#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P08473	uniprotkb:Q92835	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1380477|uniprotkb:O00145|uniprotkb:Q13544|uniprotkb:Q13545|uniprotkb:Q6P5A4|uniprotkb:Q92656|uniprotkb:Q9UE80|ensembl:ENSP00000405338|ensembl:ENSP00000487191	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ship1_human(display_long)|uniprotkb:INPP5D(gene name)|psi-mi:INPP5D(display_short)|uniprotkb:SHIP(gene name synonym)|uniprotkb:SHIP1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001017915.1|refseq:NP_005532.2|ensembl:ENST00000359570|ensembl:ENSP00000352575|ensembl:ENSP00000405338|ensembl:ENST00000629761|ensembl:ENSP00000486669|ensembl:ENSP00000487191|ensembl:ENSG00000168918(gene)|ensembl:ENSG00000281614(gene)|ensembl:ENST00000445964(transcript)|ensembl:ENST00000630854(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050777"(negative regulation of immune response)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|mint:Q92835|rcsb pdb:2YSX|rcsb pdb:5RW2|rcsb pdb:5RW3|rcsb pdb:5RW4|rcsb pdb:5RW5|rcsb pdb:5RW6|rcsb pdb:5RW7|rcsb pdb:5RW8|rcsb pdb:5RW9|rcsb pdb:5RWA|rcsb pdb:5RWB|rcsb pdb:5RWC|rcsb pdb:5RWD|rcsb pdb:5RWE|rcsb pdb:5RWF|rcsb pdb:5RWG|rcsb pdb:5RWH|rcsb pdb:5RWI|rcsb pdb:5RWJ|rcsb pdb:5RWK|rcsb pdb:5RWL|rcsb pdb:5RWM|rcsb pdb:5RWN|rcsb pdb:5RWO|rcsb pdb:5RWP|rcsb pdb:5RWQ|rcsb pdb:5RWR|rcsb pdb:5RWS|rcsb pdb:5RWT|rcsb pdb:5RWU|rcsb pdb:5RWV|rcsb pdb:5RWW|rcsb pdb:5RWX|rcsb pdb:5RWY|rcsb pdb:5RWZ|rcsb pdb:5RX0|rcsb pdb:5RX1|rcsb pdb:5RX2|rcsb pdb:5RX3|rcsb pdb:5RX4|rcsb pdb:5RX5|rcsb pdb:5RX6|rcsb pdb:5RX7|rcsb pdb:5RX8|rcsb pdb:5RX9|rcsb pdb:5RXA|rcsb pdb:5RXB|rcsb pdb:5RXC|rcsb pdb:5RXD|rcsb pdb:5RXE|rcsb pdb:5RXF|rcsb pdb:5RXG|rcsb pdb:5RXH|rcsb pdb:5RXI|rcsb pdb:5RXJ|rcsb pdb:5RXK|rcsb pdb:5RXL|rcsb pdb:5RXM|rcsb pdb:5RXO|rcsb pdb:5RXP|rcsb pdb:5RXQ|rcsb pdb:5RXR|rcsb pdb:5RXS|rcsb pdb:5RXT|rcsb pdb:5RXU|rcsb pdb:5RXV|rcsb pdb:5RXW|rcsb pdb:5RXX|rcsb pdb:5RXY|rcsb pdb:5RXZ|rcsb pdb:5RY0|rcsb pdb:5RY1|rcsb pdb:5RY2|rcsb pdb:5RY3|rcsb pdb:5RY4|rcsb pdb:5RY5|rcsb pdb:5RY6|rcsb pdb:5RY7|rcsb pdb:5RY8|rcsb pdb:5RY9|rcsb pdb:5RYA|rcsb pdb:5RYB|rcsb pdb:5RYC|rcsb pdb:5RYD|rcsb pdb:5RYE|rcsb pdb:5RYF|rcsb pdb:5RYG|rcsb pdb:5RYH|rcsb pdb:5RYI|rcsb pdb:5RYJ|rcsb pdb:5RYK|rcsb pdb:5RYL|rcsb pdb:6IBD|rcsb pdb:6XY7|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-202424|reactome:R-HSA-210990|reactome:R-HSA-912526	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:lM4QLD8DUZmagYuz8qoKAZqjJOI9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	intact:EBI-1563412	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	-	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:loc653596_human_protein(display_short)|psi-mi:EBI-1563412(display_long)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	genbank_protein_gi:73969988(primary-reference)	omim:176807(primary-reference)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	-	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O75844	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1056377|uniprotkb:Q8NDZ8|uniprotkb:Q9UBQ2|uniprotkb:B3KQI7|uniprotkb:D3DPU7|ensembl:ENSP00000361845	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:face1_human(display_long)|uniprotkb:ZMPSTE24(gene name)|psi-mi:ZMPSTE24(display_short)|uniprotkb:FACE1(gene name synonym)|uniprotkb:STE24(gene name synonym)|uniprotkb:Prenyl protein-specific endoprotease 1(gene name synonym)|uniprotkb:Farnesylated proteins-converting enzyme 1(gene name synonym)|uniprotkb:Zinc metalloproteinase Ste24 homolog(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_005848.2|ensembl:ENSG00000084073(gene)|ensembl:ENST00000372759(transcript)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003229"(ventricular cardiac muscle tissue development)|go:"GO:0003231"(cardiac ventricle development)|go:"GO:0003417"(growth plate cartilage development)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006508"(proteolysis)|go:"GO:0006925"(inflammatory cell apoptotic process)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008235"(metalloexopeptidase activity)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030327"(prenylated protein catabolic process)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0043007"(maintenance of rDNA)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043979"(histone H2B-K5 acetylation)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048145"(regulation of fibroblast proliferation)|go:"GO:0048538"(thymus development)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0050905"(neuromuscular process)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060993"(kidney morphogenesis)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061762"(CAMKK-AMPK signaling cascade)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070302"(regulation of stress-activated protein kinase signaling cascade)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:1903025"(regulation of RNA polymerase II regulatory region sequence-specific DNA binding)|go:"GO:1903463"(regulation of mitotic cell cycle DNA replication)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990164"(histone H2A phosphorylation)|go:"GO:2000618"(regulation of histone H4-K16 acetylation)|go:"GO:2000730"(regulation of termination of RNA polymerase I transcription)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR001915(Peptidase M48, Ste24p)|interpro:IPR027057|interpro:IPR032456|rcsb pdb:2YPT|rcsb pdb:4AW6|rcsb pdb:5SYT|rcsb pdb:6BH8|dip:DIP-39641N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:OPwBYiVhnltoUrmk2Jtj07QDSCg9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q8NEG4	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1563144|uniprotkb:Q96FD6|ensembl:ENSP00000330432	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:fa83f_human(display_long)|uniprotkb:FAM83F(gene name)|psi-mi:FAM83F(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_612444.2|ensembl:ENSG00000133477(gene)|ensembl:ENST00000333407(transcript)|go:"GO:0007165"(signal transduction)|go:"GO:0019901"(protein kinase binding)|interpro:IPR012461(Protein of unknown function DUF1669)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:qx4tus6FUUDrHnN8Qxuq9aQsoU89606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q3ZCM7	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-302558|ensembl:ENSP00000456206|intact:EBI-1390656|uniprotkb:Q5SQX9|uniprotkb:Q8WZ78	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:tbb8_human(display_long)|uniprotkb:TUBB8(gene name)|psi-mi:TUBB8(display_short)|uniprotkb:Tubulin beta 8 class VIII(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-9619483|ensembl:ENSG00000261456(gene)|ensembl:ENST00000568584(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001556"(oocyte maturation)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007056"(spindle assembly involved in female meiosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072687"(meiotic spindle)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q3ZCM7|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-380320|reactome:R-HSA-437239|reactome:R-HSA-5617833|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|refseq:NP_817124.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:bTJnhl0qEm2ACoHQ7IOcn5Rx7xM9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q14978	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-396155|uniprotkb:Q15030|intact:EBI-1055664|uniprotkb:Q9BUV3|uniprotkb:Q5VV70|ensembl:ENSP00000474710	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:nolc1_human(display_long)|uniprotkb:NOLC1(gene name)|psi-mi:NOLC1(display_short)|uniprotkb:KIAA0035(gene name synonym)|uniprotkb:Nucleolar 130 kDa protein(gene name synonym)|uniprotkb:140 kDa nucleolar phosphoprotein(gene name synonym)|uniprotkb:Nucleolar phosphoprotein p130(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 13(gene name synonym)|uniprotkb:NS5ATP13(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_004732.2|refseq:NP_001271317.1|refseq:NP_001271318.1|ensembl:ENSG00000166197(gene)|ensembl:ENST00000605788(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007000"(nucleolus organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0015030"(Cajal body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031428"(box C/D RNP complex)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0033979"(box H/ACA RNA metabolic process)|go:"GO:0034512"(box C/D RNA binding)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0062064"(box C/D snoRNP complex binding)|go:"GO:0062065"(box H/ACA snoRNP complex binding)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR007718(SRP40, C-terminal)|mint:Q14978	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:G3ClYMfSSjWsDzkxtahX5lLRzzQ9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P0C0S8	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390628|uniprotkb:P02261|uniprotkb:Q2M1R2|uniprotkb:Q76PA6|intact:EBI-1642354|ensembl:ENSP00000351589|ensembl:ENSP00000352119|ensembl:ENSP00000352627|ensembl:ENSP00000482431|ensembl:ENSP00000482538	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:h2a1_human(display_long)|uniprotkb:H2AC11(gene name)|psi-mi:H2AC11(display_short)|uniprotkb:H2AC13(gene name)|psi-mi:H2AC13(display_short)|uniprotkb:H2AC15(gene name)|psi-mi:H2AC15(display_short)|uniprotkb:H2AC16(gene name)|psi-mi:H2AC16(display_short)|uniprotkb:H2AC17(gene name)|psi-mi:H2AC17(display_short)|uniprotkb:H2AFC(gene name synonym)|uniprotkb:H2AFD(gene name synonym)|uniprotkb:H2AFI(gene name synonym)|uniprotkb:H2AFN(gene name synonym)|uniprotkb:H2AFP(gene name synonym)|uniprotkb:HIST1H2AG(gene name synonym)|uniprotkb:HIST1H2AI(gene name synonym)|uniprotkb:HIST1H2AK(gene name synonym)|uniprotkb:HIST1H2AL(gene name synonym)|uniprotkb:HIST1H2AM(gene name synonym)|uniprotkb:Histone H2A/ptl(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000196747(gene)|ensembl:ENSG00000196787(gene)|ensembl:ENSG00000275221(gene)|ensembl:ENSG00000276903(gene)|ensembl:ENSG00000278677(gene)|refseq:NP_003500.1|refseq:NP_003501.1|refseq:NP_003502.1|refseq:NP_003505.1|refseq:NP_066408.1|dip:DIP-39638N|ensembl:ENST00000358739(transcript)|ensembl:ENST00000359193(transcript)|ensembl:ENST00000359611(transcript)|ensembl:ENST00000613174(transcript)|ensembl:ENST00000618958(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0019899"(enzyme binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S8|rcsb pdb:4QYL|rcsb pdb:5KGF|rcsb pdb:6R0C|rcsb pdb:6RNY|rcsb pdb:6X59|rcsb pdb:6X5A|rcsb pdb:6XJD|rcsb pdb:7JO9|rcsb pdb:7JOA|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-9609690|reactome:R-HSA-9610379	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:dpZm9c7r9ihR4gW0TZWsVfXAWJ89606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P12268	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-353389|uniprotkb:Q6LEF3|ensembl:ENSP00000321584	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:imdh2_human(display_long)|uniprotkb:IMPDH2(gene name)|psi-mi:IMPDH2(display_short)|uniprotkb:IMPD2(gene name synonym)|uniprotkb:Inosine-5'-monophosphate dehydrogenase type II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_000875.2|ensembl:ENSG00000178035(gene)|ensembl:ENST00000326739(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003938"(IMP dehydrogenase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0007623"(circadian