#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QWL7	uniprotkb:Q3U0V2	intact:EBI-309015|uniprotkb:A2A4G6|uniprotkb:Q61783|ensembl:ENSMUSP00000079699	intact:EBI-1544032|ensembl:ENSMUSP00000034359	psi-mi:k1c17_mouse(display_long)|uniprotkb:Krt17(gene name)|psi-mi:Krt17(display_short)|uniprotkb:Krt1-17(gene name synonym)|uniprotkb:Keratin-17(gene name synonym)|uniprotkb:Cytokeratin-17(gene name synonym)	psi-mi:tradd_mouse(display_long)|uniprotkb:Tradd(gene name)|psi-mi:Tradd(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tong et al. (2006)	pubmed:16702408|imex:IM-18876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1544031|imex:IM-18876-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034793.1|ensembl:ENSMUST00000080893(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|ensembl:ENSMUSG00000035557(gene)|interpro:IPR018039|interpro:IPR039008|reactome:R-MMU-6805567|reactome:R-MMU-6809371|dip:DIP-38042N	refseq:NP_001028333.1|dip:DIP-38039N|ensembl:ENSMUSG00000031887(gene)|ensembl:ENSMUST00000034359(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75893	-	-	-	figure legend:Figure 3A,A'|comment:Krt17 associates with endogenous TRADD.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2007/10/08	2014/10/16	rogid:uYWtsA+Ww8fmNUaN3FacAvFZ3Rc10090	rogid:mlpT7wj+kR184H5CFZnqmlPz52810090	intact-crc:703CE1AFF5F3CFC2|rigid:gXhAGF2NL678CDQv3H7vngl7yi0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z2K1	uniprotkb:Q3U0V2	intact:EBI-1544045|ensembl:ENSMUSP00000007280	intact:EBI-1544032|ensembl:ENSMUSP00000034359	psi-mi:k1c16_mouse(display_long)|uniprotkb:Krt16(gene name)|psi-mi:Krt16(display_short)|uniprotkb:Krt1-16(gene name synonym)|uniprotkb:Cytokeratin-16(gene name synonym)|uniprotkb:Keratin-16(gene name synonym)	psi-mi:tradd_mouse(display_long)|uniprotkb:Tradd(gene name)|psi-mi:Tradd(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tong et al. (2006)	pubmed:16702408|imex:IM-18876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1544056|imex:IM-18876-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032496.1|refseq:NP_001300887.1|ensembl:ENSMUSG00000053797(gene)|ensembl:ENSMUST00000007280(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031424"(keratinization)|go:"GO:0042633"(hair cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051546"(keratinocyte migration)|go:"GO:0061436"(establishment of skin barrier)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:Q9Z2K1|reactome:R-MMU-6805567|reactome:R-MMU-6809371	refseq:NP_001028333.1|dip:DIP-38039N|ensembl:ENSMUSG00000031887(gene)|ensembl:ENSMUST00000034359(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75893	-	-	-	figure legend:Figure 3A,A'|comment:Krt16 associates with endogenous TRADD.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2007/10/08	2014/10/16	rogid:wQ1QCXMjW6QE0hlRyTP7NQO8dE410090	rogid:mlpT7wj+kR184H5CFZnqmlPz52810090	intact-crc:6240D994307BDA31|rigid:sGxdjZGSBF9jBm64fW61n0ZTwkk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61781	uniprotkb:Q3U0V2	intact:EBI-1544062|uniprotkb:Q91VQ4|uniprotkb:A2A4G4|uniprotkb:Q99LE0|ensembl:ENSMUSP00000007272	intact:EBI-1544032|ensembl:ENSMUSP00000034359	psi-mi:k1c14_mouse(display_long)|uniprotkb:Krt14(gene name)|psi-mi:Krt14(display_short)|uniprotkb:Krt1-14(gene name synonym)|uniprotkb:Cytokeratin-14(gene name synonym)|uniprotkb:Keratin-14(gene name synonym)	psi-mi:tradd_mouse(display_long)|uniprotkb:Tradd(gene name)|psi-mi:Tradd(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tong et al. (2006)	pubmed:16702408|imex:IM-18876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1544072|imex:IM-18876-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058654.1|refseq:NP_001300886.1|ensembl:ENSMUSG00000045545(gene)|ensembl:ENSMUST00000007272(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0007568"(aging)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0042633"(hair cycle)|go:"GO:0045095"(keratin filament)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045178"(basal part of cell)|go:"GO:0071944"(cell periphery)|go:"GO:1990254"(keratin filament binding)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-MMU-446107|reactome:R-MMU-6805567|reactome:R-MMU-6809371	refseq:NP_001028333.1|dip:DIP-38039N|ensembl:ENSMUSG00000031887(gene)|ensembl:ENSMUST00000034359(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75893	-	-	-	figure legend:Figure 3A,A'|comment:Krt14 associates with endogenous TRADD.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2007/10/08	2014/10/16	rogid:X0xTBD0eCqpufLNoV8ANeICLNdo10090	rogid:mlpT7wj+kR184H5CFZnqmlPz52810090	intact-crc:EFA5D53FBFDBBA40|rigid:nl4RJkvhmAwY6o08+Rv3/YaXCJ4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3U0V2	uniprotkb:Q9QWL7	intact:EBI-1544032|ensembl:ENSMUSP00000034359	intact:EBI-309015|uniprotkb:A2A4G6|uniprotkb:Q61783|ensembl:ENSMUSP00000079699	psi-mi:tradd_mouse(display_long)|uniprotkb:Tradd(gene name)|psi-mi:Tradd(display_short)|uniprotkb:TNFRSF1A-associated via death domain(gene name synonym)	psi-mi:k1c17_mouse(display_long)|uniprotkb:Krt17(gene name)|psi-mi:Krt17(display_short)|uniprotkb:Krt1-17(gene name synonym)|uniprotkb:Keratin-17(gene name synonym)|uniprotkb:Cytokeratin-17(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Tong et al. (2006)	pubmed:16702408|imex:IM-18876	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1544093|imex:IM-18876-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028333.1|dip:DIP-38039N|ensembl:ENSMUSG00000031887(gene)|ensembl:ENSMUST00000034359(transcript)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0070513"(death domain binding)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR000488(Death)|interpro:IPR009095(TRADD, N-terminal)|interpro:IPR011029(DEATH-like)|interpro:IPR035712|interpro:IPR036729|reactome:R-MMU-3371378|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5675482|reactome:R-MMU-69416|reactome:R-MMU-75893	refseq:NP_034793.1|ensembl:ENSMUST00000080893(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|ensembl:ENSMUSG00000035557(gene)|interpro:IPR018039|interpro:IPR039008|reactome:R-MMU-6805567|reactome:R-MMU-6809371|dip:DIP-38042N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:"Figure 3B-B\", 3C-C\"."|comment:"It was observed that both full-length TRADD (AA 1-312) and its C-terminal moiety (AA 105-312) partially colocalize with K17 in the cytoplasm. In contrast, the N-terminus of TRADD (AA 1-105) showed a diffuse distribution in the cytoplasm and nucleus."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-epithelium)|taxid:10090(Mus musculus)	-	2007/10/08	2014/10/16	rogid:mlpT7wj+kR184H5CFZnqmlPz52810090	rogid:uYWtsA+Ww8fmNUaN3FacAvFZ3Rc10090	intact-crc:A936FB7E1FA741AB|rigid:gXhAGF2NL678CDQv3H7vngl7yi0	false	enhanced green fluorescent protein tag:?-?|sufficient binding region:?-?	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)