsb pdb:6PMP|interpro:IPR035892|reactome:R-RNO-1855204|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032835"(glomerulus development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:POdE6HNWUlj4otEVb2ewBDBzQyU10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q00900	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374455|uniprotkb:Q63725	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:zep2_rat(display_long)|uniprotkb:Hivep2(gene name)|psi-mi:Hivep2(display_short)|uniprotkb:Agie-bp1(gene name synonym)|uniprotkb:Mibp1(gene name synonym)|uniprotkb:DNA-binding protein AGIE-BP1(gene name synonym)|uniprotkb:Angiotensinogen gene-inducible enhancer-binding protein 1(gene name synonym)|uniprotkb:Myc intron-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:61988|refseq:NP_077051.1|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|mint:Q00900	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:eeXigOZpFmIiVYU72ack+PcKLl410116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q7TS60	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374259	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q7ts60_rat(display_long)|uniprotkb:Bcl2l2(gene name)|psi-mi:Bcl2l2(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR026298|refseq:XP_017455282.1|interpro:IPR013280(Apoptosis regulator, Bcl-W)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR003093(Apoptosis regulator Bcl-2 protein, BH4)|interpro:IPR020731|rgd:620717|interpro:IPR036834|go:"GO:0002931"(response to ischemia)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035795"(negative regulation of mitochondrial membrane permeability)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0060011"(Sertoli cell proliferation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905430"(cellular response to glycine)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:+0+uQWp2UHkiWqpevDYc3q7yZTw10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P55213	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374311|uniprotkb:P70543|uniprotkb:P97699|uniprotkb:Q62993|ensembl:ENSRNOP00000014096	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:casp3_rat(display_long)|uniprotkb:Apopain(gene name synonym)|uniprotkb:Cysteine protease CPP32(gene name synonym)|uniprotkb:Protein Yama(gene name synonym)|uniprotkb:SREBP cleavage activity 1(gene name synonym)|uniprotkb:LICE(gene name synonym)|uniprotkb:IRP(gene name synonym)|uniprotkb:Casp3(gene name)|psi-mi:Casp3(display_short)|uniprotkb:Cpp32(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:2275|refseq:NP_037054.1|refseq:XP_006253192.1|ensembl:ENSRNOG00000010475(gene)|ensembl:ENSRNOT00000014095(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004861"(cyclin-dependent protein serine/threonine kinase inhibitor activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007507"(heart development)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007611"(learning or memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008627"(intrinsic apoptotic signaling pathway in response to osmotic stress)|go:"GO:0009411"(response to UV)|go:"GO:0009611"(response to wounding)|go:"GO:0009749"(response to glucose)|go:"GO:0010033"(response to organic substance)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016005"(phospholipase A2 activator activity)|go:"GO:0016485"(protein processing)|go:"GO:0021766"(hippocampus development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043029"(T cell homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043200"(response to amino acid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046677"(response to antibiotic)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0061713"(anterior neural tube closure)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|mint:P55213|reactome:R-RNO-111459|reactome:R-RNO-111465|reactome:R-RNO-111469|reactome:R-RNO-140342|reactome:R-RNO-2028269|reactome:R-RNO-205025|reactome:R-RNO-264870|reactome:R-RNO-351906|reactome:R-RNO-418889|reactome:R-RNO-449836|reactome:R-RNO-5620971	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:xRKpRuOF66IXcQMQSO/3xM5M+/M10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q63716	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-918674|ensembl:ENSRNOP00000023132	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:prdx1_rat(display_long)|uniprotkb:Thioredoxin peroxidase 2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxide reductase 2(gene name synonym)|uniprotkb:Heme-binding 23 kDa protein(gene name synonym)|uniprotkb:HBP23(gene name synonym)|uniprotkb:Prdx1(gene name)|psi-mi:Prdx1(display_short)|uniprotkb:Tdpx2(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:620039|refseq:NP_476455.1|ensembl:ENSRNOG00000017194(gene)|ensembl:ENSRNOT00000023132(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000791"(euchromatin)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045321"(leukocyte activation)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR019479|interpro:IPR024706|interpro:IPR036249|mint:Q63716|rcsb pdb:1QQ2|rcsb pdb:2Z9S|reactome:R-RNO-3299685|reactome:R-RNO-5628897	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:6Yx5rIs6p9cg57ePcRAtiWUM7p010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:A1L132	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374606	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:a1l132_rat(display_long)|uniprotkb:Apex2(gene name)|psi-mi:Apex2(display_short)|uniprotkb:RGD1565983(gene name synonym)|uniprotkb:rCG_38932(orf name)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR020847|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR010666(Zinc finger, GRF-type)|refseq:NP_001073361.1|rgd:1565983|interpro:IPR036691|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")|go:"GO:0004519"(endonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0005634"(nucleus)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006284"(base-excision repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:aK7pO71lgmQlPrqZzxhoqu5wIyg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:O35353	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374407|uniprotkb:Q4V8I8|uniprotkb:Q6Q8B2	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:gbb4_rat(display_long)|uniprotkb:Gnb4(gene name)|psi-mi:Gnb4(display_short)|uniprotkb:Transducin beta chain 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1359321|refseq:NP_001013932.1|interpro:IPR020472|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322|go:"GO:0005737"(cytoplasm)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|reactome:R-RNO-1296041|reactome:R-RNO-202040|reactome:R-RNO-381676|reactome:R-RNO-392170|reactome:R-RNO-392451|reactome:R-RNO-400042|reactome:R-RNO-4086398|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-418597|reactome:R-RNO-420092|reactome:R-RNO-428930|reactome:R-RNO-432040|reactome:R-RNO-456926|reactome:R-RNO-6814122|reactome:R-RNO-8964616|reactome:R-RNO-997272|mint:O35353	