rhythm)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0046651"(lymphocyte proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR001093(IMP dehydrogenase/GMP reductase)|interpro:IPR005990(IMP dehydrogenase)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR015875(IMP dehydrogenase / GMP reductase, conserved site)|mint:P12268|rcsb pdb:1B3O|rcsb pdb:1NF7|rcsb pdb:1NFB|rcsb pdb:6I0M|rcsb pdb:6I0O|rcsb pdb:6U8E|rcsb pdb:6U8N|rcsb pdb:6U8R|rcsb pdb:6U8S|rcsb pdb:6U9O|rcsb pdb:6UA2|rcsb pdb:6UA4|rcsb pdb:6UA5|rcsb pdb:6UAJ|rcsb pdb:6UC2|rcsb pdb:6UDO|rcsb pdb:6UDP|rcsb pdb:6UDQ|reactome:R-HSA-6798695|reactome:R-HSA-73817|reactome:R-HSA-9679191	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:qGPwBxhEgtYik3OetHZbpyktoLE9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P13010	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-357997|uniprotkb:A8K3X5|uniprotkb:Q0Z7V0|uniprotkb:Q53HH7|uniprotkb:Q7M4N0|uniprotkb:Q4VBQ5|uniprotkb:Q9UCQ0|uniprotkb:Q9UCQ1|ensembl:ENSP00000375977|ensembl:ENSP00000375978	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:xrcc5_human(display_long)|uniprotkb:XRCC5(gene name)|psi-mi:XRCC5(display_short)|uniprotkb:G22P2(gene name synonym)|uniprotkb:ATP-dependent DNA helicase II 80 kDa subunit(gene name synonym)|uniprotkb:Lupus Ku autoantigen protein p86(gene name synonym)|uniprotkb:86 kDa subunit of Ku antigen(gene name synonym)|uniprotkb:Ku86(gene name synonym)|uniprotkb:Ku80(gene name synonym)|uniprotkb:Thyroid-lupus autoantigen(gene name synonym)|uniprotkb:CTC box-binding factor 85 kDa subunit(gene name synonym)|uniprotkb:Nuclear factor IV(gene name synonym)|uniprotkb:DNA repair protein XRCC5(gene name synonym)|uniprotkb:"X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)"(gene name synonym)|uniprotkb:ATP-dependent DNA helicase 2 subunit 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_066964.1|ensembl:ENST00000392132(transcript)|ensembl:ENSG00000079246(gene)|dip:DIP-31379N|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043564"("Ku70:Ku80 complex")|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045027"(DNA end binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070419"(nonhomologous end joining complex)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071475"(cellular hyperosmotic salinity response)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:0090734"(site of DNA damage)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034462"(small-subunit processome assembly)|go:"GO:0034511"(U3 snoRNA binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042493"|ensembl:ENST00000392133(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007420"(brain development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008047"(enzyme activator activity)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR005160(Ku70/Ku80 C-terminal arm)|interpro:IPR005161(Ku70/Ku80, N-terminal alpha/beta)|interpro:IPR006164(DNA helicase, ATP-dependent, Ku type)|interpro:IPR014893(Ku, C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR024193|interpro:IPR036465|interpro:IPR036494|mint:P13010|rcsb pdb:1JEQ|rcsb pdb:1JEY|rcsb pdb:1Q2Z|rcsb pdb:1RW2|rcsb pdb:3RZ9|rcsb pdb:5Y3R|rcsb pdb:6ERF|rcsb pdb:6ERG|rcsb pdb:6ERH|rcsb pdb:6ZH6|rcsb pdb:6ZHA|rcsb pdb:6ZHE|rcsb pdb:7AXZ|rcsb pdb:7K0Y|rcsb pdb:7K17|rcsb pdb:7K1J|rcsb pdb:7K1K|rcsb pdb:7K1N|rcsb pdb:7LSY|rcsb pdb:7LT3|reactome:R-HSA-164843|reactome:R-HSA-1834949|reactome:R-HSA-3270619|reactome:R-HSA-5693571|reactome:R-HSA-6798695	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:ZPJCWdA2YqOqXgfSRfDQCoEsyoA9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P40616	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1052746|uniprotkb:P80417|uniprotkb:Q53XB1|uniprotkb:B4DWW1|ensembl:ENSP00000261636|intact:EBI-11157530	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:arl1_human(display_long)|uniprotkb:ARL1(gene name)|psi-mi:ARL1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001168.1|ensembl:ENSG00000120805(gene)|ensembl:ENST00000261636(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0009404"(toxin metabolic process)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0046872"(metal ion binding)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P40616|rcsb pdb:1UPT|rcsb pdb:4DCN|rcsb pdb:5EE5|rcsb pdb:5J5C|reactome:R-HSA-6811440|interpro:IPR005225(Small GTP-binding protein)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:4sRUSYrH1mt5ol85HlMNSEn1j9M9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P62888	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-353116|uniprotkb:P04645|uniprotkb:Q502Z6|ensembl:ENSP00000287038|ensembl:ENSP00000428085|uniprotkb:B2R591	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rl30_human(display_long)|uniprotkb:RPL30(gene name)|psi-mi:RPL30(display_short)|uniprotkb:Large ribosomal subunit protein eL30(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000156482(gene)|ensembl:ENST00000287038(transcript)|ensembl:ENST00000521291(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000231(Ribosomal protein L30e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR022991|interpro:IPR029064|interpro:IPR039109|mint:P62888|rcsb pdb:3VI6|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_000980.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:xR9LwYg6N7m9njT1pYumOPKZVu49606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P56134	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-712794|ensembl:ENSP00000292475|uniprotkb:O76079|uniprotkb:Q96L83|uniprotkb:Q9BTI8|uniprotkb:C9J8H9|uniprotkb:F8W7V3|intact:EBI-11047094|uniprotkb:Q6IBB3	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:atpk_human(display_long)|uniprotkb:ATP5MF(gene name)|psi-mi:ATP5MF(display_short)|uniprotkb:ATP synthase membrane subunit f(gene name synonym)|uniprotkb:ATP5J2(gene name synonym)|uniprotkb:ATP5JL(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000241468(gene)|ensembl:ENST00000292475(transcript)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR019344|mint:P56134|reactome:R-HSA-163210|reactome:R-HSA-8949613|refseq:NP_001003713.1|refseq:NP_004880.1|refseq:NP_001003714.1|refseq:NP_001034267.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:+WS7rjFef6JE+mlZ4Q8TF2A+G0E9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P62266	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-353072|ensembl:ENSP00000296674|ensembl:ENSP00000498621|uniprotkb:P39028|uniprotkb:Q6IB08	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rs23_human(display_long)|uniprotkb:RPS23(gene name)|psi-mi:RPS23(display_short)|uniprotkb:Small ribosomal subunit protein uS12(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|ensembl:ENSG00000186468(gene)|ensembl:ENST00000296674(transcript)|ensembl:ENST00000651545(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0034063"(stress granule assembly)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|go:"GO:1990145"(maintenance of translational fidelity)|interpro:IPR005680(Ribosomal protein S23, eukaryotic/archaeal)|interpro:IPR006032(Ribosomal protein S12/S23)|rcsb pdb:5T2C|rcsb pdb:5VYC|interpro:IPR012340(Nucleic acid-binding, OB-fold)|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G4S|mint:P62266|rcsb pdb:6G4W|rcsb pdb:4CXG|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:4CXH|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:4UG0|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBW|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZOK|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|refseq:NP_001016.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:MWZPvSL/G45ocaxA5AXKCkDQxNU9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P11586	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-709638|uniprotkb:Q86VC9|uniprotkb:Q9BVP5|uniprotkb:B2R5Y2|uniprotkb:G3V2B8|intact:EBI-21358459|uniprotkb:A0A024R652|uniprotkb:A0A384N5Y3|ensembl:ENSP00000498336|ensembl:ENSP00000498511	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:c1tc_human(display_long)|uniprotkb:MTHFD1(gene name)|psi-mi:MTHFD1(display_short)|uniprotkb:MTHFC(gene name synonym)|uniprotkb:MTHFD(gene name synonym)|uniprotkb:Epididymis secretory sperm binding protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_005947.3|dip:DIP-33682N|ensembl:ENSG00000100714(gene)|ensembl:ENST00000651537(transcript)|ensembl:ENST00000652337(transcript)|go:"GO:0000105"(histidine biosynthetic process)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004477"(methenyltetrahydrofolate cyclohydrolase activity)|go:"GO:0004486"("methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity")|go:"GO:0004487"("methylenetetrahydrofolate dehydrogenase (NAD+) activity")|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006555"(methionine metabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0009069"(serine family amino acid metabolic process)|go:"GO:0009070"(serine family amino acid biosynthetic process)|go:"GO:0009086"(methionine biosynthetic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|go:"GO:0061053"(somite development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR020867|interpro:IPR027417|interpro:IPR036291|mint:P11586|rcsb pdb:1A4I|rcsb pdb:1DIA|rcsb pdb:1DIB|rcsb pdb:1DIG|rcsb pdb:6ECP|rcsb pdb:6ECQ|rcsb pdb:6ECR|reactome:R-HSA-196757	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:6ZizfpjVcaL5WNxKXL7qJpw59PI9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q8NAB2	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390557|ensembl:ENSP00000432163|ensembl:ENSP00000436262|uniprotkb:Q86X38|uniprotkb:Q96NK5|uniprotkb:Q6N066	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:kbtb3_human(display_long)|uniprotkb:KBTBD3(gene name)|psi-mi:KBTBD3(display_short)|uniprotkb:BKLHD3(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:XP_006718830.1|ensembl:ENSG00000182359(gene)|ensembl:ENST00000526793(transcript)|ensembl:ENST00000531837(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030589|refseq:NP_689646.2|refseq:NP_940841.1|refseq:XP_011540920.