#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9BZR8 uniprotkb:Q14680 intact:EBI-1385773|uniprotkb:Q96QR5|uniprotkb:Q9BZR7|uniprotkb:A8KAD0|ensembl:ENSP00000309132|ensembl:ENSP00000379653|ensembl:ENSP00000467086|ensembl:ENSP00000486050|ensembl:ENSP00000486796|ensembl:ENSP00000487330 intact:EBI-1046702|uniprotkb:Q7L3C3|ensembl:ENSP00000298048|uniprotkb:D3DRP8|uniprotkb:B1AMQ6|uniprotkb:B7Z6Y0|uniprotkb:B7Z7Q1|uniprotkb:A6P3A7|uniprotkb:A6P3A8|uniprotkb:B7Z6R8|uniprotkb:B7Z1E6|uniprotkb:F5H2R4|uniprotkb:B7Z5M5|uniprotkb:B7Z6Q7|uniprotkb:F5H0Y0|uniprotkb:F5H689 psi-mi:b2l14_human(display_long)|uniprotkb:Apoptosis regulator Bcl-G(gene name synonym)|uniprotkb:BCL2L14(gene name)|psi-mi:BCL2L14(display_short)|uniprotkb:BCLG(gene name synonym) psi-mi:melk_human(display_long)|uniprotkb:Protein kinase PK38(gene name synonym)|uniprotkb:MELK(gene name)|psi-mi:MELK(display_short)|uniprotkb:KIAA0175(gene name synonym)|uniprotkb:Protein kinase Eg3(gene name synonym)|uniprotkb:Tyrosine-protein kinase MELK(gene name synonym) psi-mi:"MI:0096"(pull down) Lin et al. (2007) pubmed:17280616 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385803 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006719214.1|refseq:XP_011519150.1|refseq:XP_011519151.1|refseq:NP_110393.1|refseq:NP_620048.1|refseq:NP_620049.1|refseq:XP_016875452.1|ensembl:ENSG00000121380(gene)|ensembl:ENSG00000281449(gene)|ensembl:ENST00000308721(transcript)|ensembl:ENST00000396367(transcript)|ensembl:ENST00000589718(transcript)|ensembl:ENST00000627413(transcript)|ensembl:ENST00000628783(transcript)|ensembl:ENST00000631317(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR033229|interpro:IPR036834|reactome:R-HSA-6803205 ensembl:ENSG00000165304(gene)|ensembl:ENST00000298048(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|rcsb pdb:4D2T|rcsb pdb:4D2V|rcsb pdb:4D2W|rcsb pdb:4IXP|rcsb pdb:4UMP|rcsb pdb:4UMQ|rcsb pdb:4UMR|rcsb pdb:4UMT|rcsb pdb:4UMU|rcsb pdb:5IH8|rcsb pdb:5IH9|rcsb pdb:5IHA|rcsb pdb:5IHC|rcsb pdb:5K00|rcsb pdb:5M5A|rcsb pdb:5MAF|rcsb pdb:5MAG|rcsb pdb:5MAH|rcsb pdb:5MAI|refseq:NP_055606.1|rcsb pdb:5TVT|rcsb pdb:5TWL|rcsb pdb:5TWU|rcsb pdb:5TWY|rcsb pdb:5TWZ|rcsb pdb:5TX3|rcsb pdb:6GVX|rcsb pdb:6VXR|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR034673|rcsb pdb:4BKY|rcsb pdb:4BKZ|rcsb pdb:4BL1|rcsb pdb:4D2P|refseq:XP_011516386.1|refseq:XP_011516378.1|refseq:XP_011516379.1|refseq:XP_011516380.1|refseq:XP_011516381.1|refseq:XP_011516383.1|refseq:XP_011516384.1|refseq:XP_011516385.1|refseq:NP_001243614.1|refseq:NP_001243616.1|refseq:NP_001243617.1|refseq:NP_001243621.1|refseq:NP_001243622.1|refseq:NP_001243618.1|refseq:NP_001243619.1 - - - figure legend:3 A|author-identifiers:BAIT gene NM_014791|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/08/22 2014/10/16 rogid:Fiejp4wLlCQA5hfsvLPFcnb1Xa89606 rogid:hGuk/IC9/WA3vu9lXaW2F6YWCpU9606 intact-crc:6DD30A87DE2CD2DF|rigid:FcYVR2W5y0shFyDSW+yN/itmBG0 false - mutation disrupting interaction:150-150 - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q9BZR8 uniprotkb:Q14680 