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:At4d9m6HkQf6Uy/oMrC2/MR+5fg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P68136	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-367530|uniprotkb:P02568|uniprotkb:P99020|ensembl:ENSRNOP00000024084	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:acts_rat(display_long)|uniprotkb:Acta1(gene name)|psi-mi:Acta1(display_short)|uniprotkb:Acta(gene name synonym)|uniprotkb:Alpha-actin-1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000017786(gene)|ensembl:ENSRNOT00000024084(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009991"(response to extracellular stimulus)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0043503"(skeletal muscle fiber adaptation)|go:"GO:0044297"(cell body)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|rcsb pdb:3U9D|reactome:R-RNO-390522|rgd:2025|refseq:NP_062085.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:2vZu8ElmMe+6GjKBliCAatNGZR410116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:O88321	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374226|ensembl:ENSRNOP00000028589	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:o88321_rat(display_long)|uniprotkb:rCG_51785(orf name)|uniprotkb:Psmd4(gene name)|psi-mi:Psmd4(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_112621.1|rgd:621109|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-2467813|reactome:R-RNO-349425|reactome:R-RNO-350562|reactome:R-RNO-382556|reactome:R-RNO-450408|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5676590|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689880|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69481|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948751|reactome:R-RNO-8951664|ensembl:ENSRNOG00000021042(gene)|ensembl:ENSRNOT00000028589(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042044"(fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1236978|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:2/lZaSxp8/70h7OKsfVjtmMFebE10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P60711	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-349272|uniprotkb:Q64316|uniprotkb:P02570|uniprotkb:P70514|uniprotkb:P99021|uniprotkb:Q11211|ensembl:ENSRNOP00000044296	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:actb_rat(display_long)|uniprotkb:Actb(gene name)|psi-mi:Actb(display_short)|uniprotkb:Beta-actin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:628837|refseq:NP_112406.1|ensembl:ENSRNOG00000034254(gene)|ensembl:ENSRNOT00000042459(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001725"(stress fiber)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0002102"(podosome)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007409"(axonogenesis)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022898"(regulation of transmembrane transporter activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030957"(Tat protein binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045121"(membrane raft)|go:"GO:0045176"(apical protein localization)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048870"(cell motility)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051621"(regulation of norepinephrine uptake)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070160"(tight junction)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0072749"(cellular response to cytochalasin B)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|reactome:R-RNO-190873|reactome:R-RNO-196025|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|reactome:R-RNO-2029482|reactome:R-RNO-3928662|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150111"(regulation of transepithelial transport)|reactome:R-RNO-418990|reactome:R-RNO-437239|go:"GO:1903076"(regulation of protein localization to plasma membrane)|reactome:R-RNO-4420097|reactome:R-RNO-445095|reactome:R-RNO-446353|reactome:R-RNO-5250924|reactome:R-RNO-5626467|reactome:R-RNO-5663213|reactome:R-RNO-5663220|reactome:R-RNO-5674135|reactome:R-RNO-5689603|reactome:R-RNO-5696394|reactome:R-RNO-8856828|reactome:R-RNO-9035034|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P60711	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:Hoge1B8Pn56kvbNTpkSLsQuHwRc10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P62919	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-438554|ensembl:ENSRNOP00000046553|ensembl:ENSRNOP00000064566|ensembl:ENSRNOP00000067080|uniprotkb:A0JMZ6|uniprotkb:P25120	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:rl8_rat(display_long)|uniprotkb:Rpl8(gene name)|psi-mi:Rpl8(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000032635(gene)|ensembl:ENSRNOG00000048456(gene)|ensembl:ENSRNOG00000048523(gene)|ensembl:ENSRNOT00000041984(transcript)|ensembl:ENSRNOT00000073724(transcript)|ensembl:ENSRNOT00000075451(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:0098794"(postsynapse)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990932"(5.8S rRNA binding)|interpro:IPR002171(Ribosomal protein L2)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR014726(Ribosomal protein L2, domain 3)|interpro:IPR022666|interpro:IPR022669|interpro:IPR022671|interpro:IPR023672|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:619827|refseq:NP_001030088.2|refseq:XP_002729189.1|refseq:XP_017450875.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:+b/ORzdCy/nqFLsKRV9VhIZgdjg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q06647	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-918179|ensembl:ENSRNOP00000002732	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:atpo_rat(display_long)|uniprotkb:Atp5po(gene name)|psi-mi:Atp5po(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:Atp5o(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)|uniprotkb:Sperm flagella protein 4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:621379|refseq:NP_620238.1|ensembl:ENSRNOG00000001991(gene)|ensembl:ENSRNOT00000002732(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903924"(estradiol binding)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:Q06647|reactome:R-RNO-163210|reactome:R-RNO-8949613	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:F/PihaxUf1uclL8LOwKpSse+dCA10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P63269	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-297811|uniprotkb:P12718|ensembl:ENSRNOP00000050322	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:acth_rat(display_long)|uniprotkb:Actg2(gene name)|psi-mi:Actg2(display_short)|uniprotkb:Acta3(gene name synonym)|uniprotkb:Actsg(gene name synonym)|uniprotkb:Smooth muscle gamma-actin(gene name synonym)|uniprotkb:Gamma-2-actin(gene name synonym)|uniprotkb:Alpha-actin-3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000029401(gene)|ensembl:ENSRNOT00000042699(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005869"(dynactin complex)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0032982"(myosin filament)|go:"GO:0044297"(cell body)|go:"GO:0071944"(cell periphery)|go:"GO:0090131"(mesenchyme migration)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P63269|reactome:R-RNO-445355|rgd:2027|refseq:NP_037025.1|refseq:XP_006236790.