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:NO/VU3phJAlMHDtRowGfoqsu8MY9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O95168	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1245485|uniprotkb:B2RUY3|uniprotkb:B9EJC7|ensembl:ENSP00000184266	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ndub4_human(display_long)|uniprotkb:NDUFB4(gene name)|psi-mi:NDUFB4(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase B15 subunit(gene name synonym)|uniprotkb:Complex I-B15(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001161803.1|refseq:NP_004538.2|ensembl:ENSG00000065518(gene)|ensembl:ENST00000184266(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR009866(NADH-ubiquinone oxidoreductase, subunit NDUFB4)|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:O7vikmRDGTcfvmDXSThJKj2ADJc9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q14498	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-395290|uniprotkb:A5D8W2|uniprotkb:B0BLV3|uniprotkb:Q14499|uniprotkb:A2RRD3|uniprotkb:E1P5S0|uniprotkb:E1P5S1|ensembl:ENSP00000253363	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rbm39_human(display_long)|uniprotkb:HCC1(gene name synonym)|uniprotkb:RBM39(gene name)|psi-mi:RBM39(display_short)|uniprotkb:RNA-binding motif protein 39(gene name synonym)|uniprotkb:RNA-binding region-containing protein 2(gene name synonym)|uniprotkb:Hepatocellular carcinoma protein 1(gene name synonym)|uniprotkb:Splicing factor HCC1(gene name synonym)|uniprotkb:RNPC2(gene name synonym)|uniprotkb:CAPER alpha(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001229528.1|refseq:NP_001229529.1|refseq:NP_004893.1|refseq:NP_909122.1|ensembl:ENSG00000131051(gene)|ensembl:ENST00000253363(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050733"(RS domain binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029123|interpro:IPR035979|mint:Q14498|rcsb pdb:2JRS|rcsb pdb:2MHN|rcsb pdb:4OO6|rcsb pdb:4OZ0|rcsb pdb:4OZ1|rcsb pdb:4YUD|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|dip:DIP-32928N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:/e7HNZt0CtcDKTwF8BqSwNpyufc9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O95299	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1246361|uniprotkb:Q8WXC9|ensembl:ENSP00000252711|ensembl:ENSP00000503956|ensembl:ENSP00000504765	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:nduaa_human(display_long)|uniprotkb:NDUFA10(gene name)|psi-mi:NDUFA10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 42 kDa subunit(gene name synonym)|uniprotkb:Complex I-42kD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_004535.1|ensembl:ENSG00000130414(gene)|ensembl:ENST00000252711(transcript)|ensembl:ENST00000676929(transcript)|ensembl:ENST00000678158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|interpro:IPR027417|interpro:IPR031314|mint:O95299|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:8jwJPJ0rD9H7A4AzxPd186tpXYs9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O15321	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390491|uniprotkb:Q96FI8|uniprotkb:D3DS65|uniprotkb:Q86SZ6|intact:EBI-28976916|ensembl:ENSP00000261789|ensembl:ENSP00000494320	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:tm9s1_human(display_long)|uniprotkb:TM9SF1(gene name)|psi-mi:TM9SF1(display_short)|uniprotkb:MP70 protein family member(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001014842.1|refseq:NP_006396.2|ensembl:ENSP00000494320|ensembl:ENSP00000261789|ensembl:ENST00000396854|ensembl:ENSP00000380063|ensembl:ENST00000646500|ensembl:ENSP00000494851|refseq:NP_001275935.1|ensembl:ENSG00000100926(gene)|ensembl:ENSG00000285465(gene)|ensembl:ENST00000261789(transcript)|ensembl:ENST00000646762(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0072657"(protein localization to membrane)|interpro:IPR004240("Nonaspanin (TM9SF)")	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:y4t2+OC3qVXBRLxyH65ywVx8Ja09606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P11142	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-351896|uniprotkb:Q9H3R6|ensembl:ENSP00000227378|ensembl:ENSP00000432083|ensembl:ENSP00000437125	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hsp7c_human(display_long)|uniprotkb:HSPA8(gene name)|psi-mi:HSPA8(display_short)|uniprotkb:HSC70(gene name synonym)|uniprotkb:HSP73(gene name synonym)|uniprotkb:HSPA10(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_006588.1|refseq:NP_694881.1|refseq:XP_011541100.1|ensembl:ENSG00000109971(gene)|ensembl:ENST00000227378(transcript)|ensembl:ENST00000532636(transcript)|ensembl:ENST00000534624(transcript)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008380"(RNA splicing)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042026"(protein refolding)|go:"GO:0042470"(melanosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0043195"(terminal bouton)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061024"(membrane organization)|go:"GO:0061202"(clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0098575"(lumenal side of lysosomal membrane)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1904589"(regulation of protein import)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|mint:P11142|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:3ESK|rcsb pdb:3FZF|rcsb pdb:3FZH|rcsb pdb:3FZK|rcsb pdb:3FZL|rcsb pdb:3FZM|rcsb pdb:3LDQ|rcsb pdb:3M3Z|rcsb pdb:4H5N|rcsb pdb:4H5R|rcsb pdb:4H5T|rcsb pdb:4H5V|rcsb pdb:4H5W|rcsb pdb:4HWI|rcsb pdb:4KBQ|rcsb pdb:5AQF|rcsb pdb:5AQG|rcsb pdb:5AQH|rcsb pdb:5AQI|rcsb pdb:5AQJ|rcsb pdb:5AQK|rcsb pdb:5AQL|rcsb pdb:5AQM|rcsb pdb:5AQN|rcsb pdb:5AQO|rcsb pdb:5AQP|rcsb pdb:5AQQ|rcsb pdb:5AQR|rcsb pdb:5AQS|rcsb pdb:5AQT|rcsb pdb:5AQU|rcsb pdb:5AQV|rcsb pdb:6B1I|rcsb pdb:6B1M|rcsb pdb:6B1N|rcsb pdb:6ZYJ|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-447041|reactome:R-HSA-450408|reactome:R-HSA-6785807|reactome:R-HSA-6798695|reactome:R-HSA-72163|reactome:R-HSA-8856828|reactome:R-HSA-8876725|reactome:R-HSA-888590|reactome:R-HSA-9613354|reactome:R-HSA-9613829|reactome:R-HSA-9615710|dip:DIP-32874N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:0I+wYut3naJRzzgmMSax/1mZZwA9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P08107	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q14254	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-348613|ensembl:ENSP00000378368	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:flot2_human(display_long)|uniprotkb:FLOT2(gene name)|psi-mi:FLOT2(display_short)|uniprotkb:ESA1(gene name synonym)|uniprotkb:M17S1(gene name synonym)|uniprotkb:Epidermal surface antigen(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_004466.2|ensembl:ENSG00000132589(gene)|go:"GO:0008544"(epidermis development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016600"(flotillin complex)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0044860"(protein localization to plasma membrane raft)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098937"(anterograde dendritic transport)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099029"(anchored component of presynaptic active zone membrane)|ensembl:ENST00000394908(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0001931"(uropod)|go:"GO:0002020"(protease binding)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903905"(positive regulation of establishment of T cell polarity)|interpro:IPR001107(Band 7 protein)|interpro:IPR027705|interpro:IPR031905|interpro:IPR036013|mint:Q14254|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8849932|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9696264|reactome:R-HSA-9696273|refseq:XP_016879883.1|refseq:XP_016879884.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:P9htlLzTYk+eDKKesqCEPe/1BJA9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q04609	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390372|uniprotkb:O43748|uniprotkb:Q16305|uniprotkb:Q9NP15|uniprotkb:Q9NYE2|uniprotkb:Q9P1P8|uniprotkb:B7Z312|uniprotkb:E9PDX8|uniprotkb:A9CB79|uniprotkb:B7Z343|uniprotkb:Q541A4|uniprotkb:Q8TAY3|uniprotkb:A4UU12|uniprotkb:D3DQS5|ensembl:ENSP00000256999	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:folh1_human(display_long)|uniprotkb:Glutamate carboxypeptidase II(gene name synonym)|uniprotkb:Membrane glutamate carboxypeptidase(gene name synonym)|uniprotkb:N-acetylated-alpha-linked acidic dipeptidase I(gene name synonym)|uniprotkb:Pteroylpoly-gamma-glutamate carboxypeptidase(gene name synonym)|uniprotkb:Folylpoly-gamma-glutamate carboxypeptidase(gene name synonym)|uniprotkb:Folate hydrolase 1(gene name synonym)|uniprotkb:Prostate-specific membrane antigen(gene name synonym)|uniprotkb:FOLH1(gene name)|psi-mi:FOLH1(display_short)|uniprotkb:FOLH(gene name synonym)|uniprotkb:NAALAD1(gene name synonym)|uniprotkb:PSM(gene name synonym)|uniprotkb:PSMA(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 27 protein(gene name synonym)|uniprotkb:GIG27(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001014986.1|refseq:NP_001180400.1|refseq:NP_001180401.1|refseq:NP_001180402.1|refseq:NP_004467.1|refseq:XP_016872923.1|refseq:XP_016872924.1|refseq:XP_016872926.1|refseq:XP_016872931.1|refseq:XP_016872932.1|refseq:XP_016872933.1|refseq:XP_016872934.1|refseq:XP_016872935.1|refseq:XP_016872936.1|refseq:XP_016872937.1|refseq:XP_016872925.1|ensembl:ENSG00000086205(gene)|ensembl:ENST00000256999(transcript)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004181"(metallocarboxypeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016805"(dipeptidase activity)|go:"GO:0035609"(C-terminal protein deglutamylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904492"(Ac-Asp-Glu binding)|go:"GO:1904493"("tetrahydrofolyl-poly(glutamate) polymer binding")|interpro:IPR003137(Protease-associated PA)|rcsb pdb:2PVW|interpro:IPR007365(Transferrin receptor-like, dimerisation)|interpro:IPR007484(Peptidase M28)|interpro:IPR036757|interpro:IPR039373|rcsb pdb:1Z8L|rcsb pdb:2C6C|rcsb pdb:2C6G|rcsb pdb:2C6P|rcsb pdb:2CIJ|rcsb pdb:2JBJ|rcsb pdb:2JBK|rcsb pdb:2OOT|rcsb pdb:2OR4|rcsb pdb:2XEF|rcsb pdb:2XEG|rcsb pdb:2PVV|rcsb pdb:2XEI|rcsb pdb:2XEJ|rcsb pdb:3BHX|rcsb pdb:3BI0|rcsb pdb:3BI1|rcsb pdb:3BXM|rcsb pdb:3D7D|rcsb pdb:3D7F|rcsb pdb:3D7G|rcsb pdb:3D7H|rcsb pdb:3IWW|rcsb pdb:3RBU|rcsb pdb:3SJE|rcsb pdb:3SJF|rcsb pdb:3SJG|rcsb pdb:3SJX|rcsb pdb:4JYW|rcsb pdb:4JZ0|rcsb pdb:4LQG|rcsb pdb:4MCP|rcsb pdb:4MCQ|rcsb pdb:4MCR|rcsb pdb:4NGM|rcsb pdb:4NGN|rcsb pdb:4NGP|rcsb pdb:4NGQ|rcsb pdb:4NGR|rcsb pdb:4NGS|rcsb pdb:4NGT|rcsb pdb:4OC0|rcsb pdb:4OC1|rcsb pdb:4OC2|rcsb pdb:4OC3|rcsb pdb:4OC4|rcsb pdb:4OC5|rcsb pdb:4MCS|rcsb pdb:4OME|rcsb pdb:4P44|rcsb pdb:4P45|rcsb pdb:4P4B|rcsb pdb:4P4D|rcsb pdb:4P4E|rcsb pdb:4P4F|rcsb pdb:4P4I|rcsb pdb:4P4J|rcsb pdb:4W9Y|rcsb pdb:4X3R|rcsb pdb:5D29|rcsb pdb:5ELY|rcsb pdb:5F09|rcsb pdb:5O5R|rcsb pdb:5O5T|rcsb pdb:5O5U|rcsb pdb:5OF0|rcsb pdb:6ETY|rcsb pdb:6EZ9|rcsb pdb:6F5L|rcsb pdb:6FE5|rcsb pdb:6H7Y|rcsb pdb:6H7Z|rcsb pdb:6HKJ|rcsb pdb:6HKZ|rcsb pdb:6RBC|rcsb pdb:6RTI|rcsb pdb:6S1X|rcsb pdb:6SGP|rcsb pdb:6SKH|reactome:R-HSA-8963693	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:qclBRSa6uxBaG+vzziop8uEuoDU9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P22830	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P53985	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1054708|uniprotkb:Q9NSJ9|uniprotkb:Q5T8R6|uniprotkb:Q49A45|ensembl:ENSP00000416167|ensembl:ENSP00000441065|ensembl:ENSP00000485688|ensembl:ENSP00000358640|ensembl:ENSP00000397106|ensembl:ENSP00000399104|ensembl:ENSP00000486000|ensembl:ENSP00000505879	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:mot1_human(display_long)|uniprotkb:Solute carrier family 16 member 1(gene name synonym)|uniprotkb:SLC16A1(gene name)|psi-mi:SLC16A1(display_short)|uniprotkb:MCT1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001159968.1|refseq:NP_003042.3|refseq:XP_011540328.1|refseq:XP_011540329.1|ensembl:ENSG00000155380(gene)|ensembl:ENSG00000281917(gene)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0032094"(response to food)|ensembl:ENST00000369626(transcript)|ensembl:ENST00000429288(transcript)|ensembl:ENST00000443580(transcript)|ensembl:ENST00000458229(transcript)|ensembl:ENST00000538576(transcript)|ensembl:ENST00000628110(transcript)|ensembl:ENST00000630362(transcript)|ensembl:ENST00000679803(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008028"(monocarboxylic acid transmembrane transporter activity)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015129"(lactate transmembrane transporter activity)|go:"GO:0015130"(mevalonate transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015718"(monocarboxylic acid transport)|go:"GO:0015728"(mevalonate transport)|go:"GO:0016020"(membrane)|go:"GO:0035879"(plasma membrane lactate transport)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0046943"(carboxylic