intact:EBI-1385773|uniprotkb:Q96QR5|uniprotkb:Q9BZR7|uniprotkb:A8KAD0|ensembl:ENSP00000309132|ensembl:ENSP00000379653|ensembl:ENSP00000467086|ensembl:ENSP00000486050|ensembl:ENSP00000486796|ensembl:ENSP00000487330 intact:EBI-1046702|uniprotkb:Q7L3C3|ensembl:ENSP00000298048|uniprotkb:D3DRP8|uniprotkb:B1AMQ6|uniprotkb:B7Z6Y0|uniprotkb:B7Z7Q1|uniprotkb:A6P3A7|uniprotkb:A6P3A8|uniprotkb:B7Z6R8|uniprotkb:B7Z1E6|uniprotkb:F5H2R4|uniprotkb:B7Z5M5|uniprotkb:B7Z6Q7|uniprotkb:F5H0Y0|uniprotkb:F5H689 psi-mi:b2l14_human(display_long)|uniprotkb:Apoptosis regulator Bcl-G(gene name synonym)|uniprotkb:BCL2L14(gene name)|psi-mi:BCL2L14(display_short)|uniprotkb:BCLG(gene name synonym) psi-mi:melk_human(display_long)|uniprotkb:Protein kinase PK38(gene name synonym)|uniprotkb:MELK(gene name)|psi-mi:MELK(display_short)|uniprotkb:KIAA0175(gene name synonym)|uniprotkb:Protein kinase Eg3(gene name synonym)|uniprotkb:Tyrosine-protein kinase MELK(gene name synonym) psi-mi:"MI:0096"(pull down) Lin et al. (2007) pubmed:17280616 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1385832 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006719214.1|refseq:XP_011519150.1|refseq:XP_011519151.1|refseq:NP_110393.1|refseq:NP_620048.1|refseq:NP_620049.1|refseq:XP_016875452.1|ensembl:ENSG00000121380(gene)|ensembl:ENSG00000281449(gene)|ensembl:ENST00000308721(transcript)|ensembl:ENST00000396367(transcript)|ensembl:ENST00000589718(transcript)|ensembl:ENST00000627413(transcript)|ensembl:ENST00000628783(transcript)|ensembl:ENST00000631317(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR033229|interpro:IPR036834|reactome:R-HSA-6803205 ensembl:ENSG00000165304(gene)|ensembl:ENST00000298048(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|rcsb pdb:4D2T|rcsb pdb:4D2V|rcsb pdb:4D2W|rcsb pdb:4IXP|rcsb pdb:4UMP|rcsb pdb:4UMQ|rcsb pdb:4UMR|rcsb pdb:4UMT|rcsb pdb:4UMU|rcsb pdb:5IH8|rcsb pdb:5IH9|rcsb pdb:5IHA|rcsb pdb:5IHC|rcsb pdb:5K00|rcsb pdb:5M5A|rcsb pdb:5MAF|rcsb pdb:5MAG|rcsb pdb:5MAH|rcsb pdb:5MAI|refseq:NP_055606.1|rcsb pdb:5TVT|rcsb pdb:5TWL|rcsb pdb:5TWU|rcsb pdb:5TWY|rcsb pdb:5TWZ|rcsb pdb:5TX3|rcsb pdb:6GVX|rcsb pdb:6VXR|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR034673|rcsb pdb:4BKY|rcsb pdb:4BKZ|rcsb pdb:4BL1|rcsb pdb:4D2P|refseq:XP_011516386.1|refseq:XP_011516378.1|refseq:XP_011516379.1|refseq:XP_011516380.1|refseq:XP_011516381.1|refseq:XP_011516383.1|refseq:XP_011516384.1|refseq:XP_011516385.1|refseq:NP_001243614.1|refseq:NP_001243616.1|refseq:NP_001243617.1|refseq:NP_001243621.1|refseq:NP_001243622.1|refseq:NP_001243618.1|refseq:NP_001243619.1 - - - figure legend:3 D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/08/22 2014/10/16 rogid:Fiejp4wLlCQA5hfsvLPFcnb1Xa89606 rogid:hGuk/IC9/WA3vu9lXaW2F6YWCpU9606 intact-crc:DC362438FFC38A1A|rigid:FcYVR2W5y0shFyDSW+yN/itmBG0 false - his tag:?-?