#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03265	uniprotkb:P10144	intact:EBI-7322567|intact:MINT-216016	intact:EBI-2505785|ensembl:ENSP00000216341|uniprotkb:Q8N1D2|uniprotkb:Q9UCC1	psi-mi:dnb2_ade05(display_long)|uniprotkb:DBP(gene name)|psi-mi:DBP(display_short)|uniprotkb:Early 2A protein(gene name synonym)|uniprotkb:Early E2A DNA-binding protein(gene name synonym)	psi-mi:grab_human(display_long)|uniprotkb:GZMB(gene name)|psi-mi:GZMB(display_short)|uniprotkb:CGL1(gene name synonym)|uniprotkb:CSPB(gene name synonym)|uniprotkb:CTLA1(gene name synonym)|uniprotkb:GRB(gene name synonym)|uniprotkb:Granzyme-2(gene name synonym)|uniprotkb:T-cell serine protease 1-3E(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase 2(gene name synonym)|uniprotkb:SECT(gene name synonym)|uniprotkb:Cathepsin G-like 1(gene name synonym)|uniprotkb:CTLA-1(gene name synonym)|uniprotkb:Fragmentin-2(gene name synonym)|uniprotkb:Human lymphocyte protein(gene name synonym)|uniprotkb:C11(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Andrade et al. (2007)	pubmed:17363894|imex:IM-10796|mint:MINT-5219757	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7322589|mint:MINT-4790323|imex:IM-10796-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03265|refseq:AP_000213.1|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019028"(viral capsid)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0039687"(viral DNA strand displacement replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|rcsb pdb:1ADU|rcsb pdb:1ADV|rcsb pdb:1ANV|rcsb pdb:2WAZ|rcsb pdb:2WB0|interpro:IPR003176(Viral DNA-binding protein)|interpro:IPR005376(Early E2A, DNA and zinc binding)|interpro:IPR036362|interpro:IPR036367|interpro:IPR036368|interpro:IPR037540|mint:MINT-4790324(identity)	ensembl:ENSG00000100453(gene)|ensembl:ENST00000216341(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019835"(cytolysis)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044194"(cytolytic granule)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070269"(pyroptosis)|go:"GO:0140507"(granzyme-mediated programmed cell death signaling pathway)|go:"GO:1900740"(positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P10144|rcsb pdb:1FQ3|rcsb pdb:1IAU|reactome:R-HSA-2197563|reactome:R-HSA-5620971|reactome:R-HSA-75108|refseq:NP_004122.2|mint:MINT-4790325(identity)	-	function:Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding|comment:mint	-	figure legend:F2A|figure legend:F3C|figure legend:F3D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/05	2014/10/16	rogid:mhqOeQsoyUQ1xu2MGWfHN8d758o28285	rogid:LyVQovcoKi8uNg/tzR4x0051nII9606	intact-crc:8565F54821BA18C3|rigid:ZqzNbv7mgN763L9+0JCxFAozRps	false	-	mutation decreasing interaction:118-118(MINT-4790386)|mutation decreasing interaction:121-121(MINT-4790383)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20718	uniprotkb:P24933	intact:EBI-7322641|uniprotkb:G3V2C5|intact:MINT-4790347|uniprotkb:Q6XGZ1|uniprotkb:Q6XGZ0|ensembl:ENSP00000216338	intact:EBI-7322614|intact:MINT-4790370|uniprotkb:P03268	psi-mi:grah_human(display_long)|uniprotkb:GZMH(gene name)|psi-mi:GZMH(display_short)|uniprotkb:CGL2(gene name synonym)|uniprotkb:CTSGL2(gene name synonym)|uniprotkb:Cytotoxic T-lymphocyte proteinase(gene name synonym)|uniprotkb:Cathepsin G-like 2(gene name synonym)|uniprotkb:CCP-X(gene name synonym)|uniprotkb:Cytotoxic serine protease C(gene name synonym)	psi-mi:shut_ade05(display_long)|uniprotkb:L4(gene name)|psi-mi:L4(display_short)|uniprotkb:100 kDa protein(gene name synonym)|uniprotkb:100K-chaperone protein(gene name synonym)|uniprotkb:L4-100K(gene name synonym)|uniprotkb:Shutoff protein 100K(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Andrade et al. (2007)	pubmed:17363894|imex:IM-10796|mint:MINT-5219757	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7322633|mint:MINT-4790334|imex:IM-10796-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001257710.1|refseq:NP_219491.1|ensembl:ENSG00000100450(gene)|ensembl:ENST00000216338(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0019835"(cytolysis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR018114|interpro:IPR033116|interpro:IPR043504|mint:P20718|rcsb pdb:1LXV|rcsb pdb:3TJU|rcsb pdb:3TJV|rcsb pdb:3TK9|rcsb pdb:4GAW|reactome:R-HSA-2022377|reactome:R-HSA-381426|mint:MINT-4790337(identity)	mint:P24933|refseq:AP_000214.1|go:"GO:0003723"(RNA binding)|go:"GO:0019060"(intracellular transport of viral protein in host cell)|go:"GO:0030430"(host cell cytoplasm)|go:"GO:0039704"(viral translational shunt)|go:"GO:0046729"(viral procapsid)|go:"GO:0039657"(suppression by virus of host gene expression)|interpro:IPR003381(Late 100 kDa protein)|mint:MINT-4790335(identity)	-	function:This enzyme is probably necessary for target cell lysis in cell-mediated immune responses|comment:mint	comment:mint|function:The 100 kDa protein is a late nonstructural protein involved in transport of hexon from cytoplasm to the nucleus	figure legend:F6A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/06/05	2014/10/16	rogid:MaXv2me5t/fmLH8Rx31EyfGserw9606	rogid:dQi/1/3flMCURjeE6zcmD4NzSXI28285	intact-crc:BDD1059439C8B2FC|rigid:uvg9/0YKXx5uhpO/sIyDxjb9KLQ	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)