acid transmembrane transporter activity)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0051780"(behavioral response to nutrient)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:0016021"(integral component of membrane)|interpro:IPR004743(Monocarboxylate transporter)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR030757|interpro:IPR036259|mint:P53985|go:"GO:1905039"(carboxylic acid transmembrane transport)|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-210991|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:pwaf5lRwviMRyOg4DN2/6J/iMwc9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q92973	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-286693|intact:EBI-1760498|uniprotkb:Q92957|uniprotkb:Q92975|intact:EBI-1965561|uniprotkb:B4DVC6|ensembl:ENSP00000336712	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:tnpo1_human(display_long)|uniprotkb:TRN(gene name synonym)|uniprotkb:TNPO1(gene name)|psi-mi:TNPO1(display_short)|uniprotkb:KPNB2(gene name synonym)|uniprotkb:MIP1(gene name synonym)|uniprotkb:Importin beta-2(gene name synonym)|uniprotkb:Karyopherin beta-2(gene name synonym)|uniprotkb:M9 region interaction protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_002261.3|refseq:NP_694858.1|refseq:XP_005248557.1|dip:DIP-29335N|ensembl:ENSG00000083312(gene)|ensembl:ENST00000337273(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040122|mint:Q92973|rcsb pdb:1QBK|rcsb pdb:2H4M|rcsb pdb:2OT8|rcsb pdb:2QMR|rcsb pdb:2Z5J|rcsb pdb:2Z5K|rcsb pdb:2Z5M|rcsb pdb:2Z5N|rcsb pdb:2Z5O|rcsb pdb:4FDD|rcsb pdb:4FQ3|rcsb pdb:4JLQ|rcsb pdb:4OO6|rcsb pdb:5J3V|rcsb pdb:5TQC|rcsb pdb:5YVG|rcsb pdb:5YVH|rcsb pdb:5YVI|rcsb pdb:7CYL|reactome:R-HSA-450513|reactome:R-HSA-5620924|reactome:R-HSA-9615933	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:n8Q3n1rmTiJAp6f8DBcBV6j6lac9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P45880	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-354022|ensembl:ENSP00000361686|ensembl:ENSP00000443092|uniprotkb:Q5VWK1|uniprotkb:Q5VWK3|uniprotkb:Q6IB40|uniprotkb:Q7L3J5|uniprotkb:Q9BWK8|uniprotkb:Q9Y5I6	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:vdac2_human(display_long)|uniprotkb:VDAC2(gene name)|psi-mi:VDAC2(display_short)|uniprotkb:Outer mitochondrial membrane protein porin 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000165637(gene)|ensembl:ENST00000332211(transcript)|ensembl:ENST00000543351(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0006820"(anion transport)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008308"(voltage-gated anion channel activity)|go:"GO:0015288"(porin activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031966"(mitochondrial membrane)|refseq:NP_001171712.1|refseq:NP_001171752.1|refseq:NP_003366.2|refseq:NP_001311017.1|go:"GO:0032272"(negative regulation of protein polymerization)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045121"(membrane raft)|go:"GO:0046930"(pore complex)|go:"GO:0097001"(ceramide binding)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001925(Porin, eukaryotic type)|interpro:IPR023614|interpro:IPR027246|interpro:IPR030277|mint:P45880|reactome:R-HSA-5689880|reactome:R-HSA-8949215	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:seQxCd19Z2HmpXcwb48osAuuafA9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9H8H3	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390168|uniprotkb:Q9H7R3|uniprotkb:Q9UHZ7|uniprotkb:Q9Y422|ensembl:ENSP00000331787|ensembl:ENSP00000447542|ensembl:ENSP00000448785	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:met7a_human(display_long)|uniprotkb:Protein AAM-B(gene name synonym)|uniprotkb:METTL7A(gene name)|psi-mi:METTL7A(display_short)|uniprotkb:PRO0066(orf name)|uniprotkb:UNQ1902/PRO4348(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_054752.3|refseq:XP_006719395.1|ensembl:ENSG00000185432(gene)|ensembl:ENST00000332160(transcript)|ensembl:ENST00000547104(transcript)|ensembl:ENST00000548553(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0016020"(membrane)|go:"GO:0032259"(methylation)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR013216(Methyltransferase type 11)|interpro:IPR029063|mint:Q9H8H3|reactome:R-HSA-6798695	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:b8PnE+BClVn1MzOlg0uIaqDSOaU9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9Y6F6	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1563108|uniprotkb:Q9UNY1|uniprotkb:B7Z3T4|uniprotkb:B7Z9A3|uniprotkb:F5H6A1|uniprotkb:J3KQZ7|uniprotkb:B7Z6I2|uniprotkb:Q17S00|ensembl:ENSP00000432436|uniprotkb:E9PQY6	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:irag1_human(display_long)|uniprotkb:IRAG1(gene name)|psi-mi:IRAG1(display_short)|uniprotkb:IRAG(gene name synonym)|uniprotkb:Inositol 1,4,5-trisphosphate receptor-associated cGMP kinase substrate(gene name synonym)|uniprotkb:JAW1-related protein MRVI1(gene name synonym)|uniprotkb:JAW1L(gene name synonym)|uniprotkb:MRVI1(gene name synonym)|uniprotkb:Protein MRVI1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001193809.1|refseq:NP_569056.4|refseq:NP_001092049.2|refseq:NP_001093633.1|refseq:NP_001093637.1|refseq:NP_001193810.1|ensembl:ENSG00000072952(gene)|ensembl:ENST00000531107(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0031095"(platelet dense tubular network membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008677(MRVI1)|mint:Q9Y6F6|reactome:R-HSA-418457	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:VcjVQPpBjKrNG6c94yC5WwitU2Y9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P68104	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-352162|uniprotkb:P04719|uniprotkb:P04720|intact:EBI-2834776|intact:EBI-8011754|intact:MINT-4903558|uniprotkb:Q6IQ15|ensembl:ENSP00000330054|ensembl:ENSP00000339053|ensembl:ENSP00000339063|ensembl:ENSP00000348651|ensembl:ENSP00000392366|ensembl:ENSP00000479055|ensembl:ENSP00000503192|ensembl:ENSP00000503249|ensembl:ENSP00000503823|ensembl:ENSP00000504335|intact:EBI-16423274	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ef1a1_human(display_long)|uniprotkb:EEF1A1(gene name)|psi-mi:EEF1A1(display_short)|uniprotkb:EEF1A(gene name synonym)|uniprotkb:EF1A(gene name synonym)|uniprotkb:LENG7(gene name synonym)|uniprotkb:Eukaryotic elongation factor 1 A-1(gene name synonym)|uniprotkb:Elongation factor Tu(gene name synonym)|uniprotkb:Leukocyte receptor cluster member 7(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:XP_011533816.1|ensembl:ENSG00000156508(gene)|ensembl:ENST00000309268(transcript)|ensembl:ENST00000316292(transcript)|ensembl:ENST00000331523(transcript)|ensembl:ENST00000356303(transcript)|ensembl:ENST00000455918(transcript)|ensembl:ENST00000615060(transcript)|ensembl:ENST00000676710(transcript)|ensembl:ENST00000677236(transcript)|ensembl:ENST00000678508(transcript)|ensembl:ENST00000678702(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0016020"(membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1900022"(regulation of D-erythro-sphingosine kinase activity)|go:"GO:1904714"(regulation of chaperone-mediated autophagy)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P68104|rcsb pdb:1SYW|rcsb pdb:3C5J|rcsb pdb:6ZMO|reactome:R-HSA-156842|reactome:R-HSA-156902|reactome:R-HSA-3371511|reactome:R-HSA-6798695|reactome:R-HSA-8876725|reactome:R-HSA-9613829|dip:DIP-31277N|refseq:NP_001393.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:d3REF87FDKboAjyvlJJEXtqhrcw9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9H2X3	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1391211|uniprotkb:Q69F40|uniprotkb:Q969M4|uniprotkb:Q96QP3|uniprotkb:Q96QP4|uniprotkb:Q96QP5|uniprotkb:Q96QP6|uniprotkb:Q9BXS3|uniprotkb:Q9H2Q9|uniprotkb:Q9H8F0|uniprotkb:Q9Y2A8|uniprotkb:A6NKI4|uniprotkb:A8K8B3|ensembl:ENSP00000316228	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:clc4m_human(display_long)|uniprotkb:CD209 antigen-like protein 1(gene name synonym)|uniprotkb:Dendritic cell-specific ICAM-3-grabbing non-integrin 2(gene name synonym)|uniprotkb:DC-SIGN-related protein(gene name synonym)|uniprotkb:Liver/lymph node-specific ICAM-3-grabbing non-integrin(gene name synonym)|uniprotkb:CLEC4M(gene name)|psi-mi:CLEC4M(display_short)|uniprotkb:CD209L(gene name synonym)|uniprotkb:CD209L1(gene name synonym)|uniprotkb:CD299(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:XP_006722678.1|refseq:NP_001138377.1|refseq:NP_001138378.1|refseq:NP_001138379.1|refseq:NP_001138380.1|refseq:NP_001138381.1|refseq:NP_001138382.1|refseq:NP_001138383.1|refseq:NP_055072.3|ensembl:ENSG00000104938(gene)|ensembl:ENST00000327325(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005537"(mannose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009988"(cell-cell recognition)|go:"GO:0016020"(membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0019079"(viral genome replication)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042605"(peptide antigen binding)|go:"GO:0043657"(host cell)|go:"GO:0045087"(innate immune response)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046790"(virion binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046968"(peptide antigen transport)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0075733"(intracellular transport of virus)|interpro:IPR001304(C-type lectin)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR033989|rcsb pdb:1K9J|rcsb pdb:1SL6|rcsb pdb:1XAR|rcsb pdb:1XPH|rcsb pdb:1Z0Y|rcsb pdb:3JQH	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:FR9EEv0vaGUvH/qu0Hg6gLa0yOw9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O60313-2	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1391166|ensembl:ENSP00000354681	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:o60313-2(display_long)|uniprotkb:OPA1(gene name)|psi-mi:OPA1(display_short)|uniprotkb:KIAA0567(gene name synonym)|uniprotkb:Optic atrophy protein 1(gene name synonym)|uniprotkb:7(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	intact:EBI-1054131(opa1_human)|ensembl:ENSG00000198836(gene)|ensembl:ENST00000361908(transcript)|uniprotkb:O60313-2(isoform-parent)	omim:176807(primary-reference)	-	isoform-comment:"Proteolytic processing near Gln-220 produces form S2 (Ref.9). Variant in position: 229:R->H (in OPA1) (Ref.28)."	