#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q3Y5Z3	uniprotkb:Q3Y5Z3	intact:EBI-7264459|intact:MINT-4563461|uniprotkb:Q95MQ4|uniprotkb:A5D7A8	intact:EBI-7264459|intact:MINT-4563461|uniprotkb:Q95MQ4|uniprotkb:A5D7A8	psi-mi:adipo_bovin(display_long)|uniprotkb:ADIPOQ(gene name)|psi-mi:ADIPOQ(display_short)|uniprotkb:ACRP30(gene name synonym)|uniprotkb:APM1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipose most abundant gene transcript 1 protein(gene name synonym)	psi-mi:adipo_bovin(display_long)|uniprotkb:ADIPOQ(gene name)|psi-mi:ADIPOQ(display_short)|uniprotkb:ACRP30(gene name synonym)|uniprotkb:APM1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipose most abundant gene transcript 1 protein(gene name synonym)	psi-mi:"MI:0401"(biochemical)	Suzuki et al. (2007)	pubmed:17292892|imex:IM-11347|mint:MINT-5219629	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7264537|mint:MINT-4563476|imex:IM-11347-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q3Y5Z3|refseq:NP_777167.1|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR028572|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|mint:MINT-4563477(identity)	mint:Q3Y5Z3|refseq:NP_777167.1|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR028572|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|mint:MINT-4563477(identity)	-	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW|comment:"Stoichiometry: 18.0"	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW|comment:"Stoichiometry: 18.0"	figure legend:F1|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-serum)|taxid:9913(Bovine serum)	-	2007/05/08	2014/10/16	rogid:V31R+IxjLdLV3rF30rsMdvVNuVs9913	rogid:V31R+IxjLdLV3rF30rsMdvVNuVs9913	intact-crc:C77B82AFA582CC1C|rigid:C2LUg3oPG+Bm+7SOttMLLNMyPjk	false	-	-	18	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q60994	uniprotkb:Q60994	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	intact:EBI-7264589|uniprotkb:Q9DC68|uniprotkb:Q62400|uniprotkb:Q6GTX4|intact:MINT-4563800|ensembl:ENSMUSP00000023593	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:adipo_mouse(display_long)|uniprotkb:Apm1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipocyte-specific protein AdipoQ(gene name synonym)|uniprotkb:Adipoq(gene name)|psi-mi:Adipoq(display_short)|uniprotkb:Acdc(gene name synonym)|uniprotkb:Acrp30(gene name synonym)	psi-mi:"MI:0404"(comigration in non denaturing gel electrophoresis)	Suzuki et al. (2007)	pubmed:17292892|imex:IM-11347|mint:MINT-5219629	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7264687|mint:MINT-4563734|imex:IM-11347-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N|mint:MINT-4563735(identity)	refseq:NP_033735.3|ensembl:ENSMUST00000023593(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007584"(response to nutrient)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009617"(response to bacterium)|go:"GO:0009744"(response to sucrose)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014823"(response to activity)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051384"(response to glucocorticoid)|ensembl:ENSMUSG00000022878(gene)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070543"(response to linoleic acid)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR028572|mint:Q60994|rcsb pdb:1C28|rcsb pdb:1C3H|reactome:R-MMU-163680|dip:DIP-44111N|mint:MINT-4563735(identity)	-	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW|comment:"Stoichiometry: 18.0"	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW|comment:"Stoichiometry: 18.0"	figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-3t3_l1)|taxid:10090(Mus musculus embryonic cells  Fibroblast-like. Adipose like when confluent)	-	2007/05/08	2014/10/16	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	rogid:gWG6bUFwmZsDW8jVpPjubtFADgI10090	intact-crc:3F91B9979766CDF0|rigid:o3yDjKcViYpTJf5qQIe/TMLF9sw	false	-	-	18	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3Y5Z3	uniprotkb:Q3Y5Z3	intact:EBI-7264459|intact:MINT-4563461|uniprotkb:Q95MQ4|uniprotkb:A5D7A8	intact:EBI-7264459|intact:MINT-4563461|uniprotkb:Q95MQ4|uniprotkb:A5D7A8	psi-mi:adipo_bovin(display_long)|uniprotkb:ADIPOQ(gene name)|psi-mi:ADIPOQ(display_short)|uniprotkb:ACRP30(gene name synonym)|uniprotkb:APM1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipose most abundant gene transcript 1 protein(gene name synonym)	psi-mi:adipo_bovin(display_long)|uniprotkb:ADIPOQ(gene name)|psi-mi:ADIPOQ(display_short)|uniprotkb:ACRP30(gene name synonym)|uniprotkb:APM1(gene name synonym)|uniprotkb:Adipocyte, C1q and collagen domain-containing protein(gene name synonym)|uniprotkb:30 kDa adipocyte complement-related protein(gene name synonym)|uniprotkb:Adipocyte complement-related 30 kDa protein(gene name synonym)|uniprotkb:Adipose most abundant gene transcript 1 protein(gene name synonym)	psi-mi:"MI:0040"(electron microscopy)	Suzuki et al. (2007)	pubmed:17292892|imex:IM-11347|mint:MINT-5219629	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7264707|mint:MINT-4563501|imex:IM-11347-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q3Y5Z3|refseq:NP_777167.1|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR028572|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|mint:MINT-4563502(identity)	mint:Q3Y5Z3|refseq:NP_777167.1|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009749"(response to glucose)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033034"(positive regulation of myeloid cell apoptotic process)|go:"GO:0033691"(sialic acid binding)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034383"(low-density lipoprotein particle clearance)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035690"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045721"(negative regulation of gluconeogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045923"(positive regulation of fatty acid metabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050805"(negative regulation of synaptic transmission)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0071639"(positive regulation of monocyte chemotactic protein-1 production)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090317"(negative regulation of intracellular protein transport)|go:"GO:0110113"(positive regulation of lipid transporter activity)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000467"("positive regulation of glycogen (starch) synthase activity")|go:"GO:2000478"(positive regulation of metanephric glomerular visceral epithelial cell development)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000534"(positive regulation of renal albumin absorption)|go:"GO:2000584"(negative regulation of platelet-derived growth factor receptor-alpha signaling pathway)|go:"GO:2000590"(negative regulation of metanephric mesenchymal cell migration)|interpro:IPR028572|interpro:IPR001073(Complement C1q protein)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR008983(Tumour necrosis factor-like)|mint:MINT-4563502(identity)	-	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	comment:mint|function:Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW	figure legend:F4|comment:It is hardly visible an oligomeric architecture.|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/05/08	2014/10/16	rogid:V31R+IxjLdLV3rF30rsMdvVNuVs9913	rogid:V31R+IxjLdLV3rF30rsMdvVNuVs9913	intact-crc:D060AEB4CD8C56AB|rigid:C2LUg3oPG+Bm+7SOttMLLNMyPjk	false	-	-	-	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)