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:tp0JsXhrGsRl5i4Wg2dyaPGUPxA10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q5QJC9	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374246|ensembl:ENSRNOP00000015333|ensembl:ENSRNOP00000071757	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:bag5_rat(display_long)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym)|uniprotkb:Bag5(gene name)|psi-mi:Bag5(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:XP_008763199.1|refseq:XP_008763200.1|refseq:XP_008763201.1|refseq:XP_008763202.1|refseq:XP_008774543.1|refseq:XP_008774544.1|refseq:XP_008774545.1|rgd:1310847|refseq:NP_001008526.1|refseq:XP_006240663.1|refseq:XP_006240664.1|refseq:XP_006240665.1|ensembl:ENSRNOG00000011527(gene)|ensembl:ENSRNOG00000058841(gene)|ensembl:ENSRNOT00000015333(transcript)|ensembl:ENSRNOT00000085594(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|rcsb pdb:2ALN|reactome:R-RNO-3371453	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:eoKOO1bCmyY3JM2Yz5GrPn6s1sA10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P62738	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-915799|uniprotkb:P03996|uniprotkb:P04108|uniprotkb:P70476	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:acta_rat(display_long)|uniprotkb:Alpha-actin-2(gene name synonym)|uniprotkb:Acta2(gene name)|psi-mi:Acta2(display_short)|uniprotkb:Actsa(gene name synonym)|uniprotkb:Actvs(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005856"(cytoskeleton)|go:"GO:0005869"(dynactin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009615"(response to virus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030485"(smooth muscle contractile fiber)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044297"(cell body)|go:"GO:0061041"(regulation of wound healing)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0061874"(positive regulation of hepatic stellate cell contraction)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090131"(mesenchyme migration)|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|go:"GO:0001725"(stress fiber)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|rgd:621676|refseq:NP_112266.1|interpro:IPR004000(Actin/actin-like)|interpro:IPR020902|interpro:IPR004001(Actin, conserved site)|interpro:IPR043129|reactome:R-RNO-445355	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:mRZGUdL/jBuj6nVHtxoasZuA7yA10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P02401	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374191|uniprotkb:Q499W9|ensembl:ENSRNOP00000038214|ensembl:ENSRNOP00000053863	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:rla2_rat(display_long)|uniprotkb:Rplp2(gene name)|psi-mi:Rplp2(display_short)|uniprotkb:Rp2(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:XP_003749061.1|refseq:XP_008772967.1|rgd:621775|refseq:NP_001025192.1|ensembl:ENSRNOG00000002116(gene)|ensembl:ENSRNOG00000037607(gene)|ensembl:ENSRNOT00000038691(transcript)|ensembl:ENSRNOT00000057030(transcript)|go:"GO:0002182"(cytoplasmic translational elongation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005506"(iron ion binding)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:1904401"(cellular response to Thyroid stimulating hormone)|interpro:IPR027534|interpro:IPR038716|interpro:IPR044076|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:Rnu4hOvHXAFaiAD7FiCACOFK82A10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P22934	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374918|uniprotkb:Q5U1X6|uniprotkb:Q91V30|uniprotkb:Q91Y93	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:tnr1a_rat(display_long)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:621237|refseq:NP_037223.1|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR033993|interpro:IPR033994|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5669034|reactome:R-RNO-75893|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043235"(receptor complex)|go:"GO:0043279"(response to alkaloid)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:rGM2BDffz9IRnK5mHBvLPYctxSU10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q63610	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374845|uniprotkb:Q63599|uniprotkb:Q63600|uniprotkb:Q63601|ensembl:ENSRNOP00000023567	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:tpm3_rat(display_long)|uniprotkb:Tpm3(gene name)|psi-mi:Tpm3(display_short)|uniprotkb:Tpm5(gene name synonym)|uniprotkb:Tpm-5(gene name synonym)|uniprotkb:Tropomyosin-3(gene name synonym)|uniprotkb:Gamma-tropomyosin(gene name synonym)|uniprotkb:Tropomyosin-5(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_001288215.1|rgd:621546|refseq:NP_476556.2|refseq:NP_775134.1|ensembl:ENSRNOG00000017441(gene)|ensembl:ENSRNOT00000023567(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007420"(brain development)|go:"GO:0030426"(growth cone)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0043005"(neuron projection)|go:"GO:0051015"(actin filament binding)|interpro:IPR000533(Tropomyosin)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|mint:Q63610	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:XHAZCusR15h8uFhXleR0wPakhZY10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q80WY6	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374940|uniprotkb:Q5YLP0|ensembl:ENSRNOP00000022478	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:tnr1b_rat(display_long)|uniprotkb:Tnfrsf1b(gene name)|psi-mi:Tnfrsf1b(display_short)|uniprotkb:Tnfr2(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 2(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type II(gene name synonym)|uniprotkb:p75(gene name synonym)|uniprotkb:p80 TNF-alpha receptor(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:621238|refseq:NP_569110.1|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030424"(axon)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043196"(varicosity)|go:"GO:0045121"(membrane raft)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050779"(RNA destabilization)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0150077"(regulation of neuroinflammatory response)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:0150098"(glial