#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P10815	uniprotkb:P04551	intact:EBI-1187843|uniprotkb:Q9UU16|ensemblfungi:"SPBC582.03.1:pep"	intact:EBI-1187862|ensemblfungi:"SPBC11B10.09.1:pep"	psi-mi:cg23_schpo(display_long)|uniprotkb:cdc13(gene name)|psi-mi:cdc13(display_short)|uniprotkb:SPBC582.03(orf name)	psi-mi:cdk1_schpo(display_long)|uniprotkb:cdc2(gene name)|psi-mi:cdc2(display_short)|uniprotkb:swo2(gene name synonym)|uniprotkb:SPBC11B10.09(orf name)|uniprotkb:pi002(orf name)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:cdk1(gene name synonym)|uniprotkb:Cell division control protein 2(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Turnbull et al. (2006)	pubmed:16390871|imex:IM-19937	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1209055|imex:IM-19937-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595171.1|ensemblfungi:SPBC582.03(gene)|ensemblfungi:SPBC582.03.1(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0051301"(cell division)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0072686"(mitotic spindle)|go:"GO:0072687"(meiotic spindle)|go:"GO:0075297"(negative regulation of ascospore formation)|go:"GO:0140013"(meiotic nuclear division)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR036915|interpro:IPR039361|go:"GO:0140445"(chromosome, telomeric repeat region)|dip:DIP-620N|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-5687128|reactome:R-SPO-5689880|reactome:R-SPO-68949|reactome:R-SPO-69656|reactome:R-SPO-75815|reactome:R-SPO-8951664|reactome:R-SPO-983168	refseq:NP_595629.1|reactome:R-SPO-176187|ensemblfungi:SPBC11B10.09(gene)|ensemblfungi:SPBC11B10.09.1(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0031031"(positive regulation of septation initiation signaling)|go:"GO:0031138"(negative regulation of conjugation with cellular fusion)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031568"(mitotic G1 cell size control checkpoint signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035974"(meiotic spindle pole body)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0061245"(establishment or maintenance of bipolar cell polarity)|go:"GO:0062123"(regulation of linear element maturation)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0072435"(response to mitotic G2 DNA damage checkpoint signaling)|go:"GO:0072441"(response to meiotic DNA replication checkpoint signaling)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110044"(regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0110045"(negative regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1902424"(negative regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902845"(negative regulation of mitotic spindle elongation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1904514"(positive regulation of initiation of premeiotic DNA replication)|go:"GO:1904537"(negative regulation of mitotic telomere tethering at nuclear periphery)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905263"(positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:1905757"(negative regulation of primary cell septum biogenesis)|go:"GO:1905785"(negative regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990820"(response to mitotic DNA integrity checkpoint signaling)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-1076N|reactome:R-SPO-68962|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-68949|reactome:R-SPO-69656	-	crc64:B2C267CF57F5FD36	-	figure legend:Figure 6A and 6B.|comment:"Western blot analysis with the anti-PSTAIR antibody revealed that the level of Cdc2 that co-precipitated with Cdc13 was reduced in cdc37ts mutant cells (cdc37-184:-ala284asp and cdc37-681:-leu285pro) incubated at 36c which may result from a breakdown of the Cdc2-Cdc13 complex, or an inability to maintain the complex. This infers that cdc37 may be involved in the formation of the cdc13-cdc2 complex."