#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P27661	uniprotkb:Q80V62	intact:EBI-495621|ensembl:ENSMUSP00000051432	intact:EBI-7268304|uniprotkb:Q9CWC7|intact:MINT-4507601|ensembl:ENSMUSP00000045667	psi-mi:h2ax_mouse(display_long)|uniprotkb:H2ax(gene name)|psi-mi:H2ax(display_short)|uniprotkb:H2a.x(gene name synonym)|uniprotkb:H2afx(gene name synonym)|uniprotkb:Hist5-2ax(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:facd2_mouse(display_long)|uniprotkb:Fancd2(gene name)|psi-mi:Fancd2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bogliolo et al. (2007)	pubmed:17304220|imex:IM-10822|mint:MINT-5219642	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7268296|mint:MINT-4507625|imex:IM-10822-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034566.1|ensembl:ENSMUSG00000049932(gene)|ensembl:ENSMUST00000052686(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P27661|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-606279|reactome:R-MMU-69473|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-5693607|mint:MINT-4507626(identity)	refseq:NP_001028416.2|ensembl:ENSMUSG00000034023(gene)|ensembl:ENSMUST00000036340(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007276"(gamete generation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR029448|mint:Q80V62|rcsb pdb:3S4W|reactome:R-MMU-6783310|mint:MINT-4507627(identity)	-	-	comment:mint|function:Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching	figure legend:F5B|figure legend:F5A|comment:Interaction occurs also inBRCA1 cells.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2007/03/26	2014/10/16	rogid:Z1pmQt/GCyjkaDs6Ot8O7Cc8rAM10090	rogid:SDdjC+n2Y85sS4peJW871/PD1ZU10090	intact-crc:352A61873E2FE437|rigid:BwXcaMuOIvbABNSeTup/KJXb6+A	false	mutation disrupting interaction:136-136,139-139(MINT-4507654)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P27661	uniprotkb:Q80V62	intact:EBI-495621|ensembl:ENSMUSP00000051432	intact:EBI-7268304|uniprotkb:Q9CWC7|intact:MINT-4507601|ensembl:ENSMUSP00000045667	psi-mi:h2ax_mouse(display_long)|uniprotkb:H2ax(gene name)|psi-mi:H2ax(display_short)|uniprotkb:H2a.x(gene name synonym)|uniprotkb:H2afx(gene name synonym)|uniprotkb:Hist5-2ax(gene name synonym)|uniprotkb:Histone H2A.X(gene name synonym)	psi-mi:facd2_mouse(display_long)|uniprotkb:Fancd2(gene name)|psi-mi:Fancd2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Bogliolo et al. (2007)	pubmed:17304220|imex:IM-10822|mint:MINT-5219642	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7268337|mint:MINT-4507659|imex:IM-10822-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034566.1|ensembl:ENSMUSG00000049932(gene)|ensembl:ENSMUST00000052686(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000786"(nucleosome)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001741"(XY body)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006342"|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042393"(histone binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090398"(cellular senescence)|go:"GO:0090734"(site of DNA damage)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P27661|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-427359|reactome:R-MMU-427413|reactome:R-MMU-5250924|reactome:R-MMU-5578749|reactome:R-MMU-5625886|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-606279|reactome:R-MMU-69473|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-5693607|mint:MINT-4507660(identity)	refseq:NP_001028416.2|ensembl:ENSMUSG00000034023(gene)|ensembl:ENSMUST00000036340(transcript)|go:"GO:0000793"(condensed chromosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007276"(gamete generation)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR029448|mint:Q80V62|rcsb pdb:3S4W|reactome:R-MMU-6783310|mint:MINT-4507667(identity)	-	-	comment:mint|function:Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching	figure legend:F5B|figure legend:F5A|comment:Interaction occurs also inBRCA1 cells.|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2007/03/26	2014/10/16	rogid:Z1pmQt/GCyjkaDs6Ot8O7Cc8rAM10090	rogid:SDdjC+n2Y85sS4peJW871/PD1ZU10090	intact-crc:A18CCB26BF1A978A|rigid:BwXcaMuOIvbABNSeTup/KJXb6+A	false	mutation disrupting interaction:139-139,136-136(MINT-4507661)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)