#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q23457	uniprotkb:Q23639	intact:EBI-1998112|uniprotkb:Q8WSQ1|ensemblmetazoa:ZK287.5.1|ensemblmetazoa:ZK287.5.2	intact:EBI-330781|ensemblmetazoa:ZK856.1.1	psi-mi:rbx1_caeel(display_long)|uniprotkb:rbx-1(gene name)|psi-mi:rbx-1(display_short)|uniprotkb:Ce-rbx-1(gene name synonym)|uniprotkb:ZK287.5(orf name)	psi-mi:cul5_caeel(display_long)|uniprotkb:cul-5(gene name)|psi-mi:cul-5(display_short)|uniprotkb:ZK856.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Sasagawa et al. (2007)	pubmed:17184777|imex:IM-11299|mint:MINT-5219499	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-3945999|imex:IM-11299-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_505496.1|wormbase:ZK287.5|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q23457|ensemblmetazoa:WBGene00004320(gene)|ensemblmetazoa:ZK287.5.1(transcript)|ensemblmetazoa:ZK287.5.2(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0051301"(cell division)|go:"GO:0051759"(sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902104"(positive regulation of metaphase/anaphase transition of meiotic cell cycle)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|reactome:R-CEL-110314|reactome:R-CEL-1234176|reactome:R-CEL-195253|reactome:R-CEL-5632684|reactome:R-CEL-5696394|reactome:R-CEL-5696395|reactome:R-CEL-6781823|reactome:R-CEL-6782135|reactome:R-CEL-6782210|reactome:R-CEL-68949|reactome:R-CEL-8854050|reactome:R-CEL-8932339|reactome:R-CEL-8939902|reactome:R-CEL-8951664|reactome:R-CEL-983168|reactome:R-CEL-4641258	refseq:NP_505616.2|wormbase:ZK856.1|mint:Q23639|dip:DIP-25847N|ensemblmetazoa:WBGene00000840(gene)|ensemblmetazoa:ZK856.1.1(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-CEL-8863795|reactome:R-CEL-8951664|reactome:R-CEL-983168	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/17	2014/10/16	rogid:K9YFXD2x8iuzCtYyPx/bYHJnT4Q6239	rogid:XQMnpPKpITpy//FRZY0i6hxXnTA6239	intact-crc:18194C068B181DF0|rigid:5239s0tLeOj9ARAKwrNwFKB2+cs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q23639	uniprotkb:P91404	intact:EBI-330781|ensemblmetazoa:ZK856.1.1	intact:EBI-3945971|ensemblmetazoa:R10A10.2.1	psi-mi:cul5_caeel(display_long)|uniprotkb:cul-5(gene name)|psi-mi:cul-5(display_short)|uniprotkb:ZK856.1(orf name)	psi-mi:p91404_caeel(display_long)|uniprotkb:R10A10.2(orf name)|uniprotkb:rbx-2(gene name)|psi-mi:rbx-2(display_short)|uniprotkb:CELE_R10A10.2(orf name)	psi-mi:"MI:0018"(two hybrid)	Sasagawa et al. (2007)	pubmed:17184777|imex:IM-11299|mint:MINT-5219499	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-3945986|imex:IM-11299-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_505616.2|wormbase:ZK856.1|mint:Q23639|dip:DIP-25847N|ensemblmetazoa:WBGene00000840(gene)|ensemblmetazoa:ZK856.1.1(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-CEL-8863795|reactome:R-CEL-8951664|reactome:R-CEL-983168	mint:P91404|ensemblmetazoa:R10A10.2.1(transcript)|ensemblmetazoa:WBGene00019993(gene)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097602"(cullin family protein binding)|reactome:R-CEL-8951664|reactome:R-CEL-983168|refseq:NP_491849.1|wormbase:R10A10.2|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/17	2014/10/16	rogid:XQMnpPKpITpy//FRZY0i6hxXnTA6239	rogid:WazhXy4W/SeL0CyZTpJVE9g9CDM6239	intact-crc:E4973889D333D820|rigid:SBCArnsNE1i+QzZt2YntaoscJFM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P91404	uniprotkb:Q23639	intact:EBI-3945971|ensemblmetazoa:R10A10.2.1	intact:EBI-330781|ensemblmetazoa:ZK856.1.1	psi-mi:p91404_caeel(display_long)|uniprotkb:R10A10.2(orf name)|uniprotkb:rbx-2(gene name)|psi-mi:rbx-2(display_short)|uniprotkb:CELE_R10A10.2(orf name)	psi-mi:cul5_caeel(display_long)|uniprotkb:cul-5(gene name)|psi-mi:cul-5(display_short)|uniprotkb:ZK856.