#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q15797	uniprotkb:Q13485	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187517|mint:MINT-4298076|imex:IM-11264-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298077(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-4298078(identity)	-	-	-	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lncap)|taxid:9606(Human caucasian prostate carcinoma)	-	2007/02/13	2014/10/16	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:B94CF056D0580379|rigid:p9fE9KQSdBzsx5uEluIc00Nq8/4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15797	uniprotkb:P10275	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187556|mint:MINT-4298130|imex:IM-11264-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298131(identity)	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N|mint:MINT-4298136(identity)	-	-	-	figure legend:F2D|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lncap)|taxid:9606(Human caucasian prostate carcinoma)	-	2007/02/13	2016/03/30	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	intact-crc:44D3CF39BF97A356|rigid:zZpMeamQbdmwxyAjQ9ViGe5c8ZA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P68366	uniprotkb:Q15797	intact:EBI-351772|uniprotkb:A8MUB1|uniprotkb:P05215|ensembl:ENSP00000248437|uniprotkb:B3KNQ6|intact:EBI-11134566	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:tba4a_human(display_long)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Testis-specific alpha-tubulin(gene name synonym)|uniprotkb:Tubulin H2-alpha(gene name synonym)|uniprotkb:TUBA1(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187544|mint:MINT-4298089|imex:IM-11264-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005991.1|ensembl:ENSG00000127824(gene)|ensembl:ENST00000248437(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68366|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|refseq:NP_001265481.1|mint:MINT-4298090(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298093(identity)	-	-	-	figure legend:F1B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-lncap)|taxid:9606(Human caucasian prostate carcinoma)	-	2007/02/13	2014/10/16	rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:9614D6A7079F2BA8|rigid:pINimf+Dgzk9VRQ+JZgl4S/MnYQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10275	uniprotkb:Q15797	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187577|mint:MINT-4298098|imex:IM-11264-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N|mint:MINT-4298099(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298102(identity)	-	-	-	figure legend:F2A|figure legend:F2B|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/02/13	2016/03/30	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:B7347CDE0F12189F|rigid:zZpMeamQbdmwxyAjQ9ViGe5c8ZA	false	-	flag tag:?-?(MINT-4298111)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10275	uniprotkb:Q15797	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187592|mint:MINT-4298170|imex:IM-11264-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N|mint:MINT-4298179(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298171(identity)	-	-	-	figure legend:F3E|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/02/13	2016/03/30	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:E03637F591D1AB7D|rigid:zZpMeamQbdmwxyAjQ9ViGe5c8ZA	false	-	flag tag:?-?(MINT-4298176)|mutation disrupting interaction:198-201(MINT-4298172)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q15797	uniprotkb:P10275	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187637|mint:MINT-4298114|imex:IM-11264-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298115(identity)	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N|mint:MINT-4298120(identity)	-	-	-	figure legend:F2C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/02/13	2016/03/30	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	intact-crc:EDDCEC7342B84983|rigid:zZpMeamQbdmwxyAjQ9ViGe5c8ZA	false	flag tag:?-?(MINT-4298117)	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10275	uniprotkb:Q15797	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0090"(protein complementation assay)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187681|mint:MINT-4298145|imex:IM-11264-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N|mint:MINT-4298149(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298146(identity)	-	-	-	figure legend:F3A|figure legend:F3C|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/02/13	2016/03/30	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:530CB99877C79A58|rigid:zZpMeamQbdmwxyAjQ9ViGe5c8ZA	false	yellow fluorescent protein tag:?-?(MINT-4298157)	yellow fluorescent protein tag:?-?