#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31424	uniprotkb:O88382	intact:EBI-2902734	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7361987|mint:MINT-4790445|imex:IM-11341-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-4790452(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-4790446(identity)	-	-	-	figure legend:F1E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/05	2014/10/16	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:F2D26D34A15DD0C8|rigid:Uc54D+UlEEyvuLwZTaVcGTcCtCs	false	flag tag:?-?(MINT-4790455)	myc tag:?-?(MINT-4790449)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8R4T5	uniprotkb:P31424	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-2902734	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7361910|mint:MINT-4790427|imex:IM-11341-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790429(identity)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-4790428(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	-	figure legend:F1E|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:E65089F2B9615E42|rigid:s4mm8r+3TThIioiMnhD9ZywjAe4	false	myc tag:?-?(MINT-4790439)	flag tag:?-?(MINT-4790433)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R4T5	uniprotkb:P31424	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-2902734	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362026|mint:MINT-4790479|imex:IM-11341-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790480(identity)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-4790486(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	-	figure legend:F1E|figure legend:SF2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:3CB11045336B997E|rigid:s4mm8r+3TThIioiMnhD9ZywjAe4	false	myc tag:?-?(MINT-4790481)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8R4T5	uniprotkb:O88382	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-696179|uniprotkb:Q9R271	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:magi2_rat(display_long)|uniprotkb:Membrane-associated guanylate kinase inverted 2(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 1(gene name synonym)|uniprotkb:Synaptic-scaffolding molecule(gene name synonym)|uniprotkb:Sscam(gene name synonym)|uniprotkb:Magi2(gene name)|psi-mi:Magi2(display_short)|uniprotkb:Acvrinp1(gene name synonym)|uniprotkb:Aip1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362006|mint:MINT-4790463|imex:IM-11341-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790464(identity)	rgd:621855|refseq:NP_446073.1|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR030036|interpro:IPR027417|mint:O88382|interpro:IPR036020|interpro:IPR036034|go:"GO:0043113"(receptor clustering)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070697"(activin receptor binding)|go:"GO:0070699"(type II activin receptor binding)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0097118"(neuroligin clustering involved in postsynaptic membrane assembly)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000809"(positive regulation of synaptic vesicle clustering)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003094"(glomerular filtration)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019894"(kinesin binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032926"(negative regulation of activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0038180"(nerve growth factor signaling pathway)|mint:MINT-4790470(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	-	figure legend:F1E|figure legend:SF2A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:aZhWv5f2U8vKQoE9oFMfsQ8rgvQ10116	intact-crc:03CBEFD28360BA6B|rigid:SADbwYVyVZRF2C4hUoNQ//ZJugM	false	myc tag:?-?(MINT-4790465)	flag tag:?-?(MINT-4790471)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8R4T5	uniprotkb:P31424	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-2902734	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362068|mint:MINT-4790500|imex:IM-11341-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790505(identity)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-4790501(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	-	figure legend:F2B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:2741753BF28AD520|rigid:s4mm8r+3TThIioiMnhD9ZywjAe4	false	tag:?-?(MINT-4790508)|binding-associated region:1-210(MINT-4790515)	tag:?-?(MINT-4790518)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R4T5	uniprotkb:Q8R4T5	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362091|mint:MINT-4790521|imex:IM-11341-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790528(identity)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790522(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	figure legend:F2C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	intact-crc:1A198EECD990531C|rigid:xDEKw0AqKvzWZJeHSx80c1Vrtbw	false	tag:?-?(MINT-4790529)|binding-associated region:96-394(MINT-4790531)	tag:?-?