#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QWL7	uniprotkb:O70456	intact:EBI-309015|uniprotkb:A2A4G6|uniprotkb:Q61783|ensembl:ENSMUSP00000079699	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	psi-mi:k1c17_mouse(display_long)|uniprotkb:Krt17(gene name)|psi-mi:Krt17(display_short)|uniprotkb:Krt1-17(gene name synonym)|uniprotkb:Keratin-17(gene name synonym)|uniprotkb:Cytokeratin-17(gene name synonym)	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Kim et al. (2006)	pubmed:16710422	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1544116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034793.1|ensembl:ENSMUST00000080893(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|ensembl:ENSMUSG00000035557(gene)|interpro:IPR018039|interpro:IPR039008|reactome:R-MMU-6805567|reactome:R-MMU-6809371|dip:DIP-38042N	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)	-	-	-	figure legend:Supplementary Figures 3a-c.|stimulant:"By okadaic acid (a serine/threonine phosphatase inhibitor) and by orthophosphates."|comment:Krt17 interacts with 14-3-3sigma in a phosphorylation-dependent manner.	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2007/10/09	2014/10/16	rogid:uYWtsA+Ww8fmNUaN3FacAvFZ3Rc10090	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	intact-crc:090364EC5B3753F1|rigid:l9oZgWgsG3ghLhgasEldoHhRpNI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O70456	uniprotkb:Q9QWL7	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	intact:EBI-309015|uniprotkb:A2A4G6|uniprotkb:Q61783|ensembl:ENSMUSP00000079699	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:k1c17_mouse(display_long)|uniprotkb:Krt17(gene name)|psi-mi:Krt17(display_short)|uniprotkb:Krt1-17(gene name synonym)|uniprotkb:Keratin-17(gene name synonym)|uniprotkb:Cytokeratin-17(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kim et al. (2006)	pubmed:16710422	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1545081	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)	refseq:NP_034793.1|ensembl:ENSMUST00000080893(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|ensembl:ENSMUSG00000035557(gene)|interpro:IPR018039|interpro:IPR039008|reactome:R-MMU-6805567|reactome:R-MMU-6809371|dip:DIP-38042N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Supplementary Figure 3d|stimulant:By wounded or stressed epithelium.|comment:"The authors noted that \". Like K17 protein , 14-3-3 sigma protein; is clearly induced in the wound edge epithelium after skin injury \"."	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2007/10/09	2014/10/16	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	rogid:uYWtsA+Ww8fmNUaN3FacAvFZ3Rc10090	intact-crc:FB3875F7C6D3C30A|rigid:l9oZgWgsG3ghLhgasEldoHhRpNI	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9QWL7	uniprotkb:O70456	intact:EBI-309015|uniprotkb:A2A4G6|uniprotkb:Q61783|ensembl:ENSMUSP00000079699	intact:EBI-1544118|uniprotkb:Q3TEZ1|ensembl:ENSMUSP00000050374	psi-mi:k1c17_mouse(display_long)|uniprotkb:Krt17(gene name)|psi-mi:Krt17(display_short)|uniprotkb:Krt1-17(gene name synonym)|uniprotkb:Keratin-17(gene name synonym)|uniprotkb:Cytokeratin-17(gene name synonym)	psi-mi:1433s_mouse(display_long)|uniprotkb:Sfn(gene name)|psi-mi:Sfn(display_short)|uniprotkb:Mkrn3(gene name synonym)|uniprotkb:Stratifin(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Kim et al. (2006)	pubmed:16710422	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1545113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034793.1|ensembl:ENSMUST00000080893(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|ensembl:ENSMUSG00000035557(gene)|interpro:IPR018039|interpro:IPR039008|reactome:R-MMU-6805567|reactome:R-MMU-6809371|dip:DIP-38042N	refseq:NP_061224.2|ensembl:ENSMUSG00000047281(gene)|ensembl:ENSMUST00000057311(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0003334"(keratinocyte development)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031424"(keratinization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0045606"(positive regulation of epidermal cell differentiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|interpro:IPR037435|mint:O70456|reactome:R-MMU-111447|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-6804114|reactome:R-MMU-75035|reactome:R-MMU-9614399|go:"GO:0030307"(positive regulation of cell growth)	-	-	-	figure legend:Supplementary Figures 4a,b.|comment:Relative to wild-type Krt17, its' interaction with 14-3-3sigma, in transfected cells, was significantly reduced in the single mutants T9A and S44A as well as with the double mutant T9A/S44A.	taxid:10036(mesau-bhk21)|taxid:10036(Mesocricetus auratus_BHK21)	-	2007/10/09	2014/10/16	rogid:uYWtsA+Ww8fmNUaN3FacAvFZ3Rc10090	rogid:6B8XqFSuqdwWT6hYap/ecmwIuaY10090	intact-crc:068788AFE532B7DB|rigid:l9oZgWgsG3ghLhgasEldoHhRpNI	false	binding-associated region:44-44|binding-associated region:9-9	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)