#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O97758	uniprotkb:Q920E1	intact:EBI-6988333|intact:MINT-1778189	intact:EBI-7400377|intact:MINT-4953365	psi-mi:zo1_canlf(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym)	psi-mi:par3_rat(display_long)|uniprotkb:F2rl2(gene name)|psi-mi:F2rl2(display_short)|uniprotkb:Par3(gene name synonym)|uniprotkb:Thrombin receptor-like 2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 2(gene name synonym)	psi-mi:"MI:0428"(imaging technique)	Feng et al. (2007)	pubmed:17476308|imex:IM-10917|mint:MINT-5219905	taxid:9615(canlf)|taxid:9615("Canis familiaris (dog)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7400368|mint:MINT-4953380|imex:IM-10917-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR035597|go:"GO:0005516"(calmodulin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0009986"(cell surface)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0070160"(tight junction)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|refseq:NP_001003140.1|mint:O97758|interpro:IPR036028|interpro:IPR036034|mint:MINT-4953386(identity)	mint:Q920E1|refseq:NP_445765.1|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rgd:620871|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0009611"(response to wounding)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|reactome:R-RNO-375276|reactome:R-RNO-416476|reactome:R-RNO-456926|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR003943(Protease-activated receptor 3)|mint:MINT-4953381(identity)	go:"GO:0005886"(plasma membrane)	comment:mint|function:The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions	comment:mint|function:Receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis	figure legend:F6A|comment:organelles|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9615(canlf-mdck)|taxid:9615("Canis familiaris (dog) kidney epithelial cells")	-	2007/09/04	2014/10/16	rogid:ahJn9QpY395wArDFwZ2FwDxf6s89615	rogid:8k/ECGhGyyVXKzhe7Gr3mz1c+n410116	intact-crc:BD80919D7E7E341A|rigid:ysFpJTZLgnggst5xqIcKr/KE1KE	false	-	green fluorescent protein tag:?-?(MINT-4953391)|mutation disrupting interaction:13-13(MINT-4953396)|mutation disrupting interaction:70-70(MINT-4953399)	-	-	psi-mi:"MI:0661"(experimental participant identification)	psi-mi:"MI:0661"(experimental participant identification)