#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H467	uniprotkb:P06401	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248236|imex:IM-11489-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	omim:114480(primary-reference)	-	-	author-identifiers:PREY gene NM_024040|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:099AEA29246C4AA4|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	-	sufficient binding region:155-475	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9H467	uniprotkb:P06401	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248252|imex:IM-11489-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	omim:114480(primary-reference)	-	-	author-identifiers:PREY gene NM_024040|figure legend:S1|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:2824BAA19DB0F80B|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H467	uniprotkb:P06401	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248268|imex:IM-11489-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	omim:114480(primary-reference)	-	-	author-identifiers:BAIT gene NM_024040|figure legend:1 A, 1 G|comment:This interaction occurs both in the presence and absence of progesterone.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:28F7237F934EE513|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	glutathione s tranferase tag:?-?	myc tag:?-?|necessary binding region:155-475	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06401	uniprotkb:Q9H467	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248370|imex:IM-11489-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	omim:114480(primary-reference)	-	-	author-identifiers:BAIT gene NM_024040|figure legend:1 H|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/26	2014/10/16	rogid:czItioijDkn48QgjyRtP9IaOvM09606	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	intact-crc:779FA0480A89B676|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	myc tag:?-?	glutathione s tranferase tag:?-?|necessary binding region:133-180	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P03372	uniprotkb:Q9H467	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248387|imex:IM-11489-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	omim:114480(primary-reference)	-	-	author-identifiers:PREY gene NM_024040|figure legend:S2 B|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/26	2014/10/16	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	intact-crc:34F49AFCD001B8BB|rigid:FD7ZGc4qj4pJUpKE4pP8xchhKz4	false	glutathione s tranferase tag:?-?|sufficient binding region:180-282	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06401	uniprotkb:Q8WYK2	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	intact:EBI-1248415|uniprotkb:O95430|uniprotkb:Q9UIE4|uniprotkb:J3KN58|ensembl:ENSP00000399587|ensembl:ENSP00000409787|ensembl:ENSP00000415558|ensembl:ENSP00000498745	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:jdp2_human(display_long)|uniprotkb:JDP2(gene name)|psi-mi:JDP2(display_short)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248429|imex:IM-11489-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	