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Sasagawa et al. (2007)	pubmed:17184777|imex:IM-11299|mint:MINT-5219499	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-3945989|imex:IM-11299-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P91404|ensemblmetazoa:R10A10.2.1(transcript)|ensemblmetazoa:WBGene00019993(gene)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097602"(cullin family protein binding)|reactome:R-CEL-8951664|reactome:R-CEL-983168|refseq:NP_491849.1|wormbase:R10A10.2|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766	refseq:NP_505616.2|wormbase:ZK856.1|mint:Q23639|dip:DIP-25847N|ensemblmetazoa:WBGene00000840(gene)|ensemblmetazoa:ZK856.1.1(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-CEL-8863795|reactome:R-CEL-8951664|reactome:R-CEL-983168	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/17	2014/10/16	rogid:WazhXy4W/SeL0CyZTpJVE9g9CDM6239	rogid:XQMnpPKpITpy//FRZY0i6hxXnTA6239	intact-crc:3C20E80CAC8B7C4A|rigid:SBCArnsNE1i+QzZt2YntaoscJFM	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q23457	uniprotkb:Q23639	intact:EBI-1998112|uniprotkb:Q8WSQ1|ensemblmetazoa:ZK287.5.1|ensemblmetazoa:ZK287.5.2	intact:EBI-330781|ensemblmetazoa:ZK856.1.1	psi-mi:rbx1_caeel(display_long)|uniprotkb:rbx-1(gene name)|psi-mi:rbx-1(display_short)|uniprotkb:Ce-rbx-1(gene name synonym)|uniprotkb:ZK287.5(orf name)	psi-mi:cul5_caeel(display_long)|uniprotkb:cul-5(gene name)|psi-mi:cul-5(display_short)|uniprotkb:ZK856.1(orf name)	psi-mi:"MI:0018"(two hybrid)	Sasagawa et al. (2007)	pubmed:17184777|imex:IM-11299|mint:MINT-5219499	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-3945992|imex:IM-11299-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_505496.1|wormbase:ZK287.5|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q23457|ensemblmetazoa:WBGene00004320(gene)|ensemblmetazoa:ZK287.5.1(transcript)|ensemblmetazoa:ZK287.5.2(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0051301"(cell division)|go:"GO:0051759"(sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902104"(positive regulation of metaphase/anaphase transition of meiotic cell cycle)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|reactome:R-CEL-110314|reactome:R-CEL-1234176|reactome:R-CEL-195253|reactome:R-CEL-5632684|reactome:R-CEL-5696394|reactome:R-CEL-5696395|reactome:R-CEL-6781823|reactome:R-CEL-6782135|reactome:R-CEL-6782210|reactome:R-CEL-68949|reactome:R-CEL-8854050|reactome:R-CEL-8932339|reactome:R-CEL-8939902|reactome:R-CEL-8951664|reactome:R-CEL-983168|reactome:R-CEL-4641258	refseq:NP_505616.2|wormbase:ZK856.1|mint:Q23639|dip:DIP-25847N|ensemblmetazoa:WBGene00000840(gene)|ensemblmetazoa:ZK856.1.1(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|reactome:R-CEL-8863795|reactome:R-CEL-8951664|reactome:R-CEL-983168	-	-	-	figure legend:Fig 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/01/17	2014/10/16	rogid:K9YFXD2x8iuzCtYyPx/bYHJnT4Q6239	rogid:XQMnpPKpITpy//FRZY0i6hxXnTA6239	intact-crc:C0AE9C83F4A0B99A|rigid:5239s0tLeOj9ARAKwrNwFKB2+cs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)