#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04657	uniprotkb:Q9VFJ3	intact:EBI-139169|uniprotkb:Q9VJJ4|ensemblmetazoa:FBpp0080445|ensemblmetazoa:FBpp0307140	intact:EBI-86306|ensemblmetazoa:FBpp0082446|ensemblmetazoa:FBpp0303078	psi-mi:cyc1_drome(display_long)|uniprotkb:Cyt-c-d(gene name)|psi-mi:Cyt-c-d(display_short)|uniprotkb:CytC1(gene name synonym)|uniprotkb:DC3(gene name synonym)|uniprotkb:CG13263(orf name)|uniprotkb:Cytochrome c-distal(gene name synonym)	psi-mi:htra2_drome(display_long)|uniprotkb:CG8464(orf name)|uniprotkb:Omi/HtrA2(gene name synonym)|uniprotkb:HtrA2(gene name)|psi-mi:HtrA2(display_short)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Challa et al. (2007)	pubmed:17557079|imex:IM-10840|mint:MINT-5220003	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7449920|mint:MINT-5114840|imex:IM-10840-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477164.1|flybase:FBgn0086907|refseq:NP_001260509.1|dip:DIP-21160N|ensemblmetazoa:FBgn0086907(gene)|ensemblmetazoa:FBtr0080888(transcript)|ensemblmetazoa:FBtr0335141(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|go:"GO:0006123"(mitochondrial electron transport, cytochrome c to oxygen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007291"(sperm individualization)|go:"GO:0009055"(electron transfer activity)|go:"GO:0020037"(heme binding)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0046669"(regulation of compound eye retinal cell programmed cell death)|go:"GO:0046872"(metal ion binding)|go:"GO:0070469"(respirasome)|interpro:IPR002327(Cytochrome c, class IA/ IB)|interpro:IPR009056(Cytochrome c, monohaem)|interpro:IPR036909|mint:P04657|mint:MINT-5114852(identity)	refseq:NP_650366.1|flybase:FBgn0038233|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|mint:Q9VFJ3|interpro:IPR001478(PDZ/DHR/GLGF)|ensemblmetazoa:FBgn0038233(gene)|ensemblmetazoa:FBtr0082987(transcript)|ensemblmetazoa:FBtr0330045(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016006"(Nebenkern)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017171"(serine hydrolase activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|refseq:NP_001262565.1|dip:DIP-23879N|mint:MINT-5114841(identity)	go:"GO:0005739"(mitochondrion)	-	-	figure legend:F2B|comment:organelles|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2007/09/17	2014/10/16	rogid:w+jmVu2+jbmx7tURpWtGG0+6ITI7227	rogid:zCCcAb59la0gTdyw3bZOTiUI7/k7227	intact-crc:8C2B48167ADA3732|rigid:NE1uGxvFX+ZYGBuO7MWOX3TdiS0	false	-	myc tag:?-?(MINT-5114846)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)
uniprotkb:Q9VFJ3	uniprotkb:Q24306	intact:EBI-86306|ensemblmetazoa:FBpp0082446|ensemblmetazoa:FBpp0303078	intact:EBI-456419|uniprotkb:A4V1Z9|uniprotkb:Q0E8E4|uniprotkb:Q8MRM5|uniprotkb:Q9VUX5|uniprotkb:A9UN33|ensemblmetazoa:FBpp0075254|ensemblmetazoa:FBpp0075255|ensemblmetazoa:FBpp0075256|ensemblmetazoa:FBpp0305793|ensemblmetazoa:FBpp0305794|ensemblmetazoa:FBpp0305795	psi-mi:htra2_drome(display_long)|uniprotkb:CG8464(orf name)|uniprotkb:Omi/HtrA2(gene name synonym)|uniprotkb:HtrA2(gene name)|psi-mi:HtrA2(display_short)|uniprotkb:High temperature requirement protein A2(gene name synonym)|uniprotkb:Omi stress-regulated endoprotease(gene name synonym)	psi-mi:diap1_drome(display_long)|uniprotkb:Diap1(gene name)|psi-mi:Diap1(display_short)|uniprotkb:Apoptosis 1 inhibitor(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase th(gene name synonym)|uniprotkb:Iap1(gene name synonym)|uniprotkb:Inhibitor of apoptosis 1(gene name synonym)|uniprotkb:Protein thread(gene name synonym)|uniprotkb:th(gene name synonym)|uniprotkb:CG12284(orf name)|uniprotkb:RING-type E3 ubiquitin transferase Diap1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Challa et al. (2007)	pubmed:17557079|imex:IM-10840|mint:MINT-5220003	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7449962|mint:MINT-5114857|imex:IM-10840-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_650366.1|flybase:FBgn0038233|interpro:IPR001940(Peptidase S1C, HrtA/DegP2/Q/S)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036034|mint:Q9VFJ3|interpro:IPR001478(PDZ/DHR/GLGF)|ensemblmetazoa:FBgn0038233(gene)|ensemblmetazoa:FBtr0082987(transcript)|ensemblmetazoa:FBtr0330045(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008233"(peptidase activity)|go:"GO:0016006"(Nebenkern)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017171"(serine hydrolase activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0035234"(ectopic germ cell programmed cell death)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|refseq:NP_001262565.1|dip:DIP-23879N|mint:MINT-5114859(identity)	refseq:NP_524101.2|refseq:NP_730097.1|refseq:NP_730098.1|flybase:FBgn0260635|refseq:NP_001261916.1|refseq:NP_001261917.1|refseq:NP_001261918.1|go:"GO:0006915"(apoptotic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007289"(spermatid nucleus differentiation)|go:"GO:0007298"(border follicle cell migration)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0022416"(chaeta development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0045035"(sensory organ precursor cell division)|go:"GO:0045116"(protein neddylation)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046673"(negative regulation of compound eye retinal cell programmed cell death)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048800"(antennal morphogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0089720"(caspase binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|go:"GO:1903688"(positive regulation of border follicle cell migration)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|ensemblmetazoa:FBgn0260635(gene)|ensemblmetazoa:FBtr0075499(transcript)|ensemblmetazoa:FBtr0075500(transcript)|ensemblmetazoa:FBtr0075501(transcript)|ensemblmetazoa:FBtr0333617(transcript)|ensemblmetazoa:FBtr0333618(transcript)|ensemblmetazoa:FBtr0333619(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|mint:Q24306|rcsb pdb:1JD4|rcsb pdb:1JD5|rcsb pdb:1JD6|rcsb pdb:1Q4Q|rcsb pdb:1SDZ|rcsb pdb:1SE0|rcsb pdb:3SIP|rcsb pdb:3SIQ|reactome:R-DME-111465|reactome:R-DME-111469|reactome:R-DME-3769402|reactome:R-DME-390150|reactome:R-DME-5675482|reactome:R-DME-8948747|reactome:R-DME-8948751|mint:MINT-5114865(identity)	-	-	-	figure legend:F6B|figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/17	2014/10/16	rogid:zCCcAb59la0gTdyw3bZOTiUI7/k7227	rogid:loBQ//cKQ1NYhq3gnIKwRBn5vZg7227	intact-crc:855668F584C024F0|rigid:gTAEOZPg85q3UpR325NMgceVn/M	false	-	binding-associated region:229-294(MINT-5114880)|glutathione s tranferase tag:?-?(MINT-5114870)	-	-	psi-mi:"MI:0709"(polyclonal antibody immunostaining)	psi-mi:"MI:0396"(predetermined participant)