(MINT-4298160)|mutation disrupting interaction:198-201(MINT-4298162)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10275	uniprotkb:Q15797	intact:EBI-608057|ensembl:ENSP00000363822|ensembl:ENSP00000484033|uniprotkb:A2RUN2|uniprotkb:B1AKD7|uniprotkb:Q9UD95|intact:EBI-11476138|uniprotkb:A0A0B4J1T2|uniprotkb:C0JKD3|uniprotkb:C0JKD4|uniprotkb:E7EVX6	intact:EBI-1567153|uniprotkb:Q16636|uniprotkb:D3DNZ9|uniprotkb:A8KAJ0|uniprotkb:Q9UFT8|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568	psi-mi:andr_human(display_long)|uniprotkb:Dihydrotestosterone receptor(gene name synonym)|uniprotkb:Nuclear receptor subfamily 3 group C member 4(gene name synonym)|uniprotkb:AR(gene name)|psi-mi:AR(display_short)|uniprotkb:DHTR(gene name synonym)|uniprotkb:NR3C4(gene name synonym)	psi-mi:smad1_human(display_long)|uniprotkb:Mad-related protein 1(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)|uniprotkb:Transforming growth factor-beta-signaling protein 1(gene name synonym)|uniprotkb:JV4-1(gene name synonym)|uniprotkb:SMAD1(gene name)|psi-mi:SMAD1(display_short)|uniprotkb:BSP1(gene name synonym)|uniprotkb:MADH1(gene name synonym)|uniprotkb:MADR1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Qiu et al. (2007)	pubmed:17183365|imex:IM-11264|mint:MINT-5219486	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-7187714|mint:MINT-4298190|imex:IM-11264-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000169083(gene)|ensembl:ENST00000374690(transcript)|ensembl:ENST00000612452(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003073"(regulation of systemic arterial blood pressure)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005496"(steroid binding)|go:"GO:0005497"(androgen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0019102"(male somatic sex determination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030518"(intracellular steroid hormone receptor signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0033327"(Leydig cell differentiation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045720"(negative regulation of integrin biosynthetic process)|go:"GO:0045726"(positive regulation of integrin biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0048638"(regulation of developmental growth)|go:"GO:0048645"(animal organ formation)|go:"GO:0048808"(male genitalia morphogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0051117"(ATPase binding)|go:"GO:0060520"(activation of prostate induction by androgen receptor signaling pathway)|go:"GO:0060571"(morphogenesis of an epithelial fold)|go:"GO:0060599"(lateral sprouting involved in mammary gland duct morphogenesis)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060748"(tertiary branching involved in mammary gland duct morphogenesis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070974"(POU domain binding)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071394"(cellular response to testosterone stimulus)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001103(Androgen receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P10275|rcsb pdb:1E3G|rcsb pdb:1GS4|rcsb pdb:1T5Z|rcsb pdb:1T63|rcsb pdb:1T65|rcsb pdb:1XJ7|rcsb pdb:1XOW|rcsb pdb:1XQ3|rcsb pdb:1Z95|rcsb pdb:2AM9|rcsb pdb:2AMA|rcsb pdb:2AMB|rcsb pdb:2AO6|rcsb pdb:2AX6|rcsb pdb:2AX7|rcsb pdb:2AX8|rcsb pdb:2AX9|rcsb pdb:2AXA|rcsb pdb:2HVC|rcsb pdb:2OZ7|rcsb pdb:2PIO|rcsb pdb:2PIP|rcsb pdb:2PIQ|rcsb pdb:2PIR|rcsb pdb:2PIT|rcsb pdb:2PIU|rcsb pdb:2PIV|rcsb pdb:2PIW|rcsb pdb:2PIX|rcsb pdb:2PKL|rcsb pdb:2PNU|rcsb pdb:2Q7I|rcsb pdb:2Q7J|rcsb pdb:2Q7K|rcsb pdb:2Q7L|rcsb pdb:2YHD|rcsb pdb:2YLO|rcsb pdb:2YLP|rcsb pdb:2YLQ|rcsb pdb:2Z4J|rcsb pdb:3B5R|rcsb pdb:3B65|rcsb pdb:3B66|rcsb pdb:3B67|rcsb pdb:3B68|rcsb pdb:3BTR|rcsb pdb:3L3X|rcsb pdb:3L3Z|rcsb pdb:3RLJ|rcsb pdb:3RLL|rcsb pdb:3V49|rcsb pdb:3V4A|rcsb pdb:3ZQT|rcsb pdb:4HLW|rcsb pdb:4K7A|rcsb pdb:4OEA|rcsb pdb:4OED|rcsb pdb:4OEY|rcsb pdb:4OEZ|rcsb pdb:4OFR|rcsb pdb:4OFU|rcsb pdb:4OGH|rcsb pdb:4OH5|rcsb pdb:4OH6|rcsb pdb:4OHA|rcsb pdb:4OIL|rcsb pdb:4OIU|rcsb pdb:4OJ9|rcsb pdb:4OJB|rcsb pdb:4OK1|rcsb pdb:4OKB|rcsb pdb:4OKT|rcsb pdb:4OKW|rcsb pdb:4OKX|rcsb pdb:4OLM|rcsb pdb:4QL8|rcsb pdb:5CJ6|rcsb pdb:5JJM|rcsb pdb:5T8E|rcsb pdb:5T8J|rcsb pdb:5V8Q|rcsb pdb:5VO4|reactome:R-HSA-3371497|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-8940973|refseq:NP_000035.2|ensembl:ENSP00000363822|ensembl:ENST00000504326|ensembl:ENSP00000421155|ensembl:ENSP00000484033|refseq:NP_001011645.1|refseq:NP_001334990.1|refseq:NP_001334992.1|refseq:NP_001334993.1|dip:DIP-125N|mint:MINT-4298199(identity)	refseq:XP_006714280.1|refseq:NP_001003688.1|refseq:NP_005891.1|refseq:XP_011530263.1|refseq:XP_011530264.1|refseq:XP_011530265.1|refseq:XP_011530266.1|refseq:XP_005263049.1|ensembl:ENSP00000305769|ensembl:ENSP00000377652|ensembl:ENSP00000426568|dip:DIP-38538N|ensembl:ENSG00000170365(gene)|ensembl:ENST00000302085(transcript)|ensembl:ENST00000394092(transcript)|ensembl:ENST00000515385(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007276"(gamete generation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15797|rcsb pdb:1KHU|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LAZ|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:3Q47|rcsb pdb:3Q4A|rcsb pdb:5ZOK|reactome:R-HSA-201451|reactome:R-HSA-5689880|reactome:R-HSA-8941326|mint:MINT-4298191(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:F5A|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2007/02/13	2016/03/30	rogid:fsxn0EE6wCkb0Y9BsdUtB+FmHAg9606	rogid:cdDNFpwLw2+hPeP0l6ArvDs3LMo9606	intact-crc:38C32B47793C6FC4|rigid:zZpMeamQbdmwxyAjQ9ViGe5c8ZA	false	yellow fluorescent protein tag:?-?(MINT-4298212)	yellow fluorescent protein tag:?-?(MINT-4298192)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)