|mutation disrupting interaction:150-150 - - psi-mi:"MI:0427"(Identification by mass spectrometry) psi-mi:"MI:0427"(Identification by mass spectrometry) uniprotkb:Q14680 uniprotkb:Q9BZR8 intact:EBI-1046702|uniprotkb:Q7L3C3|ensembl:ENSP00000298048|uniprotkb:D3DRP8|uniprotkb:B1AMQ6|uniprotkb:B7Z6Y0|uniprotkb:B7Z7Q1|uniprotkb:A6P3A7|uniprotkb:A6P3A8|uniprotkb:B7Z6R8|uniprotkb:B7Z1E6|uniprotkb:F5H2R4|uniprotkb:B7Z5M5|uniprotkb:B7Z6Q7|uniprotkb:F5H0Y0|uniprotkb:F5H689 intact:EBI-1385773|uniprotkb:Q96QR5|uniprotkb:Q9BZR7|uniprotkb:A8KAD0|ensembl:ENSP00000309132|ensembl:ENSP00000379653|ensembl:ENSP00000467086|ensembl:ENSP00000486050|ensembl:ENSP00000486796|ensembl:ENSP00000487330 psi-mi:melk_human(display_long)|uniprotkb:Protein kinase PK38(gene name synonym)|uniprotkb:MELK(gene name)|psi-mi:MELK(display_short)|uniprotkb:KIAA0175(gene name synonym)|uniprotkb:Protein kinase Eg3(gene name synonym)|uniprotkb:Tyrosine-protein kinase MELK(gene name synonym) psi-mi:b2l14_human(display_long)|uniprotkb:Apoptosis regulator Bcl-G(gene name synonym)|uniprotkb:BCL2L14(gene name)|psi-mi:BCL2L14(display_short)|uniprotkb:BCLG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Lin et al. (2007) pubmed:17280616 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1385823 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165304(gene)|ensembl:ENST00000298048(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|rcsb pdb:4D2T|rcsb pdb:4D2V|rcsb pdb:4D2W|rcsb pdb:4IXP|rcsb pdb:4UMP|rcsb pdb:4UMQ|rcsb pdb:4UMR|rcsb pdb:4UMT|rcsb pdb:4UMU|rcsb pdb:5IH8|rcsb pdb:5IH9|rcsb pdb:5IHA|rcsb pdb:5IHC|rcsb pdb:5K00|rcsb pdb:5M5A|rcsb pdb:5MAF|rcsb pdb:5MAG|rcsb pdb:5MAH|rcsb pdb:5MAI|refseq:NP_055606.1|rcsb pdb:5TVT|rcsb pdb:5TWL|rcsb pdb:5TWU|rcsb pdb:5TWY|rcsb pdb:5TWZ|rcsb pdb:5TX3|rcsb pdb:6GVX|rcsb pdb:6VXR|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR034673|rcsb pdb:4BKY|rcsb pdb:4BKZ|rcsb pdb:4BL1|rcsb pdb:4D2P|refseq:XP_011516386.1|refseq:XP_011516378.1|refseq:XP_011516379.1|refseq:XP_011516380.1|refseq:XP_011516381.1|refseq:XP_011516383.1|refseq:XP_011516384.1|refseq:XP_011516385.1|refseq:NP_001243614.1|refseq:NP_001243616.1|refseq:NP_001243617.1|refseq:NP_001243621.1|refseq:NP_001243622.1|refseq:NP_001243618.1|refseq:NP_001243619.1 refseq:XP_006719214.1|refseq:XP_011519150.1|refseq:XP_011519151.1|refseq:NP_110393.1|refseq:NP_620048.1|refseq:NP_620049.1|refseq:XP_016875452.1|ensembl:ENSG00000121380(gene)|ensembl:ENSG00000281449(gene)|ensembl:ENST00000308721(transcript)|ensembl:ENST00000396367(transcript)|ensembl:ENST00000589718(transcript)|ensembl:ENST00000627413(transcript)|ensembl:ENST00000628783(transcript)|ensembl:ENST00000631317(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR033229|interpro:IPR036834|reactome:R-HSA-6803205 - - - figure legend:3 C, E, F|delivery method:Q14680; Q9BZR8 transfection|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2007/08/22 2014/10/16 rogid:hGuk/IC9/WA3vu9lXaW2F6YWCpU9606 rogid:Fiejp4wLlCQA5hfsvLPFcnb1Xa89606 intact-crc:36FF0BE6322E1CDE|rigid:FcYVR2W5y0shFyDSW+yN/itmBG0 false ha tag:?-? flag tag:?-?