cell-neuron signaling)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:2001141"(regulation of RNA biosynthetic process)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR020411|interpro:IPR033996|reactome:R-RNO-5668541|reactome:R-RNO-5669034|reactome:R-RNO-6798695|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|ensembl:ENSRNOG00000016575(gene)|ensembl:ENSRNOT00000022478(transcript)|go:"GO:0002718"(regulation of cytokine production involved in immune response)|go:"GO:0002724"(regulation of T cell cytokine production)|go:"GO:0003176"(aortic valve development)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:sVQrgdWF/gyE2voNp9UpgLNyy7M10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q923Z2	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374896|uniprotkb:F7FK40|ensembl:ENSRNOP00000047134	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q923z2_rat(display_long)|uniprotkb:rCG_56696(orf name)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Tpm1_v4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:3898|refseq:NP_001029243.1|ensembl:ENSRNOG00000018184(gene)|ensembl:ENSRNOT00000040808(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|interpro:IPR000533(Tropomyosin)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:x/yEbYC4D0PzYvlt6HFoGlDV5OU10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q6AZ25	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374904	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q6az25_rat(display_long)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Tpm1_v6(gene name synonym)|uniprotkb:Tpm1_v2(gene name synonym)|uniprotkb:Tpm1_v3(gene name synonym)|uniprotkb:Tpm1_v4(gene name synonym)|uniprotkb:Tpm1_v7(gene name synonym)|uniprotkb:Tpm1_v8(gene name synonym)|uniprotkb:rCG_56696(orf name)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	interpro:IPR000533(Tropomyosin)|refseq:NP_001029241.1|refseq:NP_001029242.1|refseq:NP_001029243.1|refseq:NP_001029245.1|refseq:NP_001029246.1|refseq:NP_062004.1|rgd:3898|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:W6x8rRifQrk6Wlyuh9lcb+YTwZk10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q63607	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374885|ensembl:ENSRNOP00000054446	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q63607_rat(display_long)|uniprotkb:rCG_56696(orf name)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:alpha-tropomyosin 3(gene name synonym)|uniprotkb:Tpm1_v3(gene name synonym)|uniprotkb:Tpm1_v4(gene name synonym)|uniprotkb:Tpm1_v1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_001029240.1|refseq:NP_001029242.1|refseq:NP_001029243.1|rgd:3898|ensembl:ENSRNOG00000018184(gene)|ensembl:ENSRNOT00000057641(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|interpro:IPR000533(Tropomyosin)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:B5hJTs3FvNPUaxPlolau+0+bS4s10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P31000	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-368510	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:vime_rat(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046697"(decidualization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|rgd:621646|refseq:NP_112402.1|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|interpro:IPR027699|interpro:IPR039008|reactome:R-RNO-264870|reactome:R-RNO-390522|reactome:R-RNO-9013422|reactome:R-RNO-9646399|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0009314"(response to radiation)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|go:"GO:0032355"(response to estradiol)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033280"(response to vitamin D)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0010043"(response to zinc ion)|mint:P31000|dip:DIP-31882N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:gXqxWYjgPhNbQNfJNwdt/Q4D4u010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q91XN6	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374874|ensembl:ENSRNOP00000024493	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q91xn6_rat(display_long)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Tpm1_v5(gene name synonym)|uniprotkb:rCG_56696(orf name)|uniprotkb:Tpm1_v1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_001029240.1|refseq:NP_001029244.1|rgd:3898|ensembl:ENSRNOG00000018184(gene)|ensembl:ENSRNOT00000024493(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005856"(cytoskeleton)|interpro:IPR000533(Tropomyosin)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:IxlyCO6oY7N00MmrOBj7Xt661WM10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P62142	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-352326|ensembl:ENSRNOP00000006190|uniprotkb:P37140	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:pp1b_rat(display_long)|uniprotkb:Ppp1cb(gene name)|psi-mi:Ppp1cb(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000004612(gene)|ensembl:ENSRNOT00000006190(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0005981"(regulation of glycogen catabolic process)|rgd:3376|refseq:NP_037197.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0017018"(myosin phosphatase activity)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016791"(phosphatase activity)|go:"GO:0042587"(glycogen granule)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0046872"(metal ion binding)|go:"GO:0050115"(myosin-light-chain-phosphatase activity)|go:"GO:0051301"(cell division)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|interpro:IPR031675|reactome:R-RNO-2565942|reactome:R-RNO-5625740|reactome:R-RNO-5627123|reactome:R-RNO-5673000|go:"GO:0032922"(circadian regulation of gene expression)|refseq:XP_008762727.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:VtNJVyimeiEuRDDWtGswTqoSOH810116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P08592	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-286155|uniprotkb:Q547B7|ensembl:ENSRNOP00000041613	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:a4_rat(display_long)|uniprotkb:Alzheimer disease amyloid A4 protein homolog(gene name synonym)|uniprotkb:ABPP(gene name synonym)|uniprotkb:Amyloidogenic glycoprotein(gene name synonym)|uniprotkb:App(gene name)|psi-mi:App(display_short)|uniprotkb:Amyloid precursor protein(gene name synonym)|uniprotkb:A4(gene name synonym)|uniprotkb:AD1(gene name synonym)|uniprotkb:Alzheimer disease amyloid protein(gene name synonym)|uniprotkb:"Amyloid-beta (A4) precursor protein"(gene name synonym)|uniprotkb:Amyloid-beta A4 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:2139|refseq:NP_062161.1|dip:DIP-618N|refseq:XP_006248073.1|ensembl:ENSRNOG00000006997(gene)|ensembl:ENSRNOT00000048854(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001878"(response