(MINT-4790523)|binding-associated region:96-394(MINT-4790540)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R4T5	uniprotkb:Q8R4T5	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362128|mint:MINT-4790544|imex:IM-11341-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790553(identity)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790553(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"|comment:"Stoichiometry: 2.0"	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"|comment:"Stoichiometry: 2.0"	figure legend:F4|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	intact-crc:B2C531EC0DB86941|rigid:QmFGuCJI8iG2Xx27ImcvAE9aY6Q	false	binding-associated region:96-198(MINT-4790556)	binding-associated region:96-198(MINT-4790556)	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R4T5	uniprotkb:P31424	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-2902734	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362143|mint:MINT-4790569|imex:IM-11341-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790576(identity)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-4790570(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"|comment:"Stoichiometry: 2.0"	comment:"Stoichiometry: 2.0"	figure legend:F7A|figure legend:F7B|figure legend:F7C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:123A6033F39AED78|rigid:s4mm8r+3TThIioiMnhD9ZywjAe4	false	binding-associated region:96-198(MINT-4790579)	binding-associated region:c-c(MINT-4790593)	2	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8R4T5	uniprotkb:P31424	intact:EBI-7361884|intact:MINT-1790327|ensembl:ENSRNOP00000009979	intact:EBI-2902734	psi-mi:grasp_rat(display_long)|uniprotkb:Tamalin(gene name)|psi-mi:Tamalin(display_short)|uniprotkb:95 kDa postsynaptic density protein discs-large ZO-1 domain-containing protein(gene name synonym)|uniprotkb:Grasp(gene name synonym)|uniprotkb:PSD-95 PDZ domain-containing protein(gene name synonym)|uniprotkb:Tamalin(gene name synonym)	psi-mi:grm5_rat(display_long)|uniprotkb:Grm5(gene name)|psi-mi:Grm5(display_short)|uniprotkb:Gprc1e(gene name synonym)|uniprotkb:Mglur5(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Sugi et al. (2007)	pubmed:17396155|imex:IM-11341|mint:MINT-5219822	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7362193|mint:MINT-4790596|imex:IM-11341-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:70554|refseq:NP_620249.1|ensembl:ENSRNOG00000007346(gene)|ensembl:ENSRNOT00000009979(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008104"(protein localization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR036034|mint:Q8R4T5|rcsb pdb:2EGK|rcsb pdb:2EGN|rcsb pdb:2EGO|mint:MINT-4790602(identity)	go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001639"(PLC activating G protein-coupled glutamate receptor activity)|go:"GO:0001640"(adenylate cyclase inhibiting G protein-coupled glutamate receptor activity)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002029"(desensitization of G protein-coupled receptor signaling pathway)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006448"(regulation of translational elongation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007206"(phospholipase C-activating G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007216"(G protein-coupled glutamate receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007611"(learning or memory)|go:"GO:0007612"(learning)|go:"GO:0007626"(locomotory behavior)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0040013"(negative regulation of locomotion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0050808"(synapse organization)|go:"GO:0050890"(cognition)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|go:"GO:0051966"(regulation of synaptic transmission, glutamatergic)|go:"GO:0008066"(glutamate receptor activity)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:0097449"(astrocyte projection)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099170"(postsynaptic modulation of chemical synaptic transmission)|go:"GO:0099530"(G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|go:"GO:0099583"(neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration)|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000162(GPCR, family 3, metabotropic glutamate receptor)|interpro:IPR000202(GPCR, family 3, metabotropic glutamate receptor 5)|interpro:IPR000337(GPCR, family 3)|interpro:IPR001828(Extracellular ligand-binding receptor)|interpro:IPR011500(GPCR, family 3, nine cysteines region)|interpro:IPR017978|interpro:IPR017979|interpro:IPR019588|interpro:IPR028082|interpro:IPR038550|rcsb pdb:1DDV|reactome:R-RNO-416476|reactome:R-RNO-420499|reactome:R-RNO-6794361|rgd:2746|refseq:NP_058708.1|refseq:XP_017444267.1|refseq:XP_017444268.1|refseq:XP_017444269.1|refseq:XP_017444270.1|refseq:XP_006229721.1|dip:DIP-41263N|mint:P31424|mint:MINT-4790597(identity)	-	comment:mint|function:"Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses"	-	figure legend:T3|figure legend:F7D|kinetics:kd 85,3 micromolar|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/05	2014/10/16	rogid:smyLXChRlyYJg2UheuxqeUYRDeY10116	rogid:ZXlFrgUfGF+zPgfi7QuTXqMSZvk10116	intact-crc:55059B058DC4D385|rigid:s4mm8r+3TThIioiMnhD9ZywjAe4	false	binding-associated region:96-198(MINT-4790604)|mutation decreasing interaction:114-114(MINT-4790619)	binding-associated region:c-c(MINT-4790599)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)