#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P62993 uniprotkb:O14939 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9 psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short) psi-mi:"MI:0096"(pull down) Di et al. (2006) imex:IM-14947|pubmed:16407827|mint:MINT-6731738 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1382080|imex:IM-14947-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N psi-mi:"MI:0469"(intact) - - figure legend:1 and 2|comment:Purified Grb2 caused an 80% reduction in mycPLD2 bound to Sepharose beads.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2007/08/09 2014/10/16 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606 intact-crc:EAB01C2EE89A5C7D|rigid:2zXcO5GZM9YlFnF4aR9CkMDopJg false glutathione s tranferase tag:n-n|mutation decreasing interaction strength:86-86 myc tag:n-n - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O14939 intact:EBI-1263369 intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9 - psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short) psi-mi:grb2_cerae_protein(display_short)|psi-mi:EBI-1263369(display_long) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Di et al. (2006) imex:IM-14947|pubmed:16407827|mint:MINT-6731738 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1382108|imex:IM-14947-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P62993 figure legend:3, 4b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/08/09 2014/10/16 rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606 - intact-crc:2AF1C3790C3CAAED false myc tag:?-?|O4'-phospho-L-tyrosine:178-178|mutation decreasing interaction:178-180|mutation decreasing interaction:179-179|mutation decreasing interaction:179-179,181-181 - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O14939 intact:EBI-1263369 intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9 - psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short) psi-mi:grb2_cerae_protein(display_short)|psi-mi:EBI-1263369(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Di et al. (2006) imex:IM-14947|pubmed:16407827|mint:MINT-6731738 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1382164|imex:IM-14947-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:Similar to P62993 figure legend:3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/08/09 2014/10/16 rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606 - intact-crc:DBCE4C31C566C725 false myc tag:?-?|mutation decreasing interaction:169-169|mutation disrupting interaction:179-179,169-169|mutation decreasing interaction:179-179 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O14939 intact:EBI-1382019 intact:EBI-1053996|uniprotkb:O43540|uniprotkb:O43579|uniprotkb:O43580|uniprotkb:Q96BY3|uniprotkb:Q6PGR0|ensembl:ENSP00000263088|uniprotkb:I3L2C9 - psi-mi:pld2_human(display_long)|uniprotkb:Choline phosphatase 2(gene name synonym)|uniprotkb:Phosphatidylcholine-hydrolyzing phospholipase D2(gene name synonym)|uniprotkb:PLD1C(gene name synonym)|uniprotkb:PLD2(gene name)|psi-mi:PLD2(display_short) psi-mi:sos_chlae_protein(display_short)|psi-mi:EBI-1382019(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Di et al. (2006) imex:IM-14947|pubmed:16407827|mint:MINT-6731738 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9534(chlae)|taxid:9534(Chlorocebus aethiops) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-1382185|imex:IM-14947-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001230037.1|refseq:NP_002654.3|ensembl:ENSG00000129219(gene)|ensembl:ENST00000263088(transcript)|go:"GO:0004630"(phospholipase D activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006654"(phosphatidic acid biosynthetic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0038096"(Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:0048017"(inositol lipid-mediated signaling)|go:"GO:0048870"(cell motility)|go:"GO:0070290"(N-acylphosphatidylethanolamine-specific phospholipase D activity)|go:"GO:0098793"(presynapse)|interpro:IPR001683(Phox-like)|interpro:IPR001736(Phospholipase D/Transphosphatidylase)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015679(Phospholipase D)|interpro:IPR016555(Phospholipase D, eukaryota)|interpro:IPR025202|interpro:IPR036871|mint:O14939|rcsb pdb:6OHM|rcsb pdb:6OHO|rcsb pdb:6OHP|rcsb pdb:6OHQ|rcsb pdb:6OHS|reactome:R-HSA-1483148|reactome:R-HSA-1483166|reactome:R-HSA-2029485|reactome:R-HSA-9013149|reactome:R-HSA-9013404|dip:DIP-38903N uniprotkb:P26675(see-also) psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:7|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2007/08/09 2014/10/16 rogid:uQUYSNYIk5D3fQ8oB/67Oo2/eOE9606 - intact-crc:705203865C83EE8A false mutation decreasing interaction:179-179|myc tag:?-?|mutation decreasing interaction:169-169 - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)