to yeast)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001967"(suckling behavior)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006878"(cellular copper ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007155"(cell adhesion)|go:"GO:0007176"(regulation of epidermal growth factor-activated receptor activity)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007617"(mating behavior)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008201"(heparin binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008542"(visual learning)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0009987"(cellular process)|go:"GO:0010288"(response to lead ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014005"(microglia development)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016199"(axon midline choice point recognition)|go:"GO:0016322"(neuron remodeling)|go:"GO:0016358"(dendrite development)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0019731"(antibacterial humoral response)|go:"GO:0019732"(antifungal humoral response)|go:"GO:0019899"(enzyme binding)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0044304"(main axon)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048143"(astrocyte activation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048669"(collateral sprouting in absence of injury)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0050803"(regulation of synapse structure or activity)|go:"GO:0050808"(synapse organization)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050890"(cognition)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051124"(synaptic assembly at neuromuscular junction)|go:"GO:0051233"(spindle midzone)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051563"(smooth endoplasmic reticulum calcium ion homeostasis)|go:"GO:0055037"(recycling endosome)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071874"(cellular response to norepinephrine stimulus)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904472"(positive regulation of endothelin production)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:1905908"(positive regulation of amyloid fibril formation)|go:"GO:1905945"(regulation of response to calcium ion)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990535"(neuron projection maintenance)|go:"GO:1990761"(growth cone lamellipodium)|go:"GO:1990812"(growth cone filopodium)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR008154(Amyloidogenic glycoprotein, extracellular)|interpro:IPR008155(Amyloidogenic glycoprotein, core)|interpro:IPR011178(Amyloidogenic glycoprotein, copper-binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013803(Amyloidogenic glycoprotein, amyloid-beta peptide)|interpro:IPR015849(Amyloidogenic glycoprotein, heparin-binding)|interpro:IPR019543|interpro:IPR019744|interpro:IPR019745|interpro:IPR020901|interpro:IPR024329|interpro:IPR028866|interpro:IPR036176|interpro:IPR036454|interpro:IPR036669|interpro:IPR036880|rcsb pdb:1M7E|rcsb pdb:1NMJ|rcsb pdb:1OQN|rcsb pdb:2LI9|reactome:R-RNO-114608|reactome:R-RNO-3000178|reactome:R-RNO-381426|reactome:R-RNO-416476|reactome:R-RNO-418594|reactome:R-RNO-432720|reactome:R-RNO-444473|reactome:R-RNO-445989|reactome:R-RNO-879415|reactome:R-RNO-8957275|reactome:R-RNO-933542|reactome:R-RNO-9609523	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:/f/w3G/V2dxj5IHJPl5kd2xTD6c10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q05140	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374805	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ap180_rat(display_long)|uniprotkb:Snap91(gene name)|psi-mi:Snap91(display_short)|uniprotkb:Clathrin coat-associated protein AP180(gene name synonym)|uniprotkb:91 kDa synaptosomal-associated protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:69276|refseq:NP_113916.1|interpro:IPR011417(ANTH)|interpro:IPR014712(Clathrin adaptor, phosphoinositide-binding, GAT-like)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q05140|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098830"(presynaptic endosome)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098894"(extrinsic component of presynaptic endocytic zone membrane)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|go:"GO:1900275"(negative regulation of phospholipase C activity)|go:"GO:1904006"(negative regulation of phospholipase D activity)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000331"(regulation of terminal button organization)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|reactome:R-RNO-8856825|reactome:R-RNO-8856828|go:"GO:0000149"(SNARE binding)|go:"GO:0000822"(inositol hexakisphosphate binding)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016185"(synaptic vesicle budding from presynaptic endocytic zone membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043679"(axon terminus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0048666"(neuron development)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0051899"(membrane depolarization)|interpro:IPR030428	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:LXxIlR8jL+mLJ94McATz+sj4xF410116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P04692	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374736|uniprotkb:P06469|uniprotkb:P18342|uniprotkb:P18343|uniprotkb:P18344|uniprotkb:P19354|uniprotkb:Q53X09|uniprotkb:Q63582|uniprotkb:Q63608|uniprotkb:Q63609|ensembl:ENSRNOP00000048499	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:tpm1_rat(display_long)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Alpha-tm(gene name synonym)|uniprotkb:Tpma(gene name synonym)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:3898|refseq:NP_001029241.1|refseq:NP_001029244.1|refseq:NP_001029245.1|refseq:NP_001029246.1|refseq:NP_001029247.1|refseq:NP_062004.1|refseq:NP_001288265.1|refseq:NP_001288665.1|dip:DIP-29020N|ensembl:ENSRNOG00000018184(gene)|ensembl:ENSRNOT00000048044(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0003065"(positive regulation of heart rate by epinephrine)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032059"(bleb)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051693"(actin filament capping)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000533(Tropomyosin)|rcsb pdb:1IHQ|rcsb pdb:1MV4|rcsb pdb:1TMZ|rcsb pdb:2B9C|rcsb pdb:2G9J|rcsb pdb:3AZD|reactome:R-RNO-390522|reactome:R-RNO-445355	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:d/imATvus0XZvr7i//2MtbXZ7Pw10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q5U303	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374716|ensembl:ENSRNOP00000021904	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:tab2_rat(display_long)|uniprotkb:Map3k7ip2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym)|uniprotkb:Tab2(gene