refseq:NP_001128519.1|refseq:NP_001128520.1|refseq:NP_001128521.1|refseq:NP_569736.1|refseq:XP_005267389.1|refseq:XP_016876463.1|refseq:XP_016876464.1|refseq:XP_016876462.1|refseq:XP_016876461.1|ensembl:ENSG00000140044(gene)|ensembl:ENST00000419727(transcript)|ensembl:ENST00000435893(transcript)|ensembl:ENST00000437176(transcript)|ensembl:ENST00000651602(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000837(Fos transforming protein)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029819|mint:Q8WYK2	omim:114480(primary-reference)	-	-	figure legend:S7 A|comment:This interaction occurred in the presence and absence of CUEDC2.|comment:PRB was bound to progesterone.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/26	2014/10/16	rogid:czItioijDkn48QgjyRtP9IaOvM09606	rogid:GlvR4o3M6B1Y3wFpzc8nA46amW49606	intact-crc:752BC5830273D7CE|rigid:OmVbRxuchiJj/JXSfmORwd8GTrQ	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06401	uniprotkb:Q9Y618	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	intact:EBI-80830|uniprotkb:Q9Y5U0|uniprotkb:O00613|uniprotkb:O15416|uniprotkb:Q13354|uniprotkb:O15421|intact:EBI-28976851|uniprotkb:Q56D06|uniprotkb:Q59GM0|ensembl:ENSP00000384018	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:ncor2_human(display_long)|uniprotkb:NCOR2(gene name)|psi-mi:NCOR2(display_short)|uniprotkb:CTG26(gene name synonym)|uniprotkb:Silencing mediator of retinoic acid and thyroid hormone receptor(gene name synonym)|uniprotkb:Thyroid-, retinoic-acid-receptor-associated corepressor(gene name synonym)|uniprotkb:T3 receptor-associating factor(gene name synonym)|uniprotkb:CTG repeat protein 26(gene name synonym)|uniprotkb:SMAP270(gene name synonym)	psi-mi:"MI:0096"(pull down)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248439|imex:IM-11489-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	ensembl:ENSP00000384018|refseq:NP_001070729.2|refseq:NP_001193583.1|refseq:NP_006303.4|dip:DIP-951N|ensembl:ENSG00000196498(gene)|ensembl:ENST00000405201(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007595"(lactation)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0032355"(response to estradiol)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017884|interpro:IPR017930|interpro:IPR031557|mint:Q9Y618|rcsb pdb:1KKQ|rcsb pdb:1R2B|rcsb pdb:1XC5|rcsb pdb:2GPV|rcsb pdb:2L5G|rcsb pdb:2LTP|rcsb pdb:2ODD|rcsb pdb:2RT5|rcsb pdb:3R29|rcsb pdb:3R2A|rcsb pdb:4A69|rcsb pdb:4OAR|rcsb pdb:5X8Q|rcsb pdb:5X8X|rcsb pdb:5ZOO|rcsb pdb:5ZOP|rcsb pdb:6A22|rcsb pdb:6IVX|rcsb pdb:6PDZ|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-2173795|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214815|reactome:R-HSA-350054|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-3899300|reactome:R-HSA-400206|reactome:R-HSA-9022537|reactome:R-HSA-9022692|reactome:R-HSA-9029569|reactome:R-HSA-9609690|reactome:R-HSA-9623433|reactome:R-HSA-9707564	omim:114480(primary-reference)	-	-	figure legend:S7 A|comment:This interaction occurred in the presence and absence of CUEDC2.|comment:PRB was bound to progesterone.