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:OVu3+c609Du+Bm7rJ4ikmmT+y6I9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P36776	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P51648	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1391128|uniprotkb:Q93011|uniprotkb:Q96J37|uniprotkb:Q6I9T3|ensembl:ENSP00000176643|ensembl:ENSP00000461916|ensembl:ENSP00000463637|ensembl:ENSP00000500092	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:al3a2_human(display_long)|uniprotkb:Aldehyde dehydrogenase 10(gene name synonym)|uniprotkb:Microsomal aldehyde dehydrogenase(gene name synonym)|uniprotkb:ALDH3A2(gene name)|psi-mi:ALDH3A2(display_short)|uniprotkb:ALDH10(gene name synonym)|uniprotkb:FALDH(gene name synonym)|uniprotkb:Fatty aldehyde dehydrogenase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_000373.1|refseq:NP_001026976.1|refseq:XP_011522034.1|refseq:XP_011522035.1|refseq:XP_016879845.1|refseq:XP_016879846.1|ensembl:ENST00000672357(transcript)|go:"GO:0004028"(3-chloroallyl aldehyde dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006714"(sesquiterpenoid metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008544"(epidermis development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033306"(phytol metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0046458"(hexadecanal metabolic process)|go:"GO:0046577"(long-chain-alcohol oxidase activity)|go:"GO:0050061"(long-chain-aldehyde dehydrogenase activity)|go:"GO:0052814"(medium-chain-aldehyde dehydrogenase activity)|interpro:IPR012394("Aldehyde dehydrogenase NAD(P)-dependent")|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P51648|rcsb pdb:4QGK|reactome:R-HSA-1660661|reactome:R-HSA-389599|reactome:R-HSA-9603798|reactome:R-HSA-9609523|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENSG00000072210(gene)|ensembl:ENST00000176643(transcript)|ensembl:ENST00000579855(transcript)|ensembl:ENST00000581518(transcript)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:ADi5/NMf5JsjzaonzFIbHZebIlQ9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P35579	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q8N2F6	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390675|uniprotkb:Q75K91|uniprotkb:Q75MG6|uniprotkb:Q75ML8|uniprotkb:Q8IZC1|uniprotkb:Q8IZC2|uniprotkb:Q8IZC3|uniprotkb:Q9BTM6|uniprotkb:A8K703|uniprotkb:B4DWJ8|uniprotkb:F5GX65|ensembl:ENSP00000319412	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:arm10_human(display_long)|uniprotkb:Splicing variant involved in hepatocarcinogenesis protein(gene name synonym)|uniprotkb:ARMC10(gene name)|psi-mi:ARMC10(display_short)|uniprotkb:SVH(gene name synonym)|uniprotkb:PSEC0198(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001154481.1|refseq:NP_001154482.1|refseq:NP_001154484.1|refseq:NP_114111.2|refseq:NP_001154483.1|refseq:NP_001154485.1|ensembl:ENSG00000170632(gene)|ensembl:ENST00000323716(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0040008"(regulation of growth)|go:"GO:0040010"(positive regulation of growth rate)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:iP1bkLPGuKxPCyZStXI0OIamvJ49606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P12004	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-358311|uniprotkb:B2R897|uniprotkb:D3DW02|ensembl:ENSP00000368438|ensembl:ENSP00000368458	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:pcna_human(display_long)|uniprotkb:PCNA(gene name)|psi-mi:PCNA(display_short)|uniprotkb:Cyclin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_002583.1|refseq:NP_872590.1|ensembl:ENSG00000132646(gene)|ensembl:ENST00000379143(transcript)|ensembl:ENST00000379160(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000701"(purine-specific mismatch base pair DNA N-glycosylase activity)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005813"(centrosome)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006287"(base-excision repair, gap-filling)|go:"GO:0006298"(mismatch repair)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0030894"(replisome)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0032077"(positive regulation of deoxyribonuclease activity)|go:"GO:0032139"(dinucleotide insertion or deletion binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043596"(nuclear replication fork)|go:"GO:0043626"(PCNA complex)|go:"GO:0044849"(estrous cycle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070557"(PCNA-p21 complex)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0097421"(liver regeneration)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902990"(mitotic telomere maintenance via semi-conservative replication)|interpro:IPR000730(Proliferating cell nuclear antigen, PCNA)|interpro:IPR022648|interpro:IPR022649|interpro:IPR022659|mint:P12004|rcsb pdb:1AXC|rcsb pdb:1U76|rcsb pdb:1U7B|rcsb pdb:1UL1|rcsb pdb:1VYJ|rcsb pdb:1VYM|rcsb pdb:1W60|rcsb pdb:2ZVK|rcsb pdb:2ZVL|rcsb pdb:2ZVM|rcsb pdb:3JA9|rcsb pdb:3P87|rcsb pdb:3TBL|rcsb pdb:3VKX|rcsb pdb:3WGW|rcsb pdb:4D2G|rcsb pdb:4RJF|rcsb pdb:4ZTD|rcsb pdb:5E0T|rcsb pdb:5E0U|rcsb pdb:5E0V|rcsb pdb:5IY4|rcsb pdb:5MAV|rcsb pdb:5MLO|rcsb pdb:5MLW|reactome:R-HSA-5651801|rcsb pdb:5MOM|rcsb pdb:5YCO|rcsb pdb:5YD8|rcsb pdb:6CBI|rcsb pdb:6EHT|rcsb pdb:6FCM|rcsb pdb:6FCN|rcsb pdb:6GIS|rcsb pdb:6GWS|rcsb pdb:6HVO|rcsb pdb:6K3A|rcsb pdb:6QC0|rcsb pdb:6QCG|rcsb pdb:6S1M|rcsb pdb:6S1N|rcsb pdb:6S1O|rcsb pdb:6TNY|rcsb pdb:6TNZ|rcsb pdb:6VVO|rcsb pdb:7EFA|rcsb pdb:7KQ0|rcsb pdb:7KQ1|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1362277|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174437|reactome:R-HSA-4615885|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685942|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804114|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-8866654|reactome:R-HSA-5655862|dip:DIP-1098N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:5JUv5dKFwQAAaXm5aEiwCXVoAOM9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q14554	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-953879|ensembl:ENSP00000323313|uniprotkb:D3DN95|uniprotkb:Q9BV43	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:pdia5_human(display_long)|uniprotkb:Protein disulfide isomerase-related protein(gene name synonym)|uniprotkb:PDIA5(gene name)|psi-mi:PDIA5(display_short)|uniprotkb:PDIR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000065485(gene)|ensembl:ENST00000316218(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0022900"(electron transport chain)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR041865|rcsb pdb:4I6X|reactome:R-HSA-381038|refseq:NP_006801.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:HhJNzAyAeysPEGdQL3Cz0piSjAM9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q86UE4	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1046588|ensembl:ENSP00000338235|uniprotkb:Q8TCX3|uniprotkb:Q6PK07|uniprotkb:Q05DH2|uniprotkb:Q52QU9	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:lyric_human(display_long)|uniprotkb:Lysine-rich CEACAM1 co-isolated protein(gene name synonym)|uniprotkb:3D3/LYRIC(gene name synonym)|uniprotkb:Metastasis adhesion protein(gene name synonym)|uniprotkb:Astrocyte elevated gene-1 protein(gene name synonym)|uniprotkb:MTDH(gene name)|psi-mi:MTDH(display_short)|uniprotkb:AEG1(gene name synonym)|uniprotkb:LYRIC(gene name synonym)|uniprotkb:Metadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000147649(gene)|ensembl:ENST00000336273(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR031402|mint:Q86UE4|rcsb pdb:4QMG|refseq:NP_848927.2	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:daZhKhAOeoKGjfl0IXt1fZXn/I09606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O43187	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-447733|uniprotkb:B4DQZ6|uniprotkb:Q08AG6|uniprotkb:Q5K546|ensembl:ENSP00000256458	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:irak2_human(display_long)|uniprotkb:IRAK2(gene name)|psi-mi:IRAK2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001561.3|dip:DIP-31800N|ensembl:ENSG00000134070(gene)|ensembl:ENST00000256458(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010008"(endosome membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR033611|interpro:IPR042151|mint:O43187|rcsb pdb:3MOP|reactome:R-HSA-166058|reactome:R-HSA-168638|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-975138|reactome:R-HSA-975155|reactome:R-HSA-975163|reactome:R-HSA-975871	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:8sh0M2M7p7IdXoGbxbRsaGJi/gk9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q96JB5-1	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-718836|ensembl:ENSP00000344683	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:q96jb5-1(display_long)|uniprotkb:CDK5RAP3(gene name)|psi-mi:CDK5RAP3(display_short)|uniprotkb:IC53(gene name synonym)|uniprotkb:CDK5 activator-binding protein C53(gene name synonym)|uniprotkb:Protein HSF-27(gene name synonym)|uniprotkb:MSTP016(orf name)|uniprotkb:OK/SW-cl.114(orf name)|uniprotkb:PP1553(orf name)|uniprotkb:LXXLL/leucine-zipper-containing ARF-binding protein(gene name synonym)|uniprotkb:LZAP(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	intact:EBI-718818(ck5p3_human)|ensembl:ENSG00000108465(gene)|ensembl:ENST00000338399(transcript)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:K1S/DQ6fYeOm+MiiGicED0chJAw9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P04792	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	omim:176807(primary-reference)	-	crc64:1B4DC44A6F6606D5	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P54707	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1389639|uniprotkb:Q13816|uniprotkb:Q13817|uniprotkb:Q16734|uniprotkb:Q5W035|uniprotkb:Q8N5U2|ensembl:ENSP00000371372|intact:EBI-28967764	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:at12a_human(display_long)|uniprotkb:Proton pump(gene name synonym)|uniprotkb:"Non-gastric H(+)/K(+) ATPase subunit alpha"(gene name synonym)|uniprotkb:ATP12A(gene name)|psi-mi:ATP12A(display_short)|uniprotkb:ATP1AL1(gene name synonym)|uniprotkb:HK alpha 2(gene name synonym)|uniprotkb:"Non-gastric Na(+)/K(+) ATPase subunit alpha"(gene name synonym)|uniprotkb:Sodium pump(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENST00000218548|ensembl:ENSP00000218548|ensembl:ENSP00000371372|refseq:NP_001172014.1|refseq:NP_001667.4|ensembl:ENSG00000075673(gene)|ensembl:ENST00000381946(transcript)|go:"GO:0005391"("P-type sodium:potassium-exchanging transporter activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005889"("potassium:proton exchanging ATPase complex")|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0008900"("P-type potassium:proton transporter activity")|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030007"(cellular potassium ion homeostasis)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005775(ATPase, P-type cation exchange, alpha subunit, eukaryotic)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030318|interpro:IPR036412|go:"GO:1990573"(potassium ion import across plasma membrane)|interpro:IPR044492|reactome:R-HSA-936837	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:kxYW6TOIahuX5mJSpXeBAGxHXXI9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q8NBM4	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-724045|uniprotkb:Q0VAB5|uniprotkb:Q5W0W6|uniprotkb:Q5W0W9|uniprotkb:Q6GQR2|uniprotkb:Q6P4B0|uniprotkb:Q8N2E8|uniprotkb:Q96NW2|uniprotkb:B3KNV7|ensembl:ENSP00000383911	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ubac2_human(display_long)|uniprotkb:PHGDHL1(gene name synonym)|uniprotkb:Phosphoglycerate dehydrogenase-like protein 1(gene name synonym)|uniprotkb:UBAC2(gene name)|psi-mi:UBAC2(display_short)|uniprotkb:PSEC0110(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001137544.1|refseq:NP_808882.1|ensembl:ENSG00000134882(gene)|ensembl:ENST00000403766(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR035952|interpro:IPR041928|mint:Q8NBM4|refseq:XP_011519386.1|refseq:XP_006720011.