name)|psi-mi:Tab2(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1309527|refseq:NP_001012062.1|ensembl:ENSRNOG00000016054(gene)|ensembl:ENSRNOT00000021905(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|reactome:R-RNO-168638|reactome:R-RNO-202424|reactome:R-RNO-2871837|reactome:R-RNO-445989|reactome:R-RNO-450302|reactome:R-RNO-450321|reactome:R-RNO-5357956|reactome:R-RNO-5607764|reactome:R-RNO-9020702|reactome:R-RNO-937042|reactome:R-RNO-9645460|reactome:R-RNO-975163	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:JAc7lOcfhGkUzR4VGy0s4IDfHlM10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q5XID1	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374711|ensembl:ENSRNOP00000021769	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:cpin1_rat(display_long)|uniprotkb:Ciapin1(gene name)|psi-mi:Ciapin1(display_short)|uniprotkb:Cytokine-induced apoptosis inhibitor 1(gene name synonym)|uniprotkb:Fe-S cluster assembly protein DRE2 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1549737|refseq:NP_001007690.1|refseq:XP_006255168.1|refseq:XP_006255169.1|refseq:XP_006255170.1|ensembl:ENSRNOG00000016234(gene)|ensembl:ENSRNOT00000021769(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006915"(apoptotic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0030097"(hemopoiesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR007785(Protein of unknown function DUF689)|interpro:IPR029063	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:jtdu8+bhxaDPNVzsR6dbS2bYeGc10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:O35552	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-710340|uniprotkb:O35096|uniprotkb:O35553|uniprotkb:O35554|uniprotkb:O35555|uniprotkb:O35556|uniprotkb:O35557|uniprotkb:Q9QWQ5|uniprotkb:Q9QWQ6|ensembl:ENSRNOP00000062965	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:f263_rat(display_long)|uniprotkb:6PF-2-K/Fru-2,6-P2ase brain-type isozyme(gene name synonym)|uniprotkb:RB2K(gene name synonym)|uniprotkb:Pfkfb3(gene name)|psi-mi:Pfkfb3(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSRNOG00000018911(gene)|ensembl:ENSRNOT00000068354(transcript)|go:"GO:0003873"(6-phosphofructo-2-kinase activity)|go:"GO:0004331"(fructose-2,6-bisphosphate 2-phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006003"(fructose 2,6-bisphosphate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0007420"(brain development)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR003094(Fructose-2,6-bisphosphatase)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR013079(6-phosphofructo-2-kinase)|interpro:IPR027417|interpro:IPR029033|reactome:R-RNO-9634600|rgd:619776|refseq:NP_476476.1|refseq:XP_006254254.1|refseq:XP_006254255.1|refseq:XP_006254258.1|refseq:XP_006254259.1|refseq:XP_006254260.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:+NT0ohNpQfdbQt57aS/1v4BOHCs10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q64620	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1187315|uniprotkb:Q6AZ47|ensembl:ENSRNOP00000021176	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:ppp6_rat(display_long)|uniprotkb:Protein phosphatase V(gene name synonym)|uniprotkb:Ppp6c(gene name)|psi-mi:Ppp6c(display_short)|uniprotkb:Ppv(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:708460|refseq:NP_598273.2|ensembl:ENSRNOG00000015145(gene)|ensembl:ENSRNOT00000021176(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR029052|mint:Q64620|reactome:R-RNO-171319|reactome:R-RNO-204005	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:R0jsZoqJLoRaSNMNCLRkQ40CC+o10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q6P6U2	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374652|ensembl:ENSRNOP00000015757	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q6p6u2_rat(display_long)|uniprotkb:rCG_27374(orf name)|uniprotkb:Psmc3(gene name)|psi-mi:Psmc3(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:61905|refseq:NP_113783.1|ensembl:ENSRNOG00000011414(gene)|ensembl:ENSRNOT00000015757(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030163"(protein catabolic process)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:8njcru3CI0vk4dpAV5oY7Z2Kuk010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q700K0	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374690|ensembl:ENSRNOP00000037189	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:sspo_rat(display_long)|uniprotkb:Sspo(gene name)|psi-mi:Sspo(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1549716|refseq:NP_001007017.1|ensembl:ENSRNOG00000025848(gene)|ensembl:ENSRNOT00000035906(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007155"(cell adhesion)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031012"(extracellular matrix)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR001846(von Willebrand factor, type D)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002919(Protease inhibitor I8, cysteine-rich trypsin inhibitor-like)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR014853(Region of unknown function DUF1787)|interpro:IPR023415|interpro:IPR030119|interpro:IPR036055|interpro:IPR036084|interpro:IPR036383|reactome:R-RNO-5173214	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:JXPZkL1mfjiEL3SWVJ3lvTY2N8k10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q2TVU3	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374821	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q2tvu3_rat(display_long)|uniprotkb:Dnaja3(gene name)|psi-mi:Dnaja3(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	refseq:NP_001033685.1|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|rgd:1306527|interpro:IPR036410|interpro:IPR036869|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:jQDmSX0FHPMxnxRaKKjtVlURFcg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q9WU10	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374666	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q9wu10_rat(display_long)|uniprotkb:Fath(gene name synonym)|uniprotkb:Fat1(gene name)|psi-mi:Fat1(display_short)|uniprotkb:Fat(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:621254|refseq:NP_114007.1|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR001791(Laminin G)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003412"(establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030175"(filopodium)|go:"GO:0031252"(cell leading edge)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0098609"(cell-cell adhesion)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:KwTpGyq6PmNHMeT6l3vtpUxs4lE10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q9Z0Z2	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374616	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q9z0z2_rat(display_long)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	