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/04/26	2018/09/18	rogid:czItioijDkn48QgjyRtP9IaOvM09606	rogid:58SZfHIXN3dZN93fsiVHbbEwD0g9606	intact-crc:08BA485A4E49E419|rigid:EQnKj/XGrWQedg+AJi9ot8yhc1Y	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06401	uniprotkb:Q9H467	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248288|imex:IM-11489-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	omim:114480(primary-reference)	-	-	author-identifiers:BAIT gene NM_024040|figure legend:1 B|comment:This interaction occurs both in the presence and absence of progesterone.|delivery method:Q9H467; P06401 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/04/26	2014/10/16	rogid:czItioijDkn48QgjyRtP9IaOvM09606	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	intact-crc:ACDE8E4E712BADAE|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H467	uniprotkb:P03372	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78473|uniprotkb:Q6MZQ9|ensembl:ENSP00000387500|ensembl:ENSP00000342630|ensembl:ENSP00000206249|ensembl:ENSP00000405330|uniprotkb:Q13511|uniprotkb:Q14276|uniprotkb:Q9NU51|uniprotkb:Q9UDZ7|uniprotkb:Q9UIS7|intact:EBI-28988800|uniprotkb:Q5T5H7	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:esr1_human(display_long)|uniprotkb:ESR1(gene name)|psi-mi:ESR1(display_short)|uniprotkb:ESR(gene name synonym)|uniprotkb:NR3A1(gene name synonym)|uniprotkb:Estradiol receptor(gene name synonym)|uniprotkb:ER-alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group A member 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248300|imex:IM-11489-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENSG00000091831(gene)|ensembl:ENST00000206249(transcript)|ensembl:ENST00000338799(transcript)|ensembl:ENST00000440973(transcript)|ensembl:ENST00000443427(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|refseq:NP_000116.2|refseq:NP_001116212.1|refseq:NP_001116213.1|refseq:NP_001116214.1|refseq:XP_011533845.1|refseq:XP_011533846.1|refseq:XP_011533847.1|refseq:XP_006715438.1|ensembl:ENSP00000206249|ensembl:ENSP00000342630|ensembl:ENSP00000405330|ensembl:ENSP00000387500|refseq:NP_001278159.1|refseq:NP_001278170.1|refseq:NP_001315029.1|refseq:XP_016865865.1|refseq:XP_016865866.1|refseq:XP_016865867.1|refseq:XP_016865868.1|refseq:XP_016865869.1|refseq:XP_016865870.1|dip:DIP-5965N|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000785"(chromatin)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001547"(antral ovarian follicle growth)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005496"(steroid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008209"(androgen metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008584"(male gonad development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030284"(estrogen receptor activity)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034056"(estrogen response element binding)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0035327"|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060065"(uterus development)|go:"GO:0060068"(vagina development)|go:"GO:0060523"(prostate epithelial cord elongation)|go:"GO:0060527"(prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis)|go:"GO:0060687"(regulation of branching involved in prostate gland morphogenesis)|go:"GO:0060745"(mammary gland branching involved in pregnancy)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060750"(epithelial