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:wOJ8u9ZDDuqYRij5EjsFm4hLRUQ9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q16795	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1045087|uniprotkb:Q14076|uniprotkb:Q2NKX0|ensembl:ENSP00000266544	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ndua9_human(display_long)|uniprotkb:NADH-ubiquinone oxidoreductase 39 kDa subunit(gene name synonym)|uniprotkb:Complex I-39kD(gene name synonym)|uniprotkb:NDUFA9(gene name)|psi-mi:NDUFA9(display_short)|uniprotkb:NDUFS2L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_004993.1|ensembl:ENSG00000139180(gene)|ensembl:ENST00000266544(transcript)|go:"GO:0003954"(NADH dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006814"(sodium ion transport)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009749"(response to glucose)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1901006"(ubiquinone-6 biosynthetic process)|interpro:IPR001509(NAD-dependent epimerase/dehydratase)|interpro:IPR036291|mint:Q16795|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|dip:DIP-38526N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:eM2zUsbdjMEILIcUedVOyEMwAzU9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q13423	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1391318|uniprotkb:Q16796|uniprotkb:Q2TB60|uniprotkb:Q8N3V4|ensembl:ENSP00000264663|ensembl:ENSP00000343873|ensembl:ENSP00000499249|ensembl:ENSP00000499281|ensembl:ENSP00000499494|ensembl:ENSP00000499527|ensembl:ENSP00000499611|ensembl:ENSP00000499639	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:nntm_human(display_long)|uniprotkb:NNT(gene name)|psi-mi:NNT(display_short)|uniprotkb:Nicotinamide nucleotide transhydrogenase(gene name synonym)|uniprotkb:Pyridine nucleotide transhydrogenase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_036475.3|refseq:NP_892022.2|refseq:XP_011512303.1|refseq:XP_016864782.1|refseq:XP_005248331.1|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903285"(positive regulation of hydrogen peroxide catabolic process)|interpro:IPR007698(Alanine dehydrogenase/PNT, C-terminal)|interpro:IPR007886(Alanine dehydrogenase/PNT, N-terminal)|interpro:IPR008142(Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-1)|interpro:IPR008143(Alanine dehydrogenase/pyridine nucleotide transhydrogenase, conserved site-2)|interpro:IPR024605|interpro:IPR026255|interpro:IPR029035|interpro:IPR034300|interpro:IPR036291|mint:Q13423|rcsb pdb:1DJL|rcsb pdb:1PT9|rcsb pdb:1U31|reactome:R-HSA-71403|ensembl:ENSG00000112992(gene)|ensembl:ENST00000264663(transcript)|ensembl:ENST00000344920(transcript)|ensembl:ENST00000653251(transcript)|ensembl:ENST00000656666(transcript)|ensembl:ENST00000662525(transcript)|ensembl:ENST00000669601(transcript)|ensembl:ENST00000670904(transcript)|ensembl:ENST00000671668(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003957"("NAD(P)+ transhydrogenase (B-specific) activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005746"(mitochondrial respirasome)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006740"(NADPH regeneration)|go:"GO:0008746"("NAD(P)+ transhydrogenase activity")|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0033273"(response to vitamin)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0050661"(NADP binding)|go:"GO:0051287"(NAD binding)|go:"GO:0072593"(reactive oxygen species metabolic process)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:iDKBuEy/JvV9q3s4/aHuu58+Gyk9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P13645	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-465144|ensembl:ENSP00000269576|uniprotkb:Q14664|uniprotkb:Q8N175	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:k1c10_human(display_long)|uniprotkb:KRT10(gene name)|psi-mi:KRT10(display_short)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:KPP(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000186395(gene)|ensembl:ENST00000269576(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P13645|rcsb pdb:3ASW|rcsb pdb:4F1Z|rcsb pdb:4ZRY|rcsb pdb:6E2J|rcsb pdb:6EC0|rcsb pdb:6UUI|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000412.3	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:z100yyq3b63P0ARy2lE2ELyJeik9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9H1E3	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1390111|uniprotkb:Q5PXE7|uniprotkb:Q9H1D6|uniprotkb:Q9H723|uniprotkb:Q54AC0|ensembl:ENSP00000356110	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:nucks_human(display_long)|uniprotkb:P1(gene name synonym)|uniprotkb:NUCKS1(gene name)|psi-mi:NUCKS1(display_short)|uniprotkb:NUCKS(gene name synonym)|uniprotkb:JC7(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_073568.2|mint:Q9H1E3|interpro:IPR026633|ensembl:ENSG00000069275(gene)|ensembl:ENST00000367142(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0019046"(release from viral latency)|go:"GO:0031297"(replication fork processing)|go:"GO:0035822"(gene conversion)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0060382"(regulation of DNA strand elongation)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990968"(modulation by host of RNA binding by virus)|go:"GO:1990969"(modulation by host of viral RNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:KYG9QwIUKWdRofCU7BAlbRdZe+Y9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P02545	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-351935|uniprotkb:B4DI32|uniprotkb:E7EUI9|uniprotkb:P02546|uniprotkb:Q969I8|uniprotkb:Q96JA2|uniprotkb:D6RAQ3|uniprotkb:Q5I6Y4|uniprotkb:Q5I6Y6|uniprotkb:Q6UYC3|uniprotkb:Q5TCJ2|uniprotkb:Q5TCJ3|uniprotkb:D3DVB0|intact:EBI-28988787|ensembl:ENSP00000355292|ensembl:ENSP00000357283|ensembl:ENSP00000502256|ensembl:ENSP00000506771	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:lmna_human(display_long)|uniprotkb:LMNA(gene name)|psi-mi:LMNA(display_short)|uniprotkb:LMN1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_005563.1|refseq:NP_733821.1|refseq:NP_733822.1|refseq:NP_001244303.1|refseq:NP_001269553.1|refseq:NP_001269554.1|refseq:NP_001269555.1|ensembl:ENSG00000160789(gene)|ensembl:ENST00000361308(transcript)|ensembl:ENST00000368300(transcript)|ensembl:ENST00000675939(transcript)|ensembl:ENST00000683032(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030951"(establishment or maintenance of microtubule cytoskeleton polarity)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:1900114"(positive regulation of histone H3-K9 trimethylation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|go:"GO:1990683"(DNA double-strand break attachment to nuclear envelope)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|mint:P02545|rcsb pdb:1IFR|rcsb pdb:1IVT|rcsb pdb:1X8Y|rcsb pdb:2XV5|rcsb pdb:2YPT|rcsb pdb:3GEF|rcsb pdb:3V4Q|rcsb pdb:3V4W|rcsb pdb:3V5B|rcsb pdb:6GHD|rcsb pdb:6JLB|rcsb pdb:6RPR|rcsb pdb:6SNZ|rcsb pdb:6YF5|rcsb pdb:6YJD|reactome:R-HSA-1221632|reactome:R-HSA-2980766|reactome:R-HSA-2995383|reactome:R-HSA-352238|reactome:R-HSA-381038|reactome:R-HSA-4419969|reactome:R-HSA-6802952|reactome:R-HSA-8862803|ensembl:ENSP00000503633|ensembl:ENST00000682650|ensembl:ENSP00000506904|ensembl:ENST00000677389|ensembl:ENSP00000506771|ensembl:ENSP00000355292|ensembl:ENST00000368299|ensembl:ENSP00000357282|ensembl:ENSP00000357283|ensembl:ENST00000368301|ensembl:ENSP00000357284|ensembl:ENST00000448611|ensembl:ENSP00000395597|ensembl:ENST00000473598|ensembl:ENSP00000421821|ensembl:ENSP00000502256|ensembl:ENST00000676385|ensembl:ENSP00000502091|dip:DIP-32948N|dip:DIP-58162N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:OS/QDFLGOD2PElQ6mCpBtk6xh/09606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P61225	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-750871|uniprotkb:P17964|uniprotkb:Q96EG5|uniprotkb:Q9CXG0|ensembl:ENSP00000319096	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rap2b_human(display_long)|uniprotkb:RAP2B(gene name)|psi-mi:RAP2B(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_002877.2|ensembl:ENSG00000181467(gene)|ensembl:ENST00000323534(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030168"(platelet activation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0035579"(specific granule membrane)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061097"(regulation of protein tyrosine kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0070821"(tertiary granule membrane)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR020849|interpro:IPR027417|interpro:IPR041840|rcsb pdb:1N4P|rcsb pdb:1N4Q|rcsb pdb:1N4R|reactome:R-HSA-6798695	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:dFHHIYuDf3lTGSX0Nys6IE9ONvs9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q6P587	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-597013|uniprotkb:Q6FIC7|uniprotkb:Q96RY1|uniprotkb:Q9H0N6|uniprotkb:B1AK41|uniprotkb:B1AK40|ensembl:ENSP00000398053	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:fahd1_human(display_long)|uniprotkb:FAHD1(gene name)|psi-mi:FAHD1(display_short)|uniprotkb:C16orf36(gene name synonym)|uniprotkb:Fumarylacetoacetate hydrolase domain-containing protein 1(gene name synonym)|uniprotkb:YISKL(gene name synonym)|uniprotkb:YisK-like protein(gene name synonym)|uniprotkb:Oxaloacetate decarboxylase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001018114.1|refseq:NP_001135870.1|refseq:NP_112485.1|ensembl:ENSG00000180185(gene)|ensembl:ENST00000427358(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0008948"(oxaloacetate decarboxylase activity)|go:"GO:0018773"(acetylpyruvate hydrolase activity)|go:"GO:0034545"(fumarylpyruvate hydrolase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0047621"(acylpyruvate hydrolase activity)|interpro:IPR011234(Fumarylacetoacetase, C-terminal-related)|interpro:IPR036663|rcsb pdb:1SAW|rcsb pdb:6FOG|rcsb pdb:6FOH|reactome:R-HSA-71403	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:+TBWTaRxrIz2Y0dfwkSNf8VZEcw9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P51571	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1054539|uniprotkb:Q53XY1|uniprotkb:A8K378|ensembl:ENSP00000317331|ensembl:ENSP00000359103|ensembl:ENSP00000359104	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ssrd_human(display_long)|uniprotkb:Signal sequence receptor subunit delta(gene name synonym)|uniprotkb:SSR4(gene name)|psi-mi:SSR4(display_short)|uniprotkb:TRAPD(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001191455.1|refseq:NP_006271.1|refseq:XP_011529488.1|refseq:XP_011529489.1|ensembl:ENSG00000180879(gene)|ensembl:ENST00000320857(transcript)|ensembl:ENST00000370086(transcript)|ensembl:ENST00000370087(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008855(Translocon-associated)|mint:P51571|reactome:R-HSA-1799339	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:2SNgZQH/jwi61UcuHUf7RYKZH589606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q6IAA8	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-715385|uniprotkb:Q8WZ09|uniprotkb:Q9NWT0|ensembl:ENSP00000278671	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ltor1_human(display_long)|uniprotkb:LAMTOR1(gene name)|psi-mi:LAMTOR1(display_short)|uniprotkb:PP7157(orf name)|uniprotkb:p27Kip1-releasing factor from RhoA(gene name synonym)|uniprotkb:C11orf59(gene name synonym)|uniprotkb:Lipid raft adaptor protein p18(gene name synonym)|uniprotkb:Protein associated with DRMs and endosomes(gene name synonym)|uniprotkb:PDRO(gene name synonym)|uniprotkb:Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_060377.1|ensembl:ENSG00000149357(gene)|ensembl:ENST00000278671(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001919"(regulation of receptor recycling)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0010872"(regulation of cholesterol esterification)|go:"GO:0010874"(regulation of cholesterol efflux)|go:"GO:0016197"(endosomal transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0032418"(lysosome localization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045121"(membrane