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/03/01	2014/10/16	rogid:18Ti7CkkGHpRMlPyXO+5ENZFIn4284812	rogid:Xm26f9FnmjG9I6P1hrk/9kWszzY284812	intact-crc:96E2E66FACD852A5|rigid:4AjXHPHEzVQaqstDCvZSHMm69eA	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04551	uniprotkb:O94740	intact:EBI-1187862|ensemblfungi:"SPBC11B10.09.1:pep"	intact:EBI-1209056|ensemblfungi:"SPBC9B6.10.1:pep"	psi-mi:cdk1_schpo(display_long)|uniprotkb:cdc2(gene name)|psi-mi:cdc2(display_short)|uniprotkb:swo2(gene name synonym)|uniprotkb:SPBC11B10.09(orf name)|uniprotkb:pi002(orf name)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:cdk1(gene name synonym)|uniprotkb:Cell division control protein 2(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:cdc37_schpo(display_long)|uniprotkb:cdc37(gene name)|psi-mi:cdc37(display_short)|uniprotkb:SPBC9B6.10(orf name)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:Cell division control protein 37(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Turnbull et al. (2006)	pubmed:16390871|imex:IM-19937	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	taxid:284812(schpo)|taxid:284812("Schizosaccharomyces pombe (strain ATCC 38366 / 972)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-1209245|imex:IM-19937-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_595629.1|reactome:R-SPO-176187|ensemblfungi:SPBC11B10.09(gene)|ensemblfungi:SPBC11B10.09.1(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001100"(negative regulation of exit from mitosis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030332"(cyclin binding)|go:"GO:0031031"(positive regulation of septation initiation signaling)|go:"GO:0031138"(negative regulation of conjugation with cellular fusion)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0031568"(mitotic G1 cell size control checkpoint signaling)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035974"(meiotic spindle pole body)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0044732"(mitotic spindle pole body)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0061245"(establishment or maintenance of bipolar cell polarity)|go:"GO:0062123"(regulation of linear element maturation)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0072435"(response to mitotic G2 DNA damage checkpoint signaling)|go:"GO:0072441"(response to meiotic DNA replication checkpoint signaling)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110044"(regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0110045"(negative regulation of cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0140429"(positive regulation of mitotic sister chromatid biorientation)|go:"GO:0140445"(chromosome, telomeric repeat region)|go:"GO:1902424"(negative regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902845"(negative regulation of mitotic spindle elongation)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903380"(positive regulation of mitotic chromosome condensation)|go:"GO:1903465"(positive regulation of mitotic cell cycle DNA replication)|go:"GO:1903467"(negative regulation of mitotic DNA replication initiation)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1904514"(positive regulation of initiation of premeiotic DNA replication)|go:"GO:1904537"(negative regulation of mitotic telomere tethering at nuclear periphery)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905263"(positive regulation of meiotic DNA double-strand break formation involved in reciprocal meiotic recombination)|go:"GO:1905757"(negative regulation of primary cell septum biogenesis)|go:"GO:1905785"(negative regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:1990820"(response to mitotic DNA integrity checkpoint signaling)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|dip:DIP-1076N|reactome:R-SPO-68962|reactome:R-SPO-69017|reactome:R-SPO-69202|reactome:R-SPO-68949|reactome:R-SPO-69656	refseq:NP_595752.1|interpro:IPR004918(Cdc37)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR038189|ensemblfungi:SPBC9B6.10(gene)|ensemblfungi:SPBC9B6.10.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007049"(cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0061077"(chaperone-mediated protein folding)|reactome:R-SPO-114608	-	-	-	figure legend:Figure 6C.|comment:There was an interaction between between cdc2 and cdc37 but the level of Cdc2 that co-precipitated with Cdc37 was reduced in cdc37ts mutants incubated at both 28 and 36c. Also in the reverse immunoprecipitatin using a HA-tagged strain ED1576, there was no detectable interaction between cdc2 and cdc37.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4896(schpm)|taxid:4896("Schizosaccharomyces pombe (fission yeast)")	-	2007/03/01	2014/10/16	rogid:Xm26f9FnmjG9I6P1hrk/9kWszzY284812	rogid:V4yE1QZfllW8vlgVdunL3eIkrIw284812	intact-crc:14063FCEF76416F0|rigid:ehS6Z31FGGmFuLYhiLCPoqC+uww	false	-	mutation decreasing interaction:287-287|mutation decreasing interaction:285-285	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)