cell proliferation involved in mammary gland duct elongation)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001292(Oestrogen receptor, AF1 modulatory)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR024178|interpro:IPR024736|interpro:IPR035500|mint:P03372|rcsb pdb:1A52|rcsb pdb:1AKF|rcsb pdb:1ERE|rcsb pdb:1ERR|rcsb pdb:1G50|rcsb pdb:1GWQ|rcsb pdb:1GWR|rcsb pdb:1HCP|rcsb pdb:1HCQ|rcsb pdb:1L2I|rcsb pdb:1PCG|rcsb pdb:1QKT|rcsb pdb:1QKU|rcsb pdb:1R5K|rcsb pdb:1SJ0|rcsb pdb:1UOM|rcsb pdb:1X7E|rcsb pdb:1X7R|rcsb pdb:1XP1|rcsb pdb:1XP6|rcsb pdb:1XP9|rcsb pdb:1XPC|rcsb pdb:1XQC|rcsb pdb:1YIM|rcsb pdb:1YIN|rcsb pdb:1ZKY|rcsb pdb:2AYR|rcsb pdb:2B1V|rcsb pdb:2B1Z|rcsb pdb:2B23|rcsb pdb:2BJ4|rcsb pdb:2FAI|rcsb pdb:2G44|rcsb pdb:2G5O|rcsb pdb:2I0J|rcsb pdb:2IOG|rcsb pdb:2IOK|rcsb pdb:2JF9|rcsb pdb:2JFA|rcsb pdb:2LLO|rcsb pdb:2LLQ|rcsb pdb:2OCF|rcsb pdb:2OUZ|rcsb pdb:2P15|rcsb pdb:2POG|rcsb pdb:2Q6J|rcsb pdb:2Q70|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QE4|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QXS|rcsb pdb:2QZO|rcsb pdb:2R6W|rcsb pdb:2R6Y|rcsb pdb:2YAT|rcsb pdb:2YJA|rcsb pdb:3DT3|rcsb pdb:3ERD|rcsb pdb:3ERT|rcsb pdb:3HLV|rcsb pdb:3HM1|rcsb pdb:3L03|rcsb pdb:3OS8|rcsb pdb:3OS9|rcsb pdb:3OSA|rcsb pdb:3Q95|rcsb pdb:3UU7|rcsb pdb:3UUA|rcsb pdb:3UUC|rcsb pdb:3UUD|rcsb pdb:4AA6|rcsb pdb:4DMA|rcsb pdb:4IU7|rcsb pdb:4IUI|rcsb pdb:4IV2|rcsb pdb:4IV4|rcsb pdb:4IVW|rcsb pdb:4IVY|rcsb pdb:4IW6|rcsb pdb:4IW8|rcsb pdb:4IWC|rcsb pdb:4IWF|rcsb pdb:4JC3|rcsb pdb:4JDD|rcsb pdb:4MG5|rcsb pdb:4MG6|rcsb pdb:4MG7|rcsb pdb:4MG8|rcsb pdb:4MG9|rcsb pdb:4MGA|rcsb pdb:4MGB|rcsb pdb:4MGC|rcsb pdb:4MGD|rcsb pdb:4O6F|rcsb pdb:4PP6|rcsb pdb:4PPP|rcsb pdb:4PPS|rcsb pdb:4PXM|rcsb pdb:4Q13|rcsb pdb:4Q50|rcsb pdb:4TUZ|rcsb pdb:4TV1|rcsb pdb:4XI3|rcsb pdb:4ZN7|rcsb pdb:4ZN9|rcsb pdb:4ZNH|rcsb pdb:4ZNS|rcsb pdb:4ZNT|rcsb pdb:4ZNU|rcsb pdb:4ZNV|rcsb pdb:4ZNW|rcsb pdb:5AAU|rcsb pdb:5AAV|rcsb pdb:5ACC|rcsb pdb:5AK2|rcsb pdb:5DI7|rcsb pdb:5DID|rcsb pdb:5DIE|rcsb pdb:5DIG|rcsb pdb:5DK9|rcsb pdb:5DKB|rcsb pdb:5DKE|rcsb pdb:5DKG|rcsb pdb:5DKS|rcsb pdb:5DL4|rcsb pdb:5DLR|rcsb pdb:5DMC|rcsb pdb:5DMF|rcsb pdb:5DP0|rcsb pdb:5DRJ|rcsb pdb:5DRM|rcsb pdb:5DTV|rcsb pdb:5DU5|rcsb pdb:5DUE|rcsb pdb:5DUG|rcsb pdb:5DUH|rcsb pdb:3CBM|rcsb pdb:3CBO|rcsb pdb:3CBP|rcsb pdb:5DVS|rcsb pdb:5DVV|rcsb pdb:5DWE|rcsb pdb:5DWG|rcsb pdb:5DWI|rcsb pdb:5DWJ|rcsb pdb:5DX3|rcsb pdb:5DXB|rcsb pdb:5DXE|rcsb pdb:5DXG|rcsb pdb:5DXK|rcsb pdb:5DXM|rcsb pdb:5DXQ|rcsb pdb:5DXR|rcsb pdb:5DY8|rcsb pdb:5DYB|rcsb pdb:5DYD|rcsb pdb:5DZ0|rcsb pdb:5DZ1|rcsb pdb:5DZ3|rcsb pdb:5DZH|rcsb pdb:5DZI|rcsb pdb:5E0W|rcsb pdb:5E0X|rcsb pdb:5E14|rcsb pdb:5E15|rcsb pdb:5E19|rcsb pdb:5E1C|rcsb pdb:5EGV|rcsb pdb:5EHJ|rcsb pdb:5EI1|rcsb pdb:5EIT|rcsb pdb:5FQP|rcsb pdb:5FQR|rcsb pdb:5FQS|rcsb pdb:5FQT|rcsb pdb:5FQV|rcsb pdb:5GS4|rcsb pdb:5GTR|rcsb pdb:5HYR|rcsb pdb:5JMM|rcsb pdb:5KCC|rcsb pdb:5KCD|rcsb pdb:5KCE|rcsb pdb:5KCF|rcsb pdb:5KCT|rcsb pdb:5KCU|rcsb pdb:5KCW|rcsb pdb:5KD9|rcsb pdb:5KR9|rcsb pdb:5KRA|rcsb pdb:5KRC|rcsb pdb:5KRF|rcsb pdb:5KRH|rcsb pdb:5KRI|rcsb pdb:5KRJ|rcsb pdb:5KRK|rcsb pdb:5KRL|rcsb pdb:5KRM|rcsb pdb:5KRO|rcsb pdb:5N10|rcsb pdb:5T0X|rcsb