raft)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0060620"(regulation of cholesterol import)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071986"(Ragulator complex)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR028209|rcsb pdb:5X6U|rcsb pdb:5Y39|rcsb pdb:5Y3A|rcsb pdb:6B9X|rcsb pdb:6EHP|rcsb pdb:6EHR|rcsb pdb:6NZD|rcsb pdb:6U62|rcsb pdb:5X6V|rcsb pdb:6ULG|rcsb pdb:6WJ2|rcsb pdb:6WJ3|reactome:R-HSA-1632852|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6798695|reactome:R-HSA-8943724|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013408|reactome:R-HSA-9013409|reactome:R-HSA-9013423|reactome:R-HSA-9639288|dip:DIP-39650N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:qOdH2HiC+MXwRS2+L8/XgkTRDeo9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9NXW2	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-358818|uniprotkb:Q9H6H0|uniprotkb:B7Z7I3|ensembl:ENSP00000403313	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:djb12_human(display_long)|uniprotkb:DNAJB12(gene name)|psi-mi:DNAJB12(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001002762.2|refseq:NP_060096.3|ensembl:ENSG00000148719(gene)|ensembl:ENST00000444643(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034622"|go:"GO:0036503"(ERAD pathway)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0071218"(cellular response to misfolded protein)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR015399(Protein of unknown function DUF1977, DnaJ-like)|interpro:IPR018253|interpro:IPR036869|mint:Q9NXW2|rcsb pdb:2CTP|go:"GO:0005789"(endoplasmic reticulum membrane)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:kt+aES6+wgXo7o1UhFt4E5w9wTs9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q05519	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1051785|uniprotkb:Q5T758|uniprotkb:Q8IWE6|ensembl:ENSP00000359988	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:srs11_human(display_long)|uniprotkb:Arginine-rich 54 kDa nuclear protein(gene name synonym)|uniprotkb:SRSF11(gene name)|psi-mi:SRSF11(display_short)|uniprotkb:SFRS11(gene name synonym)|uniprotkb:Splicing factor, arginine/serine-rich 11(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_004759.1|refseq:NP_001177916.1|refseq:XP_011540729.1|ensembl:ENSG00000116754(gene)|ensembl:ENST00000370950(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034447|interpro:IPR035979|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:XP_016858301.1|refseq:XP_016858302.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:F6QVk0M0PqxLXIA1dgWyoFbwFHE9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P82663	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1046734|uniprotkb:Q9H7P5|ensembl:ENSP00000253686|uniprotkb:B4DFJ5|uniprotkb:B4DQG6	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rt25_human(display_long)|uniprotkb:MRPS25(gene name)|psi-mi:MRPS25(display_short)|uniprotkb:RPMS25(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS25(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_071942.1|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000131368(gene)|ensembl:ENST00000253686(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005840"(ribosome)|interpro:IPR007741(Mitochondrial ribosome)|interpro:IPR036249|interpro:IPR040049|mint:P82663|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:DQMtBaQJW2Ic025zsKJYfN4aj1I9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9H0X4	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1389842|uniprotkb:Q7L416|uniprotkb:Q96FR1|uniprotkb:Q96MC7|uniprotkb:Q96S30|uniprotkb:D3DU45|ensembl:ENSP00000301678|ensembl:ENSP00000382814	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:f234a_human(display_long)|uniprotkb:FAM234A(gene name)|psi-mi:FAM234A(display_short)|uniprotkb:C16orf9(gene name synonym)|uniprotkb:ITFG3(gene name synonym)|uniprotkb:Protein ITFG3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001271426.1|refseq:NP_114428.1|refseq:XP_016879249.1|refseq:XP_016879250.1|refseq:XP_016879251.1|refseq:XP_011520993.1|refseq:XP_011520994.1|refseq:XP_005255679.1|ensembl:ENSG00000167930(gene)|ensembl:ENST00000301678(transcript)|ensembl:ENST00000399932(transcript)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|mint:Q9H0X4	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:nmh0mT6DweQQVTH0zgscPL5NXRk9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O00519	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1389829|uniprotkb:Q52M86|uniprotkb:Q5TDF8|uniprotkb:D3DQ19|ensembl:ENSP00000243167	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:faah1_human(display_long)|uniprotkb:Oleamide hydrolase 1(gene name synonym)|uniprotkb:Anandamide amidohydrolase 1(gene name synonym)|uniprotkb:FAAH(gene name)|psi-mi:FAAH(display_short)|uniprotkb:FAAH1(gene name synonym)|uniprotkb:Fatty acid ester hydrolase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001432.2|go:"GO:0031090"(organelle membrane)|go:"GO:0047372"(acylglycerol lipase activity)|go:"GO:0052651"(monoacylglycerol catabolic process)|go:"GO:0102077"(oleamide hydrolase activity)|go:"GO:0103073"(anandamide amidohydrolase activity)|interpro:IPR020556|interpro:IPR023631|interpro:IPR030560|interpro:IPR036928|reactome:R-HSA-2142753|ensembl:ENSG00000117480(gene)|ensembl:ENST00000243167(transcript)|go:"GO:0004040"(amidase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005856"(cytoskeleton)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017064"(fatty acid amide hydrolase activity)|go:"GO:0019369"(arachidonic acid metabolic process)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:VeMFlyWuJ+8wTUjTTWlcJ7GKPlg9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9Y265	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-353675|uniprotkb:P82276|uniprotkb:Q1KMR0|uniprotkb:Q53HK5|uniprotkb:Q53HL7|uniprotkb:Q53Y27|uniprotkb:Q9BSX9|uniprotkb:B2R5S0|ensembl:ENSP00000318297|ensembl:ENSP00000494621	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ruvb1_human(display_long)|uniprotkb:RUVBL1(gene name)|psi-mi:RUVBL1(display_short)|uniprotkb:NMP238(gene name synonym)|uniprotkb:TIP49(gene name synonym)|uniprotkb:TIP49A(gene name synonym)|uniprotkb:49 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49a(gene name synonym)|uniprotkb:Pontin 52(gene name synonym)|uniprotkb:Nuclear matrix protein 238(gene name synonym)|uniprotkb:54 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80H(gene name synonym)|uniprotkb:TIP60-associated protein 54-alpha(gene name synonym)|uniprotkb:INO80 complex subunit H(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_003698.1|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016573"(histone acetylation)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051301"(cell division)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071339"(MLL1 complex)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037938|interpro:IPR041048|mint:Q9Y265|rcsb pdb:2C9O|rcsb pdb:2XSZ|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-606279|ensembl:ENSG00000175792(gene)|ensembl:ENSG00000284901(gene)|ensembl:ENST00000322623(transcript)|ensembl:ENST00000643444(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000812"(Swr1 complex)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001306013.1|dip:DIP-29937N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:+FA/xQTUldQoWGRgad9U8vZpTHw9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9H9J2	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-713619|uniprotkb:Q53S16|uniprotkb:Q6IA62|uniprotkb:Q9H821|ensembl:ENSP00000258383|intact:EBI-21356011	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rm44_human(display_long)|uniprotkb:MRPL44(gene name)|psi-mi:MRPL44(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL44(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSG00000135900(gene)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0005886"(plasma membrane)|go:"GO:0006396"(RNA processing)|go:"GO:0016604"(nuclear body)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0070125"(mitochondrial translational elongation)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR036389|interpro:IPR044444|mint:Q9H9J2|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|ensembl:ENST00000258383(transcript)|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_075066.1	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:YNUNu4UGyhAuaSChEzFXCw2k7wk9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P46939	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-295856|intact:EBI-784141|uniprotkb:Q5SZ57|uniprotkb:Q5SYY1|uniprotkb:Q9UJ40|ensembl:ENSP00000356515	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:utrn_human(display_long)|uniprotkb:UTRN(gene name)|psi-mi:UTRN(display_short)|uniprotkb:DMDL(gene name synonym)|uniprotkb:Dystrophin-related protein 1(gene name synonym)|uniprotkb:DRP1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	ensembl:ENSP00000356515|refseq:XP_011534408.1|refseq:NP_009055.2|refseq:XP_005267187.1|dip:DIP-711N|ensembl:ENSG00000152818(gene)|ensembl:ENST00000367545(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|mint:P46939|rcsb pdb:1BHD|rcsb pdb:1QAG|rcsb pdb:6M5G|reactome:R-HSA-9619665	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:metWqbqGtzonNZ1mgNjlFrenuI89606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9Y230	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-352939|ensembl:ENSP00000473172|uniprotkb:Q6FIB9|uniprotkb:Q6PK27|uniprotkb:Q9Y361|uniprotkb:B3KQ59|uniprotkb:E7ETE5|intact:EBI-1058527	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:ruvb2_human(display_long)|uniprotkb:RUVBL2(gene name)|psi-mi:RUVBL2(display_short)|uniprotkb:TIP48(gene name synonym)|uniprotkb:TIP49B(gene name synonym)|uniprotkb:CGI-46(orf name)|uniprotkb:48 kDa TATA box-binding protein-interacting protein(gene name synonym)|uniprotkb:TIP49b(gene name synonym)|uniprotkb:Repressing pontin 52(gene name synonym)|uniprotkb:51 kDa erythrocyte cytosolic protein(gene name synonym)|uniprotkb:INO80J(gene name synonym)|uniprotkb:TIP60-associated protein 54-beta(gene name synonym)|uniprotkb:INO80 complex subunit J(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR010339(TIP49, C-terminal)|interpro:IPR027238|interpro:IPR027417|interpro:IPR037942|interpro:IPR041048|interpro:IPR042487|mint:Q9Y230|rcsb pdb:2CQA|rcsb pdb:2XSZ|rcsb pdb:3UK6|rcsb pdb:5OAF|rcsb pdb:6FO1|rcsb pdb:6H7X|rcsb pdb:6HTS|rcsb pdb:6IGM|rcsb pdb:6K0R|rcsb pdb:6QI8|rcsb pdb:6QI9|rcsb pdb:7AHO|reactome:R-HSA-171319|go:"GO:0140585"(promoter-enhancer loop anchoring activity)|reactome:R-HSA-3214847|ensembl:ENSG00000183207(gene)|ensembl:ENST00000595090(transcript)|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000791"(euchromatin)|go:"GO:0000812"(Swr1 complex)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006457"(protein folding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016020"(membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071169"(establishment of protein localization to chromatin)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0016573"(histone acetylation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097255"(R2TP complex)|go:"GO:0120293"(dynein axonemal particle)|refseq:NP_006657.1|refseq:XP_011524632.1|refseq:NP_001308120.1|dip:DIP-28153N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:APKAWLDCJVULUP3nzqIaSLHKVN49606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q6S545	