#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15304	uniprotkb:P26842	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	intact:EBI-520729|uniprotkb:B2RDZ0|ensembl:ENSP00000266557	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:cd27_human(display_long)|uniprotkb:CD27L receptor(gene name synonym)|uniprotkb:T-cell activation antigen CD27(gene name synonym)|uniprotkb:T14(gene name synonym)|uniprotkb:Tumor necrosis factor receptor superfamily member 7(gene name synonym)|uniprotkb:CD27(gene name)|psi-mi:CD27(display_short)|uniprotkb:TNFRSF7(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nestler et al. (2006)	pubmed:16683188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1392919	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304	refseq:NP_001233.1|ensembl:ENSG00000139193(gene)|ensembl:ENST00000266557(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022328|interpro:IPR034000|rcsb pdb:5TL5|rcsb pdb:5TLJ|rcsb pdb:5TLK|reactome:R-HSA-5669034	-	-	-	figure legend:2B and 2C|comment:"SIVA1 fragment 1-64 and isoform siva-2 (O15304-2) showed low interactions only."|comment:Co-expression of oxsackievirus B3 capsid protein VP2 abolished the interaction.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/10	2014/10/16	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	rogid:7kwsm9SZO70EBVpV0lNGNo6zxeE9606	intact-crc:5840E339E4C045F2|rigid:AKC2z8jyihwJhekBNn4X53oZeJs	false	binding-associated region:1-127	binding-associated region:213-260	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P07278	uniprotkb:P07278	intact:EBI-9475|ensemblfungi:YIL033C|uniprotkb:D6VVP9	intact:EBI-9475|ensemblfungi:YIL033C|uniprotkb:D6VVP9	psi-mi:kapr_yeast(display_long)|uniprotkb:YIL033C(locus name)|uniprotkb:BCY1(gene name)|psi-mi:BCY1(display_short)|uniprotkb:REG1(gene name synonym)|uniprotkb:SRA1(gene name synonym)|uniprotkb:Bypass of cyclase mutations protein 1(gene name synonym)|uniprotkb:Protein kinase A regulatory subunit(gene name synonym)	psi-mi:kapr_yeast(display_long)|uniprotkb:YIL033C(locus name)|uniprotkb:BCY1(gene name)|psi-mi:BCY1(display_short)|uniprotkb:REG1(gene name synonym)|uniprotkb:SRA1(gene name synonym)|uniprotkb:Bypass of cyclase mutations protein 1(gene name synonym)|uniprotkb:Protein kinase A regulatory subunit(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nestler et al. (2006)	pubmed:16683188	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1392926	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YIL033C(gene)|ensemblfungi:YIL033C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0036278"(positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0097271"(protein localization to bud neck)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:3OF1|rcsb pdb:6XQK|refseq:NP_012231.1|sgd:S000001295|mint:P07278|dip:DIP-551N	ensemblfungi:YIL033C(gene)|ensemblfungi:YIL033C_mRNA(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0036278"(positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0061406"(positive regulation of transcription from RNA polymerase II promoter in response to glucose starvation)|go:"GO:0097271"(protein localization to bud neck)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|rcsb pdb:3OF1|rcsb pdb:6XQK|refseq:NP_012231.1|sgd:S000001295|mint:P07278|dip:DIP-551N	-	crc64:6D7D97D8E4340AF3	crc64:6D7D97D8E4340AF3	figure legend:2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/10	2014/10/16	rogid:rSJ37UFoFiaHqc/2W5eYNx1qpbg559292	rogid:rSJ37UFoFiaHqc/2W5eYNx1qpbg559292	intact-crc:C5ECF2CD78F079CA|rigid:vIoa2MoQKXZJI1R1NavT/DJxq3c	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NR77	uniprotkb:O15304	intact:EBI-1392944|ensembl:ENSP00000321271	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	psi-mi:pxmp2_human(display_long)|uniprotkb:PXMP2(gene name)|psi-mi:PXMP2(display_short)|uniprotkb:PMP22(gene name synonym)|uniprotkb:22 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Nestler et al. (2006)	pubmed:16683188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1392951	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061133.1|ensembl:ENSG00000176894(gene)|ensembl:ENST00000317479(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|interpro:IPR007248(Mpv17/PMP22)|reactome:R-HSA-389661|reactome:R-HSA-9603798	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304	-	-	-	figure legend:3A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2007/09/10	2014/10/16	rogid:YujoZztq9Zk8jAMeODfHj8Op1gQ9606	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	intact-crc:FEF5202F14DA7179|rigid:6iOdvOz4ohgo32wE0HH5gyjCAGg	false	-	-	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NR77	uniprotkb:O15304	intact:EBI-1392944|ensembl:ENSP00000321271	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	psi-mi:pxmp2_human(display_long)|uniprotkb:PXMP2(gene name)|psi-mi:PXMP2(display_short)|uniprotkb:PMP22(gene name synonym)|uniprotkb:22 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nestler et al. (2006)	pubmed:16683188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1392967	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061133.1|ensembl:ENSG00000176894(gene)|ensembl:ENST00000317479(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|interpro:IPR007248(Mpv17/PMP22)|reactome:R-HSA-389661|reactome:R-HSA-9603798	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304	-	-	-	figure legend:3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/10	2014/10/16	rogid:YujoZztq9Zk8jAMeODfHj8Op1gQ9606	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	intact-crc:3E3FC032A255F400|rigid:6iOdvOz4ohgo32wE0HH5gyjCAGg	false	myc tag:?-?	maltose binding protein tag:?-?|binding-associated region:1-127	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NR77	uniprotkb:O15304	intact:EBI-1392944|ensembl:ENSP00000321271	intact:EBI-520756|uniprotkb:Q96P98|uniprotkb:Q9UPD6|ensembl:ENSP00000329213	psi-mi:pxmp2_human(display_long)|uniprotkb:PXMP2(gene name)|psi-mi:PXMP2(display_short)|uniprotkb:PMP22(gene name synonym)|uniprotkb:22 kDa peroxisomal membrane protein(gene name synonym)	psi-mi:siva_human(display_long)|uniprotkb:CD27-binding protein(gene name synonym)|uniprotkb:SIVA1(gene name)|psi-mi:SIVA1(display_short)|uniprotkb:SIVA(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nestler et al. (2006)	pubmed:16683188	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-1392981	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061133.1|ensembl:ENSG00000176894(gene)|ensembl:ENST00000317479(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|interpro:IPR007248(Mpv17/PMP22)|reactome:R-HSA-389661|reactome:R-HSA-9603798	refseq:NP_006418.2|refseq:NP_068355.1|ensembl:ENSG00000184990(gene)|ensembl:ENST00000329967(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005175"(CD27 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0008270"(zinc ion binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|interpro:IPR022773|mint:O15304	-	-	-	figure legend:3B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2007/09/10	2014/10/16	rogid:YujoZztq9Zk8jAMeODfHj8Op1gQ9606	rogid:ZSaEOpu8SYAilgfYzcK/EGgUoiI9606	intact-crc:5C6105B15EE1FCE1|rigid:6iOdvOz4ohgo32wE0HH5gyjCAGg	false	myc tag:?-?	glutathione s tranferase tag:?-?|binding-associated region:1-64	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)