pdb:5T1Z|rcsb pdb:5T92|rcsb pdb:5T97|rcsb pdb:5TLD|rcsb pdb:5TLF|rcsb pdb:5TLG|rcsb pdb:5TLL|rcsb pdb:5TLM|rcsb pdb:5TLO|rcsb pdb:5TLP|rcsb pdb:5TLT|rcsb pdb:5TLU|rcsb pdb:5TLV|rcsb pdb:5TLX|rcsb pdb:5TLY|rcsb pdb:5TM1|rcsb pdb:5TM2|rcsb pdb:5TM3|rcsb pdb:5TM4|rcsb pdb:5TM5|rcsb pdb:5TM6|rcsb pdb:5TM7|rcsb pdb:5TM8|rcsb pdb:5TM9|rcsb pdb:5TML|rcsb pdb:5TMM|rcsb pdb:5TMO|rcsb pdb:5TMQ|rcsb pdb:5TMR|rcsb pdb:5TMS|rcsb pdb:5TMT|rcsb pdb:5TMU|rcsb pdb:5TMV|rcsb pdb:5TMW|rcsb pdb:5TMZ|rcsb pdb:5TN1|rcsb pdb:5TN3|rcsb pdb:5TN4|rcsb pdb:5TN5|rcsb pdb:5TN6|rcsb pdb:5TN7|rcsb pdb:5TN8|rcsb pdb:5TN9|rcsb pdb:5TNB|rcsb pdb:5U2B|rcsb pdb:5U2D|rcsb pdb:5UFW|rcsb pdb:5DXP|rcsb pdb:5UFX|rcsb pdb:5W9C|rcsb pdb:5W9D|rcsb pdb:5WGD|rcsb pdb:5WGQ|rcsb pdb:6B0F|rcsb pdb:6C42|rcsb pdb:6CBZ|rcsb pdb:6CHW|rcsb pdb:6CHZ|rcsb pdb:6CZN|rcsb pdb:6D0F|rcsb pdb:6DF6|rcsb pdb:6DFN|rcsb pdb:6HHP|rcsb pdb:6HKF|rcsb pdb:6HMU|rcsb pdb:6IAR|rcsb pdb:6OWC|rcsb pdb:6PET|rcsb pdb:6PFM|rcsb pdb:6PIT|rcsb pdb:6PSJ|rcsb pdb:6SBO|rcsb pdb:6SQ0|rcsb pdb:6SUO|rcsb pdb:6TJM|rcsb pdb:6TL3|rcsb pdb:6V87|rcsb pdb:6V8T|rcsb pdb:6VGH|rcsb pdb:6VIG|rcsb pdb:6VJ1|rcsb pdb:6VJD|rcsb pdb:6VMU|rcsb pdb:6VPF|rcsb pdb:6VPK|rcsb pdb:6VVP|rcsb pdb:6WOK|rcsb pdb:6ZOQ|rcsb pdb:6ZOR|rcsb pdb:6ZOS|rcsb pdb:7JHD|rcsb pdb:7KBS|rcsb pdb:7KCA|rcsb pdb:7KCD|rcsb pdb:7MSA|rcsb pdb:7NFW|reactome:R-HSA-1251985|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5689896|reactome:R-HSA-6811558|reactome:R-HSA-8866910|reactome:R-HSA-8931987|reactome:R-HSA-8939211|reactome:R-HSA-8939256|reactome:R-HSA-8939902|reactome:R-HSA-9009391|reactome:R-HSA-9018519|rcsb pdb:6HKB	omim:114480(primary-reference)	-	-	author-identifiers:PREY gene NM_024040|figure legend:S2 A|delivery method:P03372; Q9H467 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:T8sQVUNhd5AfJXfL0mjq9TA/C/o9606	intact-crc:6EDA721F02D4E18C|rigid:FD7ZGc4qj4pJUpKE4pP8xchhKz4	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9H467	uniprotkb:P06401	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248322|imex:IM-11489-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	omim:114480(primary-reference)	-	-	author-identifiers:PREY gene NM_024040|figure legend:1 C|comment:This interaction occurs both in the presence and absence of progesterone.|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t47d)|taxid:9606(human breast cancer tumour cell line-epithelial cells)	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:966E55C34D93C46C|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P06401	uniprotkb:Q9H467	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248337|imex:IM-11489-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	omim:114480(primary-reference)|go:"GO:0005737"(cytoplasm)	-	-	author-identifiers:Q9H467 gene NM_024040|comment:This interaction occurs in the cytoplasm in the absence of progesterone and in the nucleus in the presence of progesterone.