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1573312|uniprotkb:A2CEK4|uniprotkb:A9Z1W0|uniprotkb:A6NCI1|ensembl:ENSP00000340610	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:poteh_human(display_long)|uniprotkb:POTEH(gene name)|psi-mi:POTEH(display_short)|uniprotkb:ACTBL1(gene name synonym)|uniprotkb:POTE22(gene name synonym)|uniprotkb:Prostate, ovary, testis-expressed protein on chromosome 22(gene name synonym)|uniprotkb:A26C3(gene name synonym)|uniprotkb:ANKRD26-like family C member 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001129685.1|ensembl:ENSG00000198062(gene)|ensembl:ENST00000343518(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:+/lbFqQdfvcZtFJDfb7JccwelVg9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:O14745	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:03E30U6coFBcC3BeKOYnInfG/BI9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q16630-1	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1019636|ensembl:ENSP00000391774	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:q16630-1(display_long)|uniprotkb:CPSF6(gene name)|psi-mi:CPSF6(display_short)|uniprotkb:CFIM68(gene name synonym)|uniprotkb:Cleavage and polyadenylation specificity factor 68 kDa subunit(gene name synonym)|uniprotkb:Pre-mRNA cleavage factor Im 68 kDa subunit(gene name synonym)|uniprotkb:Protein HPBRII-4/7(gene name synonym)|uniprotkb:Cleavage factor Im complex 68 kDa subunit(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	intact:EBI-358410(q16630_human)|ensembl:ENSG00000111605(gene)|ensembl:ENST00000435070(transcript)	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:nvZBuI+X/m+5MGIsfh2ToVe5nFs9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:Q9BRK5	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P46783	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-354442|uniprotkb:Q5TZC0|uniprotkb:B2R4E3|ensembl:ENSP00000481646|ensembl:ENSP00000494190|ensembl:ENSP00000494440|ensembl:ENSP00000497917	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:rs10_human(display_long)|uniprotkb:RPS10(gene name)|psi-mi:RPS10(display_short)|uniprotkb:Small ribosomal subunit protein eS10(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1389788	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001005.1|refseq:NP_001190174.1|refseq:NP_001191020.1|ensembl:ENSG00000124614(gene)|ensembl:ENST00000464218(transcript)|ensembl:ENST00000467531(transcript)|ensembl:ENST00000621356(transcript)|ensembl:ENST00000648437(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|interpro:IPR005326(Plectin/S10, N-terminal)|rcsb pdb:6G51|interpro:IPR036388|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|interpro:IPR037447|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|mint:P46783|rcsb pdb:4UG0|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:4V6X|rcsb pdb:6ZUO|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|rcsb pdb:5T2C|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957	omim:176807(primary-reference)	-	-	figure legend:Table 1|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2021/06/18	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:GWUAJh7s0w/ar/SOpx0hiIJOr2c9606	intact-crc:E65522C04300BA69	false	-	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P08473	uniprotkb:P04792	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1391418	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	omim:176807(primary-reference)	-	crc64:1B4DC44A6F6606D5	figure legend:3 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2014/10/16	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:4E6B7F9B7842FADF|rigid:a5W3ijmwXGExsvNOTTkQWt7fpDM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08107	uniprotkb:P08473	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1391423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	omim:176807(primary-reference)	-	-	figure legend:3 B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2014/10/16	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	intact-crc:4C494B81C609A290|rigid:/wJImvkB9yEQD7xD/RI/BJ1oydc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08473	uniprotkb:P08107	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-629985|uniprotkb:P19790|uniprotkb:Q5JQI4|uniprotkb:Q5SP17|uniprotkb:Q9UQL9|uniprotkb:Q9UQM0|intact:EBI-4404728|uniprotkb:B4E3B6	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hsp71_human(display_long)|uniprotkb:HSPA1A(gene name)|psi-mi:HSPA1A(display_short)|uniprotkb:HSPA1(gene name synonym)|uniprotkb:HSPA1B(gene name)|psi-mi:HSPA1B(display_short)|uniprotkb:Heat shock 70 kDa protein 1/2(gene name synonym)|uniprotkb:HSX70(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573319	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_005336.3|refseq:NP_005337.2|interpro:IPR018181|interpro:IPR013126(Heat shock protein 70)|go:"GO:0005829"(cytosol)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005739"(mitochondrion)|go:"GO:0016607"(nuclear speck)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0030529"|go:"GO:0005524"(ATP binding)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0042026"(protein refolding)|go:"GO:0006986"(response to unfolded protein)|rcsb pdb:1HJO|rcsb pdb:1S3X|rcsb pdb:1XQS|rcsb pdb:2E88|rcsb pdb:2E8A|rcsb pdb:3A8Y|rcsb pdb:3D2E|rcsb pdb:3D2F|rcsb pdb:3JXU|rcsb pdb:3LOF|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0031982"(vesicle)|go:"GO:0010467"(gene expression)|rcsb pdb:3ATU|rcsb pdb:3ATV|rcsb pdb:3AY9|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0050821"(protein stabilization)|go:"GO:0005654"(nucleoplasm)|go:"GO:1900034"(regulation of cellular response to heat)|rcsb pdb:4WV5|rcsb pdb:4WV7|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|rcsb pdb:4IO8|rcsb pdb:2LMG|go:"GO:0016235"(aggresome)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0001618"(virus receptor activity)|rcsb pdb:4J8F|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0016234"(inclusion body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044822"|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0005814"(centriole)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042623"|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR029047|interpro:IPR029048|ensembl:ENST00000375650|ensembl:ENST00000375651|ensembl:ENST00000391548|ensembl:ENST00000391555|ensembl:ENST00000400040|ensembl:ENST00000430065|ensembl:ENST00000433487|ensembl:ENST00000441618|ensembl:ENST00000445736|ensembl:ENST00000450744|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005925"(focal adhesion)|go:"GO:0031397"(negative regulation of protein ubiquitination)|rcsb pdb:4PO2|reactome:REACT_25325|reactome:REACT_6198|ensembl:ENSG00000204388|ensembl:ENSG00000204389|ensembl:ENSG00000212866|ensembl:ENSG00000215328|ensembl:ENSG00000224501|ensembl:ENSG00000231555|ensembl:ENSG00000232804|ensembl:ENSG00000234475|ensembl:ENSG00000235941|ensembl:ENSG00000237724|ensembl:ENSP00000364801|ensembl:ENSP00000364802|ensembl:ENSP00000375391|ensembl:ENSP00000375399|ensembl:ENSP00000382915|ensembl:ENSP00000393087|ensembl:ENSP00000403530|ensembl:ENSP00000404524|ensembl:ENSP00000406359|ensembl:ENSP00000408907|reactome:REACT_264075|reactome:REACT_264164|reactome:REACT_264487	omim:176807(primary-reference)	-	-	figure legend:3 A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2014/10/16	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:NFv4uj12xAWIr+OltarRlLDPr949606	intact-crc:BC821992A1113849|rigid:QE29wKuF23jn19KhA9gJUoObjJs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08473	uniprotkb:P04792	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1573319	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	omim:176807(primary-reference)	-	crc64:1B4DC44A6F6606D5	figure legend:3 A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2014/10/16	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:BC821992A1113849|rigid:QE29wKuF23jn19KhA9gJUoObjJs	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08473	uniprotkb:P04792	intact:EBI-353759|uniprotkb:Q3MIX4|uniprotkb:A8K6U6|uniprotkb:D3DNJ9|ensembl:ENSP00000353679|ensembl:ENSP00000417079|ensembl:ENSP00000418525|ensembl:ENSP00000418791|ensembl:ENSP00000419653|ensembl:ENSP00000420389|ensembl:ENSP00000420542|ensembl:ENSP00000502021|ensembl:ENSP00000505211|ensembl:ENSP00000505690	intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8	psi-mi:nep_human(display_long)|uniprotkb:MME(gene name)|psi-mi:MME(display_short)|uniprotkb:EPN(gene name synonym)|uniprotkb:Neutral endopeptidase 24.11(gene name synonym)|uniprotkb:Enkephalinase(gene name synonym)|uniprotkb:Atriopeptidase(gene name synonym)|uniprotkb:Common acute lymphocytic leukemia antigen(gene name synonym)|uniprotkb:Skin fibroblast elastase(gene name synonym)	psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Dall'Era et al. (2007)	pubmed:17342744	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1391434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000893.2|refseq:NP_009218.2|refseq:NP_009219.2|refseq:NP_009220.2|refseq:XP_011511157.1|refseq:XP_011511158.1|refseq:XP_011511159.1|ensembl:ENSG00000196549(gene)|ensembl:ENST00000360490(transcript)|ensembl:ENST00000460393(transcript)|ensembl:ENST00000462745(transcript)|ensembl:ENST00000473730(transcript)|ensembl:ENST00000491026(transcript)|ensembl:ENST00000492661(transcript)|ensembl:ENST00000493237(transcript)|ensembl:ENST00000675418(transcript)|ensembl:ENST00000680057(transcript)|ensembl:ENST00000680282(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001890"(placenta development)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0006518"(peptide metabolic process)|go:"GO:0007568"(aging)|go:"GO:0007611"(learning or memory)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008238"(exopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016485"(protein processing)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030324"(lung development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0042277"(peptide binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0046449"(creatinine metabolic process)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:0061837"(neuropeptide processing)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0090399"(replicative senescence)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098793"(presynapse)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901612"(cardiolipin binding)|interpro:IPR000718(Peptidase M13, neprilysin)|interpro:IPR008753(Peptidase M13)|interpro:IPR018497|interpro:IPR024079|interpro:IPR029727|interpro:IPR042089|rcsb pdb:1DL9|rcsb pdb:1DMT|rcsb pdb:1QVD|rcsb pdb:1R1H|rcsb pdb:1R1I|rcsb pdb:1R1J|rcsb pdb:1Y8J|rcsb pdb:2QPJ|rcsb pdb:2YB9|rcsb pdb:4CTH|rcsb pdb:5JMY|rcsb pdb:6GID|rcsb pdb:6SH1|rcsb pdb:6SH2|rcsb pdb:6SUK|rcsb pdb:6SVY|rcsb pdb:6THP|rcsb pdb:6XVP|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:XP_006713709.1|refseq:XP_006713710.1	refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N	go:"GO:0005886"(plasma membrane)|omim:176807(primary-reference)	-	crc64:1B4DC44A6F6606D5	figure legend:4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer	taxid:9606(human-c4_2)|taxid:9606(Homo sapiens c4-2 androgen-independent prostate cancer cells)	-	2007/09/03	2014/10/16	rogid:kc8XvGW1B4gXM3+1br/Ivp9+cPE9606	rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606	intact-crc:4EE15BF2564D7D28|rigid:a5W3ijmwXGExsvNOTTkQWt7fpDM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)