-	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:aZbu4dn0ZFM9Jrh3WARB5DMm7wI10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q9Z1P3	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-78982|uniprotkb:Q6AYY5|uniprotkb:Q9R289	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:mcl1_rat(display_long)|uniprotkb:Mcl1(gene name)|psi-mi:Mcl1(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0034097"(response to cytokine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051400"(BH domain binding)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0097136"(Bcl-2 family protein complex)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1903378"(positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2001020"(regulation of response to DNA damage stimulus)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|rgd:620525|refseq:NP_068618.2|interpro:IPR013281(Apoptosis regulator, Mcl-1)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR020717|interpro:IPR020726|interpro:IPR020728|interpro:IPR026298|interpro:IPR036834	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:qzZ1RBTNrN2Kn1BO+9O32U2ghjg10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q6IMX7	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374445|uniprotkb:Q9JLF4|ensembl:ENSRNOP00000024251	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:hpbp1_rat(display_long)|uniprotkb:Hspbp1(gene name)|psi-mi:Hspbp1(display_short)|uniprotkb:Hspbp(gene name synonym)|uniprotkb:Heat shock protein-binding protein 1(gene name synonym)|uniprotkb:Hsp70-interacting protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:628677|refseq:NP_640354.1|refseq:XP_006228310.1|refseq:XP_006228311.1|refseq:XP_006228312.1|ensembl:ENSRNOG00000017795(gene)|ensembl:ENSRNOT00000024251(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013918(Nucleotide exchange factor Fes1)|interpro:IPR016024(Armadillo-type fold)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:oU/Xo9THDVz3LHAgnvdeTQb3FoI10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:O88550	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374324|ensembl:ENSRNOP00000075193	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:o88550_rat(display_long)|uniprotkb:rCG_57538(orf name)|uniprotkb:Casp7(gene name)|psi-mi:Casp7(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:620944|refseq:NP_071596.1|refseq:XP_008758768.1|ensembl:ENSRNOG00000056216(gene)|ensembl:ENSRNOT00000080511(transcript)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016485"(protein processing)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0071887"(leukocyte apoptotic process)|go:"GO:0072734"(cellular response to staurosporine)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015471(Caspase-7)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|reactome:R-RNO-111459|reactome:R-RNO-111463|reactome:R-RNO-111464|reactome:R-RNO-111465|reactome:R-RNO-111469|reactome:R-RNO-264870	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:GCELtQAB9p5izDghtczR/r2h17010116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q5XIP0	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-920407|uniprotkb:F1LNN0|ensembl:ENSRNOP00000017381|ensembl:ENSRNOP00000075386	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:q5xip0_rat(display_long)|uniprotkb:Dnajb4(gene name)|psi-mi:Dnajb4(display_short)|uniprotkb:rCG_28476(orf name)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:1305826|refseq:NP_001013094.1|refseq:XP_008759772.1|refseq:XP_006233550.1|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|ensembl:ENSRNOG00000013011(gene)|ensembl:ENSRNOT00000017381(transcript)|ensembl:ENSRNOT00000086878(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:mvXSDlVog9Y+VG/Cb+t6EPzzmMM10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q920D5	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374296	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:caspc_rat(display_long)|uniprotkb:Casp12(gene name)|psi-mi:Casp12(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:621758|refseq:NP_569106.1|dip:DIP-29839N|go:"GO:0001554"(luteolysis)|go:"GO:0002020"(protease binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009409"(response to cold)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0010041"("response to iron(III) ion")|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010663"(positive regulation of striated muscle cell apoptotic process)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0034059"(response to anoxia)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035094"(response to nicotine)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0072557"(IPAF inflammasome complex)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0097169"(AIM2 inflammasome complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097264"(self proteolysis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR035713	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:r83mkgvMdRYHvUN6CwWkSnhjaTM10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P13941	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-1374361|uniprotkb:O70604|uniprotkb:Q5PQT6|ensembl:ENSRNOP00000004956	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:co3a1_rat(display_long)|uniprotkb:Col3a1(gene name)|psi-mi:Col3a1(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:71029|refseq:NP_114474.1|ensembl:ENSRNOG00000003357(gene)|ensembl:ENSRNOT00000004956(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001568"(blood vessel development)|go:"GO:0002020"(protease binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005581"(collagen trimer)|go:"GO:0005586"(collagen type III trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0034097"(response to cytokine)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048407"(platelet-derived growth factor binding)|go:"GO:0048565"(digestive tract development)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097435"(supramolecular fiber organization)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR008160(Collagen triple helix repeat)|mint:P13941|reactome:R-RNO-1442490|reactome:R-RNO-1474244|reactome:R-RNO-1650814|reactome:R-RNO-186797|reactome:R-RNO-198933|reactome:R-RNO-2022090|reactome:R-RNO-216083|reactome:R-RNO-3000171|reactome:R-RNO-3000178|reactome:R-RNO-419037|reactome:R-RNO-8874081|reactome:R-RNO-8948216	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:oVdVAcqVlcJuQJYPRDa+nzAVjyI10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P13645	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:z100yyq3b63P0ARy2lE2ELyJeik9606	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:P48679	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-917618	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:lmna_rat(display_long)|uniprotkb:Lmna(gene