|figure legend:1 E|delivery method:Q9H467; P06401 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/04/26	2014/10/16	rogid:czItioijDkn48QgjyRtP9IaOvM09606	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	intact-crc:DA4750A1A5B16FD9|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	red fluorescent protein tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H467	uniprotkb:P06401	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0010"(beta galactosidase complementation)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248407|imex:IM-11489-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	omim:114480(primary-reference)	-	-	author-identifiers:BAIT gene NM_024040|figure legend:1 F|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:1D264FE42B3FF1E1|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	-	necessary binding region:155-475	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H467	uniprotkb:P06401	intact:EBI-1248228|uniprotkb:Q9BWG8|uniprotkb:D3DR88|ensembl:ENSP00000358953	intact:EBI-78539|uniprotkb:Q8TDS3|uniprotkb:Q9UPF7|uniprotkb:A7X8B0|uniprotkb:B4E3T0|uniprotkb:A7LQ08|intact:EBI-28971228|ensembl:ENSP00000325120	psi-mi:cued2_human(display_long)|uniprotkb:CUEDC2(gene name)|psi-mi:CUEDC2(display_short)|uniprotkb:C10orf66(gene name synonym)|uniprotkb:HOYS6(orf name)	psi-mi:prgr_human(display_long)|uniprotkb:PGR(gene name)|psi-mi:PGR(display_short)|uniprotkb:NR3C3(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 3(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Zhang et al. (2007)	pubmed:17347654|imex:IM-11489|mint:MINT-5219745	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-1248350|imex:IM-11489-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076945.2|ensembl:ENSG00000107874(gene)|ensembl:ENST00000369937(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR039784|interpro:IPR039805|mint:Q9H467	ensembl:ENST00000263463|ensembl:ENSP00000263463|ensembl:ENSP00000325120|ensembl:ENST00000534013|ensembl:ENSP00000436561|refseq:NP_001258090.1|refseq:NP_000917.3|refseq:NP_001189403.1|refseq:NP_001258091.1|dip:DIP-5967N|ensembl:ENSG00000082175(gene)|ensembl:ENST00000325455(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002070"(epithelial cell maturation)|go:"GO:0003677"(DNA binding)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0038001"(paracrine signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|interpro:IPR000128(Progesterone receptor, N-terminal)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P06401|rcsb pdb:1A28|rcsb pdb:1E3K|rcsb pdb:1SQN|rcsb pdb:1SR7|rcsb pdb:1ZUC|rcsb pdb:2C7A|rcsb pdb:2OVH|rcsb pdb:2OVM|rcsb pdb:2W8Y|rcsb pdb:3D90|rcsb pdb:3G8O|rcsb pdb:3HQ5|rcsb pdb:3KBA|rcsb pdb:3ZR7|rcsb pdb:3ZRA|rcsb pdb:3ZRB|rcsb pdb:4A2J|rcsb pdb:4APU|rcsb pdb:4OAR|rcsb pdb:5CC0|reactome:R-HSA-1251985|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-9018519	omim:114480(primary-reference)|go:"GO:0005634"(nucleus)	-	-	author-identifiers:Q9H467 gene NM_024040|comment:This interaction occurs in the nucleus in the presence of progesterone but in the cytoplasm in its absence.|figure legend:1 E|delivery method:P06401; Q9H467 transfection|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2007/04/26	2014/10/16	rogid:/iO9kQPGdkbvn6qsyxW8sXG2nr89606	rogid:czItioijDkn48QgjyRtP9IaOvM09606	intact-crc:24B836FC90FD9DDC|rigid:tMVK5RUx+eJWtostsSOnhwQ7fr4	false	green fluorescent protein tag:?-?	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)