|necessary binding region:13-72 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14680 uniprotkb:Q9BZR8 intact:EBI-1046702|uniprotkb:Q7L3C3|ensembl:ENSP00000298048|uniprotkb:D3DRP8|uniprotkb:B1AMQ6|uniprotkb:B7Z6Y0|uniprotkb:B7Z7Q1|uniprotkb:A6P3A7|uniprotkb:A6P3A8|uniprotkb:B7Z6R8|uniprotkb:B7Z1E6|uniprotkb:F5H2R4|uniprotkb:B7Z5M5|uniprotkb:B7Z6Q7|uniprotkb:F5H0Y0|uniprotkb:F5H689 intact:EBI-1385773|uniprotkb:Q96QR5|uniprotkb:Q9BZR7|uniprotkb:A8KAD0|ensembl:ENSP00000309132|ensembl:ENSP00000379653|ensembl:ENSP00000467086|ensembl:ENSP00000486050|ensembl:ENSP00000486796|ensembl:ENSP00000487330 psi-mi:melk_human(display_long)|uniprotkb:Protein kinase PK38(gene name synonym)|uniprotkb:MELK(gene name)|psi-mi:MELK(display_short)|uniprotkb:KIAA0175(gene name synonym)|uniprotkb:Protein kinase Eg3(gene name synonym)|uniprotkb:Tyrosine-protein kinase MELK(gene name synonym) psi-mi:b2l14_human(display_long)|uniprotkb:Apoptosis regulator Bcl-G(gene name synonym)|uniprotkb:BCL2L14(gene name)|psi-mi:BCL2L14(display_short)|uniprotkb:BCLG(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Lin et al. (2007) pubmed:17280616 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0469"(IntAct) intact:EBI-1385851 - - psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165304(gene)|ensembl:ENST00000298048(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|rcsb pdb:4D2T|rcsb pdb:4D2V|rcsb pdb:4D2W|rcsb pdb:4IXP|rcsb pdb:4UMP|rcsb pdb:4UMQ|rcsb pdb:4UMR|rcsb pdb:4UMT|rcsb pdb:4UMU|rcsb pdb:5IH8|rcsb pdb:5IH9|rcsb pdb:5IHA|rcsb pdb:5IHC|rcsb pdb:5K00|rcsb pdb:5M5A|rcsb pdb:5MAF|rcsb pdb:5MAG|rcsb pdb:5MAH|rcsb pdb:5MAI|refseq:NP_055606.1|rcsb pdb:5TVT|rcsb pdb:5TWL|rcsb pdb:5TWU|rcsb pdb:5TWY|rcsb pdb:5TWZ|rcsb pdb:5TX3|rcsb pdb:6GVX|rcsb pdb:6VXR|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR034673|rcsb pdb:4BKY|rcsb pdb:4BKZ|rcsb pdb:4BL1|rcsb pdb:4D2P|refseq:XP_011516386.1|refseq:XP_011516378.1|refseq:XP_011516379.1|refseq:XP_011516380.1|refseq:XP_011516381.1|refseq:XP_011516383.1|refseq:XP_011516384.1|refseq:XP_011516385.1|refseq:NP_001243614.1|refseq:NP_001243616.1|refseq:NP_001243617.1|refseq:NP_001243621.1|refseq:NP_001243622.1|refseq:NP_001243618.1|refseq:NP_001243619.1 refseq:XP_006719214.1|refseq:XP_011519150.1|refseq:XP_011519151.1|refseq:NP_110393.1|refseq:NP_620048.1|refseq:NP_620049.1|refseq:XP_016875452.1|ensembl:ENSG00000121380(gene)|ensembl:ENSG00000281449(gene)|ensembl:ENST00000308721(transcript)|ensembl:ENST00000396367(transcript)|ensembl:ENST00000589718(transcript)|ensembl:ENST00000627413(transcript)|ensembl:ENST00000628783(transcript)|ensembl:ENST00000631317(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043229"(intracellular organelle)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR033229|interpro:IPR036834|reactome:R-HSA-6803205 - - - figure legend:4 B, C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:Cancer - Interactions investigated in the context of cancer taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/08/22 2014/10/16 rogid:hGuk/IC9/WA3vu9lXaW2F6YWCpU9606 rogid:Fiejp4wLlCQA5hfsvLPFcnb1Xa89606 intact-crc:149083AE5E664BEB|rigid:FcYVR2W5y0shFyDSW+yN/itmBG0 false mutation disrupting interaction:150-150 glutathione s tranferase tag:?-?|necessary binding region:12-71 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)