name)|psi-mi:Lmna(display_short)|uniprotkb:Lmn1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:620456|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|mint:P48679|interpro:IPR039008|interpro:IPR036415|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005638"(lamin filament)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035861"(site of double-strand break)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090398"(cellular senescence)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1904178"(negative regulation of adipose tissue development)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|reactome:R-RNO-352238|reactome:R-RNO-4419969	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:WBZq/9WdHqQmDRy0uyBn0AZjvY810116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:P16599	uniprotkb:Q9JLT6	intact:EBI-1374150|uniprotkb:Q6EE11|uniprotkb:Q9JI26|uniprotkb:Q9JI27|ensembl:ENSRNOP00000001110|ensembl:ENSRNOP00000074520	intact:EBI-822515|uniprotkb:Q9JK60|ensembl:ENSRNOP00000016776	psi-mi:tnfa_rat(display_long)|uniprotkb:TNF-alpha(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 2(gene name synonym)|uniprotkb:Cachectin(gene name synonym)|uniprotkb:Tnf(gene name)|psi-mi:Tnf(display_short)|uniprotkb:Tnfa(gene name synonym)|uniprotkb:Tnfsf2(gene name synonym)	psi-mi:bid_rat(display_long)|uniprotkb:p22 BID(gene name synonym)|uniprotkb:Bid(gene name)|psi-mi:Bid(display_short)	psi-mi:"MI:0096"(pull down)	Freed et al. (2007)	imex:IM-12051|pubmed:17623297	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1374179|imex:IM-12051-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_008770997.1|rgd:3876|refseq:NP_036807.1|dip:DIP-39461N|go:"GO:0001666"(response to hypoxia)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001775"(cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0002037"(negative regulation of L-glutamate import across plasma membrane)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002876"(positive regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002925"(positive regulation of humoral immune response mediated by circulating immunoglobulin)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010693"(negative regulation of alkaline phosphatase activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014823"(response to activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030730"(sequestering of triglyceride)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032724"(positive regulation of fractalkine production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043068"(positive regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043243"(positive regulation of protein-containing complex disassembly)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045994"(positive regulation of translational initiation by iron)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0050995"(negative regulation of lipid catabolic process)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051173"(positive regulation of nitrogen compound metabolic process)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060557"(positive regulation of vitamin D biosynthetic process)|go:"GO:0060559"(positive regulation of calcidiol 1-monooxygenase activity)|go:"GO:0060664"(epithelial cell proliferation involved in salivary gland morphogenesis)|go:"GO:0060693"(regulation of branching involved in salivary gland morphogenesis)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0061044"(negative regulation of vascular wound healing)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0061048"(negative regulation of branching involved in lung morphogenesis)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071219"(cellular response to molecule of bacterial origin)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0048566"(embryonic digestive tract development)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0097421"(liver regeneration)|go:"GO:0097527"(necroptotic signaling pathway)|go:"GO:0120190"(negative regulation of bile acid secretion)|go:"GO:0140460"(response to Gram-negative bacterium)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0150129"(positive regulation of interleukin-33 production)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901554"(response to paracetamol)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902565"(positive regulation of neutrophil activation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1904999"(positive regulation of leukocyte adhesion to arterial endothelial cell)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|go:"GO:1990268"(response to gold nanoparticle)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:2000334"(positive regulation of blood microparticle formation)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000351"(regulation of endothelial cell apoptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001272"(positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR002959(Tumour necrosis factor alpha/cachectin)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-RNO-5357786|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-5626978|reactome:R-RNO-5668541|reactome:R-RNO-75893|ensembl:ENSRNOG00000000837(gene)|ensembl:ENSRNOG00000055156(gene)|ensembl:ENSRNOT00000001110(transcript)|ensembl:ENSRNOT00000079677(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009314"(response to radiation)|go:"GO:0009612"(response to mechanical stimulus)	rgd:620160|refseq:NP_073175.1|refseq:XP_017448369.1|ensembl:ENSRNOG00000012439(gene)|ensembl:ENSRNOT00000016776(transcript)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002931"(response to ischemia)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007420"(brain development)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034263"(positive regulation of autophagy in response to ER overload)|go:"GO:0034349"(glial cell apoptotic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR010479(BH3 interacting)|interpro:IPR020728|interpro:IPR036834|reactome:R-RNO-111447|reactome:R-RNO-111452|reactome:R-RNO-111453|reactome:R-RNO-114294|reactome:R-RNO-75108	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supplementary Table 1|caution:"The participant EBI-1374845(Q63610) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-1572071() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Synapse - Interactions of proteins with an established role in the presynapse.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-heart)|taxid:10116(Rattus norvegicus heart)	-	2007/07/25	2019/11/15	rogid:Uv5VE94PVLHYZdPGRzLyEXiV1xA10116	rogid:nzijwPOczepjBKOQ7SJDdUktOQM10116	intact-crc:7